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(Click for frequent words.) 73 neuronal dysfunction 72 selective inhibition 72 renal fibrosis 71 allergic inflammation 71 overactivation 70 p# activation 70 mutant huntingtin protein 70 potent inhibitors 70 atherogenesis 70 lung fibrosis 70 airway remodeling 70 immunopathology 70 PDGFR 69 ERK signaling 69 protein misfolding 69 SSc 69 gastric carcinogenesis 69 COX2 69 synaptogenesis 69 EBV infection 69 mutant huntingtin 69 neurotrophic 69 COX enzymes 69 acetylcholine receptor 69 Notch1 69 mtDNA mutations 69 MAPK pathway 69 IKK2 69 Smad3 69 mitochondrial dysfunction 68 motor neuron degeneration 68 NADPH oxidase 68 mediated inhibition 68 Treg cell 68 NF kappaB activation 68 amyloid deposition 68 galanin 68 airway hyperresponsiveness 68 c myc gene 68 protein CETP 68 prostaglandin synthesis 68 neuroinflammatory 68 HbF 68 proto oncogene 68 protein kinase C 68 inverse agonist 68 epigenetic alterations 68 innate immune responses 68 hyperactivation 68 mGluR2 NAM 68 overactivated 67 fibrotic disease 67 nicotinic receptors 67 γ secretase 67 excitotoxic 67 AT1R 67 nitric oxide synthase 67 apoE 67 pleiotropic 67 upregulates 67 neuro protective 67 pro angiogenic 67 sortilin 67 colorectal carcinogenesis 67 IL 1β 67 ERK pathway 67 CCR3 67 CEACAM1 67 fatty acid synthase 67 myopathies 67 VEGF receptor 67 TGF β 67 neurodegeneration 67 cAMP signaling 67 lipoprotein metabolism 67 LRP5 67 prostate carcinogenesis 67 monogenic 67 PTPN# 67 TXNIP 67 cholesterol metabolism 67 micro RNAs 67 ERK1 2 67 arterial calcification 67 oligomerization 67 pathophysiological 67 chromosomal rearrangement 67 TMEM#B 67 FGFs 67 E#F# 67 neurite outgrowth 67 inhibitory neurotransmitters 67 lipid synthesis 66 leukocyte adhesion 66 protein tyrosine phosphatase 66 intestinal epithelium 66 systemic inflammation 66 neuron degeneration 66 Genetic predisposition 66 Clusterin 66 gastrointestinal stromal tumors GISTs 66 #beta HSD1 66 progranulin 66 PPARγ 66 HDAC2 66 cyclooxygenase 2 66 chromosomal instability 66 Dysregulation 66 activated microglia 66 pDCs 66 NKG2D 66 antibody mediated 66 upregulating 66 Angiotensin converting enzyme 66 CB2 receptor 66 IL 1ß 66 intracellular bacteria 66 virulence genes 66 oncogenesis 66 aP2 66 signaling cascades 66 antiapoptotic 66 γδ T cells 66 SIRT1 gene 66 epigenetic mechanisms 66 mitochondrial mutations 66 FGF2 66 NFkB 66 fibril formation 66 glutamate signaling 66 adenylate cyclase 66 biochemical abnormalities 66 axonal degeneration 66 eotaxin 66 secretory pathway 66 bacterial virulence 66 inflammatory cytokine 66 neuronal apoptosis 66 transgenic mouse models 66 neuro degeneration 66 IGFBP2 66 p#NTR 66 synaptic function 66 neuronal nitric oxide synthase 66 Genetic variants 66 Fas ligand 66 fibrogenesis 66 eNOS 66 microglial 66 transgene expression 66 neuronal degeneration 66 molecular mechanisms underlying 66 cytokine signaling 66 endothelial nitric oxide 66 apoptotic pathway 66 PHD2 66 glutamatergic 65 cholinergic neurons 65 mTORC1 65 PTP 1B 65 mutant proteins 65 intracellular signal transduction 65 plasma kallikrein 65 