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(Click for frequent words.) 78 β catenin 77 ERK1 2 77 autophagic 76 proteolysis 75 mitogen activated protein kinase 75 catenin 74 Phosphorylation 74 renal fibrosis 74 ERK signaling 74 secretory pathway 74 receptor subtype 73 CXCL# 73 androgen receptor AR 73 cystic fibrosis transmembrane conductance 73 TGF ß 73 aberrantly activated 73 proto oncogene 73 CD1d 72 ENaC 72 MAP kinase 72 vacuolar 72 eNOS 72 transcriptional activation 72 constitutively expressed 72 synaptogenesis 72 PKC isoforms 72 pRb 72 mediated inhibition 72 transmembrane protein 72 adipocyte 72 p# activation 72 basolateral 72 Rap1 72 lymphoid cells 72 keratinocyte 72 selective inhibition 72 acetylcholine receptor 72 microglial activation 72 IL 1ß 72 alveolar epithelial cells 72 serine protease 72 reductase 72 TNFa 72 4E BP1 72 HIF 1α 71 STAT1 71 cytokine receptor 71 VEGF receptor 71 upregulates 71 Macrophage 71 extracellular signal 71 Rab5 71 phosphorylates 71 ß catenin 71 Overexpression 71 acinar 71 hypoxia inducible factor 71 HepG2 cells 71 caveolin 71 matrix metalloproteinases 71 induces apoptosis 71 Notch signaling 71 protein kinase C 71 peroxisome 71 astrocytic 71 myofibroblast 71 phosphatidylinositol 3 71 chemokine receptor 71 prostaglandin synthesis 71 p# MAPK 71 potent inhibitors 71 muscarinic receptors 71 plasminogen 71 metabolic enzymes 71 tyrosine phosphorylation 71 transcriptional repressor 71 phosphorylate 71 Upregulation 71 podocyte 71 enzymatic activity 71 Smad3 71 Htt 71 MEK1 71 NFkB 71 chondrocyte 71 RAS RAF MEK 71 phagocytosis 71 IL 1β 71 serine threonine kinase 71 neuronal dysfunction 71 deacetylation 71 intestinal epithelium 71 induced apoptosis 71 NKG2D 70 acyl CoA 70 Notch1 70 activin 70 aminopeptidase 70 cell adhesion molecule 70 microglial 70 isoenzyme 70 apoptotic pathway 70 monomeric 70 constitutively active 70 Protein Kinase C 70 melanocyte 70 E#F# 70 ERK pathway 70 cytoplasmic domain 70 peroxisomal 70 epithelia 70 potent inhibition 70 PDGFR 70 TGF b 70 erythrocytes 70 cytokine signaling 70 p#NTR 70 cAMP signaling 70 Vps# 70 BMP signaling 70 FGFR3 70 TGF beta1 70 synaptic vesicle 70 oxidase 70 ubiquitylation 70 HIF 1alpha 70 GAPDH 70 T#M 70 NF kappaB 70 oxidative phosphorylation 70 lysosome 70 apical membrane 70 lymphoid 70 vascular endothelial cells 70 proteolytic cleavage 70 secretase 70 cysteine protease 70 MEFs 70 neurite outgrowth 70 Akt activation 70 Treg cells 70 pro angiogenic 70 effector function 70 dephosphorylation 70 beta amyloid peptide 70 mTOR signaling 70 glomerular 70 TGF β 70 c MET 70 TNFalpha 70 potent inducer 70 iNOS 70 Cdc7 70 LRAT 70 homodimers 70 lysosomal enzyme 70 endosomal 70 glycosylated 70 transgene expression 70 CEACAM1 70 Hedgehog signaling 70 pharmacological inhibition 70 PC# cells 70 dimerization 70 proteoglycan 70 TGF ß1 70 adhesion molecule 69 serine threonine 69 mediated apoptosis 69 caveolin 1 69 Nedd4 69 Flt3 69 IKKß 69 TGF alpha 69 tumor suppressor protein 69 autocrine 69 Fas ligand 69 cholinergic neurons 69 podocytes 69 retinoic acid receptor 69 PDE1 69 antiapoptotic 69 E3 ubiquitin ligase 69 Pten 69 neuronal differentiation 69 cytosolic 69 receptor mediated endocytosis 69 transmembrane receptor 69 renal tubular 69 amyloid peptide 69 secretory 69 endonuclease 69 vimentin 69 glial 69 heme