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(Click for frequent words.) 78 pathophysiology 72 etiology 70 molecular mechanisms underlying 70 pathogenic mechanisms 68 pathophysiological 68 molecular mechanisms 68 oncogenesis 66 aetiology 66 lipid metabolism 66 signaling pathway 65 transcriptional regulation 65 molecular mechanism 65 neuroinflammation 64 airway remodeling 64 dysregulation 64 signaling pathways 64 cholesterol metabolism 64 tumorigenesis 63 neuronal dysfunction 63 mitochondrial dysfunction 63 biosynthesis 63 molecular pathways 62 Raf MEK ERK 62 carcinogenesis 62 apoE 62 gastric carcinogenesis 62 molecular underpinnings 61 cell signaling pathways 61 MAPK pathway 61 viral pathogenesis 61 oncogenic 61 signal transduction 61 epigenetic regulation 61 physiological mechanisms 61 biologic pathways 61 neuropsychiatric disorders 61 Smad3 61 lipoprotein metabolism 61 Wnt signaling pathway 61 tumor metastasis 61 biochemical mechanisms 61 underlying pathophysiology 61 pathophysiological mechanisms 61 CTGF 61 neuroprotection 61 regulating gene expression 61 underlying molecular mechanisms 60 evolutionarily conserved 60 molecular pathogenesis 60 epigenetic mechanisms 60 neuronal differentiation 60 pathophysiologic 60 podocyte 60 Dysregulation 60 protein kinase C 60 upregulation 60 Wnt pathway 60 systemic inflammation 60 FOXO3a 60 cellular pathways 60 etiologic 60 pathogenetic 60 CEACAM1 60 neurodegenerative diseases 60 renal fibrosis 60 cAMP signaling 59 metabolic enzymes 59 kinase pathway 59 phosphatases 59 innate immunity 59 neurodegeneration 59 TMEM#B 59 motor neuron degeneration 59 susceptibility genes 59 cell motility 59 prostate carcinogenesis 59 hypothalamic pituitary adrenal axis 59 IL 1β 59 mitogen activated protein kinase 59 endophenotypes 59 adult neurogenesis 59 neutrophil recruitment 59 activin 59 phenotype 59 virulence genes 59 aetiological 59 eotaxin 59 biogenesis 59 synaptogenesis 59 biological pathways 59 Hedgehog signaling 59 airway hyperresponsiveness 59 AT1R 59 phosphatidylinositol 3 59 LPS induced 59 c myc gene 58 biochemical pathways 58 neuroendocrine 58 FasL 58 downregulation 58 autoimmune diseases 58 proto oncogene 58 COX2 58 eNOS 58 lysosomal 58 tumor microenvironment 58 CK2 58 neuronal signaling 58 mediated inhibition 58 SSc 58 immunomodulatory effects 58 proteinases 58 MMPs 58 proinflammatory 58 tumor angiogenesis 58 autoimmunity 58 ADAM# 58 phenotypes 58 Wnt signaling 58 potentially modifiable 58 allergic inflammation 58 ubiquitin ligase 58 hematopoiesis 58 dysregulated 58 genetic polymorphisms 58 prognostic significance 58 cytokine 58 ERK1 2 58 neoplastic 58 intracellular signaling pathways 58 pleiotropic 58 telomere dysfunction 58 innate immune 58 Wnt beta catenin 58 acetylation 58 aberrant activation 58 membrane protein 58 Stat3 58 underlying vasculopathy 58 ACE2 58 tumor suppressor protein 58 cell adhesion molecule 58 atherogenesis 58 FGFs 57 lipid synthesis 57 apoptotic pathway 57 TGF β 57 neuroprotective effects 57 protein tyrosine phosphatase 57 