Related by context. All words. (Click for frequent words.) 72 phenotypes 69 phenotype 69 genotypic 64 orthologs 63 gene expression 63 allelic 62 splice variants 62 epistasis 62 tyrosine phosphorylation 62 morphological 62 genomic 62 mRNA expression 62 miRNA expression 61 genomewide 61 transgene expression 61 transcriptional regulation 61 transcriptomes 61 morphologic 61 pathophysiological 61 Phenotypic 61 polymorphisms 61 A. thaliana 60 cDNAs 60 methylation patterns 60 germline mutations 60 histopathological 60 gene expression profiles 60 primate genomes 60 CEACAM1 60 phylogenetic 59 allele frequencies 59 mtDNA mutations 59 gene expression patterns 59 murine 59 genotypes 59 evolvability 59 #S rRNA gene 59 bacterial genomes 59 homozygosity 59 mutational 59 Jhdm2a 59 ortholog 59 etiologic 59 missense mutations 59 neoplastic 59 phenotypically 59 tumorigenicity 58 vivo 58 QTLs 58 Supplementary Fig 58 nucleotide substitution 58 transgenic mouse model 58 paralogs 58 CYP#C# [002] 58 sequence homology 58 orthologous genes 58 genotype 58 miR #a [001] 58 microRNA expression 58 evolutionarily conserved 58 microarray experiments 58 introgression 58 splice variant 58 sexual dimorphism 58 heterozygotes 58 neuroanatomical 58 neurite outgrowth 58 PTPN# 58 haematopoietic 58 genotype phenotype 58 Genotypic 58 phenotypic variation 58 chromosomal regions 58 orthologous 58 nucleotide sequence 58 genomic loci 57 multigenic 57 transcriptome 57 gene locus 57 #S rDNA 57 genotypic resistance 57 inbred strains 57 V#F mutation 57 ribosomal proteins 57 linkage disequilibrium 57 intergenic 57 mutant alleles 57 polyploidy 57 DNA methylation patterns 57 histone modification 57 substrate specificity 57 drug metabolizing enzymes 57 metazoan 57 alleles 57 mutant allele 57 Htt 57 microsatellite markers 57 #S rRNA 57 epistatic 57 peripheral blood mononuclear 57 cis regulatory 57 neuronal dysfunction 57 quantitative trait loci 57 qRT PCR 57 heritable traits 57 mtDNA 57 prion gene 57 BMP signaling 57 beta globin gene 57 HepG2 cells 57 phylogenies 57 siRNA mediated 56 FLT3 56 loci 56 MLH1 56 genetic loci 56 LIS1 56 indel 56 DNA demethylation 56 STAT4 56 genes encoding 56 miRNA 56 plasma pharmacokinetics 56 gene inactivation 56 VKORC1 56 noncoding RNAs 56 differential gene expression 56 metaplasia 56 viral genomes 56 proteomes 56 sporadic ALS 56 genetic heterogeneity 56 allelic variation 56 genetic 56 virulence genes 56 UGT#A# 56 kinase 56 serum biomarkers 56 germline 56 microarray gene expression 56 ontogenetic 56 microdeletion 56 ncRNAs 56 autosomal 56 neuronal differentiation 56 array CGH 56 mutations 56 germline cells 56 generalized vitiligo 56 pharmacodynamic 56 Leydig cell 56 chromosomal translocations 56 FGFR3 56 transcriptomic 56 alternative splicing 56 antiapoptotic 56 siRNA knockdown 56 susceptibility genes 56 Mendelian 56 eusociality 56 miRNA sequences 56 transfected cells 56 neuropsychiatric diseases 56 clinicopathological 56 syngeneic 56 gene rearrangements 56 P cadherin 56 RRM1 56 immunological responses 56 phylogenetic analyzes 56 coding exons 56 genomic variation 56 coding sequences 56 somatic mutations 56 gene duplications 56 gene loci 56 microsatellite instability 56 prion strains 56 #q#.