Related by context. All words. (Click for frequent words.) 73 predispose 63 predisposing 56 genetic predisposition 55 genes predisposing 54 predisposed 54 susceptibility 53 genetically predisposed 53 predisposition 53 induces 52 affects 51 genetic susceptibility 51 genetically inherited 51 metabolic abnormalities 51 APOE4 51 hereditary predisposition 51 inherited predisposition 51 genetically susceptible 51 underlying pathophysiology 50 biological predisposition 50 MTHFR 50 Genetic predisposition 50 Fragile X gene 50 familial hypercholesterolemia FH 50 PTPN# 50 afflicts 50 predisposing factor 49 genetic predispositions 49 exacerbates 49 autosomal recessive 49 dominantly inherited 49 insulin resistance 49 overactivity 49 metabolic dysfunction 49 APOE epsilon 4 49 excitotoxic 49 overactivated 49 prothrombotic 49 impaired glucose metabolism 49 causally linked 48 G allele 48 predisposing factors 48 aldehyde dehydrogenase 48 DQB1 * 48 inherited mutations 48 genetic trait 48 autonomic nerve 48 inhibits 48 familial adenomatous polyposis 48 ε4 48 abnormal lipids 48 dysregulated 48 metabolic abnormality 48 underactive thyroid gland 48 dopamine transporter gene 48 familial polyposis 48 e4 allele 48 PTEN mutations 48 PON1 47 manifests itself 47 alpha synuclein protein 47 fat malabsorption 47 OPRM1 gene 47 nonalcoholic fatty liver 47 autosomal recessive disease 47 susceptible 47 lethargy irritability 47 coronary microvascular 47 hyperinsulinemia 47 MYH9 gene 47 aggravates 47 shorter telomere length 47 systemic inflammation 47 untreated celiac disease 47 HLA DRB1 * 47 vascular Ehlers Danlos 47 hypothalamic amenorrhea 47 genes predispose 47 nonhereditary 47 heterozygote 47 phenotype 47 endocrine disorder 47 ovarian dysfunction 46 osteoporosis brittle bones 46 subclinical 46 atopic disorders 46 APOE ε4 46 dysregulation 46 apolipoprotein E gene 46 Oxidative stress 46 insulin resistance syndrome 46 susceptibility gene 46 normal karyotype 46 hereditary hemochromatosis 46 Lesch Nyhan syndrome 46 recessive trait 46 interferon pathway 46 cardiovascular disease osteoporosis 46 APOE gene 46 maternally transmitted 46 AUDs 46 SE alleles 46 Peripheral artery 46 Bardet Biedl Syndrome 46 neurological abnormalities 46 potentially modifiable 46 abnormal methylation 46 mitochondrial mutations 46 apoC III 46 M. catarrhalis 46 heritable 46 allele 46 atopic asthma 46 mutant huntingtin protein 46 embryonic tissues 46 neuroinflammatory 46 gestational diabetes mellitus 46 hypothalamic pituitary 46 filaggrin gene 46 gene predisposing 46 osteopenia osteoporosis 46 #q# deletion 46 IL#R 46 progranulin mutations 46 allergic sensitization 46 impairs 46 V Leiden 46 hypoactive 46 highly heritable 46 metabolic disturbances 46 circulating estrogens 46 chronicity 45 gene locus 45 developmental abnormalities 45 Dysregulation 45 parkinsonism 45 causal pathway 45 Thyroid hormone 45 Compulsive hoarding 45 progressive neurodegenerative disorder 45 genomic imprinting 45 obesity insulin resistance 45 gene variant 45 misregulation 45 insulin resistant 45 leptin deficiency 45 genomic instability 45 mental retardation epilepsy 45 nonalcoholic steatohepatitis NASH 45 Hereditary angioedema 45 penetrance 45 Genetic variation 45 BARD1 45 TP# mutation 45 neurobiological basis 45 muscular dystrophy cystic fibrosis 45 SHANK3 gene 45 multifactorial disease 45 untreated sleep apnea 45 elevated triglyceride levels 45 hypercoagulable 45 HGPS 45 inherited neurodegenerative 45 CHRNA5 gene 45 GABRA2 gene 45 chromosomal regions 45 airway hyperreactivity 45 induced cardiomyopathy 45 Breastfed infants 45 ataxias 45 LRRK2 mutations 45 KIBRA 45 premature ovarian 45 cardiac fibrosis 45 abnormal glucose metabolism 45 EP3 receptor 45 DRD4 gene 45 overactivation 45 Impulsivity 45 neuronal dysfunction 45 inhibitory transmitter 45 Hip dysplasia 45 impaired cognition 45 lupus scleroderma 45 HFE gene 45 neurological disorder characterized 45 neurodevelopmental 45 APOE e4 45 #q#.