neurobiological 57 Notch signaling 57 STAT4 57 caveolin 57 serine protease 57 neural crest 57 neurodegenerative disease 57 carbohydrate metabolism 57 CagA 57 PDGFR 57 glutamatergic 57 prognostic marker 57 proteolysis 57 p# MAPK 57 neuropsychiatric diseases 57 androgen receptor AR 57 chemokine receptor 57 mediated apoptosis 57 oligomerization 57 ERK signaling 57 pathogen interactions 57 humoral immunity 57 genetic susceptibility 57 neurotransmission 57 CCR9 57 beta catenin 57 mGluRs 57 epigenetic modification 57 autophagic 57 metabolic pathways 57 lymphocyte activation 57 lung fibrosis 57 LPA1 57 Hedgehog pathway 57 myeloproliferative disorders 57 Hh 57 protein kinases 57 AhR 57 causative 57 LRRK2 57 transactivation 57 protein misfolding 57 genetic determinants 57 glycosylation 57 receptor subtype 57 neurotrophic 57 molecular pathway 57 signaling cascades 57 fibrogenesis 57 actin cytoskeleton 57 CD1d 57 tyrosine phosphorylation 57 telomere maintenance 56 RUNX3 56 overactivation 56 selective inhibition 56 Oxidative stress 56 transgenic mouse model 56 neuronal degeneration 56 synaptic function 56 FGFR2 56 cathepsins 56 CCL5 56 ERBB2 56 Oxidative damage 56 TNFalpha 56 amyloid cascade 56 murine model 56 endocannabinoid system 56 susceptibility 56 cell adhesion molecules 56 chromosomal translocations 56 coagulation cascade 56 dopaminergic 56 LIS1 56 Six3 56 Angiotensin converting enzyme 56 intracellular signaling 56 miR #a [001] 56 immunological 56 immune mediated 56 membrane fusion 56 DISC1 56 E#F# 56 cardiac fibrosis 56 ENaC 56 Cdc7 56 MECP2 gene 56 HIF 1alpha 56 Aurora kinases 56 Genetic predisposition 56 γ secretase 56 synaptic plasticity 56 transcriptional activation 56 gene expression 56 eicosanoids 56 hepatic stellate cells 56 proapoptotic 56 VIPR2 56 β1 56 PPARγ 56 etiological 56 protein kinase 56 NF kB signaling 56 cellular metabolism 56 peroxisomal 56 isoform 56 c MET 56 synaptic transmission 56 Rap1 56 etiologic factors 56 LPA1 receptor 56 protein tyrosine kinase 56 glutamate receptors 56 immunological mechanisms 56 NS3 protease 56 GRP# 56 podocytes 56 pathophysiologic mechanism 56 tumor suppressor gene 56 GSK3B 56 Pathogenesis 56 prognostic indicator 56 paraneoplastic 56 isoenzymes 56 gastric carcinoma 56 antiapoptotic 56 GPC5 56 Src kinase 56 pDCs 56 TXNIP 56 BMP signaling 56 FOXO 56 HBx 56 missense mutations 56 S1P 56 fibrosis 56 prolyl 56 autocrine 56 Sgk1 56 IL 1ß 56 TRAIL induced apoptosis 56 Overexpression 56 extracellular signal 56 TLR4 56 Flt3 56 Galectins 56 myeloproliferative diseases 56 signal transduction pathways 56 Kv#.# 56 metalloprotease 56 acetylcholine receptor 56 iNOS 56 NKT cells 56 organogenesis 56 PI3K 56 primary cilia 56 immune dysregulation 56 metabolic abnormalities 56 mRNA expression 56 hedgehog signaling 56 susceptibility gene 56 immunomodulation 56 Helicobacter 56 cholinergic 55 antibody mediated 55 vasculopathy 55 druggable target 55 Epstein Barr Virus EBV 55 upregulates 55 myopathies 55 Activating mutations 55 subtypes 55 chemokine receptors 55 ABCA1 55 