oxygenase 69 VE cadherin 69 leukemic cell 69 hypothalamic pituitary 69 CCR7 69 LRP6 69 isoenzymes 69 cardiac myocytes 69 nitric oxide synthase 69 TGFβ 69 ubiquitination 69 Hypoxia Inducible Factor 69 protein tyrosine phosphatase 69 receptor tyrosine kinase 69 phosphate S1P 69 glial derived neurotrophic 69 phosphoprotein 69 oligomerization 69 synthetase 69 p# mitogen activated 69 ERK phosphorylation 69 H#K# methylation 69 thrombin receptor 69 glioma cells 69 adenylate cyclase 69 glutamate receptors 69 null mice 69 Dysregulation 69 CD#b 69 ectopic expression 69 NFκB 69 FasL 69 proteolytic 69 Clusterin 69 excitotoxic 69 colony stimulating factor 69 sulfatase 69 caspase activation 69 #HT#A 69 proximal tubule 69 MMP2 69 Transgenic Mice 69 nucleolar 69 SMN1 69 mitochondrial respiration 69 LPS induced 69 paxillin 69 Smoothened 69 apoE 69 Oxidative 69 p#Kip# 69 selectively inhibited 69 prostanoid 69 virulence genes 69 potently inhibited 69 proapoptotic 69 UCP2 69 MAPK pathway 69 perivascular 69 1alpha 69 hematopoietic progenitors 69 β1 69 IFN gamma 69 cellular pathways 68 glutamatergic 68 Notch receptor 68 cell motility 68 regulated kinase ERK 68 microvascular endothelial cells 68 tyrosine kinase receptor 68 AT1R 68 intestinal mucosa 68 ubiquitin ligase 68 Epithelial 68 isotypes 68 polycystin 68 acetyl CoA 68 neuromuscular junction 68 lysates 68 syntaxin 68 Chemokine Receptor 68 hydrolases 68 tumorigenicity 68 cytoprotective 68 serine proteases 68 dysregulated 68 pDC 68 axonal degeneration 68 transactivation 68 tau protein 68 lymphangiogenesis 68 hydroxylase 68 cathepsin B 68 LDL receptor 68 murine 68 Ca2 + 68 effector functions 68 JNK1 68 cytolytic 68 leptin receptor 68 NKT cell 68 Rac1 68 ADAMTS# 68 γ secretase 68 sphingolipid 68 leukocyte recruitment 68 FUS1 68 factor HGF 68 downregulates 68 downregulation 68 RhoA 68 actin cytoskeleton 68 fatty acid oxidation 68 cathepsins 68 alveolar macrophages 68 oncoprotein 68 UCP1 68 fibrogenesis 68 Th1 cells 68 enzyme cytochrome 68 H#K# [002] 68 chemokine 68 myeloid 68 endothelial nitric oxide synthase 68 transferase 68 Oncogenic 68 anterior pituitary 68 DGAT1 68 effector memory 68 DNMT1 68 kinase pathway 68 inducible nitric oxide synthase 68 JAK2 enzyme 68 protein biosynthesis 68 IRAK1 68 gut mucosa 68 intracellular protein 68 hepatocyte growth 68 endogenous ligands 68 FOXO3a 68 cellular senescence 68 HIF 1a 68 phosphatases 68 EGFR signaling 68 β amyloid 68 adipogenesis 68 #ß 68 uPA 68 glycolipids 68 threonine 68 TORC2 68 pleiotropic 68 myofibroblasts 68 hepatocyte 68 biogenesis 68 receptor mediated 68 lymphocyte activation 68 NF κB 68 NADPH oxidase 68 M1 muscarinic 68 MT1 MMP 68 NKT cells 68 neuronal migration 68 transcriptional regulation 68 miR #a [002] 68 PI3K Akt 68 PECAM 1 68 thymidylate synthase TS 68 endocytosis 68 Mcl 1 68 c myc 68 intracellularly 68 PGC 1α 68 ATPase 68 isoform 68 cytosol 68 toxic beta amyloid 68 outer membrane proteins 68 ERK activation 68 osteoblast 68 erythropoiesis 68 proteinase 68 Abeta# 68 lymphoid organs 68 mineralocorticoid 68 Akt signaling 68 pDCs 68 stem cell pluripotency 68 calcium homeostasis 68 hyperactivation 68 endocytic 68 mitotic progression 68 B lymphocytes 68 mutant huntingtin protein 68 mutant huntingtin 68 circadian clock genes 68 SIRT2 68 β2 68 apoptotic 68 motor neuron degeneration 