# [002] 45 genetic polymorphism 45 familial clustering 45 genetically predetermined 45 root caries 45 genetically programmed 45 autonomic dysfunction 45 hypokalemia hypomagnesemia 45 coinfection 45 ventromedial 45 mitochondrial defects 45 GABRA2 45 ADH1B 45 hypertension diabetes mellitus 45 Meckel Gruber 45 Diabetic neuropathy 45 autoimmune thyroid 45 epigenetic changes 45 SCD1 45 poorer prognosis 45 Zinc deficiency 45 Subclinical 45 germline mutations 45 Iron deficiency 45 chronic relapsing 45 genetic variant 44 recessive genetic 44 autosomal dominant 44 phenotypic expression 44 coma convulsions 44 STAT4 44 glial tumors 44 apolipoprotein E4 44 amyloid beta plaque 44 carbohydrate intolerance 44 potent inducer 44 dopamine receptor gene 44 gene polymorphism 44 malignant phenotype 44 pathophysiological mechanisms 44 Physical inactivity 44 familial predisposition 44 nucleus Chinnery 44 commonest cause 44 alpha synuclein gene 44 orexin receptors 44 Frontal lobe 44 Excessive daytime sleepiness 44 breast cancer genes BRCA1 44 traumatic disabling neurological 44 behavioral disinhibition 44 arthritis lupus 44 chronic obstructive airway 44 fatal myelination disorder 44 reproductive abnormalities 44 causes stomach ulcers 44 genetic defect 44 monogenic 44 progressive neurodegenerative 44 TMEM#B 44 NOD2 44 missense mutations 44 Hashimoto thyroiditis 44 anabolism 44 Dr. Ivashkiv 44 stathmin 44 Cowden syndrome 44 Prenatal exposure 44 beta1 integrin 44 eczema hay fever 44 genetically disposed 44 Apolipoprotein E4 44 overactive thyroid gland 44 Leydig cell 44 chromosomal anomalies 44 APOE4 gene 44 coronary artery atherosclerosis 44 disorder Ketchmark 44 impulsive behaviors 44 mal absorption 44 COMT gene 44 2 diabetes T2D 44 hereditary nonpolyposis colorectal cancer 44 Li Fraumeni syndrome 44 Factor XIII 44 GSTT1 44 improves insulin sensitivity 44 disregulation 44 Treg cell 44 genetic determinants 44 irritability mood swings 44 biologically predisposed 44 neuroinflammation 44 growth hormone secretion 44 skeletal muscles 44 comorbid psychiatric 44 serotonin 2A 44 dopamine signaling 44 puerperal psychosis 44 fatal neuromuscular disorder 44 MAOA genotype 44 cortical thinning 44 autosomal recessive disorder 44 airway responsiveness 44 DRD2 gene 44 nondemented 44 gene mutations 44 dizziness nausea headaches 44 hippocampal function 44 menstrual irregularity 44 TNFAIP3 44 underactive 44 hereditary nonpolyposis colon cancer 44 dysgenesis 44 lipoprotein lipase 44 pathological hallmark 44 Insulin resistance 44 neurons degenerate 44 lipoprotein metabolism 44 convulsive disorders 44 Fatty liver 44 painful menstrual periods 44 phthalate syndrome 44 attenuates 44 susceptibility genes 44 Myotonic dystrophy 44 diabetes cardiovascular disease 44 airborne fungal spores 44 DAT1 44 amyloid plaque formation 44 act synergistically 44 heterotaxy 44 paraneoplastic 44 genetic mutations 44 stimulate insulin secretion 44 epigenetic modification 44 Klinefelter syndrome 44 LDL receptor 44 CYP#D# gene 44 hyperresponsiveness 44 familial hypercholesterolemia 43 Vitamin D insufficiency 