Related by context. All words. (Click for frequent words.) 63 diagnosis PGD 62 thrombophilia 62 aneuploidy screening 61 amniocentesis 61 PGD 60 prenatally diagnosed 60 preimplantation genetic diagnosis PGD 59 prenatal ultrasound 59 unexplained infertility 59 hereditary breast cancer 59 preimplantation genetic diagnosis 58 BRCA mutations 58 Amniocentesis 58 karyotyping 58 BRCA mutation 57 recurrent miscarriage 57 coronary CTA 57 Rh incompatibility 57 recurrent miscarriages 56 fetal aneuploidy 56 Prenatal diagnosis 56 TTTS 56 invitro fertilization 56 molar pregnancy 56 BRCA mutation carriers 56 amnio 56 breech babies 56 chromosomal abnormalities 56 LQTS 55 Preimplantation Genetic Diagnosis PGD 55 aneuploidy 55 RhD negative 55 intracytoplasmic sperm injection 55 trisomy 55 BRCA carriers 55 embryo biopsy 55 surgical biopsies 55 tubal reversal 55 infertility 55 assisted reproduction 55 diagnosed prenatally 55 singleton pregnancy 55 fetal chromosomal abnormalities 55 fetal anomalies 55 haplotyping 54 reproductive endocrine 54 genetic abnormalities 54 infertility treatments 54 prenatal diagnostic 54 fetal abnormalities 54 fetal echocardiography 54 implantation genetic 54 chromosome abnormalities 54 HNPCC 54 prophylactic mastectomy 54 axillary dissection 54 prenatal 54 chromosomal defects 54 causative gene 54 ICD implantation 54 chromosomal disorders 54 perinatal outcomes 54 IVF 54 antenatal depression 54 ovarian hyperstimulation 54 noninvasive imaging 54 diagnosis 54 curative therapy 54 RhD 54 IVF ICSI 54 warfarin dosing 54 multidetector row 54 obstetric ultrasound 53 sentinel node biopsy 53 aneuploidies 53 preimplantation genetic screening 53 CHDs 53 tandem mass spectrometry 53 Pre implantation genetic 53 polycystic ovary syndrome 53 fine needle aspiration 53 ovulation induction 53 Vitro Fertilisation IVF 53 chromosomal aberrations 53 Liver transplantation 53 Newborn screening 53 core needle biopsy 53 IVF treatment 53 undergoing IVF 53 preoperative staging 53 surgical biopsy 53 genetic syndromes 53 myelomeningocele 53 BRCA 53 uterus transplants 53 IUGR 53 hysteroscopy 53 MCAD deficiency 53 chromosomal anomaly 53 Vitro Fertilization 53 uncomplicated pregnancies 53 Vitro Fertilization IVF 53 placental malaria 53 colposcopy 52 cervical precancer 52 sentinel lymph node biopsy 52 exome sequencing 52 postpartum hemorrhage 52 perioperative morbidity 52 fetal abnormality 52 microdeletions 52 vasectomy reversal 52 elective caesarean 52 vitro fertilization IVF 52 needle biopsies 52 chlamydial infection 52 prognostic markers 52 uterus didelphys 52 prenatal Down syndrome 52 BRCA1 52 sonographic examination 52 diagnostic modality 52 SLN biopsy 52 blocked fallopian tubes 52 breast MRI 52 pelvic lymphadenectomy 52 ectopic pregnancies 52 pre implantation genetic 52 abort fetus 52 Retinopathy 52 preterm deliveries 52 transfusion syndrome 52 invasive prenatal 52 pelvic ultrasound 52 ovarian stimulation 52 cesarean births 52 mammographic density 52 premature menopause 52 SLNB 52 prostate biopsy 52 chorionic villus sampling 52 operable breast cancer 52 BRCA1 mutations 51 BRCA2 mutation 51 lymph node dissection 51 recanalisation 51 elective Caesarean 51 adjuvant radiation 51 ovary transplant 51 lymphadenectomy 51 epithelial ovarian cancer 51 presymptomatic 51 genomic profiling 51 chromosomal anomalies 51 endoscopic ultrasound 51 BRCA gene 51 holoprosencephaly 51 placenta praevia 51 caesarean delivery 51 epidural analgesia 51 stem cell transplantation 51 Apert syndrome 51 stratifying patients 