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(Click for frequent words.) 80 signaling pathways 78 molecular pathway 76 molecular mechanism 74 Wnt signaling 74 Wnt pathway 74 molecular pathways 74 Notch signaling 74 tumor suppressor gene 73 biochemical pathway 73 MAPK 73 metabolic enzymes 73 tumorigenesis 73 synapse formation 73 signaling molecule 73 FOXO3a 73 NF kB 72 transcription factors 72 beta catenin 72 cell signaling pathway 72 androgen receptor 72 signaling cascade 71 STAT3 71 transcription factor 71 Src 71 Smad3 71 tumor suppressor 71 protein kinase 71 actin cytoskeleton 71 ubiquitination 71 PPAR alpha 71 receptor protein 71 ERK1 2 71 proteins 71 Akt 71 enzyme 71 cell signaling pathways 70 Hedgehog signaling 70 mTOR 70 calcineurin 70 calpain 70 receptor 70 Notch pathway 70 micro RNAs 70 hedgehog pathway 70 phosphorylation 70 mitogen activated protein kinase 70 catenin 70 tumor suppressor genes 70 glutamate receptors 70 tumor suppressor protein 70 microRNAs 70 DISC1 70 Skp2 69 Myc 69 Cdc# 69 cellular pathways 69 Hedgehog pathway 69 Nrf2 69 MAPK pathway 69 protein kinases 69 oncogenic 69 gene transcription 69 oncogene 69 oncoprotein 69 p# [001] 69 MAP kinase 69 receptor gamma 69 SIRT1 69 molecular mechanisms 69 phosphatases 69 protein kinase C 69 protein synthesis 69 EGFR signaling 69 PPARγ 69 cyclins 69 proto oncogene 68 receptor molecule 68 cell motility 68 kinase 68 Akt1 68 cyclin D1 68 autophagy 68 tyrosine kinase 68 NF kappaB 68 tumor angiogenesis 68 XBP1 68 activin 68 S1P 68 c Myc 68 β catenin 68 peroxisome proliferator activated 68 oncogenes 68 transcriptional activation 68 glucocorticoid receptor 68 uPAR 68 estrogen receptors 68 metabolic pathways 68 biochemical pathways 68 Smoothened 68 PPAR gamma 68 caveolin 1 68 NF κB 67 Kv#.# 67 RANKL 67 mTORC1 67 proteases 67 miRNAs 67 neuromuscular junction 67 casein kinase 67 adhesion molecule 67 epigenetic mechanisms 67 signaling molecules 67 Wnt signaling pathway 67 MeCP2 67 Cdk5 67 regulates gene expression 67 histone deacetylases 67 receptors 67 caspases 67 oxidative phosphorylation 67 p# gene 67 ubiquitin ligase 67 intracellular 67 mTOR pathway 67 mTOR signaling 67 HSP# 67 tyrosine phosphorylation 67 integrin 67 intracellular signaling 67 p# protein 67 FOXO1 67 kinase pathway 67 TGF b 67 PKM2 67 ligases 67 neurite outgrowth 67 TGF beta 67 ion channels 67 Wnt 67 E3 ligase 67 gamma secretase 67 p# pathway 67 regulating gene expression 67 upregulation 67 pRb 67 biosynthesis 67 cyclic AMP 67 phosphorylated 67 STAT1 67 kinases 67 RNA splicing 67 p# MAPK 66 SIRT3 66 IL 1β 66 NMDA receptor 66 S#K# 66 TRAF6 66 E cadherin 66 PIP2 66 Smurf1 66 Notch1 66 encodes protein 66 Stat3 66 tyrosine kinases 66 AMPA receptor 66 IRAK1 66 Ago2 66 PAK1 66 tumor suppressors 66 metabolic pathway 66 Wnts 66 acetylation 66 NFκB 66 IGF 1R 66 integrins 66 transcriptional regulation 66 NKT cells 66 SGK1 66 PI3K pathway 66 TGF beta pathway 66 Th# cells 66 signaling cascades 66 androgen receptor AR 66 Foxp3 66 NF kB pathway 66 NFAT 66 ERK signaling 66 cholesterol metabolism 66 phosphorylates 66 serine threonine kinase 66 glycolysis 66 autophagic 66 