Related by context. All words. (Click for frequent words.) 75 protein kinases 73 JNK pathway 72 cell signaling pathways 72 signaling pathways 72 kinase PI3K pathway 71 phosphoinositide 3 70 cellular pathways 68 chemokine receptors 68 Smad3 68 tyrosine kinases 68 MAPK 68 phosphatidylinositol 3 67 mitogen activated protein kinase 67 signaling cascades 67 Hedgehog signaling 67 tumor suppressor genes 66 transcription factors 66 kinase PI3K Akt pathway 66 proto oncogene 66 Wnt signaling pathway 66 molecular pathway 66 intracellular signaling 66 PI3K pathway 66 potent inhibitors 65 ERK1 2 65 HDACs 65 molecular pathways 65 MAP kinases 65 intracellular pathways 65 transcriptional regulation 65 modulates Akt 65 mTOR pathway 65 cell signaling pathway 65 apoptotic pathway 65 serine proteases 65 phosphorylates 65 metabolic enzymes 65 intracellular signaling pathways 65 biologic pathway 65 c MET 64 NFκB 64 cell adhesion molecules 64 biochemical signaling pathways 64 tyrosine kinase 64 mTOR mammalian target 64 phosphatases 64 RAS RAF MEK 64 oncogenes 64 NF kappa B 64 histone modifications 64 hypoxia inducible factor 64 tumor microenvironment 64 encodes protein 64 signaling pathway 64 signaling molecules 64 cyclin dependent kinases 64 MAPK pathway 64 neurite outgrowth 64 microRNA molecules 64 interleukins 64 serine threonine 64 pRb 64 protein kinase C 64 ERK pathway 63 biological pathways 63 epigenetic mechanisms 63 Hedgehog pathway 63 biochemical mechanisms 63 NF κB 63 VEGF receptor 63 E#F# 63 coupled receptors 63 kinases 63 genes encoding 63 Akt 63 TNFalpha 63 MAP kinase 63 NF kB 63 FGFR 63 extracellular signal 63 regulates gene expression 63 catenin 63 serine threonine kinase 63 adhesion molecule 63 cytoskeletal 63 oncogenic 63 Aurora kinases 63 tumorigenesis 63 protein tyrosine phosphatases 63 proteases 63 cathepsins 63 myelofibrosis polycythemia vera 63 histone deacetylases 63 protein kinase 63 signaling molecule 63 cell motility 62 signal transduction 62 JAK2 62 PKC isoforms 62 STAT3 62 phosphate S1P 62 glutamate receptors 62 c Myc 62 PI3K Akt 62 Notch signaling 62 hedgehog pathway 62 FGFs 62 Arp2 3 62 RUNX3 62 Factor VEGF 62 DNA methyltransferases 62 androgen receptor AR 62 peroxisome proliferator activated 62 regulating gene expression 62 signaling cascade 62 splice variants 62 oncogenic proteins 62 non coding RNA 62 tumor suppressor protein 62 p# mitogen activated 62 cellular metabolism 62 Wnt pathway 62 V#F mutation 62 IGF 1R 62 rapamycin mTOR 62 cyclins 62 membrane receptors 62 tumor suppressors 62 neuronal differentiation 62 MAP kinase pathway 62 oncogenesis 62 serine threonine kinases 62 beta catenin 62 glycosylation 62 FGFR1 62 mediating pathological inflammation 61 oncoprotein 61 cellular signaling pathways 61 HER3 61 sortilin 61 Flt3 61 MAPKs 61 cellular organelles 61 PI3 kinase 61 factor receptor FGFR 61 mTOR signaling 61 Mcl 1 61 serine protease 61 receptor gamma 61 glycolipids 61 miR #b [002] 61 ERK1 61 Sox2 61 uPAR 61 