Related by context. All words. (Click for frequent words.) 71 breast carcinomas 70 Hurthle cell 70 basal cell carcinoma BCC 70 Squamous 70 neoplasm 70 epithelial tumors 70 mucinous 69 pancreatic adenocarcinoma 69 histologic subtype 69 neoplasias 69 histologies 69 GISTs 69 nonmelanoma skin cancers 68 papillary 68 hepatocellular carcinomas 68 epithelioid 68 Papillary 68 papillary renal cell carcinoma 68 osteosarcomas 68 neoplastic 67 pancreatic carcinoma 67 ASCUS 67 thymoma 67 gastric adenocarcinoma 67 metastatic neuroendocrine tumors 67 cell carcinoma 67 hyperplastic 67 neurofibromas 67 essential thrombocythemia 67 ANCA associated 67 endometrioid 67 sarcomatoid 67 urothelial carcinoma 67 renal cell carcinomas 66 HBeAg negative 66 histological subtype 66 grade cervical intraepithelial 66 leiomyoma 66 pleomorphic 66 lung carcinomas 66 non squamous 66 pheochromocytoma 66 metaplasia 66 myelofibrosis polycythemia vera 66 cervical carcinoma 66 Basal cell 66 Sezary syndrome 66 nodular 66 carcinoid 66 gastrointestinal stromal tumor 66 intestinal metaplasia 66 pituitary adenomas 66 MALT lymphoma 66 non squamous NSCLC 66 skeletal metastases 66 renal tumors 66 squamous cell carcinoma SCC 66 hamartomas 66 follicular thyroid cancer 66 superficial basal cell carcinoma 65 histopathologic examination 65 mycosis fungoides 65 bullous 65 basal cell nevus syndrome 65 esophageal carcinoma 65 adenomatous polyps 65 metastatic GIST 65 paraganglioma 65 leiomyomas 65 meningiomas 65 paragangliomas 65 polypoid 65 solar keratoses 65 malignant fibrous histiocytoma 65 tumor xenograft models 65 cell carcinomas 65 prostate carcinoma 65 adenocarcinomas 65 papillomas 65 HGPIN 65 NMIBC 65 gastric carcinoma 65 histologic 65 Immunohistochemical staining 65 carcinomas 65 carcinoids 65 elevated LDH 65 Histologically 64 lymph node metastases 64 histopathologic 64 tumoral 64 squamous cell cancers 64 calculi 64 CIN3 64 tigecycline 64 K ras mutations 64 cutaneous melanoma 64 KRAS wild 64 pT3 64 bronchogenic carcinoma 64 invasive carcinomas 64 neoplastic lesions 64 malignant ovarian 64 unresectable 64 microsatellite instability 64 metastatic lesions 64 pulmonary metastasis 64 carcinoid tumors 64 immunohistochemical 64 colorectal carcinoma 64 Soft Tissue Sarcoma 64 granulomatous 64 advanced adenomas 64 fallopian tube cancers 64 SCCHN 64 neoplasms 64 lobular carcinoma 64 familial amyloidotic polyneuropathy FAP 64 pleural fluid 64 metastatic malignant melanoma 64 hematologic disorders 64 benign neoplasms 64 candidemia 64 squamous cell 64 resectable 63 situ CIS 63 Leukemias 63 nonmelanoma skin cancer 63 cytologically confirmed 63 nonmetastatic 63 radiochemotherapy 63 completely resected 63 eccrine 63 recurrent glioblastoma multiforme 63 Wegener granulomatosis 63 schwannomas 63 cisplatin resistant 63 solar keratosis 63 neuroendocrine tumors 63 extracranial 63 intestinal polyps 63 eosinophilic 63 Cutaneous T 63 FLT3 63 anterior uveitis 63 ovarian carcinoma 63 relapsing remitting 63 immunohistochemical staining 63 T#I [002] 63 myeloproliferative diseases 63 gefitinib Iressa 63 cholelithiasis 63 malignant neoplasm 63 nonsmall cell lung cancer 63 PNET 63 lung adenocarcinomas 63 lymphocytic leukemia 63 CYT# potent vascular disrupting 63 endocervical 63 invasive carcinoma 63 malignant lesions 63 fallopian tube carcinoma 63 squamous