51 mosaicism 51 atypical hyperplasia 51 proband 51 fFN 51 colonoscopic 51 varicoceles 51 BRCA testing 51 oncologic outcomes 51 singleton pregnancies 51 pregnancies 51 transcatheter aortic valve implantation 51 ovarian transplant 51 baseline mammogram 51 sonographic diagnosis 51 VCUG 51 endometrial cancers 51 diagnosing autism 51 Trisomy 51 infertile couples 51 postexposure prophylaxis 51 advanced neoplasia 51 donor insemination 51 somatic mutations 51 choriocarcinoma 51 cerebral angiography 51 Caesarean Section 51 folate supplementation 51 fetal ultrasound 51 trimester ultrasound 51 Sentinel Lymph Node Biopsy 51 HbF 51 Premature Ovarian Failure 51 sonographic evaluation 51 ACOG guidelines 51 embryo implantation 51 genomewide 51 microsatellite instability 51 catheter angiography 51 cranial radiation 51 leiomyomas 51 ultrasonographic 51 intracytoplasmic sperm injection ICSI 51 elective caesarean section 51 Tay Sachs 51 Hurler syndrome 51 invasive diagnostic 51 GISTs 51 newborn screening 51 preimplantation 51 breast cancer gene mutations 51 prophylactic oophorectomy 50 invasive biopsy 50 Meckel Gruber 50 pre eclamptic 50 perinatal depression 50 Moyamoya disease 50 cytoreduction 50 ASCUS 50 endometrial biopsy 50 thyroid nodules 50 BRCA2 mutation carriers 50 transvaginal sonography 50 fertility treatments 50 abnormal mammograms 50 breast MRIs 50 BRCA2 mutations 50 ependymoma 50 urine dipstick 50 abnormal cervical 50 terminating pregnancy 50 thyroglobulin 50 sperm cryopreservation 50 invasive biopsies 50 inherited mutations 50 uterine fibroid embolization 50 BRCA gene mutation 50 colorectal cancer CRC 50 congenital adrenal hyperplasia CAH 50 Heavy menstrual bleeding 50 sCJD 50 vitro fertilization 50 hepatectomy 50 Vitro fertilization 50 membrane rupture 50 BRCA genes 50 endometrial carcinoma 50 nuchal translucency 50 urolithiasis 50 PPCM 50 vascular anomalies 50 spontaneous vaginal 50 Sonography 50 Sonograms 50 adenomatous polyps 50 breast biopsies 50 transabdominal 50 preoperative diagnosis 50 peritoneal cancer 50 adenomyosis 50 recurrent ovarian 50 diagnostic biomarker 50 BRCA2 carriers 50 bladder exstrophy 50 bronchopulmonary dysplasia BPD 50 Intra Cytoplasmic Sperm Injection 50 IgA deficiency 50 eSET 50 PGD PGS 50 ductal lavage 50 adnexal mass 50 ultrasonography 50 lung biopsy 50 intrapartum 50 therapy IMRT 50 cervical cerclage 50 hereditary diseases 50 reperfusion therapy 50 Buhimschi 50 serologic testing 50 Hutchinson Gilford progeria 50 EBUS 50 sentinel lymph node 50 excisional biopsy 50 penetrance 50 Fragile X gene 50 miscarriages stillbirths 50 Klinefelter syndrome 50 transesophageal echocardiography 50 pelvic lymph node dissection 50 GIST tumors 50 preimplantation genetic 50 ultrasound scans 50 histopathologic findings 50 spontaneous preterm birth 50 Aneuploidy 50 de novo mutations 49 radioiodine therapy 49 HBV vaccination 49 CMV infection 49 Down syndrome 49 abdominal ultrasounds 49 artery embolization 49 invasive carcinoma 49 BRCA1 gene 49 Doppler ultrasound 49 mtDNA mutations 49 teratoma 49 premature ovarian 49 abnormal mammogram 49 Islet transplantation 49 INVO procedure 49 chimerism 49 varicocele 49 HLA typing 49 abnormal Pap tests 49 fetal malformations 49 nephron sparing surgery 49 primary ovarian insufficiency 49 MSH2 49 noninvasive prenatal 49 vitro maturation 49 pregnancy 49 screening mammography 49 extracolonic findings 49 maternal serum 49 sentinel node 49 microdeletion 49 Ultrasonography 49 histologic diagnosis 49 IUI 49 Dravet syndrome 49 undergoing