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(Click for frequent words.) 78 pathogenesis 74 etiology 69 molecular mechanisms underlying 69 pathophysiological 68 pathogenic mechanisms 67 aetiology 67 pathophysiologic 66 pathophysiological mechanisms 65 underlying pathophysiology 63 neuroprotection 62 molecular mechanisms 62 lipid metabolism 62 oncogenesis 62 airway remodeling 62 lipoprotein metabolism 61 pathophysiologic mechanism 61 transcriptional regulation 61 neuronal dysfunction 61 cholesterol metabolism 61 neurobiological 60 pathogenetic 60 multifactorial 60 neuroinflammation 60 atherogenesis 60 etiologic 60 biopsychosocial 60 neuropsychiatric diseases 60 renal fibrosis 60 endophenotypes 60 AT1R 60 neuropsychiatric disorders 60 neurogenic 59 dysregulation 59 muscular dystrophies 59 molecular underpinnings 59 neurochemistry 59 physiological mechanisms 59 underlying molecular mechanisms 59 neuroanatomical 59 pathophysiologic mechanisms 59 epigenetic regulation 59 motor neuron degeneration 59 signal transduction 58 coagulation cascade 58 molecular mechanism 58 biologic pathways 58 mitochondrial dysfunction 58 pain syndromes 58 autoimmune diseases 58 Dysregulation 58 biological pathways 58 neurodegenerative diseases 58 immunomodulation 58 signaling pathways 57 etiologic factors 57 underlying vasculopathy 57 cAMP signaling 57 Kraepelin 57 SSc 57 clinicopathological 57 etiologies 57 neoplastic 57 physiologic mechanisms 57 Genetic predisposition 57 aberrant activation 57 COX2 57 genetic underpinnings 57 aetiological 57 Raf MEK ERK 57 chronicity 57 prostate carcinogenesis 57 dopaminergic 57 nosology 57 c myc gene 57 mGluR5 inhibition 57 metabolic enzymes 56 Brodmann Area 56 neuronal signaling 56 pharmacological interventions 56 molecular pathways 56 apoptotic pathway 56 efferent 56 neurodegenerative disease 56 protein kinase C 56 etiological 56 physiology 56 hypothalamic pituitary adrenal axis 56 biochemical pathways 56 neurodegeneration 56 nicotinic receptor 56 carcinogenesis 56 potent inhibitors 56 systemic inflammation 56 synaptogenesis 56 neuronal differentiation 56 psychobiological 56 gastric carcinogenesis 56 genetic polymorphisms 56 amyloid cascade 56 genetic determinants 56 hyperalgesia 56 cell signaling pathways 56 neuropathologic 56 demyelination 56 neuroanatomy 55 modulatory 55 molecular pathogenesis 55 selective inhibition 55 Wnt pathway 55 mGluRs 55 susceptibility genes 55 extracellular signal 55 biopsychosocial model 55 genetics immunology 55 viral pathogenesis 55 tumorigenesis 55 paraneoplastic 55 neuroendocrine 55 somatoform disorders 55 gene polymorphisms 55 biochemical mechanisms 55 mediated inhibition 55 CaM kinase II 55 Wnt signaling pathway 55 potentially modifiable 55 intracellular signal transduction 55 prognostic indicators 55 adult neurogenesis 55 cardiac fibrosis 55 neuropathology 55 genetic loci 55 immunological mechanisms 55 carbohydrate metabolism 55 ANCA associated 55 phenotypic expression 55 heritable disorders 55 hypothalamic 55 organogenesis 55 DNA methylation patterns 55 myeloproliferative disorders 55 synaptic function 55 allergic inflammation 55 neurohormonal 55 cardiac hypertrophy 55 syndromes 55 pharmacologic 55 prognostic significance 55 myopathies 55 autonomic dysfunction 55 pathogenetic mechanisms 55 demyelinating diseases 55 immunopathology 