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(Click for frequent words.) 66 non invasively 64 Pulse CO Oximeter 62 tissue oxygenation 61 reproducibly 61 Magnetic resonance 61 noninvasive 60 Masimo Rainbow SET 60 breakthrough noninvasive 60 SpMet 60 non invasive 59 physiological parameters 59 Masimo Rainbow SET Pulse 59 intravascular ultrasound 59 SpCO 59 SpO2 59 noninvasively measures 59 transcranial Doppler 58 ® Pulse CO 58 noninvasive imaging 58 Doppler ultrasound 58 tissue perfusion 57 miRview ™ squamous 57 Masimo Radical 7 57 transesophageal echocardiography 57 cardiac perfusion 57 carboxyhemoglobin SpCO 57 Flow cytometry 57 intravascular 57 tonometry 57 near infrared spectroscopy 57 Elastography 57 lung nodule 56 Corus CAD 56 CO Oximetry 56 Doppler echocardiography 56 Coronary CT angiography 56 optical coherence tomography OCT 56 noninvasively detect 56 intracoronary 56 cCTA 56 SPECT CT imaging 56 blood oxygenation 56 bioluminescence imaging 56 FFR measurements 56 KineMarker TM 56 needle aspiration 56 transthoracic 56 transabdominal 56 noninvasive diagnostic 56 multiplexed assays 56 TOF mass spectrometry 56 Masimo SpHb 56 stratify patients 56 vascular blockages 56 biophotonic 56 laser Doppler 56 minimally invasive technique 56 guided percutaneous 55 PD2i R 55 Positron emission tomography PET 55 SELDI TOF MS 55 EBUS 55 blood oxygen saturation 55 diagnostic modality 55 electrocardiography ECG 55 Rainbow SET 55 electrical impedance 55 noninvasively measuring 55 detect abnormalities 55 methemoglobin 55 eTag assays 55 percutaneous biopsy 55 biomarker assay 55 lung nodules 55 hypervascular tumors 55 NF kappaB activation 55 catheter angiography 55 Computed tomography 55 multidetector row 55 EnSite Velocity System 55 TM carboxyhemoglobin SpCO 55 transplanted embryonic 55 MDCT angiography 54 Penumbra System 54 optical coherence tomography 54 x ray angiography 54 cerebral oximetry 54 cardioplegic arrest 54 CO Oximeter 54 Perfusion Index 54 radiotherapy IMRT 54 metabolomic profiling 54 intramyocardial 54 SPECT imaging 54 intravascular imaging 54 immunochemical 54 FDG uptake 54 EUS FNA 54 stratifying patients 54 respiratory gating 54 oximetry 54 RT qPCR 54 microdialysis 54 Scintigraphy 54 CO Oximetry breakthrough 54 computed tomographic 54 OptiVol 54 immunohistochemical 54 Cardiac catheterization 54 Computed Tomography CT scans 54 rate variability HRV 54 Optical coherence tomography 54 intracavitary 54 RQ PCR 54 HeartNet 54 CellSearch 54 cytolytic activity 54 #F fluorodeoxyglucose 54 differentiate squamous 54 physiologically relevant 54 Cerebral Somatic Oximeter 54 stereotactic radiotherapy 54 ductal lavage 54 angiography CTA 54 tomographic images 54 SELDI 53 NGAL 53 SpHb 53 manometry 53 laser capture microdissection 53 coronary vessels 53 Functional magnetic resonance 53 microRNA profiling 53 anatomical landmarks 53 myocardial infarct size 53 perfusion imaging 53 CT angiography CTA 53 monocyte derived stem cells 53 Tr DNA 53 magnetic resonance spectroscopy MRS 53 high throughput MALDI 53 angiographically 53 elastography 53 radioimmunoassay 53 noninvasive technique 53 electrocardiographic 53 interstitial fluid 53 PET positron emission tomography 53 CellSearch System 53 myocardial perfusion 53 bronchoscopic procedures 53 Vasotrac 53 Capsule endoscopy 53 SiMoA 53 protein albumin 53 adipose stem 53 photon laser 53 transesophageal 53 PET imaging 53 tracheal intubation 53 mouse mammary 53 pleural fluid 53 computed tomographic scans 53 viral tropism 53 Doppler ultrasonography 53 Positron