68 Ser# 68 hydroxylation 68 tropomyosin 68 glucose transporter 68 striatal neurons 68 Skp2 68 vWF 68 histone acetylation 68 coronary vasodilation 68 SMAD4 67 CCL# 67 NF KB 67 FGF2 67 bile acid 67 Aß 67 epithelial barrier 67 N methyl 67 cell lysis 67 glucocorticoid receptor 67 mitogenic 67 COL#A# 67 SCD1 67 GPR# [002] 67 ubiquitinated 67 cell signaling pathway 67 EGF receptor 67 IL 1beta 67 transthyretin 67 ß1 67 Wnt signaling pathway 67 LKB1 67 nucleoli 67 posttranslational modification 67 peptidase 67 leukocyte adhesion 67 Microtubule 67 von Willebrand factor 67 constitutively 67 costimulatory 67 phosphorylated tau 67 coexpression 67 cyclins 67 PTPN# 67 mTORC1 67 tau phosphorylation 67 gluconeogenesis 67 substrate specificity 67 guanosine 67 heterodimers 67 GluR1 67 dopaminergic neurons 67 polyamine 67 inverse agonist 67 Id1 67 focal adhesions 67 intracellular signaling 67 cyclin dependent kinase inhibitor 67 GABAergic interneurons 67 E3 ligase 67 p# pathway 67 cardiac fibroblasts 67 MAPK 67 peroxynitrite 67 noradrenergic 67 Src kinase 67 suppressor cells 67 E cadherin 67 hydrolase 67 Drp1 67 mutated protein 67 NFAT 67 toxic amyloid beta 67 Purkinje cell 67 ouabain 67 CFTR protein 67 mice lacking 67 metalloproteinase 67 nAChR 67 PTP 1B 67 siRNA mediated 67 OGG1 67 Cytochrome 67 PIP3 67 receptor activation 67 N Myc 67 phosphatase 67 proteosome 67 V#F mutation 67 hepatic glucose production 67 adrenergic receptors 67 PP2A 67 thyroid hormone receptor 67 antiproliferative activity 67 lipoxygenase 67 transduced 67 pathophysiological effects 67 decarboxylase 67 triphosphate 67 Wnt pathway 67 β cells 67 ribonuclease 67 PPARg 67 TRPV3 67 monocytes macrophages 67 histone deacetylases 67 LNCaP cells 67 prostate epithelial cells 67 telomere maintenance 67 Th2 67 induce apoptosis 67 CD4 + T lymphocytes 67 Th1 67 GLUT1 67 presynaptic 67 miR# 67 receptor subtypes 67 cellular metabolism 67 upregulation 67 67 Leydig cells 67 cyclic nucleotide 67 replicase 67 immunostimulatory 67 adipogenic 67 Secretase 67 chloride channels 67 thyrotropin 67 osteoclast activity 67 caveolae 67 synovial cells 67 cyclic adenosine monophosphate cAMP 67 chaperone proteins 67 annexin V 67 proteolytic processing 67 gastric mucosa 67 leukemic stem cells 67 overactivation 67 lung epithelium 67 Wnt beta catenin 67 PTHrP 67 NAD + 67 fibrotic disease 67 estrogen receptor beta 67 PPARγ 67 huntingtin gene 67 F actin 67 Activating mutations 67 microtubule dynamics 67 erythroid 67 Vpr 67 LIS1 67 selenoproteins 67 Leydig cell 67 Extracellular 67 Histone 67 PLA2 67 mitochondrial biogenesis 67 superoxide dismutase 67 costimulation 67 IFN γ 67 downregulated 67 tumorigenesis 67 tubulin 67 hematopoietic cells 67 1α 67 elastase 67 neurotrophin 67 murine model 67 Rho GTPase 67 upregulating 67 isoleucine 67 amyloid β 67 cyclin dependent kinase 67 matrix metalloproteinase 67 monocyte 67 XBP1 67 Ras pathway 67 missense mutations 67 NF kB pathway 67 Eg5 67 subcellular compartments 67 FOXO1 67 c Src 67 SUMOylation 67 protein tyrosine kinase 67 mesenchymal cell 67 Hh pathway 67 exocytosis 67 uPAR 67 heme oxygenase 1 67 histone H3 67 cholesterol homeostasis 67 prostaglandin E 67 glutamate receptor 67 intracellular 67 mitogen activated protein kinases 67 ncRNA 67 glycosyltransferase 67 oncoproteins 67 phagocyte 67 NS5A 67 activate