hysterectomy 49 breast irradiation 49 dimensional ultrasonography 49 mitochondrial disorders 49 histological diagnosis 49 preterm delivery 49 vasa previa 49 FXTAS 49 Cesarean deliveries 49 familial hypercholesterolaemia FH 49 growth restriction IUGR 49 vascular anatomy 49 postoperative pulmonary 49 NGAL 49 psychotherapeutic treatment 49 CT angiography 49 perfusion imaging 49 colonography 49 screening colonoscopy 49 precursor lesions 49 thromboprophylaxis 49 diagnoses 49 Ectopic pregnancy 49 embryologists 49 urine cytology 49 pre operatively 49 spontaneous miscarriages 49 abnormal Pap test 49 Colposcopy 49 hydrops 49 prenatally 49 placenta accreta 49 hydronephrosis 49 preimplantation screening 49 radiotherapy SBRT 49 postnatally 49 oocyte donation 49 renal biopsy 49 egg retrieval 49 transvaginal ultrasound 49 multimodality therapy 49 antiretroviral prophylaxis 49 fetal fibronectin 49 color Doppler sonography 49 Cystoscopy 49 PCOD 49 obstetric complications 49 neural tube defect 49 Infertility 49 coronary arteriography 49 Wiskott Aldrich syndrome 49 genetic defects 49 vaginal delivery 49 twin transfusion 49 Li Fraumeni 49 oocyte retrieval 49 Male infertility 49 preventative mastectomy 49 cystectomy 49 gynecological examination 49 relapsed ALL 49 ovarian malignancy 49 Genetic testing 49 fetal chromosomal 49 congenital diaphragmatic hernia 49 DXA scan 49 incidentalomas 49 familial adenomatous polyposis 49 colonoscopy screenings 49 testicular biopsy 49 uterine fibroids 48 prognostic indicators 48 antiviral therapy 48 Preimplantation genetic diagnosis 48 endoscopic resection 48 autosomal 48 chromosomal imbalance 48 heritable genetic 48 interventional radiology procedures 48 Kufs disease 48 serological tests 48 radical nephrectomy 48 multiple gestations 48 newborn infants 48 BSGI 48 radiation therapy SBRT 48 atypia 48 curable cancers 48 congenital CMV infection 48 Hirschsprung disease 48 congenital toxoplasmosis 48 noninvasive painless 48 Cesarean delivery 48 needle biopsy 48 color Doppler 48 renal tumors 48 chlamydial 48 molecular profiling 48 Langerhans cell histiocytosis 48 mutation 48 microchimerism 48 pyloric stenosis 48 mutated K ras 48 Flexi Scope 48 MCADD 48 elective cesarean delivery 48 cervical carcinoma 48 assisted reproductive 48 fetal microchimerism 48 orchiectomy 48 neoadjuvant therapy 48 deCODE BreastCancer TM 48 chromosomal abnormality 48 thoracic aortic disease 48 psychosocial distress 48 sperm retrieval 48 ultrasounds 48 maternally inherited 48 adrenalectomy 48 Accelerated Partial Breast Irradiation 48 inheritable diseases 48 endoscopic examinations 48 conventional angiography 48 DEXA scan 48 sperm donor offspring 48 postnatal depression 48 TomoDirect 48 Abdominal ultrasound 48 coronary angiography 48 neurogenic bladder 48 cell transplantation 48 sonographic findings 48 neuroblastomas 48 tubal 48 abruption 48 tumor resection 48 BRCA1 mutation 48 intrauterine infection 48 EUS FNA 48 TargetScan 48 gynecologic 48 prostate cancer CaP 48 polycystic ovaries 48 Embryo donation 48 tumor histology 48 glaucoma sufferers 48 micrometastases 48 invasive coronary angiography 48 mitochondrial DNA mtDNA 48 congenital cytomegalovirus 48 gene mutations 48 transrectal 48 colorectal screening 48 Mendelian disorders 48 extracorporeal membrane oxygenation ECMO 48 breech births 48 screening mammogram 48 Rh factor 48 VUR 48 caesarian sections 48 Fanconi anemia 48 Brugada syndrome 48 cytological 48 abnormal cytology 48 Multiple logistic regression 48 nodal metastases 48 islet