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(Click for frequent words.) 70 modulating 68 modulates 60 selectively inhibit 60 modulated 60 downregulate 60 transduce 60 habenula 59 upregulate 59 FGFs 59 mitogenic 59 prostaglandin E2 PGE2 58 inhibit 58 modulatory 58 inhibitory 58 induce apoptosis 57 AMPA receptor 57 inhibitory neurotransmitters 57 nociceptive 56 nAChR 56 attenuate 56 inhibit tumor 56 regulate gene expression 56 inhibit viral replication 56 receptor gamma 56 act synergistically 56 potentiate 56 neuromuscular junction 56 acetylcholine receptor 56 feedforward 56 pro angiogenic 56 reversibly 56 glutamatergic 56 acetylcholine receptors 56 ion channels 56 downregulates 55 GABAergic 55 receptors 55 nitric oxide synthase NOS 55 neuropeptides 55 glucocorticoid receptors 55 NF kappaB activation 55 cytokine secretion 55 hormone secretion 55 neuro protective 55 Androgen receptor 55 coactivators 55 GABAA receptors 55 serotonergic 55 opioid peptides 55 ERK pathway 55 mineralocorticoid 55 dysregulated 55 PPARg 55 neurotransmitter receptors 55 MMP2 55 SIRT1 gene 55 phosphoinositide 55 somatostatin 55 neurotransmission 55 inflammatory cytokine 54 sensory neurons 54 intracellular pathways 54 pyramidal cells 54 IL 1β 54 contractility 54 IL #p# 54 transmit nerve impulses 54 #HT#A 54 cyclic AMP cAMP 54 glutamate receptors 54 glucocorticoid receptor 54 proinflammatory 54 endogenous opioid 54 nicotinic receptor 54 inhibits tumor 54 selectively inhibited 54 morphogen 54 ErbB4 54 FOXO3a 54 dopamine norepinephrine 54 acid GABA 54 homeostatic 54 μ opioid receptor 54 nicotinic 54 chemical messengers 54 mu opioid receptors 54 mesolimbic 54 modulators 54 IKKß 54 GLUT4 54 osteoclast formation 54 dopaminergic 54 gamma amino butyric 54 upregulates 54 phosphorylate 54 VEGF signaling 54 partial agonist 54 cytokine signaling 54 allosteric mechanism 54 beta adrenergic receptors 54 HIF 1a 54 BMP signaling 54 TRPV1 receptors 54 circadian clock genes 54 neurotransmitters serotonin 54 modulation 53 acyl CoA 53 melatonin receptors 53 neurohormones 53 muscarinic receptors 53 MAP kinase 53 overactivity 53 cathepsins 53 hormone ACTH 53 Kv#.# 53 malonyl CoA 53 opioid receptor 53 serotonin receptor 53 potassium ion 53 NMDA receptors 53 GABAA 53 glutamate signaling 53 detoxify harmful 53 immunoregulatory 53 cytokine 53 sortilin 53 PDGF receptor 53 peptide hormone 53 adipokines 53 hypothalamic 53 TXNIP 53 antiapoptotic 53 neurotransmitter 53 paxillin 53 excitatory 53 CaR 53 protein kinase C 53 downregulating 53 oncogenic transformation 53 TLR4 53 opioid receptors 53 factor PDGF 53 HPA axis 53 Nav#.