chemokine 61 S1P 61 small molecule inhibitors 61 hypermethylation 61 EGFR pathway 61 microRNAs miRNAs 61 TGF b 61 tyrosine phosphorylation 61 tumor angiogenesis 61 cyclooxygenase 2 61 NF kB pathway 61 histone deacetylase 61 inhibit angiogenesis 61 Rho GTPases 61 protein tyrosine kinase 61 receptor subtypes 61 neutrophil recruitment 61 cholesterol metabolism 61 oncoproteins 61 Clusterin 61 neurofibromin 61 tyrosine kinase receptor 61 receptor tyrosine kinase 61 GTPases 61 Dysregulation 61 downregulation 61 cell adhesion 61 NF kappaB 61 cell adhesion molecule 61 hepatic stellate cells 61 VE cadherin 61 RNA splicing 61 excess TNF alpha 61 molecular biomarkers 61 virulence genes 61 chromatin structure 61 regulated kinase ERK 61 RAS pathway 61 aberrantly activated 61 Cathepsin B 61 ERBB2 61 PI3K signaling pathway 61 carbohydrate metabolism 61 PDGFR 61 STIM1 61 micro RNAs 61 PKC enzyme 61 Phosphorylation 61 metalloprotease 61 ERK signaling 61 regulate gene expression 61 G Protein Coupled 61 angiogenic 61 ß catenin 61 epigenetic alterations 60 Notch pathway 60 IL 1β 60 calcineurin 60 TSC1 60 IGF IR 60 actin cytoskeleton 60 Fibroblast Growth Factor Receptor 60 EphA2 60 ion channels 60 downstream effectors 60 NKG2D 60 Skp2 60 FGFR2 60 isoforms 60 receptor tyrosine kinases RTKs 60 Chemokines 60 myeloid cells 60 deacetylation 60 AT1R 60 Oncogenic 60 Protein Kinase C 60 FasL 60 metabolic pathways 60 Cdc# 60 SOD1 60 ERK2 60 CDKs 60 intracellular proteins 60 FLT3 60 EGF receptor 60 tRNA synthetase 60 induce apoptosis 60 secreted protein 60 angiogenic responses 60 p# activation 60 homodimers 60 transcription factor 60 proteins 60 autophagic 60 cystic fibrosis transmembrane conductance 60 cyclin dependent kinases CDKs 60 Kv#.# 60 miRNAs 60 anti apoptotic 60 selective inhibition 60 NF kappaB pathway 60 metabolic processes 60 receptors EGFR 60 synaptogenesis 60 VIPR2 60 transmembrane proteins 60 MEK ERK 60 stem cell pluripotency 60 cysteine residues 60 transient receptor 60 pro angiogenic 60 glucocorticoid receptor 60 cyclin D1 60 tropomyosin 60 NFAT 60 posttranslational modifications 60 HDAC 60 dephosphorylation 60 calpain 60 chemokines 60 CRAC channel 60 mTOR 60 Hypoxia Inducible Factor 60 proapoptotic 60 lipid metabolism 60 ubiquitin ligases 60 proteolysis 60 B Raf 60 RAF kinase VEGFR 60 HDAC enzymes 60 intracellular protein 60 tumor vasculature 60 β catenin 60 matrix metalloproteinases 60 c MYC 60 ligases 60 Upregulation 60 gene rearrangements 60 JAK STAT 60 kinase pathway 60 tissue fibrosis 59 IL 1beta 59 evolutionarily conserved 59 NFkB 59 small molecule modulators 59 vimentin 59 PTPN# 59 AhR 59 constitutively expressed 59 FOXO3a 59 SIRT2 59 Wnt beta catenin 59 factor BDNF 59 selectively inhibits 59 PI3K 59 hyperphosphorylation 59 LRP6 59 histone deacetylation 59 p# MAPK 59 GTPase 59 thioredoxin 59 CCR2 59 cytokine 59 activating mutations 59 Receptors GPCRs 59 apoptotic 59 synaptic transmission 59 biologic pathways 59 dimerization 59 mitogen