emission tomography 53 Magnetic resonance imaging 53 fluorescence quenching 53 Ejection fraction 53 gooey amyloid 53 pulmonary arterial 53 contrast echocardiography 53 bioelectrical impedance 53 rotational angiography 53 quantitate 53 xCELLigence 53 unclog arteries 53 pulmonary artery pressure 53 thymectomy 53 Ultrasonographic 53 fluorescence spectroscopy 53 protein biomarker 53 coronary vasculature 53 PD2i ® 53 Confocal microscopy 53 situ hybridization 53 hemodynamic variables 53 multislice 53 total hemoglobin SpHb 53 ablating 53 PD2i 53 graft patency 53 CardioFit 53 HSPCs 53 transient elastography 53 ischemic tissues 53 transesophageal echocardiography TEE 53 aneurysm sac 53 transduce 52 echocardiographic 52 reaction RT PCR 52 myocardial viability 52 diagnose Alzheimer disease 52 immunologically compatible 52 morphometry 52 prehospital setting 52 ablate 52 infarct size 52 tumor hypoxia 52 endotoxemia 52 electroencephalography 52 helical CT 52 electrophysiological 52 Pulmonary artery 52 Transesophageal 52 retinal tissue 52 methemoglobin SpMet 52 invasive biopsy 52 vascular anatomy 52 computerized tomographic 52 eBx 52 oxygen saturation 52 MRgFUS 52 myocardial tissue 52 qRT PCR 52 oxygen saturation SpO2 52 Tonometry 52 electrophysiologic 52 destroy cancerous cells 52 tissue oxygen saturation 52 intrathoracic 52 Catheter ablation 52 biomarkers 52 less invasively 52 sentinel lymph nodes 52 intra operative 52 cerebral oxygenation 52 physiologic parameters 52 artery embolization 52 radiotracer uptake 52 glomerular filtration 52 multi analyte 52 painless ultrasound 52 Ikoniscope 52 Radiofrequency ablation 52 Masimo noninvasive 52 aberrometer 52 Polyzene R F 52 bronchoalveolar lavage 52 lactate dehydrogenase LDH 52 COR Analyzer 52 FISH fluorescence 52 FLIPR 52 FDG PET scans 52 Electrical impulses 52 micrometastasis 52 ablate tissue 52 protein biomarkers 52 vessel occlusion 52 perfusion 52 transvaginal sonography 52 qdots 52 molecular biomarkers 52 brainwave activity 52 ptau 52 malignant nodules 52 haemodynamic 52 transcranial 52 prostate cancer metastases 52 decellularization 52 cardiac ablation procedures 52 Doppler imaging 52 intracardiac 52 immunohistochemistry IHC 52 Biopsy System 52 MALDI MS 52 Cellvizio 52 defibrillator implant 52 experimentally induced 52 xCELLigence System 52 hemodynamics 52 endoscopic ultrasound 52 PET tracers 52 microdebrider 52 fluoroscope 52 detecting polyps 52 FDG-PET/CT 52 keratoplasty 52 DNA methylation patterns 52 miRview squamous 52 VerifyNow 52 atrial pacing 52 removes endotoxin 52 balloon dilation 52 transarterial 52 treating cancerous tumors 52 TriGrid ™ 52 ImmuKnow 52 silent ischemia 52 esophagogastric 52 intraventricular 52 PET scanning 52 unstable cardiopulmonary 52 electron beam computed tomography 52 cardiac troponin 52 PICSO ® 52 thickness IMT 51 near infrared fluorescence 51 CT Angiography 51 leukocyte count 51 pulsed Doppler 51 ECG waveform 51 miRview mets 51 imaging modality 51 epicardial 51 FDG PET 51 Kinesia 51 interventional radiology procedures 51 diagnostic prognostic 51 confocal microscopy 51 functional MRI fMRI 51 individualize therapy 51 formalin fixed paraffin embedded 51 Immunosuppressive drugs 51 LTQ Velos 51 reverse transcription polymerase 51 cardiac troponin T 51 gated SPECT 51 ablations 51 quantitative reverse transcriptase 51 intra arterial 51 denervation 51 reverse transcriptase polymerase chain 51 Umbilical cord stem cells 51 dimensional echocardiography 51 #F FDG 51 Single Photon Emission Computed 51 multiphoton microscopy 