55 antiphospholipid syndrome 55 fibrotic disorders 55 neurological diseases 55 AKT1 55 receptor subtypes 55 predisposing factor 55 podocyte 55 Notch signaling 55 psychoneuroimmunology 55 valvular heart 55 GRP# 55 transgenic mouse model 55 glial 55 neuronal degeneration 54 SLC#A# [002] 54 CTGF 54 S#A# [002] 54 serotonergic 54 dysregulated 54 COX enzymes 54 NF kappaB pathway 54 neuroinflammatory 54 occlusive disease 54 pathogen interactions 54 CEACAM1 54 neuropathological 54 cellular pathways 54 chromosome #p#.# 54 alexithymia 54 ion channels 54 genetic locus 54 glutamatergic 54 membrane fusion 54 murine model 54 airway hyperresponsiveness 54 FTLD 54 cholinergic 54 mucosal immune 54 apoE 54 epigenetic mechanisms 54 synaptic transmission 54 cyclooxygenase 2 54 noradrenergic 54 immunobiology 54 comorbid anxiety 54 epilepsy Parkinson disease 54 autoimmune disorders 54 protein misfolding diseases 54 vascular inflammation 54 neurotrophic 54 cognitive dysfunction 54 incompletely understood 54 kinase pathway 54 γ secretase 54 Smad3 54 inflammatory cascade 54 ADAM# 54 Prenatal diagnosis 54 demyelinating 54 primary hyperparathyroidism 54 proteoglycan 54 ENaC 54 myeloproliferative diseases 54 Pseudomonas aeruginosa infections 54 granulomatous 54 colorectal carcinogenesis 54 renin angiotensin aldosterone 54 hyperinsulinemia 54 neurobiological mechanisms 54 tissue fibrosis 54 causal pathway 54 Hypothalamic 54 differential diagnosis 54 mimetics 54 neuro degenerative diseases 54 kinase domain 54 NMDA receptor 54 cerebellar 54 HPA axis 54 inflammatory demyelinating 54 endocannabinoid system 54 ERK1 2 54 progressive neurodegenerative disorder 54 hyperparathyroidism 54 pharmacological approaches 54 sonographic appearance 53 neuritic 53 lysosomal 53 myocardial ischemia 53 signaling cascades 53 monogenic 53 hepatic stellate cells 53 endotoxemia 53 coagulopathy 53 multiple sclerosis psoriasis 53 pathological hallmarks 53 neuroactive 53 leukotriene pathway 53 clinically heterogeneous 53 intracellular signaling pathways 53 TXNIP 53 autoimmunity 53 immune dysregulation 53 P#X# 53 druggable target 53 LPA1 53 Protein folding 53 bone metabolism 53 antisense oligonucleotides 53 dyslipidemias 53 protein misfolding 53 kidney urologic 53 microdeletion 53 Pathogenesis 53 ERK pathway 53 NF kB signaling 53 retinoid X 53 endocannabinoid signaling 53 DISC1 53 proteinases 53 subcortical 53 causative genes 53 nitric oxide synthase 53 fibrogenesis 53 hematopoiesis 53 differential diagnoses 53 oligomerization 53 hereditary predisposition 53 glutamate receptors 53 receptor subtype 53 IL 1ß 53 channelopathies 53 mitochondrial disorders 53 neurobiological underpinnings 53 glomerulonephritis 53 TMEM#B 53 Chronic inflammation 53 eotaxin 53 genetic polymorphism 53 glucose homeostasis 53 lung epithelium 53 CK2 53 pharmacological therapies 53 lymphangiogenesis 53 artery stenosis 53 symptomatology 53 peroxisomal 53 glomerular 53 dorsolateral 53 neurodegenerative disorders 53 Endothelial dysfunction 53 Hh 53 secretory pathway 53 pharmacodynamic biomarkers 53 histone methylation 53 interventional therapies 53 IRAK1 53 chromatin structure 53 urate oxidase 53 psychogenic 53 physiologic 53 hedgehog signaling 53 BMP signaling 53 MECP2 gene 53 basal ganglia 53 lupus multiple sclerosis 53 plasma kallikrein 53 mGluR5 antagonist 53 vasculopathy 