Related by context. All words. (Click for frequent words.) 69 protein misfolding 67 LIS1 66 misfolded 66 tumor suppressor protein 65 mutant huntingtin protein 65 CXCL5 65 genomic instability 65 SOD1 65 mutant proteins 65 amyloid peptide 65 amyloid formation 64 neuroligins 64 misfolded protein 64 excitotoxicity 64 neuronal dysfunction 63 OPHN1 63 mutated protein 63 mutant protein 63 p# activation 63 protein tau 63 tau protein 63 amyloid beta proteins 63 microglial cells 63 tau proteins 63 podocyte 63 SOCS1 63 alpha synuclein 63 membrane fusion 63 β catenin 62 pRb 62 synaptogenesis 62 retinoblastoma Rb 62 cellular senescence 62 protein conformation 62 amyloid beta peptides 62 CPEB 62 ADDLs 62 SOD1 protein 62 huntingtin protein 62 TMEM#B 62 axonal degeneration 62 progerin 62 HGPS 62 MAP kinase pathway 62 Pin1 62 peroxisome 62 epigenetic silencing 61 epigenetic regulation 61 regulates gene expression 61 inherited mutations 61 prion protein 61 tyrosine phosphorylation 61 Hsp# [001] 61 alpha synuclein protein 61 transcriptional repression 61 epigenetic alterations 61 amyloid fibrils 61 uPAR 61 Aβ 61 ABCA1 61 lysosomal 61 HIV reverse transcriptase 61 palladin 61 sortilin 61 chromosomal instability 61 Cyclin D1 61 overactivation 61 cohesin 61 caveolae 61 spectrin 61 micro RNAs 61 toxic amyloid beta 61 chromatin structure 61 misfold 61 dimerization 61 motor neuron degeneration 61 misregulation 61 conformational changes 61 epigenetic modifications 61 Akt signaling 61 TSC1 61 Htt 61 hyperactivation 60 alpha synuclein gene 60 COX2 60 sphingolipid 60 neuronal degeneration 60 eotaxin 60 transcriptional activation 60 protein phosphorylation 60 cell motility 60 amyloid beta peptide 60 FGFs 60 caspase activation 60 thioredoxin 60 senescent cells 60 mitochondrial mutations 60 LRP6 60 nerve degeneration 60 amyloids 60 synapse formation 60 cypin 60 intestinal epithelium 60 ADAM# 60 cytoskeletal protein 60 apoE 60 RNA polymerase II 60 fatty acid synthase 60 cytokine receptor 60 glutamate receptors 60 ectopic expression 60 γ secretase 60 biogenesis 60 mitochondrial dysfunction 60 β amyloid 60 mitochondrial fusion 60 mitogen activated protein kinase 60 podocytes 60 H#K# methylation 60 hypermethylation 60 deacetylation 60 nitric oxide synthase 60 upregulation 60 neuromuscular junction 60 primary cilia 60 microdeletion 60 neurodegeneration 60 EZH2 60 neurotransmission 60 proteolysis 60 RNA splicing 60 HCV replication 60 Notch1 60 CCR3 60 renal fibrosis 60 histone deacetylases 60 secretory pathway 60 NF KappaB 60 amyloid β 60 synuclein 60 amyloid beta plaques 60 huntingtin 60 protein clumps 60 Cdc# 60 TGF beta pathway 59 phosphatases 59 TXNIP 59 beta amyloid peptide 59 acetylcholine receptor 59 Wnt signaling pathway 59 cathepsins 59 intracellular signaling 59 cyclins 59 neuroglobin 59 SCD1 59 Abeta protein 59 myelination 59 PAR1 59 IRF5 59 APOBEC3G 59 spongiform encephalopathies 59 misfolds 59 antibody mediated 59 cyclin B1 59 Oxidative stress 59 FMR1 gene 59 DLX5 59 NF kB signaling 59 ubiquitinated 59 transcriptional regulation 59 glutamate receptor 59 beta1 integrin 59 osteoclast activity 59 nAChR 59 epigenetic modification 59 casein kinase 59 PrP 59 ERK signaling 59 granzyme B 59 intracellular proteins 59 trypanosomes 59 amyloid fibers 59 Hedgehog signaling 59 eicosanoid 59 CHD7 59 amyloidogenic 59 proto oncogene 59 proteins 59 mitotic spindle 59 