oral formulations

Related by string. oral formulation * ORAL . orals . Oral : TULSA Okla. Oral Roberts . hear oral arguments . hears oral arguments . oral arguments . Oral Roberts . Oral Suspension . Oral Suspension Oral Suspension / Formulation . Formulations : proprietary formulation . intravenous formulation . gel formulation . dosage formulations . injectable formulation . inhaled formulation * *

Related by context. All words. (Click for frequent words.) 65 topical ophthalmic 65 zileuton 65 TELINTRA 65 intravenous formulations 64 pegylated 64 capsule formulation 64 docetaxel Taxotere ® 64 oral salmon calcitonin 64 transdermal spray 64 RECOTHROM R 63 Proquin XR 63 octreotide acetate 63 topical NSAID 63 topical gel formulation 63 dexlansoprazole 63 injectable formulation 63 5 HT3 antagonist 63 acyclovir Lauriad R 63 ADP receptor antagonist 63 Preclinical studies suggest 63 tablet formulation 63 HCV protease inhibitors 63 Lubiprostone 63 PTH1 63 orally disintegrating tablets 62 cyclobenzaprine hydrochloride extended 62 prescribed proton pump 62 orally disintegrating 62 ulimorelin 62 fluoroquinolone antibiotic 62 topical formulations 62 entacapone 62 peripherally acting 62 Interferon alpha 62 PDE4 inhibitor 62 novel oral anticoagulant 62 Orally administered 62 injectable formulations 62 Dalbavancin 62 salmon calcitonin 62 inhibitor PPI 62 adipiplon 62 alfa interferon 62 Aganocide 62 INTELLITAB TM 61 ATD gel 61 topical antifungal 61 anti emetic therapy 61 RhuDex ® 61 metformin HCl 61 OSMOPREP 61 lanreotide 61 AzaSite Plus 61 DURIN TM 61 acetonide FA 61 trospium 61 Nutra Pharma wholly owned 61 buccal tablet 61 transdermal delivery 61 Fortical R 61 Gabapentin GR 61 Traficet EN 61 orally disintegrating tablet 61 MoxDuo 61 AMRIX R 61 Clonicel 61 hyaluronidase rHuPH# 61 diabetic neuropathic pain 61 Emend 61 liposomal formulation 61 azelastine 60 Relivar 60 EMBEDA ™ 60 Oral Spray 60 Ciclesonide 60 ciprofloxacin hydrochloride 60 nucleoside analogs 60 Inhalation Solution 60 VISICOL R 60 LEUKINE 60 ACUROX ® 60 orally administered 60 DuraSite 60 EpiCept NP 1 60 ORADUR 60 Tekturna HCT 60 PEGylated 60 vinorelbine tartrate 60 Indaflex TM 60 Oracea TM 60 DepoBupivacaine TM 60 faropenem 60 Oral Controlled 60 fluocinolone acetonide 60 NanoEmulsion 60 small molecule chemotherapeutic 60 CDP# 60 intranasal formulation 60 Milnacipran 60 Flutiform TM 60 Pazopanib 60 Zenpep 60 HFA MDI 60 oral transmucosal 60 DepoDur 60 carbidopa levodopa 60 Piperacillin 60 Pafuramidine 60 LNP formulations 60 Lupron Depot 60 Tapentadol 60 PROVIGIL R 60 Ganciclovir 60 Dual Opioid 60 bromfenac 60 morphine sulfate extended 60 JAK inhibitor 60 ciclesonide 60 long acting muscarinic 59 TLR agonists 59 oxybutynin gel 59 Clolar ® 59 glycopyrrolate 59 GLP1 agonist 59 eligen R technology 59 fluvoxamine maleate 59 Fosphenytoin 59 pharmacologically active isomer 59 transdermal gel 59 nucleoside analog 59 Leukine ® 59 oral formulation 59 oral taxane 59 DuraSite R 59 biodegradable implant 59 TIMERx 59 PharmFilm ® 59 prokinetic