43 Chronic pancreatitis 43 parkinsonian 43 COX2 43 neuropsychological impairments 43 immuno suppressed 43 progressive dyspnea 43 microdeletion 43 microvascular disease 43 Parkinsonian 43 diabetic kidney 43 fever dehydration 43 alexithymia 43 prenatally exposed 43 ichthyosis vulgaris 43 pleiotropic 43 alpha1 43 susceptibility alleles 43 hyperparathyroidism 43 heritable disorders 43 upregulates 43 incurable genetic 43 genes 43 Vitamin B# deficiency 43 untreated hypothyroidism 43 INF2 43 regulates gene expression 43 TMJ temporomandibular joint 43 hormonal abnormalities 43 GSTM1 gene 43 adiponectin levels 43 multifactorial 43 causes 43 teratogens 43 heritable trait 43 podocyte 43 Brugada syndrome 43 ORMDL3 43 masculinizing 43 cerebral palsy multiple sclerosis 43 multisystem disease 43 hemoglobinopathies 43 GSTM1 43 Heterozygous 43 APOE e4 gene 43 pathogenic mechanisms 43 Exertional 43 basal cell nevus syndrome 43 ApoE4 gene 43 eczema asthma 43 FGFs 43 anterior cortex 43 comorbid anxiety 43 maladaptive behavior 43 LIS1 43 endoplasmic 43 leaky gut 43 meningitis encephalitis pulmonary edema 43 HbF levels 43 abnormal vaginal bleeding 43 mevalonate 43 inappropriate antidiuretic hormone SIADH 43 KIF6 gene 43 Marc Weisskopf 43 neuropsychiatric disorders 43 Genetic variations 43 rheumatoid arthritis lupus 43 genetic variants 43 disorder characterized 43 APOE genotype 43 heterozygosity 43 meningitis encephalitis 43 methylenetetrahydrofolate reductase 43 NADPH oxidase 43 PTEN gene 43 retinal dysfunction 43 BRCA2 gene 43 metabolize cholesterol 43 dendritic spine 43 comorbid disorders 43 Hypertrophic cardiomyopathy 43 BRCA2 breast cancer 43 syndrome OSAS 43 inborn 43 Apolipoprotein E 43 folate deficiency 43 researchers hypothesised 43 galactosemia 43 mutated gene 43 pancreas pancreatitis 43 carotid atherosclerosis 43 SIADH 43 inhibitory neurotransmitters 43 causative genes 43 gene mutation 43 familial pancreatic cancer 43 serotonin transporter 43 proinflammatory 43 downregulating 43 Genetic variants 43 modifiable risk 43 polygenic 43 DRB1 * 43 strongest predictors 43 TRPV1 receptors 43 FTO variant 43 heritable component 43 lipid concentrations 43 toxemia 43 adenylate cyclase 43 beta adrenergic receptor 43 genetic mutation 43 molecular underpinnings 43 maladaptive 43 matriptase 43 biologic pathways 43 hyperinsulinemic 43 chronic hepatitis cirrhosis 43 moderately heritable 43 MYH9 43 neuritic 43 CRTC3 43 de novo mutations 43 hepatic renal 43 experimentally induced 43 metabolizing enzyme 43 prone 43 cirrhosis liver failure 43 adversely affects 43 metabolic 43 hypertension cardiovascular disease 43 outward manifestations 43 Bacterial vaginosis 43 rs# [002] 43 inherit predisposition 43 paraoxonase 43 irregular menstrual cycles 43 chronic bronchitis emphysema 43 chromosomal anomaly 43 cystic fibrosis sickle cell 43 dopamine D2 receptors 43 asthmatic airways 43 LPA gene 43 aetiological 43 pathophysiologic 43 genetically wired 43 chronic degenerative diseases 43 neuroligins 43 arterial calcification 43 huntingtin protein 43 heritable genetic 43 genus Plasmodium 43 channelopathies 43 synovial cells 43 paternally inherited 43 narcolepsy cataplexy 43 AMP kinase 43 #HT#A 43 Secondhand smoke causes 43 chromosomal aberrations 43 thyroid dysfunction 43 osteochondrosis 43 maternally derived 43 COPD emphysema 43 severely impairs 43 pathogenesis 43 clinically heterogeneous 43 prolonged immobilization 43 neurobiological 43 Chlamydia pneumoniae 43 neuronal synapses 43 virulence genes 43 psychiatric