53 molecular biomarkers 53 neural regeneration 53 isoenzymes 53 tumor angiogenesis 53 pleiotropic 53 mGluR2 NAM 53 neurocognitive deficits 53 fibrotic disease 53 IL 7R 53 ACE2 53 therapeutic interventions 53 serotonin receptor 53 kinase inhibition 53 Genetic variants 53 Hedgehog signaling 53 chromosomal rearrangement 53 muscarinic receptors 53 susceptibility gene 53 atherosclerosis 53 mitochondrial toxicity 53 hypoxemia 53 Sgk1 53 LPS induced 53 prognostic markers 53 Bardet Biedl Syndrome 53 lupus scleroderma 53 mutant huntingtin protein 53 excitotoxic 53 inverse agonist 53 heterologous expression 53 lymphocyte activation 53 neurodegenerative 53 immunomodulatory effects 53 intracellular signaling 53 viral etiology 53 chronic thromboembolic pulmonary 53 Inflammatory diseases 53 neuroprotective effects 53 chromosomal translocations 53 neurobiological basis 53 Cognitive impairment 53 facioscapulohumeral muscular dystrophy 52 vertebral subluxation 52 psoriasis psoriatic arthritis 52 virulence genes 52 mTOR signaling 52 circadian genes 52 fibrosing 52 susceptibility locus 52 biologies 52 cathepsins 52 RNA splicing 52 unknown etiology 52 FGFs 52 molecular determinants 52 pathobiology 52 neurosteroid 52 GABAA receptor 52 mechanistic 52 pharmacologic treatments 52 neuro endocrine 52 pharmacologic intervention 52 comorbid depression 52 systemic sclerosis SSc 52 intestinal motility 52 cardiometabolic disorders 52 nonalcoholic steatohepatitis 52 cell adhesion molecules 52 protein folding misfolding 52 GPC5 52 lysosomal storage disease 52 TTR amyloidosis 52 vidofludimus 52 genetic susceptibility 52 neurotransmission 52 neuromuscular junction 52 etiological factors 52 neuroimaging studies 52 biogenesis 52 fatty acid metabolism 52 neuronal plasticity 52 neurobiology 52 PDGFR 52 rheumatic diseases 52 nongenetic 52 mechanistic explanation 52 protein tyrosine phosphatases 52 evolutionarily conserved 52 Venous thromboembolism 52 Mitochondrial dysfunction 52 lysosomal storage diseases 52 levodopa induced 52 myocardial fibrosis 52 #q#.# [002] 52 serotonin signaling 52 p# mitogen activated 52 small molecule activators 52 neuronal synapses 52 innate immunity 52 tyrosine phosphorylation 52 ERK signaling 52 thromboembolic disease 52 ATG#L# 52 neurocognition 52 resolvins 52 proinflammatory 52 serine protease 52 renin angiotensin system 52 lipid homeostasis 52 biosynthesis 52 neuronal 52 antibody mediated 52 multisystem disease 52 subclinical 52 excitotoxicity 52 FOXO3a 52 MAP kinase pathway 52 Idiopathic 52 Genetic variations 52 clefting 52 Alzheimer Disease AD 52 chemokine receptor 52 glial tumors 52 pathophysiological processes 52 protein phosphorylation 52 metabolic abnormalities 52 diabetic kidney 52 histone code 52 intercellular communication 52 histone modifications 52 platelet activation 52 VIPR2 52 phosphatidylinositol 3 52 MAPK pathway 52 phosphatases 52 C. pneumoniae 52 poorly understood 52 signaling pathway 52 drug metabolizing enzymes 52 PPAR γ 52 downstream effector 52 phenomenology 52 psychopharmacologic 52 Atypical antipsychotics 52 myocyte 52 systemic lupus erythematosus 52 immunological 52 IFRD1 52 PPARγ 52 protein tyrosine kinase 52 overactivation 52 lung fibrosis 52 risk stratification 52 synaptic plasticity 52 acetylcholine receptor 52 cardiac dysfunction 52 multi factorial disease 52 epilepsies 52 rheumatologic 52 rheumatoid arthritis lupus 52 therapeutic modality 52 antiphospholipid antibodies 52 SIADH 52 p# MAPK 52 Syk 52 mechanistic insights 52 vaso occlusive crisis 52 autophagic 52 Kv#.