activated protein kinases 59 PML RARA 59 epithelial cancers 59 pro apoptotic 59 autocrine 59 adhesion molecules 59 Bcl XL 59 FOXP3 59 caveolin 59 adipokines 59 BCL6 59 coagulation cascade 59 HER2 HER3 59 glycosyltransferase 59 inhibits Akt activation 59 Src 59 ubiquitin ligase 59 beta amyloid peptide 59 histone deacetylase HDAC 59 EGF receptors 59 Rab5 59 binding proteins 59 stem cell differentiation 59 FGFR3 59 mutational status 59 induces apoptosis 59 sphingosine 1 59 histone modification 59 SIRT1 gene 59 deacetylases 59 Vascular endothelial growth 59 immunoregulatory 59 chromosomal regions 59 kinase 59 Kinases 59 prolyl 59 glial cell 59 inflammatory cytokines 59 PI3K AKT 59 lipoxygenase 59 NS5A 59 mRNA expression 59 c myb 59 kinase domain 59 CENP E 59 apoptosis pathways 59 forkhead 59 pro inflammatory cytokines 59 eNOS 59 Th# cells 59 deacetylase 59 microglial activation 59 HIF 1alpha 59 TMEM#B 59 Rap1 59 upregulation 59 PDGF receptor 59 proteoglycan 59 TGF beta 59 tumor suppressor 59 mechanotransduction 59 CXCR4 59 neuroinflammation 59 COX2 59 K + ATPase 59 receptor subtype 59 CTGF 59 ncRNAs 59 integrins 59 factor PlGF 59 potent inhibition 59 MDM2 59 Factor Receptor 59 pharmacodynamic biomarkers 59 RNAi pathway 59 Akt3 59 histone acetylation 59 PPARg 59 VEGF receptors 59 leukocyte adhesion 59 protein tyrosine kinases 59 tumor metastasis 59 Methylation 59 HMG CoA reductase 59 CaM kinase II 59 nAChRs 59 PPAR alpha 59 transcriptional activation 59 acetylation 59 heterodimers 59 Caspases 59 TTR gene 59 LDL receptor 59 microRNAs 59 kinase PI3K 58 retinoic acid receptor 58 cyclic adenosine monophosphate cAMP 58 melanocortin receptors 58 HBx 58 Akt signaling 58 anaphase promoting complex 58 Transcription factors 58 costimulatory 58 caveolin 1 58 neuroligins 58 TGF Beta 58 protein tau 58 c myc 58 Activating mutations 58 isotypes 58 TGFβ 58 renal fibrosis 58 IL 1ß 58 enzymatic pathways 58 noncoding RNAs 58 JAK2 enzyme 58 K ras mutations 58 retinoblastoma protein 58 apoE 58 Fas ligand 58 miRNA expression 58 mRNA molecules 58 TORC1 58 cAMP 58 metabolism viral replication 58 fibrotic disease 58 beta adrenergic receptors 58 gene polymorphisms 58 dysregulated 58 lysosomal 58 SWI SNF 58 transcriptional repressor 58 HCV protease 58 FOXO 58 Huntingtin 58 Treg cell 58 RANKL 58 Apoptosis 58 γ secretase 58 lipoprotein metabolism 58 nicotinic receptors 58 gene transcription 58 HDAC2 58 methylation patterns 58 sPLA2 58 Pten 58 IL #p# 58 Bcl 2 58 adipogenic 58 BCR ABL 58 NMDA receptors 58 Epstein Barr Virus EBV 58 bcl 2 58 estrogen receptor beta 58 glucagon receptor 58 cyclic AMP cAMP 58 intracellular enzymes 58 IL#R 58 neurotrophins 58 DISC1 58 receptor tyrosine kinases 58 molecular signaling pathway 58 acetylcholine receptor 58 c myc gene 58 mediated inhibition 58 tumor suppressor gene 58 HDAC inhibition 58 upregulating 58 Macrophage 58 Cdc7 58 neurotrophic factors 58 platelet derived growth 58 TXNIP 58 paracrine 58 Wnt signaling 58 clusterin 