IRAK1 55 demyelinating diseases 55 cytoskeletal 55 KLF4 55 NKG2D 55 overexpression 55 cell signaling pathway 55 modulatory 55 outer membrane proteins 55 lymphoid 55 STAT3 55 intracellular 55 epithelia 55 catenin 55 CHD7 55 upregulating 55 histone modifications 55 cellular organelles 55 TNF alpha 55 allergen induced 55 GPR# [002] 55 kinase domain 55 misregulation 55 IFRD1 55 NS5A 55 miRNAs 55 breast cancer metastasis 55 HCV replication 55 HPA axis 55 vascular inflammation 55 PICALM 55 functional polymorphism 55 NOD2 55 Kupffer cells 55 SLC#A# [002] 55 plasma kallikrein 55 leukocyte recruitment 55 hyperinsulinemia 55 Androgen receptor 55 MAP kinase pathway 55 etiologic agent 55 genetic loci 55 MAP kinase 55 splice variants 55 arginase 55 inhibitory 55 PI3 kinase 55 ectopic expression 55 kinase inhibition 55 S#A# [002] 55 FTLD 55 microbiota 55 EGFR signaling 55 FGFR3 55 mutant huntingtin protein 55 cofactor 55 steroidogenesis 55 potent inhibitors 55 NMDA receptor 55 clinically heterogeneous 55 mechanistic insights 55 Bcl xL 55 Hh signaling 55 neurodevelopmental disorders 55 potent inducer 55 MTHFR 55 ultrastructure 55 upregulated 55 mTOR signaling 55 chemokine 55 liver fibrosis 55 H#K# [002] 55 regulates gene expression 55 hypoxia inducible factor 55 causative agent 55 CCR2 55 neuromuscular junction 55 monogenic 55 miRNA expression 55 cardiolipin 55 nicotinic receptor 55 causative genes 55 pathophysiologic mechanisms 55 AKT1 55 Angiotensin II 55 RIP1 55 prognostic markers 55 glucocorticoid receptor 55 oxidases 55 superoxide dismutase 55 chromatin structure 55 neurodegenerative 55 epigenetic alterations 55 encodes protein 55 angiogenesis 55 proinflammatory cytokines 55 demyelination 55 serotonin receptor 55 gene polymorphisms 55 Nedd4 55 TGF b 55 PIK3CA 55 multiple sclerosis psoriasis 55 molecule interleukin 55 IL#R 55 excitotoxicity 55 phenotypic expression 55 neurodegenerative disorders 55 cell adhesion 55 E3 ubiquitin ligase 55 cyclooxygenase 2 55 sortilin 55 immunobiology 55 C5aR 55 axon guidance 55 muscarinic receptors 55 muscular dystrophies 55 superfamily 55 autoantigen 55 neovascularization 55 Fas ligand 55 anti inflammatory cytokine 55 receptor gamma 55 immunologic 55 Pseudomonas aeruginosa infections 55 clinicopathological 55 synapse maturation 55 intracellular pathways 55 micro RNAs 55 morphogenesis 55 homologues 55 TGFβ 55 TLRs 55 erythropoiesis 55 SIRT3 55 transcriptional 55 chronic inflammation 54 hyperphosphorylation 54 Akt signaling 54 Th# cells 54 lipid homeostasis 54 mGluR 54 viral replication 54 JAK2 54 ATG#L# 54 cytokines IL 54 ubiquitination 54 Pim kinases 54 epithelial 54 tyrosine kinase 54 p#/CBP 54 Syk 54 demethylation 54 inducible 54 tau phosphorylation 54 circadian genes 54 NADPH oxidase 54 glomerular 54 glycolipids 54 MEK1 54 glycoprotein 54 Polymorphisms 54 VE cadherin 54 C. pneumoniae 54 beta defensins 54 constitutively expressed 54 NF kappaB 54 tryptase 54 1alpha 54 beta amyloid peptide 54 ligases 54 D aspartic acid 54 serine threonine kinase 54 NF kappaB pathway 