histology 63 Histological 63 basal cell cancers 63 Metastatic 63 distant metastasis 63 colorectal neoplasms 63 CIN2 + 63 immunohistochemical analysis 63 supratentorial 63 SLNB 63 pT2 63 lymphadenopathy 63 colorectal adenocarcinoma 63 PCa 63 histologic subtypes 63 Haptoglobin 63 complement inhibitor eculizumab 63 Sjögren syndrome 63 urothelial 63 invasive ductal 63 nodal metastases 63 bladder cancers 63 leukemia AML 63 Candida infection 63 biopsy specimen 63 papillary carcinoma 63 premalignant 63 histologically 63 urine cytology 63 stage IIIB 63 lichen planus 63 severe neutropenia 63 prostate adenocarcinoma 63 malignant prostate 63 transitional cell carcinoma 63 leucopenia 63 unresectable tumors 63 lymphocytic 63 metastatic lymph nodes 63 prostate cancer PCa 63 coronary stenosis 63 T1a 63 clinico pathological 63 BRAF V#E 62 hamartoma 62 p# biomarker 62 squamous carcinoma 62 anaplastic 62 LVNC 62 underwent surgical resection 62 TRAIL R1 62 neutropaenia 62 thyroid carcinoma 62 follicular lymphoma FL 62 metastatic gastric 62 proctitis 62 FDG PET imaging 62 pheochromocytomas 62 metastatic malignant 62 precancers 62 thyroid nodules 62 cytologic 62 neovascular 62 melanocytic 62 pathologic diagnosis 62 FluCAM arm 62 peritoneal carcinomatosis 62 leukopenia 62 CLL SLL 62 small lymphocytic lymphoma 62 carboplatin paclitaxel 62 gastrointestinal stromal tumor GIST 62 invasive candidiasis 62 choroidal neovascularization CNV 62 papillary thyroid carcinoma 62 recurrent NSCLC 62 lymph node involvement 62 ADPKD 62 breast carcinoma 62 neuroendocrine cancers 62 seminomas 62 submucosa 62 squamous cell carcinomas 62 cervical lymph nodes 62 SSc 62 xenograft tumors 62 T#I mutant 62 micrometastases 62 transthyretin amyloidosis 62 endobronchial 62 biliary tract cancer 62 invasive aspergillosis 62 renal pelvis 62 polycythemia vera PV 62 liver metastasis 62 lipomas 62 adenomatous 62 recurrent metastatic 62 adriamycin 62 soft tissue sarcomas 62 papules 62 benign moles 62 synovial tissue 62 stage IIIA 62 postoperative chemotherapy 62 lymphocytosis 62 cancer mCRC 62 cell lymphoma CTCL 62 basal cell carcinomas 62 carcinoma 62 cytokeratin 62 oligodendrogliomas 62 gastrointestinal stromal tumors GIST 62 premalignant lesions 62 guaiac 62 haematologic 62 abnormal cytology 62 grade gliomas 62 Fluorouracil 62 breast cancer subtypes 62 carcinoid tumor 62 Folfox 62 malignant polyps 62 mesenteric 62 ccRCC 61 esophageal gastric 61 serous ovarian cancer 61 cholangiocarcinoma 61 histological subtypes 61 methicillin susceptible Staphylococcus aureus 61 neoadjuvant therapy 61 malignant pleural mesothelioma 61 FOLFOX4 61 FOLFOX6 61 osteochondroma 61 luminal 61 prostate cancer CaP 61 neoplasia 61 metastatic RCC 61 hepatoma 61 fungoides 61 malignant lymphomas 61 chemoradiation therapy 61 Adenomas 61 mRCC 61 TEAEs 61 papular 61 endoscopic ultrasonography 61 HER2 expression 61 ductal carcinomas 61 tumors GIST 61 primary hyperparathyroidism 61 daunorubicin 61 obstructive coronary 61 grade squamous intraepithelial 61 histologic findings 61 Trichophyton rubrum 61 pancreatic prostate 61 Gorlin syndrome 61 locoregional recurrence 61 KRAS mutations occur 61 vaginal lesions 61 Squamous cell carcinomas 61 node metastases 61 histologic diagnosis 61 pulmonary metastases 61 demonstrated antitumor activity 61 transurethral resection 61 