# 52 Parkinson Disease PD 52 protein biosynthesis 52 GRNCM1 52 melatonin receptor 52 hemoglobinopathies 52 pleiotropic effects 52 LRP5 52 essential thrombocythemia 52 ischemia reperfusion injury 52 podocytes 52 beta secretase inhibitors 52 cell adhesion molecule 52 epigenetic therapies 52 thyroid dysfunction 52 GABAergic 52 nephrogenic 52 Endothelin 52 hyperresponsiveness 52 GSK3B 52 endocrine abnormalities 52 metabolic syndromes 52 receptor antagonism 52 matrix metalloproteinases 52 morphogenetic 52 metabonomics 52 STAT4 52 protein conformation 52 HGPS 52 enzymology 52 hypoxia inducible 52 posterior cingulate 52 thyrotropin 52 HMG CoA reductase 52 immunoregulation 52 catabolism 52 TCF#L# 51 endogenous opioid 51 neuroprotective therapies 51 cardiac conduction 51 galectins 51 CCR9 51 regulating gene expression 51 ccRCC 51 Neurodegenerative diseases 51 inhibitory receptor 51 exocrine 51 tenascin 51 hindbrain 51 axonal damage 51 predisposing factors 51 activated microglia 51 endothelial activation 51 gastric carcinoma 51 PI3K inhibitors 51 autoimmune 51 progressive dyspnea 51 eNOS 51 antiplatelet therapies 51 epithelia 51 biologic plausibility 51 fibrotic lung 51 syndrome OSAS 51 sortilin 51 anti fibrotic 51 amyloid deposition 51 neurofibromatosis type 51 myeloproliferative neoplasms 51 Chlamydia pneumoniae 51 pDCs 51 beta globin gene 51 Magnesium deficiency 51 pharmacogenetics 51 NFkB 51 ORMDL3 51 axonal degeneration 51 TNFAIP3 51 chromatin remodeling 51 LIS1 51 phenotypes 51 atherosclerotic disease 51 cardio renal 51 Neuroinflammation 51 Neuronal 51 engineered RAP peptides 51 neurologic disorder 51 diabetic nephropathy 51 neurochemical 51 somatic 51 tumor microenvironment 51 causative 51 Alzheimer disease cognitive impairment 51 prognostic marker 51 molecular abnormalities 51 mPFC 51 metabolic pathways 51 Alzheimer disease pathogenesis 51 hypothalamic pituitary 51 immuno modulatory 51 peroxisome 51 TGF β 51 Brugada Syndrome 51 diabetes dyslipidemia 51 vascular dysfunction 51 receptor antagonists 51 Sjögren syndrome 51 neuropathic pain 51 Ischemic 51 cardiolipin 51 endothelial dysfunction 51 upregulation 51 cognitive affective 51 downregulation 51 innate immune 51 underdiagnosis 51 narrow QRS 51 Mechanistic studies 51 kallikrein 51 bile acid metabolism 51 somatization disorder 51 estrogen receptor beta 51 glucose transporter 51 myelination 51 chronic inflammatory 51 arterial calcification 51 neurology cardiology 51 IL 1β 51 OPRM1 51 Squalamine 51 gastrointestinal malignancies 51 JAK STAT pathway 51 immunodeficiencies 51 cellular metabolism 51 neuropathic 51 A3 adenosine receptor 51 cytoskeletal 51 galectin 51 fusogen 51 EGFR signaling 51 phenotype 51 CNTNAP2 51 VEGF receptor 51 comorbid disorders 51 Frontal lobe 51 myocardial dysfunction 51 #F FDG PET 51 neuroinflammatory diseases 51 synapse formation 51 autoimmune inflammatory 51 activin 51 PML RARA 51 ocular disorders 51 Wnt signaling 51 morphogenesis 51 biomarkers 51 presymptomatic 51 RIP1 51 remyelination 51 molecular pathway 51 NFTs 51 autocrine 51 vascular biology 51 genomic alterations 51 metabolic disturbances 51 Angiotensin