# 53 neuroendocrine 53 ERK1 2 53 nicotinic receptors 53 5 HT1A 53 neurotrophic 53 PPAR gamma receptor 53 serotonin neurons 53 neuro transmitters 53 overactivated 53 inhibitory effects 53 metabolise 53 neurone 53 SIRT2 53 TRPA1 53 signaling pathway 53 neurite outgrowth 53 TNFα 53 ligand TRAIL 53 nitric oxide synthase 53 potent inhibitors 53 neurofilament 53 intracellular signaling 53 BMP4 53 signaling pathways 52 heme oxygenase 52 inhibiting tumor 52 mGluR 52 allosteric 52 c MYC 52 TRPV3 52 podocytes 52 inhibiting enzymes 52 cytoprotective 52 neuronal nicotinic receptors NNRs 52 SCD1 52 potent stimulator 52 attenuates 52 hormone secreted 52 mTORC1 52 neurohormonal 52 5 HT2A receptor 52 AgRP 52 eicosanoid 52 pRb 52 TRP channels 52 neuronal signaling 52 synaptic transmission 52 antigen receptors 52 receptor subtype 52 aldose reductase 52 galanin 52 DARPP 52 PPARγ 52 NNRs 52 paracrine 52 amylin 52 dendritic spine 52 Wnt1 52 CB1 receptors 52 autocrine 52 gluconeogenesis 52 allergic inflammation 52 stimulate insulin secretion 52 Gleevec inhibits 52 γδ T cells 52 signaling molecules 52 inhibitory neurons 52 beta endorphin 52 secrete insulin 52 histone deacetylases 52 metabolize cholesterol 52 ABCA1 52 Hedgehog pathway 52 entrain 52 inhibiting 52 procaspase 3 52 cofactors 52 GRK2 52 PMR1 52 BMAL1 52 S6K 52 morphogens 52 beta subunit 52 KATP channels 52 activate p# 52 dopamine transporter 52 D2 receptor 52 TRPV4 52 membrane receptors 52 NNR subtypes 52 GABA receptors 52 inhibitory interneurons 52 resistin 52 enkephalin 52 Hsp# chaperone system 52 receptor subtypes 52 adrenoceptor 52 Siglec 8 52 hedgehog pathway 52 Modulating 52 physiologically relevant 52 Cdc7 52 chloride channels 52 additively 52 guanosine 52 neurochemical 52 apoptosis inducing 52 secreted protein 52 Protein Kinase C 52 dysregulation 52 drug metabolizing enzymes 52 TGFbeta 52 connexin# 52 5 HT2A serotonin 52 serine proteases 52 transcriptional activity 51 hypothalamic pituitary 51 Cdc# 51 Th2 cytokines 51 ATPase 51 striatal 51 TRPV1 receptor 51 tumor microenvironment 51 LXRs 51 receptor 51 p# MAPK 51 cytokine interleukin 51 ryanodine receptor 51 NF kappa B 51 neuroinflammatory 51 MAPK pathway 51 vasodilator 51 adenosine receptor 51 thyroid hormone receptor 51 calcitonin gene related 51 inducible 51 small molecule agonists 51 Wnts 51 inhibitory synapses 51 protein tyrosine kinase 51 ciliary 51 orexin 51 Inhibitory 51 Treg cell 51 downstream effectors 51 overactivation 51 neuropeptide Y 51 induces apoptosis 51 STAT1 51 noncoding RNA 51 receptor ligands 51 alpha subunit 51 PDGFR 51 proinflammatory cytokines 51 Dopaminergic 51 CEACAM1 51 Neuropeptide Y 51 nicotinic acetylcholine receptor 51 ACh 51 potently inhibit 51 renin angiotensin aldosterone 51 tyrosine hydroxylase 51 S#K# 51 NF KappaB 51 cyclin dependent kinase inhibitor 51 IFN γ 51 innervate 51 VEGF receptor 51 Adrenergic 51 p# mitogen activated 51 mitogen activated protein kinase 51 pDCs 51 glutamate transporters 51 activated macrophages 51 neurotransmitter glutamate 51 MAPK 51 transcriptional activation 51 anti inflammatory cytokine 51 polyamine 51 analgesic effects 51 MAP kinase pathway 51 endocannabinoid system 51 keratinocyte 51 adipogenic 51 depolarizing 51 TRPV1 51 metabolize fats 51 Thyroid hormone 51 Angiotensin II 