# [002] 56 isoforms 56 proapoptotic 56 adipogenic 56 H#K#me# 56 transgenic mice expressing 56 amino acid sequence 56 E#F# 56 mutagenesis 56 gastric carcinomas 56 pleiotropy 56 C#BL/#J 56 transgenic mouse models 56 molecular mechanisms underlying 56 subcellular localization 56 phenotypic expression 56 differentially expressed genes 56 C#Y 55 histone modifications 55 coexpression 55 cytochrome b 55 immunohistochemical 55 binding affinities 55 coevolution 55 JAK2 V#F 55 immunostaining 55 acetylation 55 immunological 55 genomic DNA 55 homozygotes 55 aCGH 55 heterozygous 55 pathogenic mechanisms 55 noncoding RNA 55 miRNAs 55 protein phosphorylation 55 piRNAs 55 epigenetic mechanisms 55 epigenetic 55 CpG island 55 p# activation 55 lymphoid cells 55 hypomethylation 55 P. patens 55 activating mutation 55 chromosome #q 55 DNMT1 55 spontaneous mutations 55 dinucleotide 55 APOE genotype 55 pharmacodynamic markers 55 somatic mutation 55 evolutionary relatedness 55 mammalian 55 S#A# [002] 55 constitutively expressed 55 HRCT 55 phylogeny 55 silico prediction 55 mitochondrial genomes 55 airway hyperresponsiveness 55 At#g# 55 budding yeast 55 spontaneous mutation 55 apoE 55 Immunohistochemical analysis 55 promoter methylation 55 fig. S1 55 multigene 55 phenotyping 55 non coding RNA 55 γ secretase 55 kinase inhibition 55 ubiquitin ligases 55 genes 55 Prox1 55 codon usage 55 karyotypes 55 LRAT 55 single nucleotide polymorphism 55 hepatocyte 55 mutation 55 nucleotide 55 mitochondrial gene 55 ESR1 55 missense 55 histone acetylation 55 homology 55 chromatin structure 55 methylated DNA 55 heterozygosity 55 indels 55 NKT cell 55 perilipin 55 H#K# [002] 55 MAPK pathway 54 chlamydial 54 ultraconserved elements 54 transcriptional 54 neuronal 54 fungal genomes 54 RFLP 54 NOD mouse 54 metabolomic profiles 54 prion protein gene 54 ultrastructural 54 replicon 54 Genetic variation 54 NF1 54 paternally inherited 54 RNAi mediated 54 homologs 54 COL#A# 54 malignant transformation 54 adenoviral 54 Drosophila genome 54 ERK signaling 54 imprinted genes 54 genetic polymorphism 54 sRNA 54 operon 54 genetic polymorphisms 54 #p#.# [002] 54 CNVs 54 prion infection 54 heterologous expression 54 intronic 54 PON1 gene 54 genetic variation 54 vasopressin receptor 54 epigenetic regulation 54 motor neuron degeneration 54 polyploid 54 NPY gene 54 amino acid sequences 54 transcriptional profiling 54 prognostic markers 54 ultrastructure 54 cDNA microarray 54 isotypes 54 ABCB1 54 mitochondrial proteins 54 transduced 54 electrophysiologic 54 morphogen 54 Alu elements 54 Fig. 1D 54 FGFR2 54 Fig. 3a 54 radial glia 54 gene 54 SIRT1 activation 54 BAC clones 54 serologic 54 monozygotic 54 histologic 54 Clusterin 54 S. cerevisiae 54 JAK2 54 plasma lipid 54 insertions deletions 54 rRNA 54 ORFs 54 inhibitory effects 54 EGFR mutations 54 cytosolic 54 immunoglobulin genes 54 Fig. 3A 54 neuroendocrine 54 rDNA 54 observable traits 54 methyltransferase 54 antiproliferative activity 54 HFE gene 54 epigenomic 54 neuroimaging studies 54 ALK mutations 54 DNA methylation 54 endophenotypes 54 gastric carcinogenesis 54 Fc receptor 54 gene polymorphisms 54 miR #a [002] 54 protein isoforms 54 oncogenic transformation 54 C#BL 6 mice 54 chromosomal aberrations 54 causative gene 54 MDR1 54 figs. 54 endostatin 54 clonally 54 microcephalin 54 hepatoma 54 gene amplification 54 overexpression 54 ligand binding 54 morphogenesis 54 intron 54 histopathologic 54 olfactory receptor 54 APOL1 54 intestinal microflora 54 ncRNA 54 chromosomal rearrangements 54 rs# [004] 54 mitochondrial DNA mtDNA 54 genome rearrangements 54 ENMD # 54 chemosensitivity 54 toxicogenomic 54 retinal ganglion cells 54 biochemical assays 54 genomically 