transplants 48 Genetic predisposition 48 susceptibility gene 48 breast cancer gene mutation 48 DNA methylation patterns 48 multifocal IOLs 48 perinatal morbidity 48 gynaecologic 48 mammographic 48 cytoreductive surgery 48 diagnosing coronary artery 48 liver metastasis 48 Adjuvant chemotherapy 48 warfarin therapy 48 needle aspiration 48 duplex ultrasonography 48 multivariate analyzes 48 intestinal biopsy 48 TOGA procedure 48 FDG-PET/CT 48 adjuvant radiotherapy 48 mammography screening 48 chromosomal defect 48 thoracoscopic lobectomy 48 infantile hemangiomas 48 pulmonary hypoplasia 48 uterine fibroid embolization UFE 48 #F FDG PET 48 prophylactic mastectomies 48 caesareans 48 neuropsychological impairments 48 imaging modality 48 chromosomal disorder 48 hemolytic disease 48 Recurrences 48 vaginal birth 48 guideline concordant 48 NovaSure procedure 48 preventive mastectomy 48 congenital anomaly 48 autosomal recessive disease 48 R0 resection 48 BRAF V#E mutation 48 BRCA2 gene mutation 48 core needle biopsies 48 transrectal ultrasound guided 48 chorioamnionitis 48 p# mutations 48 ovarian torsion 48 cranial irradiation 48 Radio Frequency Ablation 48 symptomatic fibroids 48 dysfunctional voiding 48 nephrogenic 48 thyroidectomy 48 recanalization 48 aneuploid cells 48 infertility ectopic pregnancy 48 transesophageal 48 invitro 48 ovary transplants 48 stereotactic radiotherapy 48 CFTR gene 48 Brugada Syndrome 48 fetal echocardiogram 48 HPV genotyping 48 Informed consent 47 screening mammograms 47 oocyte cryopreservation 47 GBS colonization 47 MR angiography 47 chromosomally normal 47 #D/#D ultrasound 47 bone marrow transplants 47 spontaneous regression 47 abnormal Pap smears 47 Assisted reproductive 47 preventive mastectomies 47 antithrombotic therapy 47 DCIS lesions 47 preterm infant 47 liver transplantation 47 nodal dissection 47 solid organ transplantation 47 benign lesions 47 antenatal screening 47 renal carcinoma 47 preventing premature births 47 optical colonoscopy 47 epigenetic changes 47 preeclampsia 47 Adiana 47 prenatal ultrasounds 47 facial clefts 47 microdissection 47 hysterectomy 47 immunochemical 47 Skotko 47 induce ovulation 47 scalpel vasectomy 47 STK# gene 47 cervical lesions 47 uncontrolled epilepsy 47 lymph node biopsies 47 colorectal liver metastases 47 PET CT scans 47 abnormal Pap smear 47 recessive mutations 47 diagnostic workup 47 CT Colonography 47 transcranial Doppler 47 prognostic marker 47 karyotypes 47 overt hypothyroidism 47 preoperative MRI 47 prognostic indicator 47 Sonographic 47 retinoblastoma 47 preterm labor 47 prenatal care 47 abort fetuses 47 chromosome abnormality 47 obstetrical complications 47 DIEP flap 47 intra uterine 47 aetiological 47 LV dysfunction 47 FMR1 47 simple cheek swab 47 inhibin 47 pacemaker implantation 47 axillary node dissection 47 undergoing radical prostatectomy 47 singleton babies 47 precancerous cervical 47 Biliary atresia 47 persistent pulmonary hypertension 47 reimplantation 47 infant circumcision 47 abdominal hysterectomy 47 subclinical atherosclerosis 47 gynecological 47 perfusion CT 47 donor gametes 47 tomosynthesis 47 antibiotic prophylaxis 47 immunosuppressive regimens 47 Radical prostatectomy 47 hormone hCG 47 LHRH receptor positive 47 curative treatments 47 treating uterine fibroids 47 polyhydramnios 47 axillary lymph node dissection 47 RapidArc treatments 47 Congenital Adrenal Hyperplasia 47 cytomegalovirus infection 47 pancreatic adenocarcinoma 47 grade cervical intraepithelial 47 myomas 47 apolipoprotein E gene 