51 serine protease 51 neuropeptide 51 HIF 1α 51 FGFR4 51 ENaC 51 Hypoxia Inducible Factor 51 TrkB 51 palmitoylation 51 ligand receptor 51 PDGF alpha receptor 51 MAP kinases 51 FGF ligands 51 NR2B subunit 51 monoamines 51 Dysregulation 51 cyclins 51 costimulatory 51 NFkappaB 51 PPAR gamma 51 ALDH 51 serine threonine kinase 51 mu opioid 51 serotonin reuptake 51 FOXO 51 tumor angiogenesis 51 MT1 MMP 51 Syk 51 ChR2 51 TRPA1 receptor 51 Norepinephrine 51 suppresses tumor 51 osteoblast 51 transducing 51 bioelectrical 51 focal adhesions 51 receptor inhibitor 51 interleukin 1beta 51 FasL 51 neurotransmitters 51 fibril formation 51 transduction 51 TNFalpha 51 gamma aminobutyric acid 51 secretase 51 4E BP1 51 hypothalamic pituitary adrenal axis 51 ZFP TF 51 chromatin remodeling 51 catecholamine 51 EP3 receptor 51 parasympathetic nervous system 51 neuro transmitter 51 Cathepsin B 51 PI3K/AKT 50 efferent 50 CYP#E# 50 tyrosine phosphorylation 50 mTOR signaling pathway 50 oncoproteins 50 eicosanoids 50 selective inhibition 50 inhibit angiogenesis 50 D aspartate 50 treating neuropathic pain 50 upregulating 50 PKC alpha 50 homodimers 50 cell signaling pathways 50 XBP1 50 PEPCK 50 gene transcription 50 cholesterol homeostasis 50 titrate 50 IL6 50 biological pathways 50 adipogenesis 50 ERa 50 external stimuli 50 TGF b 50 Mechanistically 50 ion channel 50 inhibit platelet aggregation 50 platypus venom 50 CYP#A# enzyme 50 lysophosphatidic acid 50 cyclic AMP 50 AT1R 50 netrin 1 50 incretin 50 inhibit vascular endothelial 50 Anticalins ® 50 induced phosphorylation 50 LRP1 50 leukotriene 50 IL 1ß 50 Smac mimetic 50 hormones neurotransmitters 50 1alpha 50 kinase pathway 50 ANGPTL4 50 TGFß 50 vitamin D receptors 50 TNFR 50 protein Hsp# 50 thermoregulatory 50 50 serotonin transporter 50 proapoptotic 50 ouabain 50 costimulation 50 Notch1 50 Flt3 50 dopamine serotonin 50 neural pathway 50 triggers apoptosis 50 immunomodulatory effects 50 GATA3 50 neuroinflammation 50 cytoskeletal 50 noradrenaline 50 COX enzymes 50 neurotransmitter serotonin 50 receptor mediated 50 M1 muscarinic 50 afferent 50 overexpressing 50 enterocytes 50 peroxisome proliferator activated 50 protein tyrosine phosphatases 50 XL# inhibits 50 Cyclin E 50 degranulation 50 PPAR alpha 50 hypothalamus pituitary 50 messenger ribonucleic acid 50 potentiator 50 P#X# receptor 50 Wnt signaling 50 5 hydroxytryptamine 50 potent inducer 50 chemically modify 50 neuropeptide Y NPY 50 abscisic acid 50 metabotropic glutamate receptors 50 NFkB 50 mitotic progression 50 casein kinase 50 γ secretase 50 prolyl 50 neuronal synapses 50 pleiotropic 50 AhR 50 pyruvate kinase 50 NMDAR 50 tetherin 50 adipocytes fat 50 modulate gene expression 50 muscarinic 50 selective modulator 50 HLA DR4 immune 50 gene expression 50 MEF2 50 gamma oscillations 50 Eg5 50 potent antiproliferative 50 downregulation 50 Notch signaling pathway 50 mediated inhibition 50 regulating gene expression 50 neurons 50 