TSLP 65 TGF ß1 65 IFN γ 65 cytoprotective 65 Hedgehog signaling 65 UCP2 65 pathogenic mechanisms 65 p# MAPK 65 PPAR γ 65 neuroprotective effects 65 serine proteases 65 interleukin 1beta 65 muscular dystrophies 65 CYP #A# 65 androgen receptor AR 65 mitochondrial enzyme 65 histone deacetylases 65 cardiac hypertrophy 65 dysregulated 65 neuropsychiatric disorders 65 ABCA1 65 genetic polymorphism 65 JAK2 enzyme 65 Th2 cytokines 65 breast cancer metastasis 65 MAP kinases 65 muscarinic receptors 65 nicotinic receptor 65 pRb 65 deacetylation 65 nicotinic acetylcholine receptors 65 CHD5 65 haematopoietic 65 interleukins 65 SCD1 65 tryptase 65 Neuropeptide Y 65 proinflammatory 65 somatostatin 65 synapse formation 65 NFκB 65 physiologic mechanisms 65 pleiotropic effects 65 proapoptotic 65 neurosteroid 65 NF kB pathway 65 neuropsychiatric diseases 65 microglial activation 65 FGFR1 65 multifactorial disease 65 eicosanoid 65 transcriptional repressor 65 neurotrophic factors 65 AhR 65 eicosanoids 65 LPS induced 65 PC# cells 65 RIP1 65 amyloid peptide 65 immunoregulatory 65 neuronal plasticity 65 leukocyte recruitment 65 beta1 integrin 65 Htt 65 Epstein Barr Virus EBV 65 Flt3 65 cardiac fibrosis 65 FMRP protein 65 vascular inflammation 65 protein misfolding diseases 65 pathogenesis 65 aberrant activation 65 Dietary restriction 65 amyloid plaque formation 65 Abeta# 65 Upregulation 65 NKX#.# 65 VEGF expression 65 platelet activation 65 heparanase 65 p# alpha [001] 65 osteopontin 65 steroidogenic 65 CagA 65 c MYC 65 enkephalin 65 superoxide anion 65 β1 65 oncogenic transformation 64 VEGF inhibitors 64 Leydig cell 64 MEK ERK 64 TGF ß 64 endocannabinoid signaling 64 underlying molecular mechanisms 64 monoamine 64 MAP kinase 64 ectopic expression 64 GSK3 64 neuroligins 64 biologic pathways 64 CTGF 64 endocannabinoid system 64 PB1 F2 64 hedgehog signaling 64 coagulation cascade 64 NKT cells 64 DNA demethylation 64 HDACs 64 CYP#B# 64 intracellular accumulation 64 chitinase 64 kinase pathway 64 phosphatases 64 habenula 64 MMP9 64 beta adrenergic receptors 64 miR #a [001] 64 cardiac myocytes 64 Brain derived neurotrophic 64 tyrosine phosphorylation 64 cellular pathways 64 proteasome inhibition 64 mGluRs 64 immunomodulatory effects 64 serotonin receptor 64 hepatic fibrosis 64 immuno modulatory 64 apoE4 64 cell signaling pathways 64 neurofibrillary 64 gene rearrangements 64 cannabinoid receptors 64 Oxidative damage 64 immunostimulatory effects 64 immunoregulation 64 histone deacetylase inhibitors 64 amyloid formation 64 NQO1 64 metabolic abnormalities 64 GRP# 64 hepatic lipase 64 sirtuin enzymes 64 GSK3B 64 glucocorticoid receptors 64 microglial cells 64 PIK3CA 64 antiproliferative effects 64 mitochondrial toxicity 64 Glucocorticoids 64 tumor suppressor protein 64 environmental toxicants 64 TNFa 64 inducible nitric oxide synthase 64 peroxisome 64 clusterin 64 activate p# 64 receptor antagonism 64 lysosomal 64 mineralocorticoid 64 beta defensins 64 idiopathic pulmonary 64 Hh 64 neuronal signaling 64 HCV replication 64 hyperalgesia 64 receptor gamma 64 upregulate 64 Magnesium deficiency 