Squamous Cell Carcinoma 61 nodal metastasis 61 leiomyosarcoma 61 histologic examination 61 hypervascular 61 enterococcal 61 malignant growths 61 adenoma 61 endometrial hyperplasia 61 fibroma 61 squamous cell skin 61 mediastinitis 61 intraepithelial 61 Asymptomatic 61 ^ sup #m 61 squamous cells 61 B Cell Lymphoma 61 Chronic lymphocytic leukemia 61 hepatocellular cancer 61 lymphoproliferative disorders 61 mcg albinterferon alfa 2b 61 MGUS 61 malignant nodules 61 fibroadenoma 61 sarcomas 61 biochemical relapse 61 cutaneous squamous cell carcinoma 61 generalized edema 61 metastatic colorectal 61 Relapsing remitting MS 61 immunocompetent 61 cervical intraepithelial neoplasia 61 cytological 61 erlotinib Tarceva ® 61 Doxil ® 61 bone metastasis 61 metastatic lung cancer 61 MLH1 61 KRAS mutation 61 pericardial effusion 61 differentiated thyroid 61 colorectal adenoma 61 idiopathic PAH 61 CIN3 + 61 mTOR inhibitors 61 geographic atrophy 61 Squamous cell 61 HER2 amplification 61 liver metastases 61 vWD 61 nevus 61 Gram stain 61 situ LCIS 61 Streptococcus pyogenes 61 choroidal neovascularization 61 BRAF mutations 61 histologically proven 61 miRview ® 61 axilla 61 prostatic adenocarcinoma 61 operable breast cancer 61 hypercalcemia 61 clinicopathologic 61 advanced adenoma 61 CIN2 61 neuroendocrine carcinoma 61 keratoses 61 chemoradiotherapy 61 hepatocellular carcinoma HCC 61 underwent resection 61 acute GvHD 61 ductal 61 leukemia CLL 61 epithelial tissues 61 Follicular Lymphoma 61 esophagitis 61 clinicopathological 61 nonmelanoma 61 intravenous bisphosphonates 61 lobular carcinomas 61 Acute lymphoblastic leukemia 61 neoplastic cells 61 EUS FNA 61 actinic keratosis AK 61 Diffuse Large B 61 malignant neoplasms 61 urothelial cancer 61 FOLPI 61 radical nephrectomy 61 LV dysfunction 61 myeloproliferative disorders 61 hilar 61 HNSCC 61 axillary lymph node 61 pain palliation 61 germline mutations 61 metachronous 61 hematopoietic cancers 61 breast pancreatic 61 neuroblastoma tumors 61 hematuria 61 interferon alfa 2a 61 HER2 overexpression 61 nasopharyngeal cancer 61 distant metastases 61 esophageal squamous cell carcinoma 61 immunohistochemistry IHC 61 Synovial sarcoma 61 metastatic tumors 61 myeloproliferative neoplasms 61 erythema nodosum 61 bronchoalveolar lavage 61 astrocytoma 60 CsA 60 melanocytic nevi 60 ALA PDT 60 actinic keratoses 60 gemcitabine Gemzar 60 desmoplastic 60 Hashimoto thyroiditis 60 bladder carcinoma 60 aplasia 60 Surgical resection 60 lung pancreatic 60 histopathological 60 radiofrequency ablation RFA 60 hypertrophic scars 60 sonographic appearance 60 precursor lesions 60 melanoma basal cell 60 metastatic prostate 60 cystic lesions 60 radical prostatectomy RP 60 proximal colon 60 lymphovascular invasion 60 Metastases 60 comedones 60 relapsed MM 60 TMPRSS2 ERG 60 FDG-PET/CT 60 extramedullary 60 hepatic metastases 60 astrocytomas 60 thalidomide Thalomid 60 morphologic 60 nephrectomy 60 lymphopenia 60 sonographic findings 60 invasive lobular 60 colorectal gastric 60 mesotheliomas 60 esophageal candidiasis 60 Gleevec resistant 60 proliferative diabetic retinopathy 60 Anaplastic 60 Radiofrequency ablation 60 varicoceles 60 Glioma 60 INCB# [003] 60 HBeAg negative patients 60 colorectal liver metastases 60 surgically resectable 60 ependymomas 60 trastuzumab Herceptin ® 60 T2 lesions 