agent 59 BEMA ® 59 inhaled formulations 59 clonidine hydrochloride 59 Tezampanel 59 Captisol Enabled 59 apomorphine 59 INT# [002] 59 cyclophilin inhibitor 59 cefixime 59 DU #b 59 methylnaltrexone bromide 59 Icatibant 59 subcutaneous formulation 59 Cancidas 59 RSD# 59 Hydrochloride 59 adapalene 59 T Pred 59 ALVESCO HFA 59 Sitagliptin 59 ZYFLO CR 59 granisetron 59 proteasome inhibitor 59 Perforomist ™ Inhalation Solution 59 BAL# [002] 59 betamethasone dipropionate 59 interferon alfa 2b 59 inhaled formulation 59 mesylate 59 Besivance 59 reslizumab 59 sufentanil 59 transdermal patch 59 intranasal delivery 59 Factor VIIa 59 #mg #mg [002] 59 Sanctura XR 59 calcipotriene 59 acting insulin analogs 59 omiganan 59 MEK inhibitors 58 Linjeta ™ 58 Orapred ODT 58 Gel repository corticotropin injection 58 mometasone 58 anti emetic 58 formulations 58 REMOXY ® 58 TRANSDUR ® 58 AAG geldanamycin analog 58 Zingo TM 58 EpiCeram 58 bepotastine 58 Rebif ® 58 ATL# [002] 58 Sumatriptan Succinate 58 LEP ETU 58 subcutaneously administered 58 YONDELIS 58 DuraSite ® 58 prostone 58 Kristalose ® lactulose 58 XOPENEX R 58 liposomal 58 containing granisetron 58 Tamibarotene 58 diclofenac sodium 58 ZEGERID Capsules 58 calcineurin inhibitors 58 immunomodulatory therapy 58 Sanvar R 58 oxymorphone ER 58 Tilidine 58 NovaBay Aganocide compounds 58 Liprotamase 58 punctal plugs 58 opioid fentanyl 58 Oxytrex 58 XOPENEX Inhalation Solution 58 liposomal formulations 58 topical dermatology 58 COREG CR 58 multitargeted 58 ZOMIG 58 NitroMist 58 Dual Opioid TM 58 macrolide antibiotics 58 ATD Gel 58 sublingual formulation 58 serotonin norepinephrine reuptake inhibitor 58 Enhanze Technology 58 SCIg 58 nasal antihistamine 58 Inhalation Aerosol 58 XOPENEX HFA 58 ALGRX 58 injected subcutaneously 58 orally inhaled 58 Cerashield 58 Anidulafungin 58 synthetic retinoid 58 thrombolytic agent 58 nalbuphine ER 58 acting injectable formulation 58 miconazole Lauriad ® 58 ketoconazole 58 luliconazole 58 raloxifene Evista 58 oxybutynin 58 Benazepril 58 miconazole 58 PharmFilm R 58 TREDAPTIVE 58 maleate 58 AeroLEF TM 58 methylnaltrexone 58 Micropump 58 opioid analgesic 58 microtubule inhibitor 58 sublingual tablets 58 GelSite R polymer 58 SNALP technology 58 TriRima 58 PERLANE 58 Elvitegravir 58 muscarinic receptor agonist 58 ONSOLIS 58 tolevamer 58 metoprolol succinate 58 Biochronomer 58 Aerosurf 58 Aversion r Technology 58 KAPVAY ™ 58 sublingual tablet 58 Novasome R 57 Civacir 57 SEROQUEL R 57 Medidur 57 Zileuton 57 Atrigel 57 Accordion Pill 57 transdermal 57 XOPENEX 57 Alexza Staccato 57 Cardene ® 57 direct thrombin inhibitors 57 amphotericin B 57 Ketotransdel TM 57 Zirgan 57 ONTAK 57 Bioral 57 tolperisone 57 KADIAN ® 57 DepoDur TM 57 NanoCrystal ® technology 57 XP# XP# 57 HCl tablets 57 AzaSite Xtra 57 xanthine oxidase inhibitor 57 Saizen R 57 nasal spray formulation 57 Vfend 57 ceftazidime 57 proton pump inhibitor PPI 57 brain penetrant 57 ipratropium bromide 57 Amrix 57 USL# 57 acting muscarinic antagonist 57 proprietary transdermal patch 