58 lymphangiogenesis 58 Polymorphisms 58 NMDA receptor 58 PIK3CA 58 CEA CD# Her2 58 matrix metalloproteinases MMPs 58 downstream effector 58 retinoid X 58 oxidases 58 estrogen receptors 58 ubiquitylation 58 paxillin 58 drug metabolizing enzymes 58 androgen receptor 58 inflammatory mediators 58 CCR7 58 Hedgehog signaling pathway 58 protein encoded 58 lectin pathway 58 genes encode proteins 58 functional polymorphism 58 Rac1 58 matrix metalloproteases 58 RNAi therapeutic targeting 58 EGFr 58 SMAD4 58 secretory pathway 58 thymidylate synthase 58 EGFR HER2 58 tRNA synthetases 58 neurosteroids 58 pathophysiological 58 phosphorylation 58 OCT4 58 neuronal signaling 58 virulence determinants 58 selectively inhibited 58 Sertoli cell 58 H#K# [002] 58 potently inhibit 58 telomerase reverse transcriptase 58 cytokines 58 Overexpression 58 coding genes 58 insulin signaling pathway 58 Leukotrienes 58 tyrosine kinase receptors 58 leukotrienes 58 antisense inhibitors 58 upregulated 58 thymidylate synthase TS 58 pathogenic mechanisms 58 PPAR gamma 58 cytochrome P# 58 COX enzymes 58 CD1d 58 chaperone protein 58 TRP channels 58 chaperone proteins 58 hydrolases 58 EphB4 58 cytokine receptors 58 micro RNA 58 dehydrogenases 58 GABAA receptors 58 cyclic adenosine monophosphate 58 circadian clock genes 58 neurotransmission 58 cytokine signaling 57 biogenesis 57 CXCL# 57 interferon IFN 57 inhibitory effects 57 prostaglandin synthesis 57 protein ADNP 57 effector functions 57 Runx2 57 cytosolic 57 protein tyrosine phosphatase 1B 57 overexpressed 57 CD# receptor 57 LIS1 57 PKM2 57 Cytotoxic T 57 overactivation 57 CTLA 4 57 effector cells 57 constitutively activated 57 myeloid 57 Smac mimetics 57 neurotrophic 57 myeloproliferative diseases 57 HSP# 57 BCR ABL1 57 Nedd4 57 gastric carcinogenesis 57 receptor CXCR4 57 Bcl xL 57 iNOS 57 N methyl 57 fibroblast growth 57 cyclic AMP 57 NADPH oxidase 57 Stat3 57 cAMP signaling 57 axon guidance 57 downregulating 57 genetic polymorphisms 57 Epidermal Growth Factor Receptor 57 POMC neurons 57 PAK1 57 tubulin 57 NOTCH1 57 derived neurotrophic factor 57 GATA3 57 exocytosis 57 molecular mechanisms underlying 57 SIRT3 57 ribonucleic acids 57 MEK1 57 glucocorticoid receptors 57 PPARgamma 57 VEGFR2 57 mitochondrial gene 57 RRM1 57 synapse formation 57 factor HGF 57 histone methylation 57 HIV AIDS neuropathic pain 57 selective inhibitors 57 CD#b 57 neural crest 57 polypeptides 57 missense mutations 57 NNRs 57 CB2 receptor 57 underlying vasculopathy 57 p#Kip# 57 chromatin remodeling 57 TGF ß 57 FoxO1 57 IL6 57 Rho proteins 57 Hh pathway 57 activin 57 neuroinflammatory 57 vascular endothelial 57 synthetase 57 alveolar macrophages 57 aberrant activation 57 Akt activation 57 HOTAIR 57 intercellular signaling 57 fusion proteins 57 potent inhibitor 57 transcriptional repression 57 EGFR signaling 57 PI3K/mTOR 57 antiapoptotic 57 PON1 57 Bcr Abl 57 ENaC 57 p# alpha [001] 57 PC# cells 57 pre mRNA splicing 57 CYP#C# [002] 57 monocytes