60 B7 H3 60 metastatic renal cell carcinoma 60 KRAS mutations 60 Lymphomas 60 perianal 60 polyposis 60 resectable pancreatic cancer 60 thyroglobulin 60 locoregional 60 pseudoaneurysms 60 stage IIIb IV 60 orchitis 60 Neutropenia 60 osteochondromas 60 seminoma 60 metastatic pancreatic 60 pediatric acute lymphoblastic 60 Parkinsonian Syndromes 60 cisplatin chemotherapy 60 lymphatic tissue 60 pan HDAC inhibitor 60 KRAS mutant 60 antiangiogenic agent 60 gastroduodenal 60 Candida infections 60 ertapenem 60 intra abdominal infections 60 unknown etiology 60 epithelial ovarian 60 HCV genotypes 60 hematologic toxicity 60 malignant lymphoma 60 sonographically guided 60 superficial bladder cancer 60 FOLFIRI 60 ABCB1 60 tonsillar 60 Histologic 60 pre cancerous lesion 60 vimentin 60 voriconazole 60 platinum refractory 60 PsA 60 gastrointestinal cancers 60 colon carcinoma 60 mononuclear 60 haematological 60 axillary lymph nodes 60 molecular subtypes 60 squamous cell cancer 60 Barrett esophagus BE 60 liposomal amphotericin B 60 intracranial hemorrhage ICH 60 synovial sarcoma 60 macules 60 telangiectasia 60 vinca alkaloids 60 imatinib resistant 60 acute leukemias 60 nonalcoholic steatohepatitis NASH 60 bevacizumab Avastin ® 60 rebleeding 60 keloid scarring 60 fibroadenomas 60 nasopharyngeal carcinoma 60 normal karyotype 60 Carcinoma 60 papule 60 Immunohistochemical analysis 60 EGFR mutations 60 hematological diseases 60 carcinomatosis 60 Rectal cancer 60 Xanafide 60 immunodeficiencies 60 gastric cancers 60 syngeneic 60 hypereosinophilic syndrome 60 corneal epithelial 60 synovial 60 Platinol ® cisplatin 60 arthrography 60 dysmotility 60 osteoid osteoma 60 systemic amyloidosis 60 purpura 60 kidney urologic 60 acute myeloid 60 Idiopathic Pulmonary Fibrosis 60 Genotypes 60 seborrheic keratoses 60 Stomatitis 60 biliary strictures 60 PAOD 60 Moraxella catarrhalis 60 granulomas 60 prostate bladder 60 obscure gastrointestinal bleeding 60 Chronic HCV 60 atypical hyperplasia 60 allogeneic HSCT 60 hepatorenal syndrome 60 curative resection 60 malignancies 60 lenalidomide dexamethasone 60 melanoma lesions 60 gastroesophageal junction 60 sorafenib Nexavar 60 preoperative chemotherapy 60 hyperintense lesions 60 HBeAg 60 histological diagnosis 60 bleomycin 60 cellularity 60 chronic myeloid 60 myeloproliferative 60 polymicrobial infections 60 chemoembolization 60 basal cell skin 60 villous 60 galiximab 60 Leydig cell 60 CD# CD# 60 carcinoma HCC 60 adjuvant radiotherapy 59 mycophenolate mofetil 59 CTEPH 59 metastatic bladder 59 surgical excision 59 oligodendroglioma 59 lymphadenectomy 59 ductal adenocarcinoma 59 intralesional 59 dermatophytes 59 Mitomycin C 59 splenic 59 epithelial cell 59 HRCT 59 neutrophil count 59 chronic eosinophilic leukemia 59 cytopenias 59 Helicobacter pylori infection 59 Hepatocellular Carcinoma HCC 59 Venous thromboembolism 59 eosin 59 Renal cell carcinoma 59 anemias 59 sulfasalazine 59 de novo AML 59 hematoxylin 59 hyperplastic polyps 59 gadolinium enhanced 59 intraoperative complications 59 crizotinib PF # 59 neutropenia dehydration dyspnea 59 osteoid 59 histopathologic findings 59 microdeletion 59 IgA deficiency 59 metastatic renal 59 RRM1 59 Squamous cell carcinoma 59 TP# mutations 59 atopic asthma 59 axillary dissection 59 idiopathic myelofibrosis 59 EGFR mutation 59 Adjuvant