disorders ATI 43 c myc gene 43 gastric carcinomas 43 habitual snoring 43 metabolizing enzymes 43 D3 receptors 43 robs sufferers 43 oxidized phospholipids 43 heterozygous familial 43 Arrhythmogenic Right Ventricular Cardiomyopathy 43 C. pneumoniae 43 antiphospholipid syndrome 43 osteomalacia 43 body fatness 43 suppresses 43 neuromuscular junction 43 Androgenetic alopecia 43 hyperactivated 43 emphysema chronic bronchitis 42 distractibility impulsivity 42 neurologic disorders 42 SIRT1 gene 42 dysthymic 42 Unhealthy diets 42 hyperinsulinism 42 hyperexcitability 42 elevated cortisol 42 multiple sclerosis cerebral palsy 42 proximal femoral focal 42 immune dysregulation 42 renal fibrosis 42 renin angiotensin system 42 GRK5 42 epiphenomenon 42 hypogonadotropic hypogonadism 42 Phenylketonuria 42 motor neuron degeneration 42 AMPK activation 42 polycystic ovary 42 hay fever asthma 42 leukocyte adhesion 42 endocrine dysfunction 42 spontaneous mutations 42 maternally inherited 42 Worthingtons testified 42 Smac mimic 42 Hutchinson Gilford progeria 42 psychosomatic illnesses 42 GBA mutations 42 nonconscious 42 myocarditis inflammation 42 cirrhotic liver 42 hepatic lipase 42 Genetic mutations 42 Untreated sleep apnea 42 remains mystery Yairi 42 Restless legs 42 CAG repeats 42 melanocortin receptor 42 APOE4 variant 42 Pathological liars 42 Pelvic inflammatory 42 lysosomal storage disease 42 gut microbes 42 cyclic AMP cAMP 42 PLMs 42 Pulmonary hypertension 42 Radiographic findings 42 pituitary tumors 42 congenital adrenal hyperplasia 42 palpitations sweating 42 Brain derived neurotrophic 42 diabetes dyslipidemia 42 neurofibrillary 42 congenital deficiency 42 Gleevec inhibits 42 catecholamine 42 synaptic function 42 metabolic alterations 42 familial adenomatous polyposis FAP 42 endophenotypes 42 glutamic acid decarboxylase 42 Raynaud syndrome 42 p# mutations 42 phenotypes 42 bone deformities 42 Thyroid gland 42 deleterious mutations 42 obese postmenopausal 42 ephrin A1 42 Brugada Syndrome 42 MC1R 42 glucocorticoid receptors 42 insulin resistance precursor 42 infertility miscarriages 42 testicular tumors 42 researchers hypothesized 42 darker pigmentation 42 Myostatin 42 genital ulcer 42 genetic polymorphisms 42 G6PD deficiency 42 pancreas secretes insulin 42 cervicitis 42 activity MAOA 42 primary ovarian insufficiency 42 hydrops 42 gene variants 42 CFTR gene 42 cortexes 42 PTP1B 42 molecular etiology 42 congential 42 FASPS 42 estrogenic effects 42 non polyposis colorectal 42 E selectin 42 innate predisposition 42 cyclin E 42 autosomal dominant disorder 42 Genetic mutation 42 Antisocial personality 42 oxidant stress 42 gastro oesophageal reflux 42 multi factorial disease 42 misperceive 42 Erythropoietic therapies may 42 lactational 42 reactive oxygen 42 neuropsychiatric disorder 42 Hypothyroidism 42 schizophreniform 42 Wernicke Korsakoff syndrome 42 allergic eczema 42 CDH1 42 inverse agonist 42 genetic variation 42 argumentativeness 42 hormone aldosterone 42 induce insulin resistance 42 folate metabolism 42 impair cognition 42 causative 42 slow caffeine metabolizers 42 hormones neurotransmitters 42 MSH2 42 hemochromatosis 42 CFH gene 42 chromosomal alterations 42 heterozygous 42 functional polymorphism 42 Oxidative damage 42 syndrome FXTAS 42 type2 diabetes 42 disease NAFLD 42 subclinical atherosclerosis 42 Dilated cardiomyopathy 42 HMPV 42 syndromes 42 disproportionately affects 42 sporadic ALS 42 disturbs 42 apo E 42 etiologic factors 42 hormone angiotensin II 42 cholesterol homeostasis 