54 haplotype map 54 heritable variation 54 epigenetic alterations 54 Arabidopsis genes 54 5 hmC 54 transfected 54 flow cytometric 54 histological 54 microdeletions 54 experimental autoimmune encephalomyelitis 54 Notch1 54 electrophysiological 54 cDNA 54 RT qPCR 54 homologues 54 isogenic 54 subcellular compartments 54 NF1 gene 54 homozygote 54 PC# cells 54 CHD7 54 pathophysiologic 54 ChIP seq 54 variant allele 54 quasispecies 54 GPR# [002] 54 genetic markers 54 breast carcinomas 54 activin 53 transmembrane protein 53 HERmark assay 53 eIF4E 53 immunogens 53 hypermethylation 53 IGFBP2 53 MTHFR 53 intracellular signaling 53 pleiotropic 53 β1 53 splice junctions 53 polymorphism 53 Sgk1 53 HBx 53 H#Y 53 APOE e4 53 mRNAs 53 transcriptional regulator 53 anti CD3 53 synthases 53 adult neurogenesis 53 chimpanzee genomes 53 Fig. 1A 53 Fig. 2a 53 gene expression profiling 53 monogenic 53 mRNA molecules 53 MicroRNA 53 Overexpression 53 DLC1 53 neutralizing antibody responses 53 histocompatibility 53 aneuploidy 53 lysosomal 53 conformational 53 phenotypic traits 53 therapeutically relevant 53 cells transfected 53 nucleotide substitutions 53 Dictyostelium 53 SNPs 53 serine protease 53 axon guidance 53 allele 53 N. gonorrhoeae 53 molecular markers 53 glomerular 53 ß1 53 μ opioid receptor 53 breast cancer subtypes 53 NPM1 gene 53 frameshift mutation 53 biodistribution 53 glycosylation 53 glial 53 estrogen receptor beta 53 antisense oligonucleotides 53 chromatin modification 53 laterality 53 exomes 53 IL#B 53 beta1 integrin 53 genomic alterations 53 hyperplastic 53 ataxias 53 pRb 53 mammalian genomes 53 biomarker identification 53 immunoreactivity 53 biomarker 53 TMPRSS2 ERG 53 cellular pathways 53 clonal 53 mitogen activated protein kinase 53 CYP#B# 53 genes CYP#C# 53 autosomal dominant 53 protein biosynthesis 53 gene expression microarrays 53 APOC3 53 RNA polymerases 53 synaptogenesis 53 gene deletions 53 molecular biomarkers 53 costimulatory 53 genetic rearrangements 53 maternally inherited 53 phylogenetically 53 sexually dimorphic 53 p tau 53 enzymatic activity 53 sequenced genomes 53 pathologic 53 CFTR gene 53 PIK3CA 53 vivo potency 53 chromosome #q#.# [002] 53 structural rearrangements 53 nucleotide sequences 53 thymocyte 53 putative biomarkers 53 midgut 53 pharmacodynamic parameters 53 CDH1 53 HER2 expression 53 pathogenic mutations 53 ciliated 53 incomplete penetrance 53 N Myc 53 podocytes 53 mosaicism 53 postsynaptic 53 inhibitory 53 major histocompatibility complex 53 Hox gene 53 cytokine receptors 53 alpha7 53 polyadenylation 53 resistant isolates 53 Xenopus 53 Fig. 1a 53 K RAS 53 prostate carcinoma 53 nongenetic 53 ligand receptor 53 renal fibrosis 53 ligase 53 rs# [001] 53 genomic imprinting 53 knockout mice 53 cDNA libraries 53 metazoans 53 amino acid substitutions 53 FUS1 53 RNA sequences 53 Histone 53 signaling pathways 53 deacetylation 53 neuropathologic 53 ERK2 53 miRs 53 Morphological 53 Western blotting 53 neuropathological 53 de novo mutations 53 pleiotropic effects 53 3'UTR 53 fluorescence intensity 53 ADRB2 53 p# mutations 53 X inactivation 53 cytopathic 53 β catenin 53 coding genes 53 biomarkers 53 eukaryotic 53 receptor gene 53 immunoregulatory 53 SLC#A# [002] 53 QTL mapping 53 shRNAs 53 DARPP 53 hypermethylated 53 allelic variants 53 serotonergic 53 zebrafish 53 vivo efficacy 53 CYP#D# gene 53 progranulin gene 53 microRNA miR 53 ubiquitination 53 hypothalamic pituitary 53 logistic regressions 