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(Click for frequent words.) 75 HepG2 cells 73 FasL 73 induced apoptosis 72 transduced 72 mice lacking 72 ERK1 2 72 deacetylation 72 downregulated 72 ChR2 71 iNOS 71 constitutively active 71 constitutively expressed 71 MAP kinase 71 inhibitory effects 71 overexpression 71 Overexpression 71 deficient mice 70 mRNA expression 70 pDC 70 c MYC 70 Rap1 70 constitutively 70 androgen receptor AR 70 caveolin 1 70 p#Kip# 69 immunoreactivity 69 cytosolic 69 PC# cells 69 Rab5 69 transiently transfected 69 transfected cells 69 IL 1β 69 BCL2 69 IFN gamma 69 protein encoded 69 wildtype 69 transgene expression 69 proto oncogene 69 induces apoptosis 69 transfected 69 catenin 69 upregulation 69 4E BP1 69 neuroblastoma cells 69 1alpha 69 EGFP 69 proteolysis 69 β catenin 68 cells transfected 68 downregulation 68 STAT1 68 tyrosine phosphorylation 68 mediated inhibition 68 mitogen activated protein kinase 68 enzymatic activity 68 ectopic expression 68 lymphoid cells 68 MnSOD 68 SMN1 68 transactivation 68 MDM2 68 overexpressing cells 68 monocyte chemotactic protein 68 inducible 68 ERK signaling 68 E#F# 68 null mice 68 upregulated 68 mediated apoptosis 68 coexpression 68 p# MAPK 68 transcriptional activation 68 homodimers 68 monocyte 68 transgenic mice expressing 68 inhibitory receptor 68 potent inhibition 68 ERBB2 68 tyrosine hydroxylase 68 isoforms 68 cyclin E 68 Jhdm2a 68 virulence genes 68 phosphorylates 68 downregulates 68 overexpress 68 transmembrane receptor 67 CEACAM1 67 antiapoptotic 67 Phosphorylation 67 Flt3 67 Hh 67 Akt signaling 67 Foxp3 67 adenylate cyclase 67 CD#c 67 HIF 1alpha 67 lacZ 67 caveolin 67 inhibitory effect 67 Clusterin 67 FUS1 67 Upregulation 67 MMP2 67 neurofilament 67 HIF 1a 67 regulated kinase ERK 67 Notch1 67 miR #b [001] 67 NKX#.# 67 HIF 1α 67 tumor suppressor proteins 67 murine 67 p# deficient 67 uPAR 67 neurite outgrowth 67 ubiquitination 67 decarboxylase 67 activin 67 MAPK pathway 67 LPS induced 67 transcriptional repressor 67 suppressor gene 67 anaphase promoting complex 67 OCT4 67 PGE2 67 cysteine protease 67 p#NTR 67 phosphorylate 67 Immunohistochemical analysis 67 glyceraldehyde 3 67 Dpp 67 SOCS3 67 kinase gene 67 hydrolase 67 PKM2 67 IL #p# 67 cotransporter 66 sequence homology 66 hTERT 66 MT1 MMP 66 overexpressed 66 vimentin 66 proteinase 66 stably expressing 66 oxidative phosphorylation 66 miR #a [001] 66 melanocyte 66 missense mutation 66 survivin 66 GLI1 66 tropomyosin 66 cells overexpressing 66 downregulate 66 kDa protein 66 CYP#B# 66 p# activation 66 ß catenin 66 MLH1 66 thioredoxin 66 c fos 66 RASSF1A 66 P cadherin 66 heterozygotes 66 Rho GTPase 66 c Fos 66 isomerase 66 deaminase 66 autophagic 66 metalloproteinase 66 pDCs 66 beta subunit 66 Cytotoxic T 66 TRAIL induced apoptosis 66 GABAergic 66 genes encoding 66 microglial activation 66 cyclin B1 66 isoenzyme 66 GTPase 66 paxillin 66 nicotinamide 66 FGFR4 66 dsRNA 66 Aβ 66 LNCaP cells 66 GRP# 66 Pten 66 SIRT2 66 ATPase 66 enterocytes 66 selectively inhibited 66 serine threonine kinase 66 Hypoxia Inducible Factor 66 intronic 66 PTPN# 66 somatostatin 66 CD# CD# 66 mutant proteins 66 cyclins 66 bronchial