cAMP 66 cytokine 66 ubiquitylation 66 SH2 B 66 FOXO 66 chromatin structure 66 Pten 66 biological pathways 66 NF kappa B 66 mammalian cells 66 secretory pathway 66 Mcl 1 66 Stat5 66 TAp# 66 synaptogenesis 66 TLR4 66 TORC2 66 4E BP1 66 ERK pathway 66 PP2A 66 synaptic transmission 66 pathogenesis 66 neuronal migration 65 caspase 65 cofilin 65 TGF ß 65 IKKa 65 Six3 65 transactivation 65 NR2B 65 SIRT1 gene 65 insulin receptors 65 messenger molecule 65 intracellular proteins 65 PI3 kinase 65 retinoblastoma protein 65 transcriptional repressor 65 Sir2 65 PGE2 65 MAP kinase pathway 65 podocyte 65 RUNX3 65 evolutionarily conserved 65 tau protein 65 LKB1 65 TSLP 65 AMPA receptors 65 PI3K 65 protein 65 phosphatidylinositol 3 65 overexpression 65 hedgehog signaling 65 tumor microenvironment 65 NMDA receptors 65 estrogen receptor alpha 65 metabolic processes 65 CTLA 4 65 cystic fibrosis transmembrane conductance 65 primary cilia 65 lipid metabolism 65 MDM2 65 c myc 65 EZH2 65 signal transduction 65 inhibitory 65 serotonin receptor 65 E1A 65 NFkB 65 c MYC 65 ATPase 65 GSK3 65 aldose reductase 65 SIRT2 65 TGF β 65 Rab# 65 apoptotic pathway 65 MEF2 65 histone modifications 65 melanocyte 65 tRNA synthetase 65 Rac1 65 genes 65 proteolysis 65 naturally occurring protein 65 homodimers 65 CaM kinase II 65 FGFs 65 glutamate 65 FGFR1 65 ABCA1 65 E3 ubiquitin ligase 65 gluconeogenesis 65 LRP6 65 glutamate receptor 65 SOD1 65 Hh pathway 65 phosphorylate 65 molecule 65 membrane protein 65 hypoxia inducible factor 65 lipid synthesis 65 ß catenin 65 receptor tyrosine kinase 65 lipoxygenase 65 GTPase 65 SWI SNF 65 gene 65 HOTAIR 65 biochemical mechanisms 65 enzymes 65 IKK2 65 enzymatic activity 65 AMPK 65 CXCL# 64 heparan sulfate 64 TIR1 64 clusterin 64 costimulatory 64 chaperone protein 64 cellular metabolism 64 BMP signaling 64 lysosomal 64 neurotransmission 64 mitogen activated protein 64 mutant huntingtin 64 PPARg 64 Akt3 64 regulated kinase ERK 64 histone 64 synthase 64 CD#L 64 Id1 64 intracellular pathways 64 chromatin remodeling 64 HDAC2 64 HDACs 64 cytokine signaling 64 SATB1 64 neurotransmitter glutamate 64 gene expression 64 PI3K Akt 64 estrogen receptor beta 64 ion channel 64 ER alpha 64 Oct4 64 eNOS 64 selective inhibition 64 NADPH oxidase 64 LIS1 64 mutated protein 64 regulate gene expression 64 alpha synuclein 64 cathepsins 64 arginase 64 miRNA 64 cytoskeletal 64 tumor suppressor p# 64 RNA polymerase II 64 serine protease 64 intracellular signaling pathways 64 autocrine 64 NAD + 64 signal transduction pathways 64 Notch signaling pathway 64 NF kappaB pathway 64 cell adhesion molecules 64 podocytes 64 LRRK2 64 EGF receptor 64 paxillin 64 PAR1 64 immune cells 64 CaMKII 64 miR 64 SCD1 64 ATF2 64 UCP2 64 mutant protein 64 HIF 1α 64 FGF# 64 cyclin dependent kinases 64 IKKß 64 NKX#.