42 Osteogenesis imperfecta 42 ABCB1 42 use disorders AUDs 42 folic acid deficiency 42 proinflammatory mediators 42 negative affectivity 42 Von Willebrand disease 42 severe obstructive pulmonary 42 diathesis 42 excitatory neurotransmitter glutamate 42 SCA5 42 degenerative neurological diseases 42 neurodegenerative disorder characterized 42 causative gene 42 SMAD4 42 TGFBR1 42 chromosomal instability 42 Cerebral palsy involves 42 MEF2A 42 hyperhomocysteinemia 42 5 HT1A receptor 42 neurodegenerative disorder 42 Th2 42 abnormal lipid 42 NF1 gene 42 β cell 42 apolipoprotein E 42 cognitive dysfunctions 42 SEPS1 42 irregular menstruation 42 telomeres shorten 42 TMPRSS6 42 epithelial barrier 42 congenital anomalies 42 digest lactose 42 olfactory dysfunction 42 upregulating 42 asthma bronchitis emphysema 42 metabolic syndrome 42 Simian Immunodeficiency Virus 42 compensatory mechanisms 42 Cognitive impairment 42 post transplant lymphoproliferative 42 adrenocortical 42 biochemical imbalances 42 inheritable genetic 42 cdk5 42 SLC#A# [002] 42 genotype 42 recurrent wheezing 42 MLH1 42 delayed gastric emptying 42 congenital muscular dystrophies 42 neuroendocrine 42 Korsakoff syndrome 42 lysyl oxidase 42 leptin resistant 42 BDNF gene 42 germline mutation 42 AAT Deficiency 42 Neuroticism 42 mammary cancers 42 Sedentary lifestyle 42 apoE 42 COX enzymes 42 hormonally sensitive 42 impaired endothelial 42 diabetic microvascular complications 42 neurodevelopment 42 tremors convulsions 42 airway reactivity 42 clonogenic 41 hereditary 41 primary ciliary dyskinesia 41 SCN9A 41 protein conformation 41 perirhinal cortex 41 tiredness irritability 41 CHD7 41 basal ganglia 41 endocannabinoid signaling 41 destroys myelin 41 Chlamydia trachomatis infection 41 constitutively active 41 schizotypal 41 genetic loci 41 oncoproteins 41 inheritable 41 nonischemic 41 mtDNA mutations 41 multisystem disorder 41 Polycystic Ovarian Syndrome PCOS 41 polydipsia 41 hormone secretion 41 abdominally obese 41 GABA aminotransferase 41 psoriatic skin 41 mitogen activated protein kinases 41 arteriosclerotic 41 polyglutamine diseases 41 precancerous cervical 41 Periodontal diseases 41 shorter telomeres 41 CYP#E# 41 bacteria Helicobacter pylori 41 metabolic syndromes 41 Helicobacter 41 cortical cataract 41 pathophysiological 41 BRCA gene mutation 41 subcortical 41 Secondhand smoke exposure 41 nicotinic receptor 41 promoter polymorphism 41 subclinical hyperthyroidism 41 estrogen deficiency 41 systemic autoimmune 41 chromosomal rearrangement 41 PPARg 41 apoptosis pathway 41 prostate carcinogenesis 41 outward manifestation 41 molecular abnormalities 41 gene DRD4 41 diabetes insipidus 41 prognostic indicator 41 neurological disorder affecting 41 causes chickenpox 41 ventricular hypertrophy 41 OCA2 41 TCF#L# 41 elevated homocysteine 41 BRCA mutation 41 Decety 41 childhood disintegrative disorder 41 immunocompromised 41 PALB2 41 KCNQ1 41 obstructive coronary artery 41 periodontal infection 41 opportunistic viral infection 41 SCN1A 41 fibrin deposition 41 neurotransmission 41 spongiform encephalopathies 41 obstructive coronary 41 Pernicious anemia 41 antidiuretic hormone 41 herpesviruses 41 5 HT2A receptor 41 IgE mediated 41 endocrine abnormalities 41 non syndromic 41 Aldosterone 41 SCN9A gene 41 Sarcopenia 41 biochemical imbalance 41 neurocognitive deficits 41 genetic alteration 41 amyloidogenic 41 Colon polyps 41 affective psychoses 41 synaptogenesis 41 eicosanoid 41 tremor slowness 41 aberrant activation 41 multi factorial 