57 KAPIDEX 57 cysteamine bitartrate 57 tenofovir Viread 57 Ketorolac 57 rhIGF-I/rhIGFBP-3 57 ARIKACE 57 transmucosal 57 Palonosetron 57 CANCIDAS 57 RELISTOR ® 57 Levofloxacin 57 PolyActive 57 Nascobal R 57 short acting bronchodilator 57 #mg #mg #mg #mg [002] 57 emulsion formulation 57 prodrugs 57 Fortamet 57 XYZAL R 57 Soriatane 57 CIP TRAMADOL ER 57 aztreonam 57 Lauriad R 57 calcitonin 57 FM VP4 57 SUSTENNA TM 57 Liposomal 57 EMSAM 57 Veregen TM 57 bioerodible 57 dosing frequency 57 topically applied 57 trospium chloride 57 Ventavis 57 torezolid phosphate 57 parenterally administered 57 Altera Nebulizer System 57 Darinaparsin 57 oxcarbazepine 57 Anticalins R 57 Lamictal ODT 57 NitroMist TM 57 topical corticosteroids 57 Keppra ® levetiracetam 57 MYCAMINE 57 BYETTA exenatide injection 57 echinocandins 57 therapeutic regimens 57 Granisetron 57 Fluconazole 57 DETERx ™ 57 heparins 57 TAFA# 57 bioabsorbable polymer 57 NanoTab 57 Zysolin TM 57 Prilosec omeprazole 57 Exenatide 57 escitalopram oxalate 57 Maribavir 57 injectable 57 gastrointestinal disorders ATI 57 Perforomist TM Inhalation Solution 57 Contramid 57 RESTYLANE R 57 ferumoxytol Injection 57 sublingual tablet formulation 57 BioSilicon 57 Lovaza TM 57 tapentadol 57 levodopa carbidopa 57 Relenza zanamivir 57 mesalazine 57 BUPHENYL R 57 Atripla combines 57 mucoadhesive 57 AstraZeneca Symbicort 56 NanoCrystal technology 56 Orally Disintegrating Tablets 56 herpetic keratitis 56 successfully commercialize Iluvien 56 GLASSIA 56 oral rivaroxaban 56 transdermally 56 nasal powder 56 Captisol enabled 56 Toctino ® alitretinoin 56 Zavesca R 56 Glycopyrrolate 56 tramadol acetaminophen 56 SOLODYN 56 Soriatane R 56 reformulates existing FDA 56 Nitrofurantoin 56 dosage regimen 56 Lauriad 56 mg Tablets 56 EMBEDA TM 56 Cobalamin 56 Budesonide 56 MNTX 56 Abstral ® 56 Pradaxa ® 56 drug NSAID 56 Ventavis ® 56 sapropterin dihydrochloride 56 topical formulation 56 rxRNA 56 soft gelatin capsule 56 antiarrhythmic agent 56 TNF alpha inhibitor 56 Kristalose 56 Carvedilol 56 Emezine 56 dosing regimens 56 Cellegesic 56 Abbokinase 56 administered intranasally 56 pioglitazone HCl 56 Dabigatran etexilate 56 Focalin XR ® 56 LEVAQUIN ® 56 pantoprazole sodium 56 oxycodone HCl 56 SPRIX ® 56 buccal delivery 56 isosorbide mononitrate 56 Galantamine 56 proteins peptides 56 Octreotide 56 Cefprozil 56 systemic antifungal 56 crofelemer 56 Ceftriaxone 56 Nascobal 56 BioNeutral antimicrobial formulations 56 naltrexone hydrochloride 56 acyclovir Lauriad ® 56 olopatadine 56 Brimonidine 56 Microcyn Technology platform 56 administered subcutaneously 56 CG# [003] 56 proteasome inhibitors 56 OMNARIS 56 intravenously administered 56 pharmacodynamic properties 56 Cefazolin 56 Rifampin 56 markets HP Acthar 56 oral dosage 56 Starlix 56 Nyloxin OTC 56 daptomycin 56 bepotastine besilate 56 Hyalgan 56 OROS ® 56 Anticalins 56 cefdinir 56 cidofovir 56 tizanidine 56 MoxDuo IR 56 cathepsin K inhibitor 56 Oral Solution 56 Zytiga 56 buccal tablets 56 NUVIGIL ® 56 PROTONIX 56 hydrophobic