# 64 Aurora kinases 64 beta arrestin 64 apoE 64 cadherin 64 ERK 64 Vpr 64 MEK1 64 genes encoding 64 coactivator 64 VEGF receptor 64 calcium homeostasis 64 LRP1 64 estrogen receptor 64 presenilin 64 molecular signaling pathway 64 palmitoylation 64 H#K# methylation 64 fatty acid synthase 64 neuronal differentiation 64 Mdm2 64 IRF5 64 GATA3 64 FANCD2 64 c MET 64 secreted protein 64 NKG2D 64 tubulin 64 PKC alpha 63 PGC 1alpha 63 oncogenesis 63 SUMOylation 63 inducible 63 morphogen 63 sortilin 63 helicase 63 downregulation 63 alternative splicing 63 c Abl 63 tropomyosin 63 carcinogenesis 63 HBx 63 neurexin 63 TRP channels 63 kinase domain 63 fatty acid synthesis 63 mRNAs 63 cellular senescence 63 protein p# 63 FoxO1 63 CB1 receptor 63 dimerization 63 anti apoptotic 63 Src kinase 63 Rho GTPases 63 protein fragment 63 apoptosis 63 RhoA 63 synaptic plasticity 63 BMP4 63 upregulated 63 PTP1B 63 matrix metalloproteinases 63 neurofibromin 63 sirtuin 63 sphingolipid 63 cAMP signaling 63 SH#B# 63 Notch receptor 63 BCL6 63 iNOS 63 Bcl xL 63 GRK2 63 ENaC 63 SOCS1 63 C EBP alpha 63 ADAM# 63 innate immune response 63 EphA2 63 protein interleukin 63 cofactor 63 aromatase 63 Rab5 63 NFkappaB 63 HSF1 63 nitric oxide synthase 63 endocannabinoid system 63 bacterial enzyme 63 paracrine 63 astrocytes 63 cell adhesion 63 VEGF 63 induces apoptosis 63 JAK2 63 invadopodia 63 beta1 integrin 63 endocytosis 63 cypin 63 glycosylation 63 thyroid hormone receptor 63 DNMT1 63 MAP kinases 63 KLF4 63 FGF signaling 63 small molecule inhibitors 63 dystroglycan 63 miR# 63 dendritic spine 63 hematopoiesis 63 inflammasome 63 pro angiogenic 63 neural crest 63 fusion protein 63 osteocalcin 63 Hypoxia Inducible Factor 63 dephosphorylation 63 CTGF 63 protein misfolding 63 focal adhesion kinase FAK 63 E#F# 63 Dpp 63 phosphatase 63 nNOS 63 GRP# 63 membrane fusion 63 gene encoding 63 WT1 63 SREBP 63 glycolipids 63 GPR# [002] 63 NRG1 63 cyclopamine 63 protease 63 VE cadherin 63 gene p# 63 BMAL1 63 phosphatidylinositol 63 pDCs 63 superoxide dismutase 63 Cyclin D1 63 epigenetic silencing 63 GLI1 63 vimentin 63 GABAergic 63 Wnt beta catenin 63 secretase 63 protein tyrosine kinase 63 angiogenesis 62 ERK2 62 cyclin dependent kinase inhibitor 62 overactivation 62 tumor suppressor proteins 62 chemokine receptor 62 PDGFR 62 abscisic acid 62 cytoplasmic domain 62 NF KappaB 62 androgen receptors 62 isoforms 62 FGFR3 62 reductase 62 endoplasmic reticulum 62 phosphoinositide 62 laminin 62 receptor proteins 62 nicotinic receptors 62 caveolin 62 induce apoptosis 62 miR #a [002] 62 PIP3 62 Sox2 62 oxidase 62 progerin 62 breast cancer metastasis 62 JAK STAT 62 neurotransmitter 62 Aβ 62 prostaglandin synthesis 62 Rad# 62 retinoic acid 62 Hedgehog signaling pathway 62 Pax6 62 mRNA translation 62 ACE2 62 isoform 62 NKT cell 62 downstream effectors 62 receptor activation 62 Rho kinase 62 cyclin dependent kinase 62 phagocytosis 62 molecular mechanisms underlying 62 TMEM#B 62 caspase activation 62 CHD5 62 extracellular signal 62 KLF# 62 Rb#/p# 62 centrosome 62 axon guidance 62 orexin 62 sphingosine 1 62 exocytosis 62 tumor suppressive 62 Hh 62 endocannabinoids 62 Phosphorylation 62 TNFalpha 62 non coding RNA 62 chemokine 62 dopamine receptor 62 Rap1 62 fatty acid metabolism 62 IRE1 62 receptor subtype 62 mRNA 62 heme oxygenase 62 CK2 62 sRNA 62 biogenesis 62 ncRNAs 62 transmembrane receptor 62 progranulin 62 HDAC 62 polyamines 62 5 lipoxygenase 62 matrix metalloproteinases MMPs 