41 BRCA1 mutations 41 cathelicidin 41 beta endorphin 41 effector molecules 41 filaggrin 41 colon carcinogenesis 41 alleles 41 blindness amputation 41 multi infarct dementia 41 inflammatory demyelinating 41 MTP inhibitor 41 motivates 41 Diabetic macular edema 41 autosomal recessive genetic 41 ApoE4 41 SORL1 gene 41 multiply uncontrollably 41 helicobacter 41 atherogenesis 41 underactive thyroid 41 Propionibacterium acnes 41 atopic 41 CETP gene 41 insertional 41 muscular stiffness 41 prosocial behavior 41 persistent pulmonary hypertension 41 vermis 41 etiologic 41 electrolyte imbalances 41 CYP#B# 41 nociception 41 arthritis gout 41 oral thrush 41 phospholipase A2 41 arterial inflammation 41 Purkinje cell 41 chromosome deletion 41 plaque buildup restricts 41 nutritional deficiency 41 psychopathological disorders 41 obesity sedentary lifestyle 41 debilitating neurodegenerative disorder 41 MECP2 gene 41 granulosa cell 41 interferon induced 41 AT1 receptor 41 obstructive sleep apnea hypopnea 41 lymphocyte activation 41 hepatocellular 41 atherosclerosis plaque buildup 41 evolutionarily novel 41 myopathies 41 premalignant 41 indwelling catheters 41 serotonin deficiency 41 Lichen planus 41 chronic idiopathic 41 allostatic load 41 vasopressin receptors 41 HLA gene variant 41 Chronic bronchitis 41 fatal arrhythmias 41 antibody mediated 41 genetic variants associated 41 klotho 41 Hyperthyroidism 41 atopy 41 #q# deletion syndrome 41 cognitive deficits 41 TTR amyloidosis 41 APOE e4 allele 41 HLA molecules 41 prefrontal regions 41 APOE allele 41 cardiovascular disease hypertension 41 unprovoked seizures 41 PI3K signaling 41 frontostriatal 41 brown adipose tissue 41 genetic variability 41 immunomodulatory effects 41 nerve degeneration 41 Psychotropic medications 41 tendinitis bursitis 41 M.tb 41 dyslipidemia hypertension 41 NKT cell 41 demyelinated 41 neonatal lupus 41 etiological 41 progranulin protein 41 dysmorphic 41 airway hyper responsiveness 41 disc degeneration 41 chemically alters 41 Gastroesophageal reflux disease 41 chromosomal disorders 41 structural abnormalities 41 gastrointestinal disturbances 41 multiple sclerosis muscular dystrophy 41 dyslipidemias 41 alveolar macrophage 41 blindness paralysis 41 neurologic disorder 41 causes genital herpes 41 unhealthy dietary habits 41 eNOS 41 infects 41 VLDL cholesterol 41 #q#.# deletion syndrome 41 5 HT1A 41 inflammatory bowel syndrome 41 cardiometabolic disorders 41 polymicrobial 41 hypercoagulability 41 muscular dystrophies 41 Oxidative 41 trophoblastic 41 progressive retinal degenerative 41 neuronal degeneration 41 UGT#B# 41 insomnia dizziness 41 tropomyosin 41 Left untreated 41 hypoxic ischemic brain 41 molecular mechanisms underlying 41 menarche 41 dopamine neuron 41 corticosterone levels 41 DICER1 gene 41 cystic fibrosis muscular dystrophy 41 molecularly defined 41 polyhydramnios 41 underlies 41 metabolically active 41 cardiac hypertrophy 41 associated tremor ataxia 41 intracranial atherosclerosis 41 TGFBR1 * 6A 41 osteodystrophy 41 MC4R gene 41 VHL gene 41 premutation 41 seizures coma 41 periodontal infections 41 nervousness irritability 41 serotonin receptor 41 proneness 41 Pdx1 41 thyroid hormone levels 41 overdiagnose 41 assortative mating 41 chorioamnionitis 41 socioemotional 41 misfolded prions 41 phenotypic variability 41 vasoconstrictor 41 progressive neurologic 41 histone modification 41 stimulates 41 oxytocin receptor 41 endogenous opioid 41 Nonalcoholic fatty liver 41 both genders chromosomal 41 Hormonal imbalance