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(Click for frequent words.) 61 reductionist 59 mechanistically 58 pathophysiological 57 transcriptional regulation 57 underlying molecular mechanisms 56 evolvability 56 phenomenological 56 mechanistic insights 55 atherogenesis 55 neurophysiological 55 atomistic 55 theoretic 54 pleiotropy 54 intracellular signaling 54 protein biosynthesis 54 biogenesis 54 neurobiological 54 mechanistic explanation 53 molecular mechanisms underlying 53 neuroanatomical 53 X ray crystallographic 53 Mechanistic 53 protein conformation 53 amyloid cascade 53 TXNIP 53 modulatory 53 neuronal signaling 53 epigenetic regulation 53 histone code 53 somatic motility 53 pathophysiologic 52 empirical 52 empirical observation 52 biosynthetic 52 pathophysiology 52 epistemological 52 neuroscientific 52 mathematical rigor 52 Hegelian dialectic 52 neurochemistry 52 myocyte 52 testable hypotheses 52 metabolic pathways 52 neuronal dysfunction 52 metabolomic profiles 52 biopsychosocial 52 gut microbiota 52 neo Darwinian 52 GPIHBP1 52 Hox gene 52 post transcriptional 52 transgenic mouse models 52 Neo Darwinism 52 psychobiological 52 theoretical underpinning 52 pathophysiological mechanisms 52 neurochemical 51 peroxisome 51 phenomenology 51 podocyte 51 molecular 51 CEACAM1 51 tumorigenicity 51 ontogeny 51 neurobiological mechanisms 51 γ secretase 51 neurotrophic 51 immunological 51 biophysical 51 miRNA expression 51 phospholipid membranes 51 neurite outgrowth 51 physiological mechanisms 51 scientifically testable 51 coexpression 51 beta1 integrin 51 neo Darwinism 51 syntheses 51 mTOR signaling pathway 51 phenotypic expression 51 epistemic 51 tyrosine phosphorylation 51 RNA polymerases 51 axon guidance 51 colorectal carcinogenesis 51 mucosal immune 51 molecular underpinnings 51 thesis antithesis 51 metacognitive 51 glutamatergic 51 physicochemical 51 hammerhead ribozyme 51 siRNA mediated 51 correlational 51 lung fibroblasts 51 embryological 51 posttranslational modification 51 DNA demethylation 51 telomere dysfunction 51 membrane fusion 51 observable phenomena 50 bicyclic 50 endogenous opioid 50 vivo 50 agonistic 50 biologic plausibility 50 SCD1 50 biochemical 50 signal transduction 50 paracrine 50 amyloid hypothesis 50 elucidate 50 DNA methylation patterns 50 NKT cell 50 pathogenesis 50 Hh pathway 50 Lamarckian 50 neurobiological basis 50 underlying pathophysiology 50 sociological theories 50 deductive 50 dialectical materialism 50 physiologically relevant 50 cardiac myocytes 50 physiological 50 entropic 50 determinist 50 testable hypothesis 50 oligodendrocyte 50 neuronal plasticity 50 transcriptomics 50 intercellular signaling 50 fibrotic disease 50 nosology 50 teleological 50 inferential statistics 50 sphingolipids 50 elucidation 50 pleiotropic 50 metabonomics 50 glycolytic 50 biologies 50 stoichiometry 50 moral intuitions 50 glucose homeostasis 50 HDAC6 50 translationally 50 HSF1 50 Cdc7 50 molecular determinants 50 pleiotropic effects 50 adult neurogenesis 50 norepinephrine reuptake inhibition 50 pharmacological 50 neuromuscular junction 50 oocyte maturation 50 molecular mimicry 50 theorization 50 epiphenomenon 50 antitumour 50 nonlinear dynamics 50 CD1d 50 anterograde 49 α synuclein 49 aberrant activation 49 COX enzymes 49 cAMP signaling 49 reductive 49 genetically encoded 49 phylogenetics 49 verified experimentally 49 mathematical formalism 49 beta globin gene 49 mechanistic insight 49 toxicogenomic 49 DARPP 49 neuronal degeneration 49 5 methylcytosine 49 prostaglandin synthesis 49 cytoskeletal 49 Nedd4 49 empiricism 49 p# activation 49 phenotypes 49 Woese 49 disordering 49 Lewontin 49 pathogenic mechanisms 49 genetic loci 49 eukaryotic cell 49 