51 aortic stiffness 51 surface plasmon resonance SPR 51 microdissected 51 3T MRI 51 microcatheters 51 esophageal manometry 51 metastatic lymph nodes 51 coronary artery blockages 51 diffusivity 51 SpO 2 51 transrectal ultrasound guided 51 semiquantitative 51 Optical Coherence Tomography 51 endoscopic retrograde cholangiopancreatography ERCGrant Parpan 51 tissue ablation 51 conventional angiography 51 Genous stent 51 ProteinChip 51 bioelectrical 51 fibrin deposition 51 Electroencephalography EEG 51 autologous cells 51 ELISA assays 51 EBUS FNA 51 Hydroxyapatite HAp 51 MSCT 51 HER2 expression 51 SpO2 pulse rate 51 NSCLC tumors 51 thyroglobulin 51 biomarker 51 bioluminescent imaging 51 transfer FRET 51 mechanical dyssynchrony 51 echocardiograph 51 glomerular filtration rate 51 abnormal heartbeats 51 prognostic marker 51 thoracoscopic lobectomy 51 tomography 51 lactate dehydrogenase 51 biodistribution 51 palpate 51 cardiac resynchronisation therapy 51 drug zotarolimus 51 tandem mass spectrometry 51 vascular malformations 51 Quantitation 51 Circulating Tumor Cells 51 adipose tissue derived 51 anesthetized rats 51 electroretinography 51 ultrasensitive detection 51 LC-MS/MS 51 photon microscope 51 Ultrasonography 51 FFR measurement 51 central corneal thickness 51 perfusion CT 51 reproducible 51 Ultrasound imaging 51 contractile function 51 PCR assay 51 color Doppler sonography 51 intravital 51 quantitative PCR 51 ELISpot 51 noninvasive outpatient 51 multidetector CT 51 mass spectrometric 51 miRNA expression 51 diffusion MRI 51 VeraTag 51 tumorigenicity 51 nanoprobes 51 EtCO2 51 lensless imaging 51 Doppler sonography 51 scanning microscopy 51 Intracardiac 51 treat menorrhagia 51 anastomotic devices 51 ultrasonographic examination 51 epicardial ablation 51 lumpectomy cavity 51 Cryoablation 51 deoxygenated hemoglobin 51 Breast Specific 51 Myoglobin 51 serum biomarkers 51 radiolabeled TM# 51 activated partial thromboplastin 51 thermogram 51 ImmuKnow assay 51 microelectrode array 51 inhaled anesthetics 51 computed tomography SPECT 51 collagen crosslinking 51 trophoblasts 51 HE4 test 51 fluoroscopically guided 51 computed tomography CT angiography 51 NPM1 mutation 51 ipRGCs 51 MR spectroscopy 51 paracentesis 51 Optical Coherence Tomography OCT 51 positron emission tomography PET 51 tumor biopsies 51 cardiac progenitor cells 51 bronchoscopic procedure 51 cultured stem cells 51 iPS derived 51 ReValving 51 Molecular imaging 51 computerized tomography scan 51 fine needle aspiration 51 intra operatively 51 microcirculatory 51 quantitative measurements 51 Oximetry ™ 51 Cardio3KG 51 endobronchial ultrasound 51 Coronary artery calcium 51 chest radiographs 51 cerebral perfusion 51 assay ELISA 51 Pulse CO Oximeters 51 sentinel lymph node 51 immunoblot 51 cerebrospinal fluid CSF 51 infarcted myocardium 51 guided radiotherapy IGRT 51 diagnostically 51 transnasal 51 perfusion defects 51 QTOF 51 cardiac catherization 51 specific antigen PSA 51 multiplex assay 50 electrophysiology procedures 50 tamponade 50 placental cells 50 AF Suppression 50 nucleated cells 50 electrophysiological recordings 50 chromosomal mutations 50 gene amplification 50 anatomical structures 50 electroencephalography EEG 50 diagnostic biomarker 50 intensity modulated radiotherapy 50 intraocular pressure IOP 50 renal artery stenting 50 quantitative gene expression 50 PLAC test 50 Masimo rainbow SET Pulse 50 computed tomography scan 50 OmniWave 50 transcranial magnetic stimulation TMS 50 directed thrombolysis 50 intima media thickness 50 