epithelial cells 66 ERalpha 66 tryptase 66 HepG2 66 lysosomal 66 alpha subunit 66 ErbB4 66 inhibitory 66 TAp# 66 adipogenic 66 CHD5 66 hepatoma 66 cathepsin B 66 Aß 66 upregulates 66 regulated kinase 66 IGF1R 66 glutathione S transferase 66 mRNA transcripts 66 PGC 1α 66 pRb 66 cathepsins 66 TGF ß 66 ERa 66 PLA2 66 protein tyrosine phosphatase 66 TGF beta1 66 Dysregulation 66 dephosphorylation 66 antisense inhibition 66 Smad3 66 Th2 66 alveolar epithelial cells 66 short hairpin RNAs 66 cyclin 66 nucleolin 66 phosphorylated 66 V#F mutation 65 LNCaP 65 Th1 65 PAX5 65 oncogenic transformation 65 cultured cells 65 polyamine 65 BMP signaling 65 Htt 65 superoxide dismutase 65 cystic fibrosis transmembrane conductance 65 TMEM#B 65 p# alpha [001] 65 induce apoptosis 65 cell adhesion molecule 65 peroxidase 65 IFNg 65 microsomal 65 lipoxygenase 65 cisplatin resistant 65 DNMT1 65 PBMCs 65 proapoptotic 65 NPD1 65 ERK pathway 65 ERK phosphorylation 65 CXCL# 65 transmembrane protein 65 transferase 65 ribosomal protein 65 NADPH oxidase 65 HER2 neu 65 hydrolases 65 FGFR3 65 glomerular 65 gene encoding 65 transmembrane domains 65 Cre recombinase 65 de novo synthesis 65 EGFRvIII 65 apoE 65 MEFs 65 MMP9 65 CDK4 65 mediated phosphorylation 65 leptin receptor 65 phosphatase 65 upregulate 65 CCL# 65 TrkB 65 IKKß 65 IL 1beta 65 inhibitory activity 65 IFN ß 65 transgenic mouse model 65 transcriptionally 65 cytoplasmic domain 65 RUNX3 65 dimeric 65 MDR1 65 phosphatidylinositol 3 65 reductase 65 prolyl 65 Mcl 1 65 CYP# [002] 65 antiproliferative activity 65 Hcrt 65 serine threonine 65 phospho 65 CD#b 65 Eg5 65 acyltransferase 65 BMAL1 65 IFN γ 65 splenocytes 65 BMP2 65 utrophin 65 Tie2 65 promoter methylation 65 gene amplification 65 unmutated 65 cyclase 65 nAChR 65 neurotrophin 65 thymidine kinase 65 LRP6 65 TNF α 65 Id1 65 Akt activation 65 H#K#me# 65 TNFalpha 65 GSTP1 65 MTHFR 65 erythrocyte 65 midgut 65 tumor suppressor protein 65 eNOS 65 EphB4 65 EZH2 65 MEK1 65 NF kappaB 65 Shp2 65 induced phosphorylation 65 cofilin 65 diphosphate 65 RRM1 65 amino terminal 65 TGF β1 65 transgenic mice 65 MAPK 65 subcellular localization 65 protein secreted 65 phosphoprotein 65 apo AI 65 RANTES 65 N acetyltransferase 65 ouabain 65 eotaxin 65 potent inducer 65 intestinal epithelial cells 65 pyruvate kinase 65 RhoA 65 ^ sup + 65 Mice lacking 65 receptor kinase 65 c myc 65 1α 65 bcl 2 65 EGF receptor 65 protein tyrosine kinase 65 PTHrP 65 immunoblotting 65 GATA3 65 65 antigen receptor 65 HLA DR4 immune 65 thymic 65 epigenetic silencing 65 WT1 65 TLR2 65 oncoprotein 65 activating mutations 65 globin 65 phospholipase 65 GAPDH 65 phosphatases 64 PON1 64 At#g# 64 phosphatidylinositol 64 colon carcinoma 64 mitogen 64 lysates 64 CD8 + 64 intratumoral injection 64 serine protease 64 Cyclin E 64 TIMP 64 c Src 64 Drosha 64 heme oxygenase 1 64 VEGFR1 64 LRAT 64 COL#A# 64 bile acid 64 UCP1 64 E cadherin 64 neuronal apoptosis 64 upregulating 64 TTR gene 64 VSV G 64 lysine residues 64 PDGFR 64 MyD# 64 missense mutations 64 Monocyte 64 Bcl XL 64 1beta 64 adipocyte 64 NKG2D 64 tyrosine kinase receptor 64 Cyclin D1 64 matrix metalloproteinases MMPs 64 PEPCK 64 FLT3 64 transgenic