64 presymptomatic 64 thromboxane A2 64 Genetic variation 64 mGluR 64 guanylate cyclase 64 UCP1 64 growth hormone secretion 64 primary cilia 64 GABAA receptors 64 underlying vasculopathy 64 pathogenetic 64 histone modification 64 serotonin uptake 64 proinflammatory cytokine 64 dysregulation 64 proteoglycan 64 PPARg 64 BCL#A 64 uPAR 64 chlamydial 64 serine protease 64 mucosal immunity 64 tumorigenesis 64 lymphangiogenesis 64 fatty acid oxidation 64 pathological hallmarks 64 SIRT3 64 metabolizing enzymes 64 intracellular pathways 64 Rap1 64 neuronal synapses 64 calcineurin 64 transgenic rats 64 NO synthase 64 neural degeneration 64 mimetics 64 hyperresponsiveness 64 MMP2 64 antitumor efficacy 64 NOD2 64 Oncogenic 64 imatinib resistance 64 β amyloid 64 neuro degenerative diseases 64 TGF b 64 Endocannabinoids 64 Eg5 64 proteolysis 64 Ets2 64 TNF α 64 neurogenic 64 ERK5 64 cholinergic 64 c MET 64 alveolar macrophages 64 sphingolipid 64 IDH mutations 64 chromatin remodeling 64 prostanoid 64 p# mutations 64 SGK1 64 polyamine 64 excitotoxicity 64 etiologic 64 p#/CBP 64 NF kB signaling 64 PI3K/mTOR 64 Oxidative stress 64 endocrine tumors 64 endoplasmic reticulum stress 64 V#F mutation 64 TGF beta1 64 GABAergic 64 STAT3 signaling 64 telomere dysfunction 64 intracellular signaling 64 kappa opioid receptors 64 PKC beta 64 impair fertility 64 Hypothalamic 64 reperfusion injury 64 peroxynitrite 64 druggable target 64 anti apoptotic 64 Protein Kinase C 64 DNA methylation patterns 64 miRNA expression 64 retinoid X 63 EphA2 63 HDAC6 63 atherosclerotic lesions 63 hepatocellular 63 Akt signaling 63 cholesterol biosynthesis 63 Kv#.# 63 autoinflammatory diseases 63 transgenic mouse model 63 cathepsins 63 inhibit viral replication 63 FasL 63 Neurodegenerative diseases 63 HDAC enzymes 63 mevalonate 63 hypothalamic pituitary adrenal axis 63 Fibroblast 63 anti angiogenic drugs 63 toxic beta amyloid 63 oxidases 63 peroxisomal 63 upregulation 63 Six3 63 epigenetic modification 63 osteogenic differentiation 63 SLC#A# [002] 63 STAT4 63 inhibiting COX 63 hypermethylation 63 biochemical mechanisms 63 TGFß 63 small molecule activators 63 mGluR5 antagonist 63 protein tau 63 Kupffer cells 63 molecular underpinnings 63 SOCS1 63 FGFR3 63 ischemia reperfusion injury 63 podocyte 63 Notch signaling 63 amyloid beta plaques 63 MAP kinase pathway 63 cell adhesion molecule 63 TRPV3 63 herpesviruses 63 Cryptococcus neoformans 63 LIS1 63 hippocampal neurogenesis 63 potent inducer 63 hedgehog pathway 63 prostaglandin E2 63 costimulation 63 PARP inhibition 63 AMPA receptor 63 humoral immunity 63 IL6 63 metalloprotease 63 Androgen receptor 63 nAChRs 63 synovial cells 63 Hh pathway 63 PINK1 63 misregulation 63 interferon γ 63 osteoblast 63 Dopaminergic 63 GCN2 63 enzyme inhibitors 63 activin 63 p#INK#a 63 protein tyrosine phosphatase 1B 63 #ß HSD1 63 extracellular dopamine 63 oxysterols 63 metabolic enzymes 63 posttranslational modifications 63 paraneoplastic 63 SOD1 gene 63 acetylcholine receptors 63 ligand TRAIL 63 CaM kinase II 63 tenascin C 63 mediated apoptosis 63 CCR1 63 V2 receptor 63 PECAM 1 63 