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(Click for frequent words.) 79 induce apoptosis 77 ERK1 2 75 mitogen activated protein kinase 75 selective inhibition 75 c MYC 75 phosphatidylinositol 3 75 potently inhibited 75 triggers apoptosis 75 MAP kinase 74 poly ADP ribose polymerase 74 upregulates 74 downregulates 74 induced apoptosis 74 cyclin dependent kinase inhibitor 73 catenin 73 FGFR3 73 antiproliferative activity 73 potent inhibitor 73 VEGF receptor 73 hypoxia inducible factor 73 mitogenic 73 phosphorylates 73 E#F# 73 pro apoptotic 73 mediated apoptosis 73 Overexpression 73 potent inducer 73 potently inhibits 73 Upregulation 72 mediated inhibition 72 Rap1 72 regulated kinase 72 NF kappaB activation 72 receptor tyrosine kinase 72 inhibits tumor 72 serine threonine 72 tyrosine kinase receptor 72 HepG2 cells 72 MMP2 72 cell adhesion molecule 72 potently inhibit 72 pRb 72 selectively inhibited 72 constitutively active 72 antiapoptotic 72 prostaglandin E2 PGE2 72 phosphate S1P 72 extracellular signal 72 sphingosine 1 71 androgen receptor AR 71 selectively inhibits 71 VEGFR2 71 kinase pathway 71 xenograft model 71 selectively binds 71 mouse xenograft models 71 MEK1 71 E3 ligase 71 irreversible inhibitor 71 lysosomal 71 autocrine 71 cisplatin resistant 71 HIF 1alpha 71 selective inhibitor 71 alpha folate receptor 71 deacetylation 71 proto oncogene 71 Oncogenic 71 Factor VEGF 71 BCL2 71 SIRT2 71 monocyte chemotactic protein 71 MAPK pathway 71 ectopic expression 71 proapoptotic 71 xenograft models 71 Akt activation 71 constitutively activated 71 Macrophage 71 HIF 1a 71 protein tyrosine phosphatase 1B 71 TGF ß 71 Factor Receptor 71 ERK signaling 71 vascular endothelial cells 71 IL 1β 71 EGF receptor 70 serine protease 70 potent inhibition 70 LRP6 70 uPAR 70 aberrantly activated 70 colorectal carcinoma 70 iNOS 70 carcinoembryonic antigen 70 DNA intercalator 70 PTHrP 70 leukocyte adhesion 70 glycogen synthase kinase 70 Protein Kinase C 70 autophagic 70 oncoprotein 70 selective agonist 70 adipogenic 70 IGF1R 70 TRAIL receptors 70 IL 1ß 70 polyamine 70 ß catenin 70 Selective inhibition 70 apoptotic pathway 70 MEK ERK 70 EGFR signaling 70 cyclooxygenase COX 70 cyclin dependent kinases CDKs 70 NKG2D 70 Cytotoxic T 70 phosphorylate 70 1α 70 mitogen activated protein 70 thymidylate synthase TS 70 ERalpha 70 transactivation 70 HCV protease 70 monocytes macrophages 70 vascular endothelial 70 β catenin 70 TGF beta1 70 FGFR4 70 activin 70 XL# inhibits 70 chemokine receptor 70 ERK pathway 70 FasL 70 mTOR mammalian target 70 LNCaP 70 mediated phosphorylation 70 p# MAPK 70 Tie2 70 GLI1 70 Clusterin 70 inducible nitric oxide synthase 70 vimentin 70 transmembrane receptor 70 constitutively expressed 70 LPS induced 69 cyclin dependent kinase 69 Flt3 69 mRNA expression 69 phosphoprotein 69 5 HT2A serotonin 69 phosphatidylinositol 69 SGLT2 69 PDGFR 69 CCR9 69 Eg5 69 factor HGF 69 IGF IR 69 WT1 69 NKX#.# 69 CCR2 69 IL #p# 69 syngeneic 69 CTGF 69 downregulated 69 cystic fibrosis transmembrane conductance 69 STAT1 69 serine threonine kinase 69 PI3K Akt 69 HepG2 69 ERBB2 69 EGFR HER2 69 eNOS 69 E selectin 69 p#NTR 69 ErbB 69 cyclic AMP cAMP 69 IFN gamma 69 c MET 69 lipoxygenase 69 transduced 69 GATA3 69 pathophysiological effects 69 upregulation 69 overexpressing 69 Kinase Inhibitor 69 cytokine signaling 69 Phosphorylation 69 potent suppressor 69 adrenoceptor 69 heme oxygenase 69 dephosphorylation 69 heme oxygenase 1 69 PI3 kinase 69 thyroid hormone receptor 69 apoptotic cell 69 caveolin 1 69 reversible inhibitor 69 HER2 HER2 69 Akt signaling 69 aurora kinase 69 NFkappaB 69 LNCaP cells 69 nitric oxide synthase 69 intratumoral injection 69 TRAIL R2 69 adhesion molecule 69 rhIL 7 69 upregulate 69 thrombin receptor 69 extracellular domain 69 inhibitory effects 69 cyclooxygenase 69 selectively inhibit 69 interleukin IL -# 69 Hypoxia Inducible Factor 69 Galectin 69 pan HDAC inhibitor 69 1beta 69 M1 muscarinic 69 immunostimulatory 69 cyclic adenosine monophosphate cAMP 69 cyclin E 69 cytochrome P 69 CagA 69 microglial activation 69 p# mitogen