X ray diffraction microscopy 50 bioartificial 50 Imaging fMRI 50 radiotracers 50 diagnose coronary artery 50 antral 50 single photon emission 50 PET CT imaging 50 pharmacodynamic effects 50 biopsy specimens 50 VSELs 50 capsule endoscope 50 Tomography SPECT 50 Hedgehog inhibitor 50 liver resection 50 glycated 50 sonographically guided 50 plasma renin activity 50 NMR LipoProfile test 50 obstructive CAD 50 computed tomography angiography 50 glucose sensor 50 situ hybridisation 50 chemosensitivity 50 B7 H3 50 Optical Biopsy System 50 Raman spectroscopy 50 FibroScan ® 50 Skin sterol 50 Cardiolite ® 50 heel lance 50 WavSTAT 50 desorption electrospray ionization 50 coronary blockages 50 metabolomic profiles 50 impedance cardiography 50 pulse oximeter 50 photon microscopy 50 methylation markers 50 transmural 50 magnetoencephalography MEG 50 cardiac computed tomography 50 radiofrequency RF 50 biomolecular interactions 50 uninterrupted chest compressions 50 luteinising hormone LH 50 lung epithelium 50 D Dimer 50 photoacoustic 50 superior mesenteric artery 50 physiologic 50 peripheral insulin sensitivity 50 MDCT 50 magnetoencephalography 50 tonometer 50 Azedra 50 iMRI 50 computerized tomography CT scan 50 computerized axial tomography 50 bronchoscopic 50 diffusion tensor imaging 50 VerifyNow P#Y# 50 proteomic profiling 50 fluorescence imaging 50 nerve stimulation 50 epicardium 50 RVOT 50 MYO VAD 50 adipose derived stem 50 multiplex PCR 50 bisulfite sequencing 50 positron emission tomography scan 50 visit www.dobimedical.com 50 endoscopic retrograde 50 color Doppler ultrasound 50 radar interferometry 50 Shape HF 50 MMP inhibitors 50 Balloon Sinuplasty TM 50 bladder tumors 50 cerebral oximeter 50 hormone human chorionic 50 PT INR 50 RT PCR assay 50 mitral valve regurgitation 50 reactive hyperemia 50 Sonographic 50 microvessel 50 definitively diagnose 50 flexible endoscope 50 Fractional Flow Reserve 50 Sentinel Lymph Node Biopsy 50 angio 50 ostial 50 electrocardiographs 50 magnetic resonance MR 50 TUMT 50 metabolomic 50 GeckoSuper ™ 50 assay detects 50 inserted percutaneously 50 Western blotting 50 lethal arrhythmias 50 treating cardiac arrhythmias 50 ClosureFAST 50 chemiluminescence 50 automated microscopy 50 coagulation abnormalities 50 MALDI TOF 50 confocal laser scanning 50 intracellular bacteria 50 implant defibrillator 50 inhibit platelet function 50 valve implantation 50 Induced pluripotent stem cells 50 proton magnetic resonance 50 transmit electrical impulses 50 Epithelial cells 50 immunohistochemical analysis 50 autologous bone marrow 50 Immunohistochemical staining 50 endovascular procedures 50 auditory brainstem response 50 VEGF expression 50 miRview ™ mets 50 PITX2 50 Xcelerant Delivery System 50 NEDD9 50 Near infrared spectroscopy 50 SpyGlass System 50 OnDose 50 INTRABEAM ® 50 ankle brachial index 50 assisted laparoscopic prostatectomy 50 endoglin 50 stimulate insulin secretion 50 obstructive coronary artery 50 functional mitral regurgitation 50 intraductal 50 fluorescent microscope 50 hemoglobin hematocrit 50 sd rxRNA 50 MP4OX 50 spectroscopic technique 50 Intraoperative 50 cardioverter defibrillator 50 methylation biomarkers 50 ablation procedures 50 arterial oxygen saturation 50 adipose cells 50 Nitric oxide NO 50 Nanoshells 50 treating peripheral arterial 50 ALA PDT 50 diseased coronary arteries 50 cryoprobe 50 immunoblotting 50 pulsatile flow 50 coronary computed tomography 50 sidebranch 50 colonography 50 catheters inserted 50 indirect calorimetry 50 pretargeting 50 GAMMAGARD 