ADAMTS# 63 beta amyloid peptide 63 autophagic 63 kidney urologic 63 NFkappaB 63 excess glutamate 63 subcellular compartments 63 cellular metabolism 63 myeloperoxidase 63 vWF 63 M1 muscarinic 63 aldose reductase 63 nAChR 63 innate immune 63 gamma secretase inhibitor 63 noradrenergic 63 iNOS 63 Smad7 63 PGC 1α 63 Raf MEK ERK 63 synaptic dysfunction 63 FKBP# 63 5 HT2A serotonin 63 cell adhesion molecules 63 C5aR 63 caveolin 1 63 liver fibrosis 63 Interferon beta 63 paxillin 63 VEGF pathway 63 diagnostic biomarker 63 TGF alpha 63 erythropoiesis 63 neurotransmission 63 spermidine 63 coronary vasodilation 63 ARF1 63 mutated protein 63 CCL# 63 HuR 63 treating neuropathic pain 63 immune modulator 63 neurotrophins 63 serotonergic 63 tumorigenicity 63 FGFR4 63 synaptic transmission 63 proliferative disorders 63 Alzheimer Disease AD 63 receptor tyrosine kinase 63 EGF receptor 63 intracellular proteins 63 Thyroid hormone 63 Prolactin 63 redox active 63 hyperinsulinemia 63 neurotransmitter GABA 63 PDGF receptor 63 regulated kinase ERK 63 enzyme cofactor 63 molecular biomarkers 63 PEDF 63 hypothalamic pituitary 63 isoenzymes 63 ß1 63 RNA silencing 63 pathophysiological effects 63 receptor inhibitor 63 receptor PPAR 63 SOCS3 63 Src kinase 63 utrophin 63 neuronal differentiation 63 Enkephalin 63 LTB4 63 HPA axis 63 antiinflammatory 63 PI3 kinase 63 adenosine A2A receptor 63 PTEN protein 63 amyloid β 63 endothelial activation 63 viral proteins 63 GPx 63 NMDAR 63 TLR4 63 miRs 63 alpha synuclein gene 63 dopamine signaling 63 prostaglandin D2 63 colonic motility 63 NK1R 63 proteinase 63 Wnts 63 cisplatin resistant 63 experimental autoimmune encephalomyelitis 63 GRK2 63 Genetic mutations 63 MEF2A 63 airway hyper responsiveness 63 XBP1 63 nNOS 63 intimal hyperplasia 62 PGE2 62 Dystrophin 62 beta catenin protein 62 myo inositol 62 4E BP1 62 deacetylase inhibitors 62 Valproic acid 62 genotoxic stress 62 lymphotoxin 62 microvascular disease 62 bone morphogenetic proteins BMPs 62 cyclooxygenase 62 p# inhibitor 62 acid GABA 62 differential gene expression 62 glutamate neurotransmission 62 Glucocorticoid 62 receptor subtypes 62 monocytes macrophages 62 CatB 62 cholesterol homeostasis 62 polyamines 62 lung epithelium 62 TNFα 62 EGFR pathway 62 histone acetylation 62 cyclic AMP cAMP 62 selectively inhibited 62 carbohydrate metabolism 62 cardiometabolic disorders 62 kinase inhibition 62 pro apoptotic 62 T#M 62 P cadherin 62 tau pathology 62 underlying pathophysiology 62 Inosine 62 cardiotoxic 62 Wnt pathway 62 oncogenic 62 nitrotyrosine 62 genomic alterations 62 aberrantly activated 62 metabolic dysfunction 62 cystic fibrosis transmembrane conductance 62 receptor activation 62 ischemic preconditioning 62 fatty acid biosynthesis 62 CYP #D# 62 cholesterol efflux 62 vimentin 62 outer membrane proteins 62 C. pneumoniae 62 prostate cancer CaP 62 neurotransmitter glutamate 62 alpha synuclein protein 62 SMAD4 62 Candida infection 62 glial derived neurotrophic 62 amyloid toxicity 62 Nrf2 62 epithelial barrier 62 leukotriene pathway 62 FANCD2 62 ouabain 62 NKT cell 62 HER2 overexpression 62 fatty