p# 67 Foxp3 67 telomere dysfunction 67 SIRT1 gene 67 KLF4 66 calpain 66 Aβ 66 plastid 66 glycoprotein 66 CCR9 66 anti apoptotic 66 Jhdm2a 66 defective CFTR protein 66 adrenal cortex 66 protein CETP 66 rRNA 66 downregulate 66 HDAC6 66 receptor gamma 66 DMT1 66 TrkB 66 galectin 66 neurotrophic factor 66 osteogenic differentiation 66 BMAL1 66 glycosaminoglycans 66 acetylcholinesterase 66 transgenic mouse model 66 receptor subunit 66 PAR1 66 IgG1 66 Androgen 66 XL# inhibits 66 lung epithelial cells 66 PKC inhibitor 66 syngeneic 66 paracrine 66 ACh 66 lyase 66 CB1 receptors 66 goblet cells 66 proteolytic enzymes 66 thymocytes 66 K + ATPase 66 anti inflammatory cytokine 66 coreceptor 66 tenascin 66 MTHFR 66 RANK Ligand 66 cyclic AMP cAMP 66 proinflammatory 66 cytidine 66 motoneurons 66 evolutionarily conserved 66 nicotinic acetylcholine receptor 66 CD#L 66 Factor VEGF 66 Interferon gamma 66 EZH2 66 Amino acid 66 matrix metalloproteinases MMPs 66 malignant transformation 66 glucocorticoid receptors 66 AMPA receptor 66 intestinal epithelial cells 66 E cadherin expression 66 proteasomes 66 SGLT2 66 Cyclin D1 66 Wnt signaling 66 TGF β1 66 FGFR1 66 HIF1 alpha 66 erythrocyte 66 intercellular adhesion molecule 66 phosphorylated 66 TNFR 66 PTP1B 66 oligomeric 66 HSP# 66 chemokine receptors 66 TGFß 66 lysine residues 66 RANTES 66 5 HT1A 66 MEK ERK 66 myogenesis 66 PARP1 66 excess glutamate 66 catabolism 66 SOD1 protein 66 endothelial activation 66 Cdc# 66 CENP E 66 Dystrophin 66 TRPV4 66 phosphorylase 66 FLT3 66 steroidogenic 66 apoptotic pathways 66 cyclin B1 66 neovascularization 66 regulated kinase 66 protein p# 66 carboxyl terminal 66 frataxin 66 LPA1 receptor 66 AhR 66 nitric oxide synthase NOS 66 mediated phosphorylation 66 monocyte derived 66 Abeta peptide 66 prolyl 66 p# alpha [001] 66 SGK1 66 antitumor efficacy 66 neural cells 66 coagulation cascade 66 PGE2 66 phosphatidylinositol 66 NR2B 66 immunoreactivity 66 CD# receptor 66 interferon γ 66 neurotrophins 66 metalloprotease 66 peroxisomes 66 serotonin reuptake 66 dioxygenase 66 STAT3 66 cotransporter 66 JAK STAT signaling 66 hematopoiesis 66 TAp# 66 prostaglandin E2 PGE2 66 agonist induced 66 protein tyrosine phosphatases 66 Angiotensin II 66 oncogenic transformation 66 C1q 66 osteoclast formation 66 VEGF expression 66 β cell 66 colon carcinoma 66 PDGF receptor 66 Endothelial 66 c myc gene 66 constitutively activated 66 MyD# 66 inflammatory cytokine 66 TNF α 66 TRAF6 66 miR #a [001] 66 multinucleated 66 Klf4 66 mevalonate 66 thymic 66 USP# 66 leukocyte 66 intracellular proteins 66 NF kappaB activation 66 leptin signaling 66 gliosis 66 primary cilia 66 P#X# 66 eIF4E 66 muscle contractility 66 cofactor 66 mRNA expression 66 activating mutations 66 acetylcholine receptors 66 overexpressing 66 neurotrophic 66 transfected cells 66 genomic instability 66 tumor vasculature 66 secreted protein 66 hypothalamic pituitary adrenal axis 66 plasmin 66 somatostatin 66 kinase domain 66 neoplastic 66 mutant protein 66 synaptic transmission 66 lymphotoxin 66 intracellular pH 66 oligodendroglial progenitor cells 66 CD4 + CD# 66 protein phosphatase 66 oncogenic 66 immunomodulation 66 myeloma cells 66 oxysterols 66 nephron 66 leukemic cells 66 regulates gene expression 66 neurofilament 66 GPI anchored 66 oxidative DNA 66 RANK ligand 66 