62 COX2 62 neurotransmitter receptor 62 transcriptional regulator 62 serotonin receptors 62 RKIP 62 innate immunity 62 anti inflammatory cytokine 62 cell adhesion molecule 62 Sox9 62 TXNIP 62 glycoprotein 62 Nedd4 62 pre mRNA splicing 62 demethylase 62 mitochondrial 62 TNFa 62 beta adrenergic receptors 62 Nanog 62 neuronal signaling 62 druggable target 62 oncoproteins 62 BACE1 62 transcriptional machinery 62 hedgehog signaling pathway 62 PGC1 62 adhesion molecules 62 LDL receptor 62 peroxisome 62 GluR1 62 Th2 62 alpha subunit 62 MMPs 62 hormone receptors 62 beta amyloid peptide 62 Arp2 3 62 mitochondria 62 PPAR γ 62 MAPKs 62 dynein 62 PTEN gene 62 RNAi pathway 62 TGFβ 62 telomere maintenance 62 lysosome 62 glioma cells 62 CPEB 62 GSK 3ß 62 MDSCs 62 transcriptional repression 62 stem cell differentiation 62 EGFR 62 Wnt proteins 62 mutant proteins 62 Keap1 62 microRNA 62 Cdc7 62 hypermethylation 62 binding proteins 62 thioredoxin 62 ERa 62 effector functions 62 effector cells 62 Hh signaling 62 genomic instability 62 FGF receptor 62 neurotransmitter receptors 62 JNK1 62 ERK1 62 plasminogen 62 WWP2 62 naturally occurring enzyme 62 Rho GTPase 62 constitutively active 61 TRPA1 61 thyroid hormones 61 glycogen synthase kinase 61 CB1 receptors 61 protein encoded 61 CCR3 61 melanocortin receptors 61 CXCR2 61 huntingtin 61 PMR1 61 Sirt1 61 PGC 1a 61 cytosolic 61 IKK beta 61 TORC1 61 glucocorticoid receptor GR 61 dysregulation 61 renal fibrosis 61 adenosine receptors 61 Pin1 61 neuroligin 61 orexin receptors 61 osteoclast formation 61 Akt signaling 61 eotaxin 61 adrenergic receptors 61 nicotinic receptor 61 FasL 61 ErbB2 61 TGFb 61 PRDM# 61 EphB2 61 S#A# [002] 61 p# activation 61 DLX5 61 Wnt1 61 Pdx1 61 SIRT6 61 Jagged1 61 Tregs 61 DLC1 61 peroxisomal 61 cytochrome P# 61 overexpressing 61 downregulated 61 receptor PPAR 61 cPLA2 61 catalytic subunit 61 LXRs 61 mitochondrial dysfunction 61 prostaglandin E2 PGE2 61 ErbB4 61 MyD# 61 XBP 1 61 auxin 61 RAS RAF MEK 61 synthetase 61 vacuolar 61 transgenic mouse model 61 enzyme HMG CoA 61 epigenetically 61 Cx# [001] 61 Htt 61 calmodulin 61 TrkB 61 B7 H1 61 circadian clock genes 61 semaphorin 61 TLRs 61 HCV replication 61 dendritic cells 61 CB2 receptor 61 apoptosis pathways 61 miRNA genes 61 homolog 61 N Myc 61 CIB1 61 cyclooxygenase 61 nAChR 61 huntingtin protein 61 TGF beta signaling 61 inflammatory cytokines 61 proteasome 61 messenger RNA mRNA 61 innate immune system 61 PKD1 61 biochemical cascade 61 defensin 61 TRPV3 61 GAPDH 61 POMC neurons 61 adult neurogenesis 61 RNA molecule 61 granzyme B 61 MT1 MMP 61 mitochondrial respiration 61 FGF2 61 primary cilium 61 PHLPP 61 cannabinoid receptors 61 Runx2 61 eukaryotic cells 61 Flt3 61 D aspartic acid 61 CD# ligand 61 Shh signaling 61 beta subunit 61 gene encodes protein 61 EGFR pathway 61 osteoclasts 61 apoptotic cell 61 proapoptotic 61 BDNF 61 GTPases 61 Smad4 61 Eg5 61 p# mitogen activated 61 inflammatory cytokine 61 TNFα 61 neuronal plasticity 61 KLF2 61 hyperactivation 61 p#/CBP 61 HDAC6 61 suppressor cells 61 gene encodes 61 microglial cells 61 neuropeptide 61 Ras pathway 61 RNAs 61 interleukins 61 