activated 69 TNF α 69 JAK2 69 NFκB 69 cytoplasmic domain 69 TGF alpha 69 antisense inhibition 69 CDK inhibitor 69 accumulate preferentially 69 telomerase reverse transcriptase 69 Pathway Inhibitor 69 RAS RAF MEK 69 selective antagonist 69 antitumor 69 constitutive activation 69 receptor CXCR4 69 anti proliferative 69 PI3K/mTOR 68 antiproliferative effects 68 Protein Kinase 68 murine model 68 TNFalpha 68 colon carcinoma 68 induces apoptosis programmed 68 mineralocorticoid receptor 68 targeting CD# 68 Smad3 68 MMP9 68 effector function 68 downstream effector 68 CD# CD# 68 IL 1beta 68 TIMP 68 fibrogenesis 68 Tumor necrosis factor 68 CD#L 68 p# subunit 68 overexpression 68 upregulating 68 Immunohistochemical analysis 68 CD#b 68 mTOR signaling 68 Antigen Specific 68 LPA1 receptor 68 receptor activation 68 inhibits protein synthesis 68 p#Kip# 68 chemoattractant 68 TNFa 68 inhibited tumor 68 homodimers 68 ERK phosphorylation 68 IGF 1R 68 anti apoptotic 68 leukemic cell 68 estrogen receptor beta 68 potent cytotoxic 68 Fibroblast Growth Factor Receptor 68 neurite outgrowth 68 receptor mediated endocytosis 68 protein secreted 68 VE cadherin 68 Î ² 68 beta amyloid peptide 68 downregulation 68 thromboxane A2 68 protein tyrosine kinase 68 protein encoded 68 lysophosphatidic acid 68 ENMD # 68 regulated kinase ERK 68 intercellular adhesion molecule 68 TRAIL induced apoptosis 68 EGFr 68 Cyclin E 68 neurotrophic 68 proprietary polysaccharide 68 PDGF B 68 phosphoinositide 3 68 Aurora kinase 68 Interferon gamma 68 CaM 68 inverse agonist 68 HER2 receptor 68 TIMP 1 68 Rho kinase 68 Janus kinase 68 CEACAM1 68 retinoic acid receptor 68 plasmacytoid dendritic cells 68 activin receptor type 68 pharmacological inhibition 68 monocytic 68 MYCN 68 AT1R 68 murine 68 histone deacetylase 68 TGF b 68 receptor subtype 68 Vidofludimus 68 somatostatin 68 tyrosine kinase 68 acetylcholinesterase AChE 68 CXCL# 68 chemokine 68 Hedgehog signaling 68 RRM1 68 selective modulator 68 cathepsin B 68 PKC inhibitor 68 covalently linked 68 matrix metalloproteinases 68 Enzastaurin 68 inhibit tumor 68 orally bioavailable 68 prostaglandin synthesis 68 antisense inhibitor 68 PARP1 68 Dysregulation 68 p# alpha [001] 68 targeted antifolate 68 TNFR 68 osteoblast 68 CYT# potent vascular disrupting 68 FGFR 68 binds selectively 68 cytokines IL 68 1alpha 68 apoptosis proteins 68 myocyte enhancer factor 68 transcriptional activation 68 alpha#beta# 68 ErbB4 68 IFN γ 68 PDGF receptor 68 Survivin 68 isoenzyme 68 targets Galectin receptors 68 HER2 neu 68 potent antiproliferative 68 EGFR receptor 68 JAK2 enzyme 68 ubiquitylation 68 monocyte 67 methionine aminopeptidase 67 cytotoxicity 67 pro angiogenic 67 annexin V 67 c myc 67 STAT3 67 hepatoma 67 vWF 67 Activating mutations 67 small molecule inhibitor 67 ERa 67 colony stimulating factor 67 IL #R 67 VEGF induced 67 glucocorticoid receptor 67 IL #E 67 #HT#A 67 paxillin 67 MET VEGFR2 67 Fas ligand 67 CYP#A# CYP#D# 67 Nedd4 67 hematopoietic progenitors 67 FOXO3a 67 5 lipoxygenase 67 tubulin 67 cathepsins 67 cells transfected 67 GPC3 67 proteoglycan 67 anti CD3 67 67 glycosylated 67 HIF 1α 67 acetylcholine receptor 67 tyrosine phosphorylation 67 Src 67 adenylate cyclase 67 glucagon receptor 67 chimeric monoclonal antibody 67 PTPN# 67 PPARgamma 67 antimitotic 67 TGFβ 67 ubiquitinated 67 T#M 67 Aβ 67 NQO1 67 Cathepsin B 67 ERK5 67 c Fos 67 transient receptor 67 Monocyte 67 V#F mutation 67 TTR gene 67 ligand TRAIL 67 lymphoid cells 67 pleiotropic 67 immunotoxin 67 pDCs 67 hydrolase 67 Proteasome 67 4E BP1 67 receptor mediated 67 IAP inhibitor 67 FUS1 67 endoplasmic reticulum stress 67 Rho GTPase 67 Pim kinases 67 intracellular accumulation 67 uPA 67 inducing apoptosis 67 derived neurotrophic factor 67 IFN g 67 DNMT1 67 tau phosphorylation 67 MGd 67 Hsp# Inhibitor 67 PTP 1B 67 fast skeletal troponin 67 γ secretase 67 HER2/neu 67 triphosphate 67 synthetase 67 HER2 ErbB2 67 TGF β1 67 cytochrome c 67 MTHFR 67 HDACi 67 S1P 67 ADAMTS# 67 noradrenergic 67 GSTP1 67 syntaxin 67 Tubulin 67 astrocytic 67 RANKL 67 pyruvate kinase 67 Androgen Receptor 67