chemotherapy 59 parathyroid carcinoma 59 non squamous histology 59 malignant ascites 59 fine needle aspiration 59 myelofibrosis MF 59 teratoma 59 refractory NSCLC 59 submucosal 59 sarcoid 59 pediatric malignancies 59 trans retinoic acid 59 ceftazidime 59 micafungin 59 TACE 59 pretransplant 59 cell lymphoma ALCL 59 V#F mutation 59 Gliomas 59 colorectal polyp 59 acute aortic dissection 59 efalizumab 59 cutaneous lesions 59 SUVmax 59 Duodenal 59 hematopoietic cell 59 myeloid 59 intravesical therapy 59 tumorigenicity 59 standard chemotherapy regimens 59 Xelox 59 thyroid carcinomas 59 Ribavirin causes 59 Irinotecan 59 fluorouracil 59 androgen independent 59 PCNSL 59 biologic DMARD 59 gastrointestinal stromal tumors 59 nonischemic 59 Histopathologic 59 myelodysplastic myeloproliferative diseases 59 glioblastoma multiforme GBM 59 Angioedema 59 invasive lobular carcinoma 59 cerebrospinal fluid CSF 59 ocular disorders 59 FOLFIRI alone 59 docetaxel Taxotere ® 59 renal cell carcinoma 59 wedge resection 59 extrahepatic 59 inflammatory lesions 59 lesional 59 hypermethylated 59 sentinel lymph nodes 59 bacteriuria 59 cytoreduction 59 proliferative retinopathy 59 Staphylococcus epidermidis 59 ano genital warts 59 FUSILEV enhances 59 contralateral breast 59 Critical Limb Ischemia CLI 59 malignant cancerous 59 immunostaining 59 BR.# 59 pathologic 59 peritumoral 59 Unresectable 59 biliary tract 59 immunoreactivity 59 SSc patients 59 resected 59 liposarcoma 59 malignant lesion 59 tunica vaginalis 59 anemia neutropenia 59 Actinic Keratosis 59 Recurrences 59 lung nodule 59 hypoechoic 59 advanced neoplasia 59 Figure 2C 59 haematopoietic 59 refractory chronic lymphocytic 59 fibrocystic 59 hypophosphatemia 59 lymphoid tissue 59 artery stenosis 59 imipenem 59 hypopigmentation 59 promoter methylation 59 Glioblastoma Multiforme GBM 59 HIV HCV coinfected 59 oropharyngeal 59 submandibular 59 transplantation HCT 59 Acute myeloid leukemia 59 lymph node metastasis 59 APOL1 59 dysplastic lesions 59 KIT mutations 59 etiologies 59 polypoid lesions 59 florbetaben 59 genotypic resistance 59 esophagogastric junction 59 erythematous 59 IV NSCLC 59 Circulating tumor cells 59 Palifosfamide 59 percutaneous biopsy 59 lopinavir r arm 59 receptor tyrosine kinase inhibitor 59 lung cancer NSCLC 59 radiotherapy RT 59 paclitaxel eluting stents 59 urethral stricture 59 monoclonal gammopathy 59 diabetes mellitus DM 59 EGFR HER2 59 E. faecalis 59 pilocytic astrocytomas 59 noncalcified 59 bevacizumab Avastin 59 osteosarcoma Ewing sarcoma 59 sporadic ALS 59 Basal Cell 59 prognostic significance 59 methicillin sensitive 59 lung metastases 59 Borrelia 59 germline mutation 59 variant allele 59 uveal melanoma 59 thyrotoxicosis 59 prostate carcinomas 59 chromophobe 59 Thrombocytopenia 59 Advanced Renal Cell 59 fosbretabulin 59 circulating endothelial cells 59 inflammatory acne 59 medically inoperable 59 pneumonectomy 59 multiple myeloma MM 59 metastatic lesion 59 allele frequencies 59 orthotopic 59 Langerhans cell histiocytosis 59 Paraplatin ® 59 micrometastasis 59 Carcinomas 59 Onychomycosis 59 Toxicities 59 hematoxylin eosin original 59 sentinel nodes 59 androgen deprivation 59 macroalbuminuria 59 ecchymosis 59 infarcts 59 S aureus 59 Computed tomography 59 thymic carcinoma 59 Metastatic Renal Cell Carcinoma 59 caspofungin 59 gemcitabine