mouse models 64 XL# inhibits 64 apoptotic 64 Activating mutations 64 syngeneic 64 vascular endothelial cells 64 p# Shc 64 c MET 64 receptor tyrosine kinase 64 p# p# 64 astrocytic 64 histone deacetylases 64 N. benthamiana 64 glutamic acid decarboxylase 64 cytotoxin 64 CCR7 64 alternatively spliced 64 acetyl CoA 64 plasmacytoid dendritic cells 64 stably transfected 64 immunoreactive 64 Fas ligand 64 osteoblast 64 factor HGF 64 poly ADP ribose polymerase 64 SETDB1 64 p# mutation 64 C#BL 6 mice 64 AhR 64 MYCN 64 CHO cells 64 presenilin 64 valine 64 efflux pumps 64 casein kinase 64 aminopeptidase 64 cyclin dependent kinase 64 ganglioside 64 gene encodes 64 Î ² 64 hydroxylase 64 STAT3 64 costimulatory 64 chitinase 64 CagA 64 polypeptide 64 oxidase 64 anti apoptotic 64 E3 ligase 64 homozygotes 64 miR# 64 TGF alpha 64 Rac1 64 trisomic 64 Supplementary Fig 64 clusterin 64 lyase 64 Hsp# [001] 64 prostaglandin E2 PGE2 64 Polymorphisms 64 Chinese Hamster Ovary 64 H#K# [001] 64 Th2 cytokines 64 cyclin dependent kinase inhibitor 64 leukemic cell 64 dinucleotide 64 lysophosphatidic acid 64 motoneurons 64 TSC1 64 mammalian cells 64 activating mutation 64 isoform 64 MUC1 64 IGF IR 64 covalently bound 64 Leydig cells 64 RCAN1 64 NOD SCID mice 64 HGF 64 NF kappaB activation 64 Bcl xL 64 histone H3 64 metabolizing enzymes 64 CatB 64 cytoplasmic 64 hypermethylation 64 aromatase 64 selective inhibition 64 isoenzymes 64 TRPV4 64 acetylcholine receptor 64 IL 1ß 64 hippocampal neurons 64 PARP1 64 mitotic progression 64 Her-2/neu 64 μM 64 IFN g 64 HDAC6 64 Wnt signaling 64 Inactivation 64 HBx 64 hepatic lipase 64 thrombospondin 64 BRAF V#E 64 hypoxia inducible factor 64 aggrecan 64 carcinoembryonic antigen 64 PP2A 64 pancreatic islet 64 SIRT6 63 metalloprotease 63 presynaptic 63 coactivator 63 TNFa 63 Rho GTPases 63 matrix metalloproteinases 63 microglial 63 erythrocytes 63 c KIT 63 TGF ß1 63 BMP4 63 PIP2 63 bone marrow stromal cells 63 xenograft tumors 63 mutant protein 63 kinase pathway 63 pleiotropic 63 Corynebacterium 63 adrenocortical 63 mitochondrial enzyme 63 db db mice 63 Histone 63 A. thaliana 63 ErbB2 63 phosphoinositide 63 Extracellular 63 acetylated 63 Chinese hamster ovary 63 protein kinase 63 TXNIP 63 intracellularly 63 histone modification 63 synthetase 63 paralogs 63 potent inhibitors 63 heterozygous 63 ubiquitylation 63 mitogenic 63 T lymphocyte 63 Jurkat cells 63 cyclooxygenase 63 tumor antigen 63 thymocytes 63 Fibroblast 63 potently inhibited 63 FAK 63 interleukin IL -# 63 matrix metalloproteases 63 ERK2 63 Mice deficient 63 spermidine 63 acyl CoA 63 ß amyloid 63 outer membrane proteins 63 cyclooxygenase COX 63 Kupffer cells 63 sFlt 1 63 cytokine signaling 63 cyclooxygenase 2 63 defensin 63 neutralizing antibody 63 tumorigenicity 63 mutant p# 63 hypermethylated 63 SGK1 63 Sp1 63 endostatin 63 radiosensitivity 63 heterochromatic 63 IRE1 63 carboxyl terminal 63 amyloid β 63 NAD + 63 extracellular signal 63 K ras mutations 63 F actin 63 H#K# [002] 63 orexin receptors 63 NFkB 63 β1 63 effector memory 63 P. gingivalis 63 effector T 63 pro apoptotic 63 CFTR 63 CD4 + CD# 63 Western blotting 63 inhibin B 63 C. albicans 63 phosphate