branching morphogenesis 49 veridical 49 theoretical 49 homeostatic 49 Sgk1 49 DNMT1 49 FGFs 49 amyloid formation 49 oligosaccharide 49 post structuralist 49 homodimers 49 overactivation 49 neuroanatomy 49 SGK1 49 protein homeostasis 49 construal 49 evolutionary origins 49 non coding RNA 49 chemoinformatics 49 phenotypic 49 enzyme catalysis 49 Bayesian methods 49 rationalistic 49 reductionistic 49 mimetic 49 asymmetric catalysis 49 autophagic 49 amyloid fibers 49 mortality salience 49 siRNA knockdown 49 transgene expression 49 transcriptomic 49 stereochemistry 49 proteasome inhibition 49 physiologic 49 Hodgkin Huxley 49 heterologous expression 49 morphogenetic 49 mutant SOD1 49 pathogenetic mechanisms 49 neuronal 49 Smoothened 49 immunoregulatory 49 Wnts 49 phenotype 49 desmosomes 49 irreducibly complex 49 Dictyostelium 49 LIS1 49 dialectical materialist 49 causal 49 apoE 49 gastric carcinomas 49 chemosensitivity 49 diathesis 49 coevolution 49 Dopaminergic 49 serotonin signaling 49 scientism 49 dopaminergic 49 vertebrate embryos 48 metabolomic 48 dopamine signaling 48 mechanistic studies 48 epigenetic mechanisms 48 physico chemical properties 48 primary cilia 48 X chromosome inactivation 48 humoral 48 neurobiological underpinnings 48 animal locomotion 48 metabolomics 48 FOXO3a 48 secretory pathway 48 irreducible complexity 48 cardiomyocyte 48 stochastic resonance 48 oligomerization 48 psychoanalytic 48 hepatic stellate cells 48 meiotic recombination 48 HPA axis 48 aetiological 48 mammalian brains 48 biochemical mechanisms 48 morphogenesis 48 Mechanistic studies 48 sociality 48 sickle cell hemoglobin 48 fibril formation 48 protein ligand interactions 48 morphogen 48 outer membrane proteins 48 actin cytoskeleton 48 NAADP 48 Lambris 48 clonal expansion 48 hydrino 48 testable predictions 48 synovial cells 48 positivistic 48 transduce 48 hypothesis 48 pharmacophore 48 noncoding RNAs 48 stereochemical 48 neural correlates 48 fission yeast 48 Htt 48 Mathematical modeling 48 endophenotypes 48 fatty acid biosynthesis 48 multigene 48 unicellular organism 48 causal inference 48 methodologic 48 hematopoiesis 48 synaptogenesis 48 atomistic simulations 48 costimulation 48 Skeletal muscle 48 teleology 48 drug metabolizing enzymes 48 glial 48 Neo Darwinian 48 organismal 48 clinicopathological 48 taxonomical 48 intracellular proteins 48 alpha synuclein protein 48 neuroprotection 48 lipoprotein metabolism 48 empirically validated 48 motor neuron degeneration 48 Olefsky 48 molecular pathways 48 bacterial flagellum 48 biomagnification 48 molecular mechanisms 48 semiotic 48 stem cell differentiation 48 molecular mechanism 48 histone modifications 48 BMP signaling 48 genetically altered mouse 48 ontology 48 ultrastructural 48 XBP1 48 anthropocentrism 48 bone metabolism 48 agonism 48 prognostic markers 48 aetiology 48 PPARγ 48 neo classical economics 48 neuronal differentiation 48 intracellular signal transduction 48 chromosome condensation 48 morphometrics 48 etiologic 48 postsynaptic 48 budding yeast 48 structuralism 48 sphingolipid 48 NKX#.# 48 glycomics 48 epistasis 48 antigenic epitopes 48 enzymatic pathways 48 TGF b 48 biopsychosocial model 48 behaviorism 48 neural substrates 48 druggable target 48 RNA silencing 48 genetic manipulations 48 S nitrosylation 48 excitotoxic 48 heparan sulfate 48 neoclassical economics 48 Guattari 48 SIRT1 activation 48 glycosylated 48 catecholamine 48 EMBL scientists 48 neural 48 piRNAs 48 Freudian theory 48 anti angiogenic drugs 48 lipid metabolism 48 Id1 48 tau phosphorylation 47 mimesis 47 Cyclin E 47 transcriptional regulator 47 psychophysiological 47 amylin 47 signaling cascades 47 mitochondrial proteins 47 amyloid peptide 47 cypin 47 developmental