ubiquitin ligase 59 Skp2 59 receptor molecule 59 tetherin 59 VHL gene 59 chaperone proteins 59 ubiquitination 59 LRRK2 59 SMN1 59 epigenetic inheritance 59 insulin signaling pathway 59 neuronal cell 59 Vpu 59 neurofibrillary tangles 59 dendritic spine 59 S#K# 59 microRNAs miRNAs 59 regulate gene expression 59 protein CETP 59 4E BP1 59 prion proteins 59 chromosomal rearrangement 59 Abeta# 59 p# pathway 59 proteins misfold 59 epigenetic changes 59 Smad3 59 DHFR 59 amyloid proteins 59 amyloid deposition 59 vimentin 59 polyamines 59 Clusterin 59 LRP5 59 receptor gamma 58 cellular pathways 58 Genetic mutations 58 postsynaptic neuron 58 calcineurin 58 oligomerization 58 FANCD2 58 caveolin 58 inhibitory receptor 58 synovial cells 58 CaMKII 58 non coding RNA 58 amyloid protein 58 SIRT3 58 Pten 58 Smoothened 58 palmitoylation 58 IL 1β 58 prostaglandin synthesis 58 misfolded proteins 58 H#K# [002] 58 copper zinc superoxide 58 CIB1 58 mammary cells 58 melanocyte 58 NKT cell 58 CXCL# 58 tumor suppressor gene 58 neurotransmitter glutamate 58 LKB1 58 LRRK2 gene 58 Wnt1 58 apoptotic pathway 58 coactivators 58 tumorigenesis 58 calpain 58 HOTAIR 58 hedgehog pathway 58 TGF b 58 synthetase 58 Aß 58 protein kinase C 58 Notch signaling 58 Wnts 58 amyloid plaque formation 58 beta catenin protein 58 caveolin 1 58 histone methylation 58 COL#A# 58 gene rearrangements 58 cAMP signaling 58 regulating gene expression 58 invadopodia 58 COX enzymes 58 GRP# 58 Methylation 58 potent inhibitors 58 ERK2 58 E#F# 58 abnormal proteins 58 TFIIH 58 RNA silencing 58 GSK3 58 NS4B 58 fibril formation 58 endogenous cannabinoids 58 PI 3K 58 Protein folding 58 RANKL 58 phosphorylate 58 galanin 58 connexin 58 tropomyosin 58 CaM kinase II 58 signaling molecule 58 dystrophin gene 58 G6PD 58 ERK1 2 58 cell adhesion molecule 58 superoxide dismutase 58 nicotinamide 58 mRNA transcripts 58 Wnt#b 58 excitotoxic 58 endosomal 58 neurexins 58 mutant huntingtin 58 dedifferentiation 58 hedgehog signaling 58 NFkB 58 aldose reductase 58 phosphorylates 58 Src kinase 58 ubiquitin ligases 58 Purkinje cells 58 oncogenic 58 neurite outgrowth 58 neurofibrillary 58 telomere shortening 58 HMG CoA reductase 58 coagulation cascade 58 signaling pathway 58 Upregulation 58 presenilin 58 cell adhesion molecules 58 signaling cascades 58 PP2A 58 cytokine signaling 58 muscular dystrophies 58 RUNX3 58 synaptic function 58 NADPH oxidase 58 modulatory 58 PTPN# 58 histone code 58 oligodendrocytes 58 FOXO3a 58 beta globin gene 58 SMAD4 58 intracellular signal transduction 58 phosphate S1P 58 SGK1 58 protein synthesis 58 eukaryotic cells 58 neuronal migration 58 neuroinflammation 58 CRISPR Cas 58 oxysterols 58 GAPDH 58 Jagged1 58 MAP kinase 58 endoplasmic reticulum 58 HSF1 57 downregulation 57 cholesterol metabolism 57 Wnt proteins 57 demyelination 57 miRNA genes 57 dysregulated 57 kinase domain 57 selective inhibition 57 cardiac hypertrophy 57 AhR 57 gamma secretase 57 molecular pathway 57 endoplasmic reticulum stress 57 transthyretin 57 cardiolipin 57 mutations 57 proteoglycan 57 multidrug resistance 57 phosphatidylinositol 3 57 Dysregulation 57 ubiquitylation 57 missense mutation 57 neuroinflammatory 57 outer membrane proteins 57 INF2 57 GluR1 57 glycolipids 57 Nedd4 57 oncogenesis 57 potent inhibition 57 MDSCs 57 evolutionarily conserved 57 Aβ# 57 tyrosine kinase 57 Prox1 57 noncoding RNA 57 cell signaling