acid metabolism 62 prothrombotic 62 IL #p# 62 adult neurogenesis 62 enzyme renin 62 Alzheimer pathology 62 neuronal function 62 c myc 62 lymphatic vasculature 62 act synergistically 62 #HT#A 62 beta subunit 62 Inhibitory 62 Chronic inflammation 62 immunomodulation 62 serotonin transporter 62 improves insulin sensitivity 62 germline mutation 62 NMDA antagonists 62 Dr. Bezprozvanny 62 cyclophilin D 62 carcinogenesis 62 endogenous ligands 62 CYT# potent vascular disrupting 62 glycolipids 62 Cyclin E 62 cyclin E 62 focal adhesions 62 somatic mutations 62 glutamate receptors 62 TGF beta signaling 62 naturally occurring molecule 62 superoxide dismutase 62 Vascular endothelial growth 62 Akt3 62 nicotinic acetylcholine receptor 62 alpha#beta# 62 BMP signaling 62 stellate cells 62 CXCL5 62 anti fibrotic 62 CCL5 62 Nf1 62 neuronal nicotinic receptors NNRs 62 isotypes 62 radiosensitivity 62 PPAR alpha 62 intracellular protein 62 ADAM# 62 downregulates 62 5 HT4 receptor 62 CD#L 62 WT1 62 PON1 62 antiphospholipid syndrome 62 heme oxygenase 1 62 Cdc7 62 inflammasome 62 endogenous cannabinoids 62 huntingtin gene 62 KLF4 62 viral pathogenesis 62 phosphatidylinositol 3 62 FGFR2 62 Hcrt 62 intracellular pathogens 62 Rho GTPases 62 mitogen activated protein kinase 62 Aldosterone 62 polyglutamine diseases 62 Th1 type 62 ligand induced 62 axonal damage 62 cartilage degeneration 62 myofibroblast 62 adenosine receptors 62 tumor suppressor proteins 62 nerve degeneration 62 Cytotoxic 62 cortical excitability 62 causative genes 62 tumor metastasis 62 prognostic markers 62 GABA receptors 62 inflammatory cytokines 62 RAS RAF MEK 62 elastase 62 isoenzyme 62 chromosomal aberrations 62 endotoxemia 62 oncomodulin 62 neuro endocrine 62 DNA methyltransferases 62 RUNX3 62 Factor Receptor 62 glioblastoma tumor 62 mitochondrial metabolism 62 adipocyte differentiation 62 predisposing factor 62 Smoothened 62 Activating mutations 62 alveolar epithelial cells 62 thyrotropin 62 hypermethylated 62 Id1 62 Oxidative 62 nicotinic 62 potent inhibition 62 Endothelial 62 adrenal hormone 62 constitutively expressed 62 Fibroblast Growth Factor Receptor 62 Wnt signaling pathway 62 neuropeptide Y 62 apoptosis induced 62 acetylation 62 downregulating 62 pressure natriuresis 62 HBx 62 acadesine 62 Helicobacter 62 TGFβ 62 miR# 62 JAK STAT 62 probiotic supplementation 62 cardiolipin 62 TTR gene 62 Cathepsin B 62 neuropeptide Y NPY 62 prognostic marker 62 glucose homeostasis 62 NR2B subunit 62 PKC alpha 62 fibrin deposition 62 beta amyloid peptides 62 MEK inhibitors 62 pro inflammatory cytokines 62 SOD1 protein 62 BMPR2 62 intestinal microflora 62 PKMzeta 62 nitric oxide synthase NOS 62 cytokine receptor 62 degenerative disorders 62 neovascularisation 62 demyelinating disease 62 NF KB 62 drug metabolizing enzymes 62 serine threonine 62 rifamycins 62 protein tyrosine kinase 62 DLX5 62 opioid peptides 62 murine model 62 Angiotensin II 62 dimerization 62 von Willebrand 62 genetic determinants 62 PI3K pathway 62 gastric carcinoma 62 PI3K signaling 62 neuro developmental disorders 62 muscarinic 62 A3 adenosine receptor 