monoamine 50 protein tyrosine kinases 50 hydrolases 50 serine threonine 50 oscillatory behavior 50 glucagon receptor 50 toxic beta amyloid 50 methyl D aspartate 50 FGFR1 50 allopregnanolone 50 brain hypothalamus 50 inhibiting COX 50 neuronal excitability 50 Acetylcholine 50 vanilloid receptor 50 Notch signaling 50 lytic 50 Fc receptors 50 signaling molecule 50 noradrenergic 50 PKC isoforms 50 catabolism 50 cell adhesion molecules 50 melanocyte stimulating hormone 50 metabolizing enzymes 50 Upregulation 50 auditory neurons 50 SOCS3 50 PPAR γ 50 metabolic enzymes 50 postsynaptic neuron 50 GABA gamma aminobutyric acid 50 trans splicing 50 norepinephrine reuptake inhibition 50 secretes hormones 50 Rb#/p# 50 N methyl 50 NK1R 50 dorsolateral 50 inhibitory receptors 50 serotonin signaling 50 synaptic plasticity 50 TPO receptor 50 TrkA 50 secrete hormones 50 hapten 50 receptor activation 50 secretory pathway 50 angiogenic 50 Src kinase 50 cyclic nucleotide 50 neurotransmitter GABA 50 mitral cells 50 metabolic 50 adenosine diphosphate ADP 50 synthesize 50 neurotransmitter receptor 50 selectively inhibiting 50 guanylate cyclase 50 Endocannabinoids 50 metabolizing enzyme 50 PDE#A 50 nAChRs 50 IFN g 50 cell signaling pathway 50 POMC neurons 50 Histone deacetylase 50 kinase domain 50 lipid homeostasis 50 RAS RAF MEK 50 amyloid β 50 1α 50 endogenously 50 AMPA receptors 50 CCL# 50 coiled coil domain 50 EP1 receptor 50 inhibition 50 microsomal 50 calpain 50 thermosensitive 50 neurochemicals 50 oligomerization 50 Hedgehog signaling pathway 50 peroxisome 50 myocyte 50 histone deacetylases HDACs 50 neurite 49 vagus nerves 49 PI3K Akt 49 cytokines 49 molecular chaperone 49 extracellular calcium 49 nano fluidic 49 orexin neurons 49 Preclinical studies suggest 49 activated protein kinase 49 intestinal epithelium 49 transcriptional regulation 49 IL 1beta 49 neurosteroid 49 carbohydrate polymer 49 detoxify carcinogens 49 SGLT2 inhibitors 49 transcriptional regulator 49 regulates gene expression 49 CDKs 49 neuronal differentiation 49 vesicle formation 49 PKM2 49 Amino acid 49 synaptotagmin 49 inhibitory neurotransmitter 49 biologic pathways 49 potentiating 49 chemokine SDF 1 49 MCF7 49 transcriptional repressor 49 p# subunit 49 inhibit enzymes 49 calcium calmodulin 49 mitogen activated protein kinases 49 mesolimbic dopamine system 49 SUMOylation 49 preferentially bind 49 proteasome inhibition 49 hypoxia induced 49 micro RNAs 49 MetAP2 49 lysyl oxidase 49 HuR 49 potent inhibitor 49 Hsp# chaperone 49 anti proliferative 49 secreted proteins 49 NADPH oxidase 49 RNA polymerase II 49 tumor suppressor PTEN 49 downregulated 49 glucocorticoid 49 calcium ion 49 matrix metalloproteinases 49 hormone norepinephrine 49 prostaglandin E2 49 adhesion proteins 49 catenin 49 inverse agonist 49 hyperexcitability 49 HepG2 cells 49 neuronal activity 49 antiviral cytokines 49 Wnt proteins 49 elastase 49 SLC#A# [002] 49 endocannabinoids 49 voltage gated 49 