docetaxel prodrug nanoparticle 56 ORADUR TM 56 dalbavancin 56 selective orally bioavailable 56 Striant 56 NEXTERONE 56 MOVIPREP 56 prescription laxative 56 rabeprazole 56 cephalosporin antibiotic 56 parenteral 56 hyperimmune products 56 oxazolidinone 56 FENTORA 56 VersaFilm 56 Allegra fexofenadine 56 Aloxi R 56 Topical Suspension 56 Tesamorelin 56 Levoleucovorin 56 rhThrombin 56 RYZOLT 56 tamsulosin hydrochloride 56 fluticasone propionate 56 KNS # 56 Vidaza azacitidine 56 AMRIX 56 overactive bladder AA# 56 palonosetron hydrochloride injection 56 lingual spray 56 hydrochloride tablets 56 Gliclazide 56 quinolone 56 Glumetza TM 56 EVIZON 56 Eligen ® Technology 56 oritavancin semi 56 carbidopa 56 opiod 56 injectable ibuprofen 56 Emselex 56 Fenofibrate 56 SOLODYN R 56 octreotide 56 antiepileptics 56 RISPERDAL ® CONSTA ® 56 H2 antagonists 56 antiemetic 56 Crofelemer 56 Argatroban 56 topical gel 56 trazodone hydrochloride 56 Somatuline R Autogel R 56 HP Acthar R 56 Squalamine 56 Seroquel quetiapine fumarate 56 ofloxacin 56 Anticalins ® 56 Extended Release Tablets 56 ALVESCO ® 56 QRxPharma 56 Renagel ® 56 RNA antagonist 56 gliclazide 56 PrevOnco 56 Xerese 56 Surfaxin LS 56 Increlex R 56 Lamotrigine 56 Roflumilast 55 1mg tablets 55 Elevess 55 Frova ® 55 pen injector 55 URG# 55 Lysteda 55 itraconazole Sporanox 55 exenatide 55 phosphate binder 55 Solulin 55 COLAZAL R 55 Nerve Targeting Drug 55 Advanced Transdermal Delivery 55 fluticasone furoate 55 Indomethacin 55 oxycodone acetaminophen 55 HCl capsules 55 Stavzor 55 Zelapar 55 echinocandin 55 Zonisamide 55 lactulose 55 basal insulins 55 injection USP 55 Myolimus 55 Extended Release 55 Itraconazole 55 Anturol ® 55 topiramate Topamax 55 Daytrana ® 55 naproxen sodium 55 Rotigotine 55 Zorbtive TM 55 Hycamtin 55 Factor Xa inhibitor 55 Kaletra lopinavir ritonavir 55 DiLA 2 55 Voltaren Gel 55 Topical treatments 55 GelVac TM 55 PROMUS Element Stent 55 novel DACH platinum 55 patented Bioral 55 vancomycin hydrochloride 55 Eligen R Technology 55 paliperidone palmitate 55 therapeutically inactive prodrug 55 Eraxis 55 RESTYLANE 55 omeprazole widely 55 REMOXY 55 non steroidal 55 EMBEDA 55 ATD TM gel 55 biologic therapeutics 55 balsalazide disodium 55 Anthim 55 1mg 2mg 55 Sanctura 55 ULTRASE 55 SEPET TM 55 Technosphere ® 55 sevelamer carbonate 55 AZILECT R 55 InvaGen 55 Fluticasone 55 pegfilgrastim 55 topical non steroidal 55 guanfacine 55 Alvesco R 55 IFN Beta CTP 55 inhalation powder 55 paliperidone 55 zidovudine AZT 55 topical diclofenac 55 Veramyst 55 Alprostadil 55 lyophilized powder 55 nebulized 55 ganciclovir 55 VaxImmune 55 FOSRENOL R 55 5mg #mg #mg 55 CYT# QbG# 55 Focalin XR 55 pregabalin Lyrica 55 INOmax 55 poorly soluble 55 tigecycline 55 Valium diazepam 55 Zomig 55 topical anti infective 55 somatostatin analogues 55 NeuroSTAT ® 55 Remodulin 55 zaleplon 55 Doxorubicin 55 Twinject ® 55 Plenaxis TM 55 FACTIVE R gemifloxacin 55 filgrastim 55 DP VPA 55 GelSite R 55 Sular formulation 55 Relistor 55 Vivaglobin 55 PPAR gamma agonists 55 granulated