47 Afib 47 sonographic appearance 47 gastrointestinal GI cancers 47 benign polyps 47 leukemia ALL 47 Tonsillectomy 47 cervical dilation 47 detecting colorectal cancer 47 Verlinsky 47 extracolonic 47 PAP smear 47 congenital malformations 47 antimicrobial prophylaxis 47 TACI mutations 47 genetic disorders 47 genotyping assay 47 kernicterus 47 HLHS 47 elastography 47 single dose nevirapine 47 Renal Cell Carcinoma RCC 47 color Doppler ultrasound 47 Hysterectomies 47 cesarean delivery 47 IVF treatments 47 neuro developmental 47 shoulder dystocia 47 placenta previa 47 Circulating tumor cells 47 balloon valvuloplasty 47 tubal sterilization 47 colorectal neoplasms 47 salpingo oophorectomy 47 vulvodynia 47 VCFS 47 diagnostic laparoscopy 47 genomic alterations 47 congenital hypothyroidism 47 laparoscopic cholecystectomy 47 gynecological procedures 47 gamete 47 ADPKD 47 neurodevelopmental outcomes 47 Capsule endoscopy 47 mammographically 47 biopsies 47 weeks gestation 47 Optical Coherence Tomography 47 oophorectomy 47 colonic polyps 47 nonsurgical treatment 47 virologic responses 47 osteoporotic compression fractures 47 haematopoietic 47 Noonan Syndrome 47 neuroblastoma tumors 47 placental abruption 47 human chorionic gonadotrophin hCG 47 retroperitoneal 47 Gestational 47 Glezerman 47 female endoscopist 47 familial hypercholesterolemia 47 transrectal ultrasonography 47 IVF clinics 47 gamete donors 47 Postnatal depression 47 oncoplastic 47 neurosensory 47 undergo mastectomy 47 phenotypic expression 47 bicuspid valve 47 cervical smears 47 autistic regression 47 ultrasound scan 47 CT coronary angiography 47 neonatal herpes 47 Intussusception 47 radical hysterectomy 47 finger prick blood 47 SEQureDx ™ 47 NICE guideline 47 breech birth 47 Polycystic Ovarian Syndrome PCOS 47 MYCN amplification 47 iron supplementation 47 ambiguous genitalia 47 transcervical 47 radical cystectomy 47 PAP smears 47 stem cell engraftment 47 conventional colonoscopy 47 diagnose Alzheimer disease 47 placental stem cells 47 fecal occult blood 47 gestational surrogacy 47 pelvic inflammatory disease 47 myocardial viability 47 KRAS mutation 47 perinatal mortality 47 cord clamping 47 SPECT imaging 47 gynecologic cancer 47 osteopathic manipulative treatment 46 aneuploid 46 pharmacologic intervention 46 congenital anomalies 46 Trichomonas vaginalis 46 congenital cardiac 46 gestational surrogate 46 EBUS FNA 46 bone marrow aspiration 46 Tay Sachs disease 46 situs inversus 46 familial ALS 46 ovarian carcinoma 46 probe amplification MLPA 46 ductal breast cancer 46 brachial plexus palsy 46 catheterisation 46 fundoplication 46 diagnostic 46 clefting 46 ICSI cycles 46 Cardiac catheterization 46 Doppler sonography 46 Coronary CT angiography 46 VATS lobectomy 46 Joubert syndromes 46 chest radiographs 46 tuberculin skin test 46 ARVD 46 multivessel coronary artery 46 thermogram 46 heritable diseases 46 homozygous FH 46 fibroma 46 MitraClip device 46 Pap smear 46 probands 46 Patient Registry 46 BRCA gene mutations 46 polycystic ovarian syndrome PCOS 46 congenital abnormalities 46 sonography 46 CIN3 46 polycystic ovary syndrome PCOS 46 K ras mutations 46 acetabular fractures 46 teratogenic 46 ectopic pregnancy 46 Virtual colonoscopy 46 hyperemesis 46 sickle cell disease 46 pre malignant lesions 46 faulty BRCA1 gene 46 caesarean deliveries 46 Ultrasound imaging 46 deriving stem cells 46 galactosemia 46 #q# deletion 46 germline mutations 46 #q deletion 46 ultrasound examinations 46 mitochondrial diseases 46 endovascular repair 