sGC 49 GPR# [002] 49 adrenal hormones 49 Aâ 49 thromboxane A2 49 neuronal 49 anti apoptotic 49 cytotoxic T lymphocyte 49 synaptogenesis 49 neuronal dysfunction 49 secretion 49 TSLP 49 SMN1 49 proteoglycan 49 Th1 type 49 NF kappaB 49 overactive 49 neurotransmitter dopamine 49 androgen hormone 49 Shp2 49 proteolytic 49 lung epithelium 49 myosin VI 49 vasoactive 49 ER alpha 49 sodium ion 49 eNOS 49 Th1 cells 49 kinesin motor 49 lipoic acid 49 NKG2D 49 c MET 49 SIRT3 49 TGF ß 49 CD#b 49 S#A# [002] 49 paraventricular nucleus 49 CD# ligand 49 urocortin 49 CRF receptors 49 #ß 49 lipopolysaccharide 49 serotonin 49 inhibited tumor 49 sphingomyelin 49 neuronal apoptosis 49 catecholamines 49 leukotrienes 49 AKT pathway 49 receptor PPAR 49 suprachiasmatic nucleus 49 miR# 49 MMP9 49 prostaglandin synthesis 49 FGFR 49 neuroactive 49 cardiac contractility 49 VEGF pathway 49 kappa opioid receptors 49 transcriptional coactivator 49 neural circuits 49 estrogen metabolism 49 Delta opioid receptor 49 GABA receptor 49 ciliary neurotrophic factor 49 proinflammatory cytokine 49 EGFr 49 Akt signaling 49 PGC1 49 regulated kinase ERK 49 steroidogenesis 49 microRNA molecules 49 brain neurotransmitter 49 actin remodeling 49 serotonin norepinephrine 49 alpha MSH 49 neurotrophins 49 eotaxin 49 cytokine receptors 49 endogenous opioids 49 EGF receptor 49 potentiated 49 reuptake 49 adipocyte 49 #β HSD1 49 Treg cells 49 potentiation 49 adrenal cortex 49 activin 49 pre mRNA splicing 49 EGFR pathway 49 hypoxia inducible factor 49 leptin signaling 49 naturally occurring molecule 49 chemoreceptors 49 c myc 49 neurones 49 PPARgamma 49 tumor vasculature 49 hypoxia inducible 49 antitumor 49 peptide GLP 1 49 norepinephrine noradrenaline 49 PIP2 49 dephosphorylation 49 insulates nerve fibers 49 dopamine synthesis 49 therapeutically relevant 49 fibrogenesis 49 signaling cascades 49 potent antitumor 49 chemotactic 49 proto oncogene 49 cholinergic 49 Myostatin 49 serotonin 2A 49 ubiquitin ligases 49 serotonergic neurons 49 derived neurotrophic factor 49 GABAB receptors 49 partial agonists 49 Smoothened 49 Signal transduction 49 neurotrophin 49 adrenergic receptors 49 effector cells 49 TRPM8 49 glycosylated 49 CXCL# 49 oligomer 49 intracellular signal transduction 49 transduced 49 NF kB pathway 49 cyclic adenosine monophosphate cAMP 49 mitogen 49 GABAergic interneurons 49 P2X 49 enzyme AMPK 49 cardiac myocytes 49 hypothalamus gland 49 intracellular 49 glutamatergic neurons 49 selectively binds 49 actin cytoskeleton 49 satiety hormone 49 serotonin dopamine 49 gastric carcinomas 49 ankyrin 49 uroguanylin 49 hyperactivation 49 receptor molecules 49 factor NGF 49 KLF4 49 macromolecular complexes 49 p# activation 49 antiproliferative 49 misregulation 49 TGF beta1 49 Sonic hedgehog 49 oscillation frequency 49 glutamate 49 thioredoxin 49 MTP inhibitor 49 antigen presenting 49 species ROS 49 upregulation 49 P cadherin 49 ERK5 49 5 HT2A 49 Myosin II 49 dermal