mesalamine 55 TYGACIL 55 RISPERDAL CONSTA 55 Polyphenon ® E 55 Sumatriptan 55 INVEGA SUSTENNA 55 SYCREST 55 tazobactam 55 DiLA2 55 WinRho SDF 55 BEMA ™ 55 Inhalation Powder 55 tablets USP 55 lyophilized 55 subcutaneous implant 55 Remicade infliximab 55 Mometasone 55 tazarotene 55 Release Tablets 55 DYSPORT 55 DermaVir 55 Colesevelam 55 topical ocular 55 Pemetrexed 55 alprostadil 55 Miacalcin 55 Sutent sunitinib 55 Urocidin 55 pharmacokinetic profiles 55 calcium acetate 55 Atrigel R 55 adefovir dipivoxil 55 Nektar pulmonary 55 oral antiviral 55 desvenlafaxine 55 Teriparatide 55 formoterol fumarate 55 eligen 55 Intravail ® 55 Formoterol 55 Desonate 55 DPP4 inhibitor 55 Intermezzo ® zolpidem tartrate 55 Omnaris 55 SSRI selective serotonin 55 Aztreonam lysine 55 Mitoxantrone 55 oxycodone hydrochloride 55 Aviptadil 55 ropinirole 55 Medisorb R 55 orally dosed 55 TRANSDUR Bupivacaine 55 macrolide antibiotic 55 Xanax alprazolam 55 Glufast 55 BioSilicon TM 55 metered dose 55 JUVISTA R Human 55 Emezine R 55 gabapentin 55 Byetta exenatide 55 Nebido 55 Orthovisc 55 Maleate 55 AstraZeneca Toprol XL 55 Valtropin 55 features biocompatible shelf 55 sodium stibogluconate 55 ZEFTERA TM Zevtera TM 55 BeneFIX 55 Captisol 55 Tasigna nilotinib 55 using VIAdel TM 55 Axid 55 oral antifungal 55 sumatriptan 54 fesoterodine 54 triptan 54 Leuprolide 54 aerosol formulation 54 Losartan Potassium 54 LUNESTA ® 54 H#N# antigen 54 INVEGA ® SUSTENNA ® 54 RH1 54 Detrol LA 54 dosage forms 54 piperacillin 54 Cetirizine 54 SUMAVEL 54 Kuvan sapropterin dihydrochloride 54 antidepressant trazodone 54 Onsolis 54 anti TNF alpha 54 Q#IR 54 PhosLo ® 54 Pegasys peginterferon alfa 2a 54 APRISO 54 latanoprost 54 #.#mg 1mg 54 quinolone antibiotic 54 oral immunomodulatory 54 irinotecan hydrochloride 54 CTA# 54 hPTH #-# 54 pancrelipase 54 BEMA TM 54 HYLENEX recombinant 54 novel prodrug 54 triptorelin 54 Mirapexin 54 Levetiracetam 54 alefacept 54 single injection viscosupplement 54 atypical antipsychotic medication 54 Glucose RapidSpray TM 54 AZILECT ® 54 S1P antibody 54 Vimpat R 54 Glucophage R 54 prodrug 54 dermal patch 54 ViaDerm 54 Lidoderm R 54 Terbinafine 54 Afresa 54 TOPROL XL 54 topical NSAIDs 54 Cardene IV 54 Eligen R B# 54 NeoVisc 54 hepatotoxic 54 Belerofon 54 budesonide inhalation suspension 54 TLR9 agonist 54 antithrombotics 54 inhalation aerosol 54 topically administered 54 VivaGel TM 54 Cefuroxime Axetil 54 Hydrochlorothiazide tablets 54 BrachySil 54 Sufentanil 54 Altabax 54 Saforis 54 prednisolone acetate 54 pioglitazone Actos 54 SyncroDose TM 54 propafenone 54 oral iron chelator 54 Opterone 54 long acting bronchodilator 54 tasocitinib 54 Theophylline 54 esomeprazole magnesium 54 situ gelling 54 synthetic peptide containing 54 semisynthetic 54 hydrochloride capsules 54 protease inhibitor PI 54 sulfamethoxazole 54 metformin hydrochloride 54 Kaletra tablets 54 Japanese Encephalitis vaccine 54 mg/#.