pathways 57 PTP 1B 57 FGFR3 57 focal adhesions 57 dephosphorylation 57 cystic fibrosis transmembrane conductance 57 oncogenes 57 peroxisomes 57 neuron degeneration 57 CFTR 57 glucocorticoid receptor 57 Wnt pathway 57 cytokinesis 57 PHD2 57 Cathepsin B 57 alternative splicing 57 molecular abnormalities 57 serine threonine kinase 57 adhesion proteins 57 Amyloid beta 57 molecular pathways 57 microRNA molecules 57 membrane lipids 57 p# MAPK 57 rifamycins 57 colocalization 57 PAK1 57 APOL1 57 tRNA synthetase 57 ryanodine receptor 57 HMGA2 57 peroxisomal 57 hyperactivated 57 Six3 57 X inactivation 57 cyclooxygenase 57 LDL receptor 57 5 hydroxymethylcytosine 57 Aâ 57 receptor mediated endocytosis 57 dimeric 57 MAPK pathway 57 intracellular protein 57 amyloid cascade 57 JAK STAT 57 caspases 57 tyrosine kinases 57 ribozyme 57 de novo mutations 57 Wnt signaling 57 #BP# 57 LDLR 57 SOD1 gene 57 presynaptic 57 MLL2 57 ACh 57 phosphorylated tau 57 induce apoptosis 57 neuronal synapses 57 Sup# 57 TIR1 57 ARF1 57 synaptic vesicle 57 WT1 57 RhoA 57 glycosylated 57 TNFR 57 progressive degeneration 57 virulence genes 57 mtDNA mutations 57 cytoskeletal 57 NKG2D 57 frameshift 57 S#A# [002] 57 clusterin 57 endosome 57 KIAA# 57 FUS1 57 sequence homology 57 MECP2 gene 57 DNMT1 57 DARPP 57 genomic rearrangements 57 GNAQ 57 tenascin 57 protein encoded 57 MLL gene 57 oncoprotein 57 c Myb 57 SH#B# 57 fatty acid biosynthesis 57 leptin resistance 57 GPC5 57 HipA 57 E1A 57 phenotypic expression 57 splice variants 57 biosynthetic pathway 57 constitutively expressed 57 autophagic 57 NKX#.# 57 TAp# 57 neuroligin 57 synaptic transmission 57 lipid synthesis 57 FGF signaling 57 PDGFR 57 paxillin 57 viral proteins 57 NMDA receptors 57 PPAR γ 57 chromosome rearrangements 57 ENaC 57 overactivated 57 Signal transduction 57 vascular endothelial cells 57 beta amyloid proteins 57 Amyloid plaques 57 transcriptional repressor 57 genes encode proteins 57 molecular mimicry 57 metabolic abnormalities 57 EGFR signaling 57 protein beta amyloid 57 endocytic 57 TORC1 57 receptor tyrosine kinase 57 amyloid beta protein 57 sRNA 57 Mdm2 57 c MET 57 secretase 57 cAMP 57 RNAs 57 interferon pathway 57 myo inositol 57 retinoic acid receptor 57 autocrine 57 FSH receptor 57 beta amyloid accumulation 57 E3 ligase 57 V#F mutation 57 c myc 57 AMPA receptor 57 PML RARA 57 SMN protein 57 astrocytic 57 serine protease 57 ribonucleoprotein 57 normal prion proteins 57 nonsense mutations 57 SUMOylation 57 tetramer 57 posttranslational modifications 57 Treg cell 56 exocytosis 56 H#K#me# 56 IRE1 56 intracellular compartments 56 pathological hallmark 56 genetic alteration 56 neurodegenerative disorder 56 underlying pathophysiology 56 JNK1 56 neurotransmitter receptor 56 PALB2 56 prostaglandin E2 PGE2 56 PKM2 56 histone modifications 56 IL 1ß 56 lysosome 56 germ cells 56 chromosome condensation 56 chromosome segregation 56 iNOS 56 p# protein 56 divide uncontrollably 56 biosynthesis 56 telomere DNA 56 Foxp3 56 metabolic enzymes 56 alternatively spliced 56 HbF 56 neurexin 56 pathogenic mechanisms 56 γδ T cells 56 epigenetic markers 56 chitinase 56 CCL5 56 catalytic subunit 56 prostaglandin E2 56 transgene expression 56 glycoproteins 56 p# gene 56 mevalonate 56 lipid molecules 56 lysosomal enzyme 56 Rev erb 56 KLF4 56 Overexpression 56 proteolytic cleavage 56 apoptosis pathway 56 motor neurones 56 RKIP 56 