converting enzyme 51 PKC inhibitors 51 IntroductionThe 51 MGUS 51 epigenomics 51 synapse maturation 51 familial clustering 51 Angiotensin II 51 destroys myelin 51 S#P# 51 neuronal cell 51 oxysterols 51 APOE genotype 51 hyperacute 51 steroidogenesis 51 differential gene expression 51 Hedgehog pathway 51 multifactorial disease 51 obesity insulin resistance 51 coronary vasodilation 51 FGFR1 51 prefrontal regions 51 CCR2 51 NS4B 51 STK# gene 51 mGluR 51 beta defensins 51 baroreflex 51 PI3K AKT 51 inflammatory bowel disease 51 metabolic acidosis 51 MMPs 51 rACC 51 renoprotective 51 tumor immunology 51 tRNA synthetases 51 NMDA N 51 HIF 1alpha 51 Parkinson disease Alzheimer disease 51 fibrosis 51 TNF alpha 51 melanocortin receptor 51 diathesis 51 beta1 integrin 51 leaky gut 51 treating neuropathic pain 51 caveolin 51 nNOS 51 intestinal microbiota 51 p#/CBP 51 cAMP pathway 51 β1 51 evolutionarily ancient 51 myelofibrosis polycythemia vera 51 muscle contractility 51 Lenzenweger 51 NKT cells 51 telomere dysfunction 51 neuro protective 51 neuro vascular 51 protein homeostasis 51 PI3K Akt 51 polycystin 1 51 nociceptive pain 51 mechanistic studies 51 Six3 51 LPA1 receptor 51 neurodevelopmental disorders 51 Stat3 51 c MET 51 cardioprotective effects 51 Molecular biology 51 nonischemic 51 neovascularization 51 pharmacotherapeutic 51 nucleosome positioning 51 multisensory integration 51 Diabetic neuropathy 51 Lambris 51 arterial hypertension 51 IGFBP2 51 carcinoid tumors 51 neuropathies 51 neuropsychological impairment 51 gene rearrangements 51 neuropsychological functioning 51 hyperammonemia 51 clinicopathologic 51 telomere maintenance 51 Notch1 51 Neuroprotection 51 baroreceptors 51 DARPP 51 mechanistically 51 nicotinic receptors 50 ABCB1 50 Epstein Barr Virus EBV 50 osteoblast differentiation 50 autoimmune thyroid 50 epigenetic alterations 50 immune mediated 50 prostate cancer CaP 50 modifiable risk 50 neutrophil recruitment 50 nonpharmacologic 50 cerebral vascular accident 50 ERBB2 50 casein kinase 50 hypercoagulable 50 Sleep disordered breathing 50 tumor suppressive 50 pathologic 50 proto oncogene 50 Hutchinson Gilford progeria 50 tumor suppressor protein 50 microvascular disease 50 diabetic microvascular complications 50 Neurofibromatosis type 50 radiographic findings 50 fibrotic 50 prion diseases 50 Apolipoprotein E 50 NS5A 50 airway inflammation 50 metabolizing enzymes 50 hypoperfusion 50 Neurochemistry 50 lipid synthesis 50 histone deacetylases 50 CYP #A# 50 endocrine diseases 50 cadherin 50 inflammatory diseases 50 Oxidative damage 50 small molecule agonists 50 HLA DRB1 50 multisystem disorder 50 PAR1 50 fibroblast growth 50 gene locus 50 virally induced 50 Heritability 50 thetreatment 50 apoE4 50 FOXO 50 pharmacological 50 cognitive deficits 50 FTIs 50 humoral 50 Inhaled nitric oxide 50 glucocorticoid receptor 50 inflammatory disorders 50 antiapoptotic 50 methylenetetrahydrofolate reductase 50 CYT# potent vascular disrupting 50 neurologic diseases 50 Factor VIIa 50 autoinflammatory diseases 50 causal pathways 50 metabolic dysfunction 50 FasL 50 causative gene 50 unmeasured confounders 50 anterior cingulate gyrus 50 ABCA1 50 IRF6 50 sGC 50 MYH9 50 upregulates 50 erythropoiesis 50 Nature Reviews Neuroscience 50 hepatic fibrosis 50 hepatobiliary 50 Dr. Ivashkiv 50 CD1d 50 functional