papilla 49 Thyroid hormones 49 beta1 integrin 48 endothelial nitric oxide 48 proteolytic degradation 48 small molecule 48 inhibits inflammation 48 orexin receptors 48 HDAC2 48 mRNA translation 48 S#P# 48 receptor modulator 48 #T# L1 48 c myc gene 48 Akt 48 COX2 48 Rab# 48 cellular organelles 48 peptides 48 Hh pathway 48 nucleolin 48 antioxidant enzymes 48 RUNX3 48 hormone angiotensin II 48 ligases 48 miR #a [001] 48 mitogen activated protein 48 lipoxygenase 48 gene polymorphisms 48 epithelial sodium 48 binding affinities 48 D3 receptors 48 dopamine neurons 48 interleukins 48 mu receptor 48 proton pump 48 thrombin receptor 48 CaM kinase II 48 enkephalins 48 Wnt beta catenin 48 interleukin 1β 48 HSP# 48 evolutionarily conserved 48 subtype selective 48 neuron 48 IRE1 48 ErbB2 48 opiate receptors 48 EBNA1 48 mitochondrial membrane 48 Tasigna prolongs 48 Integrins 48 phosphorylates 48 mechanistically 48 CB2 receptor 48 Sirt3 48 sd rxRNA 48 TGF beta 48 Clusterin 48 pluripotency genes 48 ErbB receptors 48 LT IIa 48 IL #R 48 branching morphogenesis 48 molecular pathways 48 eIF4E 48 experimentally induced 48 melanocortin 48 CaM kinase 48 reductase 48 β catenin 48 circadian pacemaker 48 estrogen receptor beta 48 aT cell 48 GABA neurotransmitter 48 beta arrestin 48 agonism 48 Anticalins R 48 inhibitory effect 48 EGFR signaling 48 gamma aminobutyric acid GABA 48 kappa opioid receptor 48 platelet activation 48 intracellular protein 48 molecular mechanism 48 monocyte 48 WT1 48 isoenzymes 48 CCR2 48 hormones cortisol 48 EF Tu 48 endoplasmic 48 Lrp5 48 phospholipase C 48 PI3 kinase 48 effector memory 48 PECAM 1 48 agonists antagonists 48 SH2 B 48 monocyte chemotactic protein 48 raphe 48 hypothalamic pituitary adrenal HPA 48 destroy cancerous cells 48 excitatory neurotransmitter 48 calcium homeostasis 48 dopamine receptors 48 dopamine D1 48 serpin 48 adrenergic 48 soluble tumor necrosis 48 JAK STAT 48 chemosensory 48 lipoprotein metabolism 48 seratonin 48 hsp# 48 endocrine glands 48 amyloid formation 48 Factor Receptor 48 lowering blood glucose 48 antibodies bind 48 phosphatases 48 GGTase 48 Wnt 48 heterodimers 48 TRPM5 48 sensory nerves 48 NKX#.# 48 HIF 1alpha 48 corticotrophin releasing factor 48 cypin 48 Pim kinases 48 aggrecan 48 HDAC6 48 peptide antigens 48 chaperone protein 48 tissue fibrosis 48 globus pallidus 48 LTB4 48 adaptive immunity 48 JAK STAT pathway 48 Hedgehog signaling 48 LDL receptor 48 fatty acid synthase 48 excitotoxic 48 insulin sensitizing 48 TLE3 48 CB1 receptor 48 receptor tyrosine kinase 48 covalently bound 48 selective agonists 48 VMAT2 48 nerve cells 48 FSH receptor 48 molecular underpinnings 48 cannabinoid receptors 48 potent anticancer 48 cells secrete 48 TMEM#B 48 glomerulus 48 cytolytic 48 vitamin D receptor VDR 48 neuronal plasticity 48 tropomyosin 48 activate AMPK 48 pericytes 48 endoplasmic reticulum stress 48 glucose homeostasis 48 THR beta agonist 48 acetylcholine 48 synapse formation