encodes protein 56 neuroprotective therapies 56 Rab5 56 PHLPP 56 pDCs 56 beta catenin 56 TP# gene 56 beta subunit 56 STAT1 56 gliosis 56 neuropeptide Y NPY 56 splice junctions 56 progressive neurodegenerative disorder 56 activating mutations 56 neural crest 56 catenin 56 biochemical mechanisms 56 S6K 56 guanylate cyclase 56 NF kappaB activation 56 SH2 B 56 BCL2 56 S nitrosylation 56 H#K# [001] 56 mRNA molecules 56 Shp2 56 BCR ABL protein 56 MAPK 56 calcium homeostasis 56 mediated inhibition 56 protein fragment 56 inflammatory cytokine 56 microglial activation 56 sphingolipids 56 Runx2 56 downregulated 56 tau phosphorylation 56 neuronal stem cells 56 FGFR1 56 laforin 56 FMRP protein 56 leukaemic stem cells 56 NPC#L# 56 PDGF alpha receptor 56 histone 56 mutant enzymes 56 FTLD 56 hydroxylation 56 Prion proteins 56 telomere dysfunction 56 transmembrane receptor 56 telomere maintenance 56 PrPC 56 beta adrenergic receptors 56 stem cell differentiation 56 tenascin C 56 Rho GTPases 56 E cadherin 56 microglial 56 superoxide 56 tyrosine kinase receptors 56 Hfq 56 MT1 MMP 56 triggers apoptosis 56 Hutchinson Gilford progeria 56 NOTCH1 56 GABAergic interneurons 56 hypermethylated 56 cellular prion protein 56 neuropsychiatric diseases 56 familial ALS 56 toxic beta amyloid 56 transmembrane domains 56 oncogenic signaling 56 endoplasmic reticulum ER 56 CD#L 56 PTEN gene 56 molecular mechanisms underlying 56 mesoderm 56 mutant SOD1 56 PTP1B 56 GPR# [002] 56 telomeric 56 oligomers 56 BubR1 56 NPC1 56 arterial calcification 56 HDAC6 56 neoplastic transformation 56 apoE4 56 SIRT2 56 causative genes 56 polyglutamine diseases 56 glial cell 56 TTR gene 56 fatty acid synthesis 56 homodimers 56 metalloproteinases 56 Ets2 56 JAK2 enzyme 56 Bcl2 56 genotoxic stress 56 TRIM# 56 stathmin 56 epigenetically 56 intestinal epithelial cells 56 tumor suppressors 56 lymphocyte activation 56 gene transcription 56 chromosomal rearrangements 56 signaling cascade 56 β1 56 chromosomal translocations 56 chimeric mice 56 protein biosynthesis 56 ChR2 56 Cdc7 56 bacterial enzyme 56 protein alpha synuclein 56 PPARγ 56 coiled coil domain 56 Smurf1 56 NFκB 56 malignant transformation 56 Rap1 56 adhesion molecule 56 excitatory neurotransmitter glutamate 56 disulfide bond 56 oligomeric 56 genetic polymorphism 56 IL 1beta 56 aberrantly activated 56 aneuploidy 56 polypeptides 56 thymidylate synthase 56 IKKa 56 serotonin receptor 56 neuronal plasticity 56 cyclic AMP cAMP 56 GABAA receptors 56 aberrant activation 56 C1q 56 constitutively active 56 tumor suppressor genes 56 RNA synthesis 56 chaperone protein 56 trimeric 56 glial cells 56 cyclooxygenase COX 56 dopamine signaling 56 Nf1 56 untranslated regions 56 kalirin 56 SOD1 mutation 56 atherogenesis 56 anti apoptotic proteins 56 proteasomes 55 unicellular organism 55 PTEN protein 55 calmodulin 55 cellular metabolism 55 GPI anchored 55 EBNA1 55 transcriptional machinery 55 STAT4 55 tubule 55 NAD + 55 transmembrane protein 55 p# mutations 55 nNOS 55 sporadic ALS 55 c Src 55 glycosylation 55 MEF2D 55 proapoptotic 55 downstream effectors 55 progranulin 55 apo E 55 DISC1 55 #beta HSD1 55 heme oxygenase 55 CFTR gene 55 neuronal signaling 55 myotonic dystrophy 55 STAT3 signaling 55 STIM1 55 centrosome 55 hypocretin neurons 55 synthesize proteins 55 KIT mutations 55 α synuclein 55 eukaryotic cell 55 BACE1 55 druggable target 55 MDM2 55 