53 Fig. 1C 53 Histopathologic 53 potent inhibition 53 colorectal tumor 53 segmental duplications 53 vitro assay 53 phosphatases 53 isoform 53 short hairpin RNAs 53 Histologic 53 somatostatin 53 neurophysiological 53 pathogenetic 53 CHEK2 53 phylogenetic relationships 53 tropism 53 mechanistic studies 53 IFN γ 53 MYH9 53 quantitative RT PCR 53 ribosomal RNA 53 antitumor effect 53 NPM1 53 mGluR5 antagonist 53 BRAF V#E 53 microRNAs miRNAs 53 proteome 53 KLF4 53 axonal 53 ChIP chip 53 heterochromatic 53 RNA splicing 53 Mutational 53 neural progenitor 53 E1A 53 UTRs 53 pharmacodynamic biomarkers 53 Haplotype 53 ABCB1 gene 53 haplotypes 53 CpG methylation 53 FMR1 53 CD#c 53 microglial 53 amino acid substitution 53 heterodimers 53 haplogroups 52 promoter hypermethylation 52 karyotype 52 NS5A 52 mammalian fatty acid 52 inducible 52 antibody antigen 52 translocations 52 clinicopathologic 52 PDGFR 52 receptor subtypes 52 missense mutation 52 physicochemical 52 colocalization 52 CD1d 52 Fig. 3b 52 potent inhibitors 52 HCV replication 52 predictive biomarker 52 protein conformation 52 pharmacodynamic PD 52 CD# expression [001] 52 metabolite concentrations 52 K ras gene 52 beta actin 52 catenin 52 intraspecific 52 SNP rs# [001] 52 HCV replicon 52 synaptic proteins 52 protein tyrosine phosphatases 52 p# MAPK 52 plasma kallikrein 52 cyclin E 52 TNFalpha 52 aneuploid 52 organismal 52 eNOS 52 IgG antibody 52 Foxp3 52 protein ligand 52 mRNA decay 52 P. falciparum 52 MECP2 gene 52 homologies 52 viral kinetics 52 mitochondrial 52 short hairpin RNA 52 ectopic expression 52 metabolomic 52 shRNA 52 monozygotic twins 52 heterologous 52 Phylogenetic 52 Transcriptional 52 allele frequency 52 SLITRK1 52 overexpressing 52 BARD1 52 underlying pathophysiology 52 genetic relatedness 52 recessive trait 52 PBMCs 52 autosomal recessive 52 suppressor gene 52 differentially regulated 52 MC1R gene 52 humoral 52 M. pneumoniae 52 Amino acid 52 Hcrt 52 amplicons 52 D. melanogaster 52 Candida species 52 independent prognostic marker 52 protein tyrosine phosphatase 52 epigenetic modifications 52 S/GSK# 52 Nedd4 52 proteolysis 52 immunocytochemistry 52 chromosomal rearrangement 52 C1q 52 phylogenetic analysis 52 effector function 52 pharmacogenetic testing 52 serine threonine kinase 52 proteolytic cleavage 52 VNTR 52 CCL#L# 52 airway responsiveness 52 transfection efficiency 52 aetiological 52 immunofluorescence staining 52 murine models 52 xenograft tumors 52 pharmacodynamic endpoints 52 OPRM1 gene 52 TRIM5 52 metabolic parameters 52 A. gambiae 52 ribosomal protein 52 heterozygote 52 nucleases 52 serotonin transporter 52 chromatin immunoprecipitation ChIP 52 androgen receptor gene 52 transmembrane 52 lentiviral 52 Cre recombinase 52 CDK inhibitor 52 thyroid carcinoma 52 cAMP signaling 52 GABAB receptors 52 genomic proteomic 52 TTR gene 52 gene mutations 52 intergenic regions 52 antiviral efficacy 52 IKKß 52 transcriptional regulators 52 myogenic 52 MEFs 52 peptide sequences 52 autophagic 52 immunohistochemical staining 52 proband 52 epigenetic reprogramming 52 Supplementary Table 52 CHO cells 52 Dysregulation 52 MDM2 52 osteoclast 52 phenotypic differences 52 wildtype 52 cytotoxicity 52 astrocyte 52 adipocyte 52 genotyped 52 neurodegeneration 52 NSCLC tumors 52 familial clustering 52 HDAC 52 chronicity 52 SSc 52 thymidylate synthase TS 52 Plasmodium 52 pharmacologic intervention 52 tumoral 52 cellular prion protein 52 subcellular 52 SCN5A 52 NF2 52 SIRT2 52 genomic sequence 52 epithelial cell 52 #q# [001] 52 Nf1 52 PrPSc 52 circadian clock genes 52 molecular determinants 52 retroviral 52 PGCs 52 microRNA molecules 52 RUNX3 52 SVZ 52 Kv#.