neuronal nitric oxide synthase 66 Cadherin 66 mitochondrial enzyme 66 cyclin dependent kinases CDKs 66 Monocyte 66 axon guidance 66 WNK1 66 Tubulin 66 6S RNA 66 NO synthase 66 metalloproteinases 66 GABAA receptors 66 downstream effectors 66 EBNA1 66 T lymphocyte 66 PON1 66 NR2B subunit 66 proinflammatory cytokines 66 EphA2 66 presenilin 66 annexin 66 endoplasmic reticulum 66 palytoxin 66 glioblastoma cells 66 thymocyte 66 Cx# [001] 66 alpha subunit 66 cysteines 66 cyclooxygenase 2 66 chaperone protein 66 lytic 66 transmembrane domains 66 pyrimidine 66 c MYC 66 NR#A# 66 secretory proteins 66 p# tumor suppressor 66 CD8 + 66 Fibroblast Growth Factor Receptor 66 ErbB3 66 Integrin 66 Kupffer cells 66 cardiolipin 66 glucokinase 65 neuronal signaling 65 IFN g 65 Factor Receptor 65 GABAergic neurons 65 acinar cells 65 SH2 domain 65 midgut 65 lymphoid tissue 65 mononuclear 65 ERK1 65 receptor signaling 65 metalloproteases 65 acyltransferase 65 thromboxane A2 65 VEGFR1 65 phospholipase 65 acetyltransferase 65 cytoskeletal 65 clonogenic 65 haematopoietic 65 excitatory neurotransmitter glutamate 65 cyclin 65 interleukins 65 IL #p# 65 skeletal muscle cells 65 TTR gene 65 mutant enzymes 65 splenocytes 65 globin gene 65 genes encoding 65 PTEN gene 65 degrading enzyme 65 ^ sup #m 65 RANKL 65 nNOS 65 epithelial cell 65 FKBP# 65 CTGF 65 arginase 65 breast epithelial cells 65 Sgk1 65 transgenic mouse models 65 dopaminergic 65 ciliated 65 NADPH 65 experimental autoimmune encephalomyelitis 65 cell adhesion molecules 65 Hh signaling 65 IGF1R 65 beta subunit 65 PTH secretion 65 metaphase 65 JAK#/JAK# 65 bone morphogenetic protein 65 innate immune responses 65 HDAC enzymes 65 ectodomain 65 phospholipid 65 beta catenin protein 65 BRAF protein 65 immunomodulatory effects 65 N cadherin 65 B lymphocyte 65 5 HT4 receptor 65 palmitoylation 65 spermidine 65 pro inflammatory cytokine 65 AChE 65 interleukin IL -# 65 P#X# receptor 65 C5aR 65 factor GDNF 65 vascular endothelial 65 phospho 65 induced neuronal 65 CCR2 65 capillary endothelial cells 65 integrin receptors 65 transcriptional regulator 65 MDSCs 65 receptor alpha 65 aryl hydrocarbon receptor 65 polypeptides 65 cytoplasmic 65 xenograft tumors 65 peptide hormone 65 CaM 65 N acetyl 65 methyltransferase 65 TrkA 65 potent inhibitor 65 adrenoceptor 65 splice variants 65 G6PD 65 Peyer patches 65 TSC1 65 phagocytic 65 DNA adducts 65 muscarinic 65 PKM2 65 myocardial tissue 65 glutamyl 65 pyrimidines 65 casein kinase 65 transgenic mice expressing 65 NMDA receptor 65 muscarinic receptor 65 adenosine receptor 65 DLC1 65 proximal tubular 65 PIP2 65 signal transduction 65 lymphocyte 65 Glucocorticoid 65 Dpp 65 senescent cells 65 cells transfected 65 cytotoxic effects 65 Hcrt 65 SMN protein 65 plasmacytoid dendritic cells 65 mitogen 65 Protein kinase 65 FGFR4 65 tyrosine kinase 65 oligodendrocyte 65 PU.1 65 beta globin gene 65 proteinases 65 BCL2 65 cofilin 65 extracellular 65 JAK STAT 65 synthases 65 PI3 kinase 65 oxidative enzymes 65 cyclooxygenase 65 CCR1 65 calcineurin 65 granzyme B 65 neuronal synapses 65 steroidogenesis 65 KLF2 65 HPA axis 65 COX2 65 dimeric 65 cyclin E 65 hepatocellular 65 Rho GTPases 65 PAK1 65 Rab# 65 TSP1 65 nAChRs 65 mRNA translation 65 Skeletal muscle 65 cytoplasmic tail 65 Aldosterone 65 Galectin 65 tumor angiogenesis 65 SIRT6