Misfolded proteins 55 DNA demethylation 55 gastrulation 55 spontaneous mutations 55 TSLP 55 intracellular 55 myopathies 55 amino acid substitutions 55 arginase 55 isoenzymes 55 AMPA receptors 55 glucocerebroside primarily 55 amyloid deposits 55 prion infections 55 CDK5 55 SETDB1 55 MSH2 55 aromatase 55 apoptosis induced 55 netrin 1 55 motor neuron 55 intracellularly 55 MEF2A 55 neurofibromin 55 focal adhesion kinase FAK 55 hematopoietic cells 55 dynein 55 B7 H1 55 inhibitory neurotransmitters 55 Purkinje cell 55 collagen VI 55 oncogenic transformation 55 polyadenylation 55 excess glutamate 55 dynamin 55 PECAM 1 55 Myc protein 55 breast cancer metastasis 55 receptor kinase 55 c Abl 55 histone modification 55 mitochondrial function 55 hnRNP 55 polymerases 55 IFN γ 55 morphogens 55 cyclin D1 55 TGFb 55 nucleolar 55 BRAF gene 55 PIP3 55 xenobiotic 55 epigenetic mechanisms 55 PPAR gamma 55 ALDH2 55 phosphorylation 55 protein secretion 55 atherosclerotic plaques 55 Hox gene 55 Genetic variants 55 filaggrin 55 DSBs 55 Bcl xL 55 molecular mechanisms 55 nanobacteria 55 nucleoli 55 Arp2 3 55 prion infection 55 beta amyloid protein 55 cyclin E 55 dystroglycan 55 ADAMTS# 55 torsinA 55 CaM kinase 55 intracellular pathogens 55 mediated apoptosis 55 glial tumors 55 tau tangles 55 TrkB 55 matrix metalloproteinases 55 signaling pathways 55 multi factorial disease 55 TRF1 55 myeloproliferative diseases 55 GPIHBP1 55 neural cells 55 RecA 55 ERK pathway 55 integrin 55 CDK4 55 MTHFR 55 neural crest stem cells 55 RAS RAF MEK 55 axonal transport 55 ARID1A 55 rRNA 55 Hh 55 costimulatory 55 huntingtin gene 55 ligases 55 intracellular bacteria 55 Stat5 55 PPARg 55 chemoresistance 55 DLC1 55 Notch receptor 55 Rab# 55 leukocyte adhesion 55 NF kappaB 55 mitochondrial membrane 55 Pax6 55 CEACAM1 55 Vps# 55 homologous recombination 55 GRK2 55 mosaicism 55 androgen receptor AR 55 catecholamine 55 HSP# 55 membrane protein 55 HOX genes 55 PI3K AKT 55 CALHM1 55 hexamer 55 anti apoptotic 55 TRPV3 55 transcriptional silencing 55 biochemical pathway 55 neuronal differentiation 55 shortened telomeres 55 enzymatic activity 55 mesenchymal cell 55 STK# [002] 55 PPAR alpha 55 Neuronal 55 coding genes 55 oxidized lipids 55 actin cytoskeleton 55 normal prion protein 55 acyl CoA 55 metabolize cholesterol 55 morphogen 55 PAX5 55 naturally occurring protein 55 HIF 1a 55 crystallin 55 Alzheimer disease pathology 55 neuronal apoptosis 55 primary cilium 55 oxidative phosphorylation 55 missense mutations 55 Akt1 55 suppressor cells 55 beta globin 55 CFTR protein 55 PrPSc 55 TRAIL induced apoptosis 55 carbenes 55 endocytosis 55 TGF β 55 phagocytic cells 55 mRNA translation 55 NKX2 55 tryptase 55 DNA adducts 55 activate p# 55 lipoxygenase 55 BRAF protein 55 KLF# 55 cdk5 55 insoluble proteins 55 TGF ß 55 malonyl CoA 55 beta amyloid peptides 55 neural precursor 55 biologic pathways 55 MMP9 55 beta amyloids 55 histone H3 55 p#NTR 55 progranulin gene 55 ribosomal protein 55 cytosolic 55 posttranslational modification 55 serotonin transporters 55 TH# cells 55 mice lacking 55 biochemical cascade 55 acetylation 55 STAT3 55 MC4R gene 55 insulin receptors 55 Jhdm2a 55 EGF receptor 55 Golgi apparatus 55 adult neurogenesis 55 mTORC1 55 cholesterol homeostasis 55 ectoderm 55 Treg cells 55 MLH1 55 endoxifen 55 GABAergic 55 DNA replication 55 fibril 55 Alu RNA 54 receptor activation 54 vacuolar