macrophages 57 JNK1 57 lipid homeostasis 57 SH2 B 57 xenograft models 57 MCSP respectively 57 molecular mechanisms 57 Sp1 57 casein kinase 57 proinflammatory 57 TGF β 57 VEGF inhibitors 57 sphingolipid 57 CCR3 57 anti inflammatory cytokine 57 adaptive immunity 57 phagocytosis 57 orally administered inhibitor 57 agonists antagonists 57 leukocyte recruitment 57 CagA 57 HDAC inhibitors 57 calcium homeostasis 57 Vps# 57 E3 ubiquitin ligase 57 oxidative phosphorylation 57 mTORC1 57 selective antagonists 57 protein synthesis 57 Plasmodium 57 inhibiting tumor 57 mediated autoimmune diseases 57 PAR1 57 E3 ligase 57 lymphocyte activation 57 steroidogenesis 57 post translational modifications 57 lipid mediators 57 A3 adenosine receptor 57 vascular endothelial cells 57 druggable target 57 Histone 57 leukotriene pathway 57 nAChR 57 NR#A# 57 ribosomal proteins 57 inactivating mutations 57 TNF α 57 Akt1 57 PTP 1B 57 C5aR 57 protein phosphorylation 57 TNF receptors 57 protein misfolding 57 PDE#A 57 carcinogenesis 57 antagomirs 57 PPARγ 57 UsiRNAs 57 hematopoietic malignancies 57 intracellular signal transduction 57 factor VEGF 57 Ras pathway 57 receptor alpha 57 receptor PPAR 57 humoral 56 antisense oligonucleotides 56 potently inhibited 56 innate immune responses 56 mitogenic 56 mesenchymal cells 56 MDR1 56 epithelial tumors 56 RNA polymerase II 56 PPAR γ 56 androgen receptor signaling 56 mRNA translation 56 Brain derived neurotrophic 56 HIF 1α 56 autoantigens 56 H#K#me# 56 erythropoiesis 56 mesenchymal cell 56 cyclin dependent kinase 56 STAT1 56 MTHFR 56 biochemical pathways 56 kinase inhibition 56 poly ADP ribose polymerase 56 Epidermal Growth Factor 56 NFkappaB 56 copper zinc superoxide 56 ubiquitinated 56 peripheral tissues 56 KLF# 56 cofactor 56 EGFR inhibitors 56 FANCD2 56 lysophosphatidic acid LPA 56 Androgen receptor 56 DNMT1 56 WT1 56 neuroendocrine 56 biochemical pathway 56 STK# [002] 56 protein coding RNAs 56 cardiolipin 56 inducible nitric oxide synthase 56 cytoprotective 56 Abeta# 56 messenger RNAs mRNAs 56 hTERT 56 HCV replication 56 TLR8 56 messenger RNAs 56 RhoA 56 mediated apoptosis 56 Rab# 56 chromosomal translocations 56 anti apoptotic proteins 56 anticancer therapies 56 phosphatase 56 ADAM# 56 tumor stroma 56 guanylate cyclase 56 keratinocyte 56 galectins 56 cofactors 56 CCR9 56 ErbB3 56 TORC2 56 integrin 56 promoter methylation 56 Fc receptor 56 essential thrombocythemia 56 GABAergic interneurons 56 telomere maintenance 56 gene loci 56 gamma secretase 56 selectively inhibit 56 ERa 56 HOX genes 56 receptors PPARs 56 HIF 1a 56 Wnt 56 TrkA 56 TSP1 56 CDH1 56 methyltransferases 56 oligomeric 56 huntingtin 56 GGTase 56 molecularly targeted 56 HER2 receptors 56 glycoproteins 56 E cadherin 56 membrane lipids 56 epithelial tissues 56 ubiquitination 56 alpha folate receptor 56 eicosanoids 56 SIRT1 56 FGF receptor 56 Klf4 56 morphogens 56 N myc 56 methylenetetrahydrofolate reductase 56 vacuolar 56 VEGF pathway 56 orally bioavailable