54 COX enzymes 54 homeostasis 54 genes encoding 54 glucocorticoid receptor GR 54 p# mitogen activated 54 genomic instability 54 hypoxia inducible 54 Pten 54 endocannabinoid signaling 54 Eg5 54 HGPS 54 microRNAs 54 neurite outgrowth 54 inhibitory receptor 54 calpain 54 tumor suppressor 54 secretory pathway 54 neuronal function 54 homeobox gene 54 Genetic variants 54 intracellular signal transduction 54 orthologs 54 mitogenic 54 immunopathology 54 renin angiotensin system 54 occludin 54 FGFR1 54 LRP5 54 cofactors 54 osteopontin 54 fibrotic 54 costimulation 54 phosphate S1P 54 caveolin 1 54 granulomatous 54 glial 54 Raf kinase 54 multifactorial 54 neuronal cell 54 Src 54 intracellular pathogens 54 IKK2 54 induced apoptosis 54 casein kinase 54 vimentin 54 humoral 54 efferent 54 PPAR γ 54 mechanotransduction 54 PTP 1B 54 dendritic spine 54 transcriptional repression 54 mGluR2 NAM 54 PI3K pathway 54 NF kB pathway 54 Rab5 54 RNA splicing 54 activated microglia 54 methylenetetrahydrofolate reductase 54 HIF 1α 54 VEGF expression 54 cytokine signaling 54 cAMP pathway 54 HCV protease 54 Smoothened 54 molecular determinants 54 potent inhibition 54 ERK pathway 54 receptor tyrosine kinase 54 lysophosphatidic acid LPA 54 calcineurin 54 neural mechanisms 54 immunoregulatory 54 Hh pathway 54 Aβ 54 inverse agonist 54 ischemia reperfusion injury 54 heparan sulfate 54 bile acid metabolism 54 oncoprotein 54 SH#B# 54 proteoglycan 54 alpha synuclein protein 54 CaM kinase II 54 binding proteins 54 Upregulation 54 inducible nitric oxide synthase 54 TSLP 54 dystroglycan 54 polycythemia vera PV 54 DNA demethylation 54 fibrotic disease 54 leukocyte adhesion 54 PTPN# 54 physiologic mechanisms 54 neuroinflammatory 54 lymphocytic 54 Rab# 54 Vpr 54 HSF1 54 Macrophage 54 regulated kinase ERK 54 TGF beta 54 tumorigenicity 54 inflammatory mediators 54 hemoglobinopathies 54 demyelinating disease 54 polymorphisms 54 autoantibody 54 mimetics 54 intracellular bacteria 54 MAPK 54 Nod1 54 germline mutations 54 Protein folding 54 peroxisome 54 neuroligins 54 estrogen receptor beta 54 NKX#.# 54 redox active 54 nNOS 54 coinfection 54 IRF6 54 p# activation 54 mutant huntingtin 54 virulence factors 54 Phosphorylation 54 adaptive immunity 54 lymphangiogenesis 54 epithelial tissues 54 β catenin 54 glucose homeostasis 54 p# mutations 54 costimulatory 54 monocyte 54 premalignant 54 chromosome #p#.# 54 Genetic variations 54 effector molecules 54 oxidative stress 54 serine proteases 54 noradrenergic 54 Prox1 54 TGF ß 54 PAR1 54 autosomal dominant disorder 54 Akt 54 chronicity 54 alternative splicing 54 WT1 54 adrenergic receptor 54 epithelial barrier 54 metastasis 54 neuroanatomical 54 COL#A# 54 glycosyltransferase 54 catabolism 54 cyclic adenosine monophosphate cAMP 54 oligomeric 54 uPAR 54 overexpressing 54 STK# [002] 54 PB1 F2 54 eukaryotic 54 TCF#L# 54 adipogenesis 54 progressive neurodegenerative disorder 54 AMPA receptor 54 PI3K Akt 54 NFkB 54 interleukin 1beta 54 Monocyte 54 eosinophils 54 vivo 54 NKT cell 53 beta globin gene 53 cadherin 