polymorphism 50 dietary interventions 50 transcriptomics 50 alpha#beta# 50 cardiac insufficiency 50 molecular mimicry 50 cardiac biomarkers 50 methyl D aspartate 50 PI3K 50 IPAH 50 Pim kinases 50 Notch pathway 50 TCF#L# gene 50 glucocorticoid receptor GR 50 melanocortin receptors 50 leptin receptor 50 immunoregulatory 50 interstitium 50 Pulmonary hypertension 50 microvascular 50 imatinib resistance 50 FGF2 50 dietary acrylamide 50 Janus kinase 50 serine proteases 50 rheumatoid arthritis multiple sclerosis 50 locus coeruleus 50 arrhythmogenic 50 p# inhibitor 50 misregulation 50 superoxide dismutase 50 vascular endothelial 50 pathophysiological effects 50 sporadic ALS 50 IDH mutations 50 neurite outgrowth 50 cardioprotection 50 antidepressant efficacy 50 anosognosia 50 Inflammatory bowel diseases 50 degenerative disorders 50 ciliopathies 50 galanin 50 autonomic nervous system 50 pharmacologic interventions 50 TNFR 50 Comorbidity 50 adrenergic receptor 50 hyperglycaemia 50 epigenetic modification 50 SMAD4 50 neuroimaging 50 missense mutations 50 GI motility disorders 50 FGFR2 50 atherosclerosis regression 50 C5aR 50 tumor metastasis 50 calcaneus 50 CB2 receptor 50 osteochondroma 50 immunological diseases 50 heparan sulfate 50 neural mechanisms 50 androgen deficiency 50 NOD2 50 anterior temporal lobe 50 compensatory mechanisms 50 subsyndromal 50 alagebrium 50 syndromal 50 multisystemic 50 AMPA receptor 50 glycolipid 50 NMDA receptors 50 intercellular signaling 50 LUTS 50 NTDDS 50 TRPV1 receptors 50 hepatic 50 cardiogenic 50 neurophysiology 50 Subclinical 50 enzymatic pathways 50 metaplasia 50 myogenesis 50 constipation predominant irritable bowel 50 NR#A# 50 ADAMTS# 50 vasomotor 50 Dr. Karsenty 50 neuronal function 50 chitinase 50 choroidal vasculopathy 50 nociception 50 TACI Ig 50 multicentric 50 Oxidative stress 50 autosomal dominant disorder 50 antiproliferative effects 50 genetic aberrations 50 microbiome 50 solid organ transplantation 50 demethylation 50 dendritic spine 50 EBV infection 50 dedifferentiation 50 transcriptional 50 CHD7 50 miR #a [001] 50 selective inhibitors 50 cognitive impairment associated 50 TRPV1 50 nicotinic acetylcholine receptors 50 interleukin 1beta 50 Galectins 50 FGFR3 50 TLR antagonists 50 metabolic disorders 50 neurological abnormalities 50 GABAA receptors 50 neuropsychiatric disorder 50 IL#R 50 preoperative diagnosis 50 eicosanoids 50 Csernansky 50 Helicobacter infection 50 genomic instability 50 protein tyrosine phosphatase 50 leukocyte recruitment 50 idiopathic pulmonary 50 peptide hormone 50 postoperative AF 50 MTHFR 50 molecular signaling pathways 50 neural crest 50 iNOS 50 antithrombotic agents 50 ion channel 50 elucidating 50 membrane proximal 50 Nonalcoholic fatty liver 50 Galectin 3 50 epigenetic inheritance 50 primary cilia 50 Myasthenia gravis 50 CP CPPS 50 Olefsky 50 peroxisome proliferator activated 50 PPAR alpha 50 Endocannabinoids 50 gene polymorphism 50 myofascial pain syndrome 50 Sudhir Agrawal D.Phil 50 periodontal infections 50 primary aldosteronism 50 liver fibrosis 50 electrophysiologic 50 CTEPH 50 carotid atherosclerosis 50 inhibit metastasis 50 renal diseases 50 neurexins 50 upregulating 50 Wernicke Korsakoff syndrome 50 mitogen activated protein kinase 50 antitumor efficacy 50 Clusterin 50 neuroligins 50 mycosis fungoides 50 urogenital