50 cerebral oxygen saturation 50 Circulating tumor cells 50 laser ablation 50 oximeter 50 minimally invasive procedure 50 viscosity measurements 50 imaging FMRI 50 evoked potentials 50 detect precancerous 50 quantitatively assess 50 Européenne Mark 49 surgical decompression 49 probe microscopes SPMs 49 Electrical stimulation 49 clinically relevant 49 Western Blotting 49 spinal metastases 49 Bone marrow stem cells 49 Echocardiogram 49 nonlinear algorithm 49 confocal fluorescence microscopy 49 spectrophotometry 49 nanosurgery 49 Virtual colonoscopy 49 retinal pigment epithelial cells 49 sputum cytology 49 transcutaneous 49 gene expression profiling 49 StO2 49 color Doppler 49 recombinant tissue plasminogen 49 abnormal glucose metabolism 49 computed tomography CT scanner 49 coronary CT angiography 49 QRS interval 49 bispectral index BIS 49 retinal ischemia 49 CINtec R 49 GeneSearch 49 nonvascular 49 cardiac contractility 49 microvessels 49 hemodynamically stable 49 coronary angiogram 49 Dr. Cadeddu 49 volumetric imaging 49 ORange 49 biofluids 49 natriuretic peptides 49 PressureWire Certus 49 electrically stimulating 49 Balloon kyphoplasty 49 direct laryngoscopy 49 lymphatic mapping 49 lung lesions 49 osteoinductive 49 cTnI 49 GLUT4 49 Masimo PVI 49 pluripotent embryonic 49 Artis zeego 49 antireflux 49 massively parallel sequencing 49 invasive angiography 49 microdissection 49 Multidetector CT 49 fluorescence detection 49 tomography scan 49 CT angiography 49 quantitative PCR qPCR 49 positron emission 49 Orbitrap 49 EndoFLIP 49 FullTerm 49 ejection fractions 49 biventricular pacemaker 49 scleral buckling 49 BioMAP 49 Situ Hybridization 49 electrochemical detection 49 Rosetta Elucidator 49 QuadraSphere 49 thoracic aortic aneurysm 49 Artida 49 Angiograms 49 antibody mediated 49 PROLARIS 49 fingerstick 49 computerized tomography scans 49 NAVISTAR R 49 therapy IMRT 49 exhaled carbon dioxide 49 miRNA biomarkers 49 vitamin D analogs 49 RF Kyphoplasty 49 urine dipstick 49 validate biomarkers 49 polyp detection 49 aggregated Abeta 49 enhanced sonography 49 fluorescent molecules 49 mass spectroscopy 49 EGFR blockers 49 core needle biopsies 49 INVOS R 49 magnetic resonance angiography 49 platelet function 49 intraoperatively 49 thermal ablation 49 cerebral arteries 49 hemodynamically unstable 49 hESC derived cardiomyocytes 49 pelvic ultrasound 49 kidney urologic 49 percutaneous coronary 49 non dispersive infrared 49 radioiodine therapy 49 intraoperative 49 Accelerated Partial Breast Irradiation 49 WS CRDS 49 exhaled nitric oxide 49 ionotropic 49 Single photon emission 49 malignant prostate 49 video assisted thoracoscopic 49 Coronary Angiography 49 prostate TURP 49 electroencephalographic 49 electrocardiograms ECG 49 cardiac fibrosis 49 EEG signals 49 ChromaFlo R 49 ultrasonographic 49 endothelial progenitor cells 49 Endothelial function 49 myogenic 49 subconjunctival injection 49 ELISPOT assay 49 unresectable tumors 49 miRview TM mets 49 multislice CT 49 nano indentation 49 cell transplantation 49 intravascular ultrasound IVUS 49 Stabilimax NZ 49 nested PCR 49 perfusion abnormalities 49 pancreatic tissue 49 vascularized 49 TAXUS stents 49 brain perfusion scans 49 Oximeter 49 stem cell engraftment 49 quantitative RT PCR 49 Breast Specific Gamma 49 myocyte 49 hERG channel 49 Electron beam 49 tomography imaging 49 contractile muscle 49 ColoMarker 49 CSF Tf 49 Nellcor OxiMax 49 delipidation 49 bronchial hyperresponsiveness 49 adipose derived stem cells 49 histopathologic examination 49 NIR spectroscopy 