46 Fragile X Syndrome 46 antenatal 46 Arch Surg 46 mammographic screening 46 Pelvic Inflammatory Disease 46 pre natal 46 childlessness 46 Recurrence Score 46 congenital scoliosis 46 IDH mutations 46 gynecologic procedures 46 tubal ligation 46 antenatal care 46 spiral CT scan 46 neuropsychological assessment 46 PANDAS 46 OSAHS 46 post natally 46 kidney allograft 46 perinatal transmission 46 methylation markers 46 nephrectomy 46 transrectal ultrasound 46 Cesarean Section 46 cochlear implantation 46 abnormal pap smear 46 aromatase inhibitor therapy 46 epidural anesthesia 46 metastatic gastric 46 thalassaemic 46 HSCT 46 carotid stenosis 46 fetal heartbeats 46 breast lesions 46 neurocognitive impairment 46 balloon sinuplasty 46 gene mutation 46 primary immunodeficiency 46 ultrasound 46 adverse perinatal 46 Levy Lahad 46 gastric carcinoma 46 oncologists 46 Lung transplantation 46 helical CT 46 mammography 46 neonatal circumcision 46 abnormal pap smears 46 allogeneic transplant 46 etiologic 46 Ebstein anomaly 46 vesicoureteral reflux 46 nulliparous women 46 Li Fraumeni Syndrome 46 allogeneic transplants 46 gene BRCA2 46 coronary angiogram 46 CIN2 + 46 ureteroscopy 46 donor nephrectomy 46 nonpharmacologic 46 myoma 46 sentinel nodes 46 uterine prolapse 46 post partum haemorrhage 46 tubal pregnancy 46 monozygotic 46 herpesviruses 46 CDH1 46 D dimer 46 tracheal intubation 46 intrauterine insemination IUI 46 deletion 5q 46 tele ophthalmology 46 plain radiographs 46 cytogenetic 46 lymph node removal 46 biopsy 46 Breast Cancers 46 CT pulmonary angiography 46 PSA screening 46 micro calcifications 46 coagulation abnormalities 46 overdiagnosis 46 pap tests 46 deleterious mutation 46 optical coherence tomography 46 uterine abnormalities 46 transarterial chemoembolization 46 pleural mesothelioma 46 Fragile X 46 intravenous thrombolysis 46 skeletal malformations 46 postoperative delirium 46 Biopsies 46 hormonal stimulation 46 pharmacogenetic testing 46 AMOR IPAT 46 transthoracic echocardiography 46 trimester prenatal 46 Antenatal 46 adenoidectomy 46 surrogacies 46 G6PD deficiency 46 hypokalemia hypomagnesemia 46 clinically localized prostate 46 genomewide association studies 46 autistic traits 46 axillary lymph nodes 46 lung transplants 46 Acute Myeloid Leukaemia AML 46 prostate cancer metastases 46 balloon brachytherapy 46 adjuvant chemotherapy 46 CT colonography CTC 46 transthoracic 46 throughput RNAi 46 episiotomies 46 endometrial ablation 46 caesarean section births 46 revascularization procedure 46 nulliparous 46 Polycystic Ovary Syndrome 46 prognostic biomarkers 46 preterm babies 46 pancreatic islet cell 46 HELLP 46 thromboembolic disease 46 defective gene 46 JAK mutations 46 Endometrial cancer 46 pharmacologic treatments 46 aborting fetus 46 autologous transplants 46 uterus womb 46 definitively diagnose 46 valve implantation 46 amniotic fluid embolism 46 pelvic radiotherapy 46 Ponseti method 46 5q deletion 46 untreated chlamydia 46 thymectomy 46 thalassemia 46 Down syndrome spina bifida 46 Hip dysplasia 46 microvascular disease 46 3T MRI 46 dizygotic twins 46 positional cloning 46 malignant nodules 46 sonographic 46 Cockayne syndrome 46 MR imaging 46 hypoplastic 46 FDG PET 46 acute lymphoid leukemia 46 urologists radiation oncologists 46 postoperative radiotherapy 46 Belldegrun 46 ESHRE 46 postoperative AF 46 CT angiogram 46 neonatal jaundice 46 Dysplasia 46 gadolinium enhanced 46 diagnostic mammogram 46 TORS 46 implanted embryos 46 KRAS variant 46 scoliosis 46 thrombolytic therapy