53 pathological hallmarks 53 pharmacodynamic biomarkers 53 RNAi therapeutic targeting 53 Janus kinase 53 atherosclerosis 53 adipokines 53 MMP2 53 lipoxygenase 53 resistin 53 colorectal carcinogenesis 53 biofilm formation 53 Rb#/p# 53 astrocytes 53 apoptosis pathways 53 NFAT 53 chromatin modifications 53 inflammasome 53 vaso occlusive crisis 53 neuropathological 53 melanocortin receptors 53 genetic underpinnings 53 nicotinic receptors 53 causal pathway 53 melatonin receptor 53 SMAD4 53 ADAMTS# 53 signaling molecule 53 LRP1 53 helicase 53 sporadic ALS 53 GABAergic 53 Notch pathway 53 neurogenic 53 HepG2 cells 53 Hedgehog signaling pathway 53 galectins 53 ErbB3 53 epigenetic inheritance 53 synapse formation 53 Factor VEGF 53 intestinal epithelium 53 subclinical 53 retinoid X 53 Notch signaling pathway 53 cardioprotective effects 53 presenilin 53 fatty acid synthase 53 anti apoptotic 53 pathogenetic mechanisms 53 Stat5 53 oncogenic transformation 53 CD#b 53 insulin resistance 53 defensin 53 pro angiogenic 53 heterologous expression 53 thioredoxin 53 ubiquitylation 53 matrix metalloproteinases 53 mitochondrial disorders 53 cytoprotective 53 FGF2 53 histone deacetylases 53 aberrantly activated 53 tumor suppressive 53 NS4B 53 Alzheimer disease pathogenesis 53 epithelial tumors 53 microglial 53 protein tau 53 CENP E 53 glomerulonephritis 53 chromosomal regions 53 Vascular endothelial growth 53 LRP6 53 tau protein 53 NR2B 53 hepatic 53 etiological agent 53 malignant transformation 53 NFκB 53 gene rearrangements 53 neurofibrillary tangles 53 VEGF receptor 53 Endothelin 53 nitric oxide synthase 53 mTOR pathway 53 Htt 53 endotoxemia 53 receptor subtypes 53 Notch1 53 POMC neurons 53 UCP2 53 SH2 B 53 vascular endothelial 53 osteogenic differentiation 53 amyloidogenic 53 hypothalamic 53 intestinal microbiota 53 neuronal apoptosis 53 Id1 53 estrogen metabolism 53 neuro endocrine 53 myogenesis 53 RANKL 53 Cytotoxic T 53 FoxO1 53 mediating pathological inflammation 53 peroxisome proliferator activated 53 PPARg 53 MAPK signaling pathway 53 Smurf1 53 TNF α 53 endogenous ligand 53 adhesion molecule 53 genetic polymorphism 53 endothelial 53 heme oxygenase 1 53 diabetic microvascular complications 53 signaling cascade 53 antiproliferative effects 53 focal adhesion kinase FAK 53 JNK1 53 caveolae 53 androgen receptor 53 non coding RNA 53 CB2 receptor 53 #q#.# [002] 53 DNA methylation patterns 53 LDL receptor 53 transgenic mouse models 53 Mitochondrial dysfunction 53 clusterin 53 Endothelial dysfunction 53 Genetic variation 53 phosphorylates 53 fusogen 53 Neuroprotection 53 TGFß 53 Chlamydia pneumoniae 53 transcriptional repressor 53 epigenetic changes 53 MMP# 53 paracrine 53 syndromes 53 amyloid peptide 53 gene locus 53 mesenchymal transition 53 MAP kinases 53 tissue fibrosis 53 ESR1 53 GTPase 53 biochemical processes 53 PEDF 53 protein tyrosine phosphatases 53 lymphatic vasculature 53 Aß 53 epithelial cell 53 microglial activation 53 endothelial dysfunction 53 abnormal angiogenesis 53 essential thrombocythemia 