neurotoxicity 47 histone H4 47 intestinal microbiota 47 siRNA conjugates 47 adenosine A2A receptor 47 DLX5 47 evolutionarily ancient 47 targeting PCSK9 47 subcellular localization 47 SH2 B 47 cyto 47 Muotri 47 epigenomic 47 multigenic 47 hypothalamic pituitary 47 telomere maintenance 47 transcriptional machinery 47 multiplicative 47 partial agonists 47 quantum computation 47 enzymes catalyze 47 Wnt signaling pathway 47 endocannabinoid signaling 47 dialectical 47 activated macrophages 47 additively 47 reciprocal altruism 47 nucleosome positioning 47 epistemology 47 inductive logic 47 Th2 immune 47 meta analytic 47 QSAR 47 oxysterols 47 deductive logic 47 site directed mutagenesis 47 TBC#D# 47 Hsp# [001] 47 synaptic transmission 47 hermeneutical 47 introgression 47 pharmacological interventions 47 intercellular communication 47 signaling pathway 47 endogenous 47 synaptotagmin 47 renal fibrosis 47 causal pathways 47 gamma oscillations 47 prion hypothesis 47 vitalism 47 CB2 receptor 47 generative grammar 47 calpain 47 genomewide 47 osteoblast 47 protein secretion 47 fibril 47 receptor mediated 47 NOD mouse 47 macromolecular 47 multifactorial 47 philosophical naturalism 47 Molecular biology 47 Darwinian evolutionary 47 incommensurability 47 comparative genomics 47 intellectualized 47 spatio temporal 47 molecular abnormalities 47 Karlseder 47 electrophysiologic 47 HMGCR 47 bone morphogenetic proteins BMPs 47 causative 47 biomolecular interactions 47 genetic determinism 47 CPEB 47 Maxwell equations 47 methodological approaches 47 oxidases 47 prokaryotic 47 ARF1 47 Myb 47 mammalian 47 transgenic mice expressing 47 signaling pathways 47 MC4R 47 mitogenic 47 replicative 47 genomic variation 47 nematode Caenorhabditis elegans 47 neural progenitor 47 morphometry 47 murine models 47 proteomic analysis 47 ERK1 2 47 histopathological 47 pharmacologic approaches 47 primary cilium 47 nongenetic 47 conceptualizations 47 p#/CBP 47 iPSC 47 medial frontal cortex 47 baroreceptor 47 metabolomic profiling 47 mammalian fatty acid 47 immunological responses 47 objectivism 47 EGFR signaling 47 macromolecular complexes 47 chromatin structure 47 QbD 47 subcellular 47 transcriptional coactivator 47 Marxian 47 electrophilic 47 synaptic function 47 cognition 47 nephron 47 unfalsifiable 47 receptor subtypes 47 congenital muscular dystrophies 47 #T# L1 47 IGFBP2 47 Mendelian genetics 47 dedifferentiation 47 plausible hypothesis 47 etiology 47 noetic 47 empirically testable 47 physico chemical 47 ERK signaling 47 selfing populations 47 Androgen receptor 47 PECAM 1 47 malignant transformation 47 physiologic mechanisms 47 Darwinian 47 metabolic pathway 47 synaptic proteins 47 neocortical 47 cellular prion protein 47 lipid synthesis 47 enzymology 47 Freud theories 47 adipocyte 47 synthesis 47 oligomeric 47 genetic determinants 47 Hypothalamic 47 psychodynamic 47 visuomotor 47 biominerals 47 lysosomal 47 metaanalysis 47 epigenetic modification 47 incompletely understood 47 perilipin 47 synthetic lethality 47 orexin receptors 47 astrocytic 47 photochemical processes 47 etiological 47 redox active 47 epistatic 47 axonal degeneration 47 FMRP 47 biomarker identification 47 ultrastructure 47 neurohormonal 47 neurotransmitter receptor 47 alpha7 NNR 47 microglial 47 bioenergetic 47 BMAL1 47 posteriori 47 processive 46 focal adhesions 46 airway remodeling 46 antibody mediated 46 surrogate markers 46 FGF signaling 46 metabolic enzymes 46 homochirality 46 splice variant 46 isoprenoid 46 anthropocentric 46 functionalism 46 hypoxia inducible 46 tumor microenvironment 46 sRNA 46 tyrosine phosphatase 46 evolutionarily conserved 46 mass spectrometric 46 eigenvalue 46 MT1 MMP 46 noncoding RNA 46 hypothalamic pituitary