62 Cytokines 62 respiratory viral infections 62 histone modifications 62 hepatotoxic 62 vasodilatation 62 PKC inhibitors 62 hematopoietic cells 62 NRG1 62 Orexin 62 neovascularization 62 potently inhibit 62 vitamin D receptors 62 TLR8 62 ovarian hormones 62 PI3K/Akt pathway 62 apoptosis inducing 62 RNAi therapeutic targeting 62 BCR ABL protein 62 Bcl xL 62 D2 receptor 62 inhibitory effects 62 cytotoxic effects 62 tumor suppressive 62 methicillin susceptible Staphylococcus aureus 62 nicotinamide 62 germline mutations 62 TRAIL induced apoptosis 62 induce apoptosis 62 peroxisome proliferator activated 61 transthyretin 61 membrane permeability 61 GABAergic interneurons 61 S#A# [002] 61 mitogen activated protein kinases 61 telomere maintenance 61 N Myc 61 proinflammatory cytokines 61 IgG4 61 Elevated serum 61 epigenetic silencing 61 transcriptional activation 61 dopaminergic 61 cytopathic 61 inhibit enzymes 61 Hedgehog pathway 61 CD#c 61 filaggrin 61 cholesteryl ester transfer 61 P#X# 61 secreted protein 61 pharmacological inhibition 61 5 HT1A 61 immune dysregulation 61 EGFR inhibition 61 cyclin dependent kinase inhibitor 61 amyloid cascade 61 ACh 61 LKB1 61 KRAS oncogene 61 TRPV4 61 glycosyltransferase 61 thioredoxin 61 aneuploid cells 61 Neuroinflammation 61 adrenal cortex 61 p tau 61 malignant transformation 61 protein conformation 61 ERBB2 61 peptide antigens 61 gene polymorphisms 61 choroidal neovascularization 61 HMG CoA reductase 61 glomerular 61 abnormal angiogenesis 61 transmembrane receptor 61 osteoclast activity 61 p#Kip# 61 molecular mechanism 61 neurodegenerative disorder 61 Mycoplasma pneumoniae 61 anti inflammatory cytokines 61 biomarker assay 61 autocrine 61 S#K# 61 missense mutations 61 pathophysiological mechanisms 61 B7 H3 61 Angiotensin 61 D aspartic acid 61 ankyrin repeat 61 insulin signaling pathway 61 IL #R 61 serotonin reuptake 61 gastric carcinomas 61 Aβ 61 casein kinase 61 cyclins 61 histone deacetylase 61 Adrenergic 61 susceptibility gene 61 inhibiting enzymes 61 Prox1 61 non coding RNA 61 potentially modifiable 61 multidrug resistance 61 PTP1B 61 PAR1 61 antitumour 61 amyloidogenic 61 alpha MSH 61 osteopontin OPN 61 atherosclerotic disease 61 immunomodulatory properties 61 CCR2 61 SH2 B 61 experimentally induced 61 proteinases 61 neuronal stem cells 61 missense mutation 61 PTEN mutations 61 TET2 61 enzyme inhibitor 61 fibrocytes 61 glucocorticoid receptor 61 Src kinases 61 induced apoptosis 61 immune modulating 61 HepG2 cells 61 phosphate S1P 61 CB1 receptor 61 protein alpha synuclein 61 chemopreventive 61 hydrolase 61 Tissue Factor 61 diabetic kidney 61 JAK STAT pathway 61 torsade de pointes 61 epigenetic inheritance 61 enzymatic pathways 61 matrix metalloproteinases 61 tyrosine kinase receptor 61 immunological responses 61 palmitoylation 61 endocannabinoids 61 hypoperfusion 61 mTOR inhibitors 61 degranulation 61 overactivity 61 dopamine transporter 61 estrogen metabolism 61 palmitoleate 61 glycogen metabolism 61 EGFR signaling 61 excitatory neurotransmitter glutamate 61 SIRT1 activation 61 osteoclast formation 61 receptor subtype