53 differentially regulated 53 serotonergic 53 transcription factor 53 beta1 integrin 53 phospholipase A2 53 PPAR alpha 53 Oncogenic 53 SIRT1 53 downstream effector 53 sphingolipid 53 hypothalamic pituitary 53 pathological hallmark 53 protein conformation 53 ribosomal protein 53 tyrosine kinase receptor 53 IGF IR 53 demyelinating 53 tumor suppressor genes 53 molecular biomarkers 53 gut microbiota 53 Wnt 53 excitotoxic 53 cyclin dependent kinase inhibitor 53 Bardet Biedl Syndrome 53 small molecule agonists 53 pRb 53 receptor antagonism 53 gene encodes 53 RANK ligand 53 TNFAIP3 53 NR#A# 53 receptor CD# 53 astrocytic 53 HDAC 53 nephronophthisis 53 transcriptional regulator 53 intracellular protein 53 neuropathology 53 progranulin 53 N Myc 53 modifiable risk 53 endocytosis 53 A3 adenosine receptor 53 small molecule inhibitors 53 homolog 53 protein misfolding diseases 53 pathogenic 53 dedifferentiation 53 gene polymorphism 53 cholesterol homeostasis 53 RANK Ligand 53 fibroblast growth 53 transmembrane receptor 53 receptor protein 53 secreted protein 53 H#K# methylation 53 mammalian 53 melanocyte 53 T lymphocyte 53 induces apoptosis 53 genetic aberrations 53 vesicle formation 53 metalloproteinase 53 fascin 53 induce apoptosis 53 chromosomal rearrangement 53 Wnt proteins 53 C. albicans 53 susceptibility locus 53 neurological diseases 53 gene transcription 53 cyclins 53 paxillin 53 secretion 53 mutational status 53 p#INK#a 53 Apolipoprotein E 53 anti fibrotic 53 potent inhibitor 52 malignant lymphomas 52 small molecule defensin 52 metazoan 52 GATA3 52 transmembrane protein 52 matrix metalloproteinases MMPs 52 cytokines 52 gene loci 52 angiogenic 52 monocyte chemoattractant protein 52 alveolar epithelial cells 52 gene encoding 52 TTR gene 52 microglial cells 52 proteases 52 myeloproliferative neoplasms 52 XBP1 52 glutamatergic neurons 52 homodimers 52 receptor molecule 52 apolipoprotein E 52 IDH mutations 52 mucosal immune 52 poly ADP ribose polymerase 52 airway hyperreactivity 52 isotypes 52 V#F mutation 52 neurotrophic factors 52 IL8 52 glycogen synthase kinase 52 alveolar macrophages 52 antisense inhibitor 52 NMDA N 52 inflammatory demyelinating 52 autoantigens 52 autoimmune 52 retinol binding protein 52 calcium homeostasis 52 glucose transporter 52 GSK 3ß 52 noncoding RNAs 52 HLA DRB1 52 Prognostic factors 52 splice variant 52 CD# expression [002] 52 interleukins 52 IFN gamma 52 ccRCC 52 acetyltransferase 52 PC# cells 52 innate immune response 52 proximal tubule 52 histone methylation 52 PI3K AKT 52 renin angiotensin aldosterone 52 PTHrP 52 plexin D1 52 primary cilium 52 neurochemistry 52 chitinase 52 Cytokines 52 kallikrein 52 scavenger receptor 52 insulin signaling pathway 52 mitochondrial mutations 52 enzymatic activity 52 macrophage 52 immunoregulation 52 alpha7 NNR 52 extramedullary 52 vacuolar 52 autoimmune disorders 52 GTPases 52 MicroRNA 52 apoE4 52 receptor alpha 52 TTR amyloidosis 52 oxysterols 52 MMP7 52 Akt activation 52 steroidogenic 52 basal ganglia 52 pathophysiological effects