adrenal HPA 46 potent inhibitors 46 perturbation theory 46 TGF beta signaling 46 neurites 46 incretin 46 cholesterol homeostasis 46 biochemical pathways 46 p# MAPK 46 histone deacetylases 46 nociceptive 46 mutagenesis 46 homologues 46 viral kinetics 46 thermoregulatory 46 amyloid deposition 46 Ago2 46 glomerular 46 neuronal circuits 46 P gp 46 gene inactivation 46 epistemologically 46 HtrA2 46 genomic alterations 46 trans splicing 46 GABAergic 46 transdifferentiation 46 Dysregulation 46 act synergistically 46 vesicle fusion 46 chloride channels 46 homologies 46 organogenesis 46 falsifiability 46 estrogen metabolism 46 myocardial dysfunction 46 protein misfolding 46 nonequilibrium 46 experimentally validated 46 mesoscopic 46 computational methods 46 neuro endocrine 46 vasopressin receptor 46 thermodynamic stability 46 electron microscopic 46 TRPV4 46 diagrammatic 46 Mendelian 46 bipedal locomotion 46 colon carcinogenesis 46 FGF2 46 ontogenetic 46 pharmacologic intervention 46 plasma proteome 46 contrastive 46 immunomodulation 46 MALAT1 46 biochemical processes 46 PI3K AKT 46 protein folding 46 genetic polymorphism 46 amyloid plaque formation 46 mirror neuron 46 psychologic 46 CENP E 46 Hegelian 46 homeostasis 46 muscle contractility 46 GLP 1R 46 TGFβ 46 statistical correlations 46 neural crest 46 androgen signaling 46 theoretical underpinnings 46 rhythmicity 46 HMG CoA reductase 46 ribozyme 46 Wnt proteins 46 metazoan 46 phagocytosis 46 inbred strains 46 jasmonate 46 IntroductionThe 46 photoreceptor cell 46 habenula 46 biological molecules 46 endocytic 46 neurosteroid 46 glutamate signaling 46 P cadherin 46 cellular senescence 46 immunological synapse 46 connexin# 46 abstract 46 computational fluid 46 biological macromolecules 46 glutamate receptors 46 striatal 46 cleavage furrow 46 tissue homeostasis 46 paralogs 46 epigenetic inheritance 46 bacterial genomes 46 proteolysis 46 reductionism 46 deontological 46 Proteostasis Network 46 Hh 46 myelination disorders 46 amino acid substitutions 46 tumor suppressor PTEN 46 adipokines 46 FoxO1 46 serotonin dopamine 46 neuroimaging studies 46 carcinogenesis 46 oncogene addiction 46 neural pathway 46 mitochondrial oxidative 46 S1P 46 pRb 46 atherosclerosis regression 46 epithelial mesenchymal transition 46 therapeutic modality 46 parkinsonian 46 oncogenesis 46 aneuploid 46 combinatorial libraries 46 MCH neurons 46 cholinergic 46 Xenopus embryos 46 ubiquitin ligase 46 dystrophic 46 xenobiotic 46 convergent validity 46 ERK pathway 46 PI3K signaling 46 bacterial ribosome 46 ischemia induced 46 neuroinflammation 46 untestable 46 myosin VI 46 Hayekian 46 discursive 46 cotransporter 46 signaling cascade 46 eIF4E 46 dysbindin 46 neurodegeneration 46 pseudo scientific 46 invariants 46 operant conditioning 46 multiscale 46 post structuralism 46 equilibria 46 proton pump 46 toxicogenomics 46 mGluR5 inhibition 46 priori 46 netrin 1 46 Leeuwenburgh 46 hormesis 46 cellular pathways 46 metabolic 46 mammalian embryo 46 non pharmacological interventions 46 Nod1 46 hypotheses 46 chemical reactivity 46 JAK STAT 46 PDZ domains 46 Pol IV 46 hedgehog pathway 46 pathogenetic 46 Fc receptor 46 Sejnowski 46 essentialist 46 myogenesis 46 perseverative 46 theoretical frameworks 46 phylogeographic 46 economism 46 enzyme kinetics 46 isoenzymes 46 Gadamer 46 typological 46 ADME Tox 46 NKG2D 46 environmental toxicants 46 reductionists 46 podocytes 46 micro RNAs 46 anthropic 46 methodologically 46 transgenerational 46 polyamine 46 exocytosis 46 spatial cognition 46 polyploid 46 μ opioid receptor 46 GABAA receptors 46 neuronal function 46 subcellular compartments 46 HIF 1α 46 JNK1 46 chromatin remodeling 46 mRNA decay 46 Induced pluripotent stem cells 46 