carboplatin 59 griseofulvin 59 precancer 59 MGd 59 papillary RCC 59 â ‰ ¥ 59 candidiasis 59 cTnI 59 adenocarcinoma 59 Stage IIIb 59 HER2 positive metastatic breast 59 glomerulonephritis 59 cytologically 59 cervical dysplasia 59 bFGF 59 revascularization procedures 59 plasmacytoid 59 dacarbazine DTIC 59 HSCT 59 follicular lymphoma 59 tumor metastases 59 Glioblastomas 59 prostate cancer mCRPC 59 LHRH receptor positive 59 hyperplasia 59 debulking surgery 59 Chronic lymphocytic leukemia CLL 59 peripheral blood mononuclear 59 dacarbazine 59 resected pancreatic cancer 59 benign lesions 59 endometrial adenocarcinoma 59 leukocytosis 59 Cholangiocarcinoma 59 orthotopic model 59 ^ Tc 59 liposomal doxorubicin 59 activating mutations 59 peritoneal cancer 58 alkylating 58 homozygous familial hypercholesterolemia 58 erythematosus 58 demyelinating 58 K#N 58 essential thrombocythemia ET 58 prognostic factor 58 Glioblastoma Multiforme 58 collagenous colitis 58 Metastatic breast cancer 58 periventricular 58 pigmented skin lesions 58 alkylating agent 58 specific antigen PSA 58 ERBB2 58 breast lesions 58 paraneoplastic 58 pleurodesis 58 serrated polyps 58 subependymal giant cell 58 prostate cancer CRPC 58 noninflammatory 58 follicular lymphomas 58 infantile onset 58 intraepithelial neoplasia 58 Radical prostatectomy 58 FDG uptake 58 ureteral stones 58 intraductal 58 extranodal 58 cranial irradiation 58 ethambutol 58 IIIb 58 imiquimod 58 Carcinoid tumors 58 Multiple Myeloma MM 58 N. gonorrhoeae 58 nephrotoxicity 58 bexarotene 58 vesicoureteral reflux 58 docetaxel chemotherapy 58 superficial femoral 58 posaconazole 58 calcineurin inhibitors 58 Myelodysplastic Syndrome MDS 58 mitomycin C 58 carotid plaque 58 hormone receptor negative 58 nanomolar 58 Basal cell carcinoma 58 mesothelial cells 58 radiographic findings 58 para aortic 58 cutaneous T 58 T1c 58 cytoreductive surgery 58 cervical lesions 58 imatinib Gleevec 58 System IPSS 58 Fas ligand 58 metastatic carcinoma 58 Retreatment 58 plain radiographs 58 keloid 58 renal cortical 58 azacytidine 58 recurrent glioblastoma multiforme GBM 58 nodal dissection 58 needle aspiration 58 myelodysplastic syndrome MDS 58 chloride secretion 58 leukoplakia 58 choriocarcinoma 58 CHOP chemotherapy 58 fluorodeoxyglucose positron emission tomography 58 lobular breast cancer 58 CP CPPS 58 p = #.# [003] 58 scintigraphic 58 apocrine 58 dysplastic 58 Hypertrophic 58 ritonavir boosted 58 JAK2 V#F 58 monogenic 58 febrile neutropenia 58 HDACi 58 HBeAg positive patients 58 Vitaxin 58 choroidal 58 histologically confirmed 58 HLA DR 58 pegylated liposomal doxorubicin 58 laboratory abnormalities 58 UGT#A# 58 BRCA1 BRCA2 58 dysuria 58 HBsAg 58 serum prostate 58 gastric atrophy 58 cisplatin gemcitabine 58 idarubicin 58 colorectal lung 58 hydronephrosis 58 pentamidine 58 atypical ductal hyperplasia 58 Interferon alfa 58 sclerosing 58 doxorubicin Adriamycin 58 chromosomal mutations 58 intra abdominal abscess 58 gastric pancreatic 58 castrate resistant 58 pCR 58 cetuximab Erbitux R 58 DLTs 58 Zolinza 58 localized prostate 58 biochemical recurrence 58 lymphoid malignancies 58 anaplastic astrocytoma AA 58 angiosarcoma 58 clade B 58 pulmonary hypertension PH 58 mosaicism 58 generalized vitiligo 58 novel VDA molecule 58 prostate TURP 58 Synovial 58 somatic mutations 58 Decitabine