49 electroencephalograph EEG 49 OnControl 49 neutrophil gelatinase associated lipocalin 49 cardiac myocytes 49 capnography 49 functional Magnetic Resonance 49 immunohistochemical staining 49 transcranial Doppler ultrasound 49 arteries dilate 49 endoluminal 49 thrombus formation 49 Fetal Fibronectin Test 49 MR imaging 49 Surface Plasmon Resonance SPR 49 underwent coronary angiography 49 absorption spectroscopy 49 plasma triglycerides 49 IOL implantation 49 pre operatively 49 amyloid plaque formation 49 hypoxia induced 49 CellPort Technologies 49 TOGA procedure 49 HIV tropism 49 carotid ultrasound 49 micronuclei 49 lung fibroblasts 49 body contouring procedure 49 Fourier domain 49 explanted 49 dorsalis pedis 49 surrogate markers 49 surgical resection cavity 49 Single Molecule Array SiMoA 49 S. maltophilia 49 FGFs 49 Raman scattering 49 stereotactic biopsy 49 exome sequencing 49 proteomic analysis 49 spectrophotometric 49 Noninvasive 49 retinal nerve 49 epididymal 49 CryoMaze 49 VH IVUS 49 genetic polymorphisms 49 invasive procedures 49 serum potassium 49 endomicroscopy 49 Imaging BSGI 49 CT computed tomography 49 Photodynamic therapy PDT 49 prime fibrinogen 49 urography 49 fetal echocardiography 49 microfluidic chip 49 MSMB 49 pulmonic 49 choroidal vasculopathy 49 Infrared spectroscopy 49 TriGrid 49 ablated 49 spectroscopic imaging 49 diagnosing coronary artery 49 RF ablation 49 cardiac magnetic resonance 49 FDG PET CT 49 mycobacterial 49 occlusive disease 49 lymphatics 49 balloon sinuplasty 49 thickness CIMT 49 parathyroid gland 49 AlloMap 49 T wave alternans 49 infected macrophages 49 DEV DA TOMAR NEXT 49 bone marrow aspiration 49 MassTag PCR 49 magnetic coil 49 aneuploidies 49 microarray analysis 49 extracorporeal 49 hydrostatic weighing 49 Intra operative 49 cerebrospinal fluid 49 intrathoracic impedance 49 quantitative coronary angiography 49 targeted muscle reinnervation 49 replace diseased aortic 49 BIOTRONIK Home 49 C Reactive Protein 49 intranasal delivery 49 Microstream R capnography 49 International Normalized Ratio 49 iontophoresis 49 diffusion coefficient 49 DCE MRI 49 malignant tissues 49 Cone Beam Computed Tomography 49 hemoglobin Hb 49 osteoconductive 49 Mass spectrometry 49 photoactivation 49 valve prosthesis 49 metabolize glucose 49 diagnosing osteoporosis 49 saphenous veins 49 endocardial 49 transfection efficiency 49 CareEngine System 49 INVOS 49 albumin protein 49 phakic 49 ultrashort pulses 49 throughput mass spectrometry 49 gastric imbrication 49 esophageal tissue 49 malpositioned 49 ABLAVAR ™ 48 Aethlon Hemopurifier R 48 thyroid nodules 48 detect amyloid plaque 48 Image Guided Radiation Therapy 48 microgrippers 48 Holter monitor 48 neuro stimulation 48 leukapheresis 48 cyclic voltammetry 48 treat arrhythmias 48 SERCA2a 48 haplotyping 48 multiplanar reconstruction 48 mucociliary clearance 48 thoracic aortic aneurysms 48 minimally invasive 48 eosinophil count 48 transplanted islets 48 terminally sterilized 48 Hair follicles 48 elastase 48 positron emission topography 48 Immunohistochemistry IHC 48 bronchoalveolar lavage fluid 48 mammographically 48 Tasigna prolongs 48 galvanic skin response 48 BioScanIR R System 48 nCounter 48 electrocardiogram EKG 48 intact parathyroid hormone 48 arterial calcification 48 ligand induced 48 hypovolemic 48 electrocardiography 48 cerebral somatic oximeter 48 MTT assay 48 sonographic evaluation 48 Angiographic 48 Cystoscopy 48 umbilical vein 48 BoneScalpel 48 proprietary nanofabrication 48 resected tumor 48 ® nonlinear algorithm