dehydrogenase 63 oxidative metabolism 63 IgG1 63 costimulation 63 osteogenic differentiation 63 Hh pathway 63 ovalbumin 63 miR #a [002] 63 S#K# 63 Secretase 63 Th1 type 63 replicase 63 glucokinase 63 KLF4 63 orthologs 63 plasmacytoid 63 c Myb 63 HER2 HER2 63 beta actin 63 Oncogenic 63 ZNF# 63 telomerase reverse transcriptase 63 cytotoxicity 63 p# [001] 63 forkhead 63 intercellular adhesion molecule 63 phospholipase C 63 MDCK cells 63 tumor suppressive 63 mRNA encoding 63 adenoviral 63 cyclic adenosine monophosphate cAMP 63 tumor suppressor PTEN 63 cytokine secretion 63 amyloid peptide 63 DLC1 63 Transgenic Mice 63 PC3 cells 63 intracellular signaling 63 knockout mice 63 fusion protein 63 glioma cells 63 FGFs 63 AT1R 63 inhibited tumor 63 inflammatory cytokine 63 P2X 63 bleomycin 63 5 lipoxygenase 63 splice variants 63 leukemic stem cells 63 potently inhibit 63 basolateral 63 IGFBP2 63 adduct 63 tubulin 63 ciliated 63 prion gene 63 colocalization 63 glucocorticoid receptor 63 UCP2 63 TrkA 63 hematopoietic progenitors 63 isoleucine 63 cAMP 63 ErbB receptors 63 gene polymorphism 63 GluR1 63 inhibits tumor 63 CaM 63 cytokeratin 63 CD# + [001] 63 PPARγ 63 DLX5 63 Amino acid 63 adenomatous polyposis coli 63 TET2 63 ENaC 63 HER2/neu 63 IL8 63 microRNA miR 63 TIMP 1 63 AMACR 63 mRNA 63 Hepatocytes 63 proteolytic cleavage 63 TGF β 63 synthases 63 transcriptional regulation 63 Aâ 63 Sertoli cell 63 myo inositol 63 secretase 63 acinar 63 extracellular domain 63 ER alpha 63 allelic variants 63 agonist induced 63 proximal tubule 63 K + ATPase 63 pro angiogenic 63 SPINK1 63 FOXO3a 63 oligomerization 63 prostate epithelial cells 63 immunotoxin 63 prostaglandin E 63 calpain 63 uracil 63 Transcriptional 63 synaptogenesis 63 prion protein PrP 63 Runx2 63 mitogen activated protein 63 c Abl 63 experimental autoimmune encephalomyelitis 63 Cdc# 63 ^ sup ^ 63 yeast Saccharomyces cerevisiae 63 MDMX 63 C#Y 63 CD#L 63 lipopolysaccharide LPS 63 glycosylated 62 apical membrane 62 matrix metalloproteinase 62 methyltransferase 62 isotypes 62 renal fibrosis 62 alpha synuclein gene 62 fibril formation 62 Stat1 62 dependent protein kinase 62 interferon γ 62 trophoblast 62 mutant BRAF 62 sortilin 62 encodes protein 62 deacetylase 62 selectively binds 62 cyclin D1 62 phagocytosis 62 estrogen receptor beta 62 erythroid 62 HDAC2 62 RKIP 62 hyperactivation 62 ESR1 62 neuronal cell 62 Peyer patches 62 IKK2 62 xenografts 62 mutational status 62 S#A# [002] 62 cultured hippocampal neurons 62 receptor CXCR4 62 P selectin 62 peroxisomal 62 keratinocyte 62 Cdc7 62 beta globin 62 beta1 integrin 62 transcriptional activity 62 ornithine decarboxylase 62 Fig. 1C 62 secreted protein 62 rs# [004] 62 caspase activation 62 GABAergic neurons 62 heterodimers 62 hypomethylation 62 LDLR 62 proline 62 megakaryocytes 62 interleukins 62 N Myc 62 beta catenin 62 lymphoid organs 62 SUMOylation 62 phosphorylated tau 62 glycolipids 62 GSTT1 62 embryonal carcinoma 62 PAK1 62 constitutive activation 62 5 HT2A serotonin 62 glycosylation 62 inducible nitric oxide synthase 62 myeloid derived 62 Heterozygous 62 NFAT 62 #ß 62 receptor gene 62 IGFBP 62 cyclic AMP cAMP 62 Foxp3 + 62 operon 62 