mimics 56 Mutational 56 XBP1 56 Notch1 56 osteoclast activity 56 adhesion proteins 56 JAK#/JAK# 56 CHD7 56 Jagged1 56 transmembrane receptor 56 receptor protein 56 PGE2 56 transmembrane protein 56 mPGES 1 56 ALN TTR 56 microglial 56 mu opioid receptors 56 fusogen 56 protein interleukin 56 intestinal epithelium 56 molecular signaling pathways 56 glucocorticoid receptor GR 56 mGluR4 56 D aspartic acid 56 hematopoiesis 56 GSK3B 56 transthyretin 56 Wnt proteins 56 adipocyte 56 T lymphocytes 56 Abl 56 demethylation 56 neuropsychiatric diseases 56 IKK beta 56 proliferative diseases 56 cholinergic neurons 56 TGF beta pathway 56 anticancer agents 56 caspases 56 ectopic expression 56 porphyrins 56 cMET 56 M2 subunit 56 tyrosine kinase inhibitors 56 Cyclin E 56 miR# 56 gene expression patterns 56 PKC alpha 56 neuronal migration 56 Oxidative stress 56 isoenzymes 56 glioblastoma cells 56 hypothalamic pituitary adrenal axis 56 LRP5 56 microtubule dynamics 56 untranslated regions 56 transcriptional machinery 56 extracellular domain 56 coronary vasodilation 56 thrombospondin 56 GABAB receptors 56 SIRT1 activators 56 MiRNAs 56 Six3 56 cardiac fibroblasts 56 innate immunity 56 CDK5 56 beta globin gene 56 membrane fusion 56 transferrin receptor 56 CK2 56 T lymphocyte 56 methyltransferase 56 OPHN1 56 macrophage activation 56 DNA demethylation 56 transactivation 56 BRAF protein 56 airway remodeling 56 viral proteins 56 myogenesis 56 elastase 56 TPO receptor 56 endocrine glands 56 interferon γ 56 biosynthesis 56 pathophysiological effects 56 miRNA molecules 56 acetylcholine receptors 56 pathogenesis 56 fibrogenesis 56 inhibiting enzymes 56 BMP4 56 immunological mechanisms 56 transcriptional regulators 56 Tumor necrosis factor 56 dendritic spine 56 downregulate 56 mGluR2 56 protein biosynthesis 56 serotonin receptor 56 muscarinic receptors 56 catalytic subunit 56 neurotransmitter GABA 56 SGK1 56 IFN γ 56 CDK9 56 causal variants 56 chitinase 56 neuropeptides 56 endothelial nitric oxide synthase 56 endocytosis 56 Notch receptor 56 homologues 56 miR #a [002] 56 osteoblast 56 tumor suppressor proteins 56 eukaryotic cells 56 mitotic kinesin 56 NS4B 56 intracellular calcium 56 antioxidant enzymes 56 NR2B 56 Pim kinases 56 factor GDNF 56 granulocyte macrophage colony stimulating 56 Chemokine Receptor 56 proteins encoded 56 superfamily 56 PI3K/Akt 56 neuromuscular junction 55 p# pathway 55 androgen receptors 55 hypothalamic pituitary 55 pyrimidines 55 Nrf2 55 polycythemia vera PV 55 AKT pathway 55 gene expression 55 alternative splicing 55 FUS1 55 inflammatory cytokine 55 glial derived neurotrophic 55 HER1 55 USP# 55 gastrin 55 Th1 type 55 Th1 cells 55 habenula 55 epigenetically 55 GRP# 55 oncogenic transformation 55 vascular endothelial growth 55 deacetylase inhibitors 55 phosphoprotein 55 IGFBP2 55 ErbB4 55 epigenetic enzymes 55 muscular dystrophies 55 circadian genes 55 bacterial enzyme 55 PIP3 55 epigenetic regulation 55 enzyme cofactor 55 epithelia