Th2 responses 46 peptoid 46 mutant huntingtin protein 46 SMAD4 46 neurotransmission 46 E#F# 46 boron neutron capture 46 iPS derived 45 DISC1 45 prokaryote 45 cardiac fibrosis 45 calcineurin 45 unnatural amino acids 45 posttranslational modifications 45 GRK2 45 putative biomarkers 45 XBP 1 45 extracellular proteins 45 selective inhibition 45 ribosomal subunits 45 Evolutionary biologists 45 LRRK2 mutation 45 metazoans 45 FSH receptor 45 cholesterol metabolism 45 membrane permeability 45 pharmacodynamic parameters 45 Freudian psychoanalysis 45 beta adrenergic receptors 45 pharmacoeconomic 45 biobehavioral 45 homology modeling 45 C1q 45 eukaryotic cells 45 antidepressive 45 Notch signaling pathway 45 neuronal stem cells 45 inductive reasoning 45 transgenic mouse model 45 XBP 1s 45 neuropathologic 45 functionalist 45 mirror neuron system 45 prostate carcinogenesis 45 intracellular 45 Big Bang cosmology 45 positivist 45 Luthey Schulten 45 structuralist 45 humoral immunity 45 glycolipids 45 phylogenies 45 NR2B subunit 45 T lymphocyte 45 urate oxidase 45 alternative splicing 45 dystroglycan 45 neural plasticity 45 oscillatory behavior 45 transcriptomes 45 proteomic 45 molecular pathway 45 silico prediction 45 adenosine receptors 45 #BP# 45 excitotoxicity 45 urocortin 45 occludin 45 philosophic 45 viral pathogenesis 45 Kraepelin 45 mitochondrial defects 45 hierarchical structures 45 economistic 45 histone modification 45 anorectic 45 insulin signaling pathways 45 Rab5 45 morphologic 45 gastric mucosa 45 effector function 45 quasispecies 45 S. pombe 45 transcriptional activation 45 proteolytic 45 RNAi mediated 45 Enlightenment rationalism 45 supramolecular 45 microsaccades 45 sensory neuron 45 macromolecule 45 Dr. Rafii 45 epiphenomena 45 cortical circuits 45 fruitflies 45 antitumor effect 45 materialist 45 residual confounding 45 gene expression 45 hyperuricaemia 45 fatty acid metabolism 45 nonpharmacologic 45 serum biomarkers 45 x ray crystallographic 45 Wnt signaling 45 lymphoid cells 45 heavy fermion 45 MAPK pathway 45 epigenetic alterations 45 dialectic 45 protein ligand 45 neuroinflammatory 45 antiapoptotic 45 somatostatin 45 bounded rationality 45 S#A# [002] 45 myofibroblast 45 neuroactive 45 c Myb 45 Weberian 45 dimensional nanostructures 45 sd rxRNA 45 sociobiology 45 pharmaco 45 transcriptionally 45 cis regulatory 45 zebrafish larvae 45 nitrotyrosine 45 mechanotransduction 45 mammalian circadian clock 45 mechanisms 45 gastrulation 45 intracellular bacteria 45 psychoneuroimmunology 45 ontological 45 IVIVC 45 glucocorticoid receptors 45 underlie 45 tumorigenesis 45 unmeasured confounders 45 Eukaryotes 45 TRPV1 receptor 45 depersonalised 45 kinase assay 45 plasma lipid 45 cytochrome P# inhibition 45 PPARg 45 stochastic simulation 45 paxillin 45 #beta HSD1 45 Signal transduction 45 ADME properties 45 inferential 45 spectrin 45 hierarchically organized 45 metabolizing enzymes 45 potentiation 45 CETP inhibition 45 Jhdm2a 45 Smad3 45 kinesin motor 45 genomic proteomic 45 genome annotation 45 β catenin 45 assimilative 45 receptor subunits 45 metacognition 45 consequentialist 45 sequence homology 45 dynamical systems 45 electron electron 45 hierarchic 45 baroreceptor reflex 45 interleukin 1beta 45 spatio 45 omics 45 myosins 45 immunomodulatory effects 45 epigenetic markers 45 molecular biomarkers 45 methodological individualism 45 PKC alpha 45 ERK2 45 gene duplications 45 TFIIH 45 5 hydroxymethylcytosine 45 catabolism 45 scientistic 45 biological plausibility 45 genotype phenotype 45 neuronal synapses 45 receptor activation 45 frameshift 45 hypothalamic 45 V2 receptor 45 biosynthetic pathway 45 osmotic stress 45 Fig. 1D 45 ideational 45 Notch signaling 45 anthropic principle