perilipin 62 glycosyltransferase 62 prostaglandin synthesis 62 posttranslational modification 62 diacylglycerol 62 phagocyte 62 mucins 62 acetyltransferase 62 AMPA receptor 62 heme oxygenase 62 alkaline phosphatase ALP 62 alkaline phosphatase 62 clonogenic 62 Saccharomyces cerevisiae 62 anti inflammatory cytokine 62 receptor CD# 62 mouse xenograft models 62 thymidylate synthase TS 62 HbF 62 rRNA 62 synthase 62 adrenoceptor 62 homodimer 62 FGF receptor 62 tumorigenesis 62 IGFBP7 62 breast epithelial cells 62 PECAM 1 62 antigenic epitopes 62 tyrosinase 62 PHD2 62 inverse agonist 62 ABCA1 62 thymocyte 62 pharmacological inhibition 62 GPR# [002] 62 Elevated serum 62 Src kinase 62 dehydrogenase 62 Cathepsin B 62 kinase domain 62 effector function 62 GABAergic interneurons 62 estrogen receptor alpha 62 neurturin 62 functional polymorphism 62 cultured neurons 62 ABCB1 62 leptin receptors 62 IL #R 62 tyrosine kinase 62 deletion mutant 62 VE cadherin 62 survival motor neuron 62 GLUT1 62 N acetyl 62 ERK activation 62 CD8 T cells 62 keratinocytes 62 EBNA1 62 luciferase reporter 62 demethylase 62 neuronal dysfunction 62 innate immune responses 62 enzyme inhibitor 62 LDL receptor 62 intracellular accumulation 62 podocytes 62 CD4 + T lymphocytes 62 Cytoplasmic 62 proteins encoded 62 glutamatergic 62 calcineurin 62 Leydig cell 62 p#INK#a 62 CpG island 62 Germline 62 mutated p# 62 gene rearrangements 62 glutamate receptors 62 tubulin polymerization 62 antibody mediated 62 amino acid substitutions 62 vesicular stomatitis virus 62 primordial germ cells 62 PI3K/Akt pathway 62 cofactor 62 miRNA expression 62 gastric carcinogenesis 62 receptor activation 62 subcellular compartments 62 CaMKII 62 transcriptional repression 62 sphingolipid 62 GSTM1 62 untranslated regions 62 xenograft model 62 redox active 62 GTPases 62 interferon IFN 62 oncogenic 62 SMN2 gene 62 Calcineurin 62 cytotoxic T lymphocyte 62 TRAF6 62 hepatocyte growth 62 HSCs 62 alpha MSH 62 methylation patterns 62 RAS RAF MEK 62 tRNA synthetase 62 potent inhibitor 62 mutant huntingtin 62 P glycoprotein 62 beta amyloid peptide 62 Smoothened 62 substrate specificity 62 adenosine diphosphate ADP 62 Nf1 62 CLL cells 62 IMPDH 62 heparanase 62 potentiated 62 immunostimulatory 62 Rho kinase 62 TOP2A 62 HEK# cells 62 osteoprotegerin 62 AgRP 62 glycoproteins 62 monomeric 62 epithelia 62 syntaxin 62 FGFR2 62 autoreactive 62 intracellular 62 homozygosity 62 FGFR1 62 JAK STAT 62 Cx# [001] 62 Akt1 62 JAK2 62 RIP1 62 nitric oxide synthase 62 PTP1B 62 acetylcholinesterase 62 FKBP# 62 myocyte enhancer factor 62 N cadherin 62 thyroid hormone receptor 62 histone deacetylation 62 lymphotoxin 62 mesenchymal cells 62 thymidine 62 phosphate S1P 62 phorbol 62 Immunohistochemical staining 62 NMDA receptors 62 toxic beta amyloid 62 IGFBP 3 62 immunodominant 62 guanosine 62 RNA polymerases 62 fig. S2 62 B7 H1 62 haematopoietic 62 Cystic Fibrosis Transmembrane Conductance 62 myeloid cells 62 Nampt 62 microRNA molecule 62 Hedgehog signaling 62 esterase 62 ALDH 62 cytochrome 62 metabolizing enzyme 62 tissue transglutaminase 62 ubiquitin ligase 62 Histone H3 62 FOXO1a 62 glioblastoma cells 62 cell adhesion molecules