# mg [003] 54 NOXAFIL 54 HepaGam B 54 leuprolide acetate 54 Onbrez Breezhaler 54 Alcortin 54 neuraminidase inhibitor 54 Nasal Spray 54 Heparins 54 Irinotecan 54 Fentanyl TAIFUN R 54 pancreatic enzyme 54 AMITIZA ® 54 Mycamine 54 Humalog ® 54 AMEVIVE 54 Saquinavir 54 Nestorone 54 ProAlgaZyme 54 #beta estradiol 54 GeneraMedix 54 Foradil Aerolizer 54 Hydrelle 54 dispersible tablet 54 PegIntron 54 Zuplenz 54 cytotoxics 54 applied topically 54 Synerx Pharma 54 dosage strengths 54 racemic 54 Noxafil 54 XYZAL 54 ONSOLIS ™ 54 transdermal patches 54 liposomal delivery 54 Ketoprofen 54 Gabapentin 54 EXALGO 54 Zn DTPA 54 basal insulin analogue 54 Paclitaxel 54 intravesical instillation 54 balsalazide tablet 54 gastric retentive 54 injectable diclofenac 54 BIO SET 54 Taclonex 54 Somatuline Autogel 54 aluminum hydroxide adjuvant 54 Vaxfectin 54 prefilled syringe 54 estradiol transdermal spray 54 Sporanox 54 gel formulations 54 Intranasal 54 Cefepime 54 biocompatible shelf stable 54 Lamivudine 54 Rectogesic 54 diclofenac potassium 54 ketorolac 54 OLEPTRO 54 Restoraderm 54 EUFLEXXA R 54 Pitavastatin 54 tinidazole 54 Truvada emtricitabine 54 Arixtra 54 afamelanotide 54 mg dosages 54 OROS R 54 Vivelle Dot 54 desloratadine 54 Oxiplex 54 Extina 54 Duromist ™ 54 Auxilium transmucosal film 54 IntelGenx proprietary 53 long acting beta2 53 treat enlarged prostate 53 MIRCERA 53 Cefdinir 53 Edoxaban 53 CRIXIVAN 53 Olmesartan 53 prokinetic 53 alpha blocker 53 Fortovase 53 GAMMAGARD LIQUID 53 Amnesteem Claravis 53 gluteal injection 53 Besylate 53 anti androgen 53 topical steroid 53 Topotecan 53 Lauriad ® 53 Tekturna Rasilez 53 Opana R 53 proprietary DuraSite ® 53 nonstimulant 53 Amlodipine Besylate 53 topical acne 53 VPRIV 53 Levetiracetam Tablets 53 rxRNA TM compounds 53 GLP toxicology studies 53 Injectable 53 TRISENOX R 53 BiDil XR 53 CB1 antagonists 53 Clindamycin 53 zolpidem tartrate sublingual tablet 53 Intelence 53 Carbidopa Levodopa 53 THALOMID 53 leucovorin 53 Dovonex 53 hydrobromide 53 intravenous AAT 53 dopamine receptor agonist 53 Known generically 53 NexACT ® 53 antagonist LAMA 53 Kristalose R 53 rosiglitazone maleate 53 Fortigel 53 RNAi compounds 53 Topiramate 53 nab docetaxel 53 baclofen 53 Rapaflo 53 Ropinirole 53 lamivudine zidovudine 53 topical gels 53 guanfacine extended release 53 CIP ISOTRETINOIN 53 tramadol HCl 53 Androgel R 53 Glassia 53 Alphagan P 53 Zolpidem Tartrate 53 Zolpimist 53 Ralivia TM 53 mecamylamine hydrochloride 53 Sycrest 53 zafirlukast 53 Taclonex Scalp R 53 RFF Pen 53 Loramyc 53 Astelin 53 Indaflex 53 pioglitazone hydrochloride 53 monohydrate 53 Didronel 53 biosurgical 53 immune modulatory 53 Enkephalin 53 #mg tablet [001] 53 Invisicare 53 GPR# agonists 53 Cerashield ™ 53 BEMA Fentanyl 53 Riluzole 53 tanespimycin KOS 53 prednisolone sodium phosphate 53 oral anticoagulant 53 levocetirizine 53 Fortesta 53 Suprax 53 ABRAXANE ® 53 Wellbutrin XL R 53 REYATAZ R 53 DispersinB R 53 tetracycline antibiotic 53 mesalamine 53 atypical antipsychotic 53 convenient dosing regimens 53 Loramyc ® 53 oral treprostinil 53 pancreatic enzyme replacement

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