mutant huntingtin protein 61 insulin signaling pathway 61 cellular signaling pathways 61 presynaptic 61 HIF 1alpha 61 protein CETP 61 IL 1beta 61 STIM1 61 small molecule inhibitor 61 antiapoptotic 61 chloroplast 61 Sox# 61 epigenetic regulation 61 glucose transporter 61 BCR ABL 61 neuroprotection 61 DARPP 61 TFIIH 61 Bcr Abl 61 myeloid cells 61 RANK ligand 61 MEF2D 61 deacetylation 61 protein phosphatase 61 immunoregulatory 61 PGC 1α 61 ARF1 61 Wnt#b 61 dynamin 61 TSP1 61 synapse maturation 61 microRNA miR 61 PKC isoforms 61 osteopontin 61 Prox1 61 TNFR 61 Overexpression 61 caveolae 61 fibrogenesis 61 hepcidin 61 glial cell 61 ryanodine receptor 61 inhibition 61 MMP2 61 actin 61 NF KB 61 FAK 61 protein tau 61 polypeptides 61 IL# receptor 61 CFTR 61 T lymphocyte 61 RNA sequences 61 estrogen metabolism 61 thrombospondin 61 organelle 61 tumor cells 60 Klf4 60 H#K# [001] 60 cyclophilin D 60 CRAC channel 60 factor kappa B 60 nAChRs 60 retinoic acid receptor 60 intracellular protein 60 ubiquitin ligases 60 neuropeptide Y 60 chloroplasts 60 myogenesis 60 IRS1 60 Abl 60 H#K# [002] 60 upregulating 60 membrane receptors 60 kinase enzymes 60 RANK Ligand 60 microRNAs miRNAs 60 noncoding RNAs 60 anaphase promoting complex 60 CEACAM1 60 ubiquitin 60 RNA binding 60 transcriptional 60 APOBEC3G 60 neurogenesis 60 vascular endothelial cells 60 oligodendrocyte precursor cells 60 PPAR delta 60 enzyme COX 60 syntaxin 60 subunit 60 alpha synuclein gene 60 TNF alpha 60 reactive oxygen species 60 biosynthetic pathway 60 glucocorticoid receptors 60 insulin secretion 60 FMRP 60 Sonic hedgehog 60 cyclin 60 neuroinflammation 60 Argonaute 60 costimulation 60 ERK5 60 glucokinase 60 biochemical processes 60 microtubule dynamics 60 potent inhibitor 60 MALAT1 60 miR #b [002] 60 peptide hormone 60 constitutively 60 adipogenesis 60 mitochondrial enzyme 60 p#INK#a 60 focal adhesions 60 selective inhibitors 60 COX enzymes 60 muscarinic receptors 60 Sp1 60 osteoblast 60 IFN gamma 60 Syk 60 receptor alpha 60 TLR3 60 BCL2 60 adaptive immunity 60 GSK3B 60 protein phosphorylation 60 secretion 60 PrP 60 tyrosine kinase receptors 60 factor receptor 60 angiogenic 60 apoE4 60 CDK4 60 receptors PPARs 60 histone methylation 60 p# tumor suppressor 60 histone acetylation 60 acetylcholine receptor 60 selectively inhibit 60 sensory neurons 60 intestinal epithelial 60 matriptase 60 kinase PI3K 60 NK1R 60 neural cells 60 proNGF 60 adipocyte 60 HIP1 60 TRPV1 60 adipokines 60 spermatogenesis 60 insulin secreting cells 60 NAADP 60 Hfq 60 heterodimers 60 actin remodeling 60 CCL# 60 cyclin B1 60 coreceptor 60 leukotrienes 60 FGFR 60 Vpu 60 induced apoptosis 60 coagulation cascade 60 leukocyte recruitment 60 Fas ligand 60 histone modification 60 keratinocyte 60 VHL gene 60 histone deacetylase 60 monocyte 60 vasopressin 60 phosphate S1P 60 epigenetic 60 endogenous 60 metabolizing enzymes 60 morphogenesis 60 VIPR2 60 Caspase 60 aberrantly activated 60 cyclic AMP cAMP 60 polyamine 60 neuronal dysfunction 60 hsp# 60 nerve cells 60 mediated apoptosis 60 netrin 1 60 hormone leptin 60 CD# receptor 60 macrophage activation 60 breast epithelial cells