# 52 MTT assay 52 genomic deletions 52 VIPR2 52 RASSF1A 52 ERK1 2 52 metabolomic profiling 52 germline mutation 52 RNA transcripts 52 eIF2 52 Smad3 52 isoenzymes 52 genetic determinants 52 PDGF receptor 52 autism susceptibility genes 52 microRNA 52 induce apoptosis 52 pseudogenes 52 carcinoids 52 deuterostomes 52 lymphangiogenesis 52 transcriptomics 52 alternatively spliced 52 genetic alterations 52 HOTAIR 52 HIV RNA 52 bexarotene 52 neutralizing antibody 52 outer membrane proteins 52 CYP# [002] 52 situ hybridization 52 Fig. 2B 52 proteomic analyzes 52 glutamatergic 52 autoantibody 52 Sanger sequencing 52 pDCs 52 clinically relevant 52 conditional logistic regression 52 Fig. 4a 52 IL 1ß 52 xenograft models 52 N glycan 52 GSTP1 52 proteolytic activity 52 SNP arrays 52 Drosophila 52 T#M 52 taxa 52 adaptive immunity 52 HMGA2 52 HLA DRB1 * 52 antitumor efficacy 52 logistic regression 52 IFN α 52 cortical neurons 52 chromosomal instability 52 CagA 52 vidofludimus 52 KRAS mutation 52 deleterious mutations 52 proteomic 52 mucinous 52 modifier genes 52 Apobec3 52 tyrosine kinase receptor 52 genotyping 52 TLR8 52 physiologic mechanisms 52 mitochondrial metabolism 52 erythropoiesis 52 eukaryote 52 GABAergic neurons 52 BioMAP 52 antigenic epitopes 52 Hh 52 Cytogenetic 52 MT1 MMP 52 TGF ß 52 transcriptionally 52 quantitative PCR 52 EGFR signaling 52 fascin 52 NOD SCID mice 52 secretory pathway 52 pharmacogenetic 52 RT PCR assay 52 granulocyte 52 biologic pathways 51 inhibitory receptor 51 CAG repeats 51 multivariate logistic regression 51 huntingtin gene 51 synteny 51 biogenesis 51 dopamine transporter gene 51 gambiae 51 ERBB2 51 epigenomes 51 ENaC 51 ERK pathway 51 IL 1β 51 microsatellite loci 51 splenocytes 51 mammary stem cells 51 chromosome aberrations 51 microbiomes 51 skin fibroblasts 51 SIRT3 51 phylogenetic trees 51 unmutated 51 Haptoglobin 51 MYH9 gene 51 comparative genomics 51 Fig. 2C 51 mediated inhibition 51 chromosomal deletions 51 clades 51 Parkinsonian 51 DNA methyltransferases 51 NNRTI resistance 51 transcriptome sequencing 51 colon carcinoma 51 iNOS 51 bioinformatic approaches 51 mutational analysis 51 downregulation 51 carcinoembryonic antigen 51 BCL#A 51 EGF receptors 51 fibrotic disease 51 pathogen interactions 51 IFN alpha 51 phylogenetic tree 51 JAK2 inhibitors 51 genetic variants 51 SCD1 51 preclinically 51 vimentin 51 organism genome 51 antitumour 51 NKG2D 51 transgenes 51 BMP4 51 homodimers 51 #p# [003] 51 pathogenetic mechanisms 51 Hh pathway 51 causative genes 51 glycosylated 51 galectins 51 chromosome rearrangements 51 WT1 51 univariate 51 circadian genes 51 lipid metabolism 51 TGF β 51 K ras mutations 51 X chromosome inactivation 51 potent antitumor activity 51 PKM2 51 Dopaminergic 51 neuritic 51 glycosyltransferase 51 metabolic enzymes 51 thrombophilia 51 XL# inhibits 51 immunodominant 51 Heterozygous 51 K#R [002] 51 pseudogene 51 HIF 1alpha 51 kinase pathway 51 C. jejuni 51 tumor antigen 51 AT1R 51 5 hydroxymethylcytosine 51 HERV 51 flavopiridol 51 PCR amplified 51 geldanamycin 51 HLA DR 51 TLR2 51 Alleles 51 inferential statistics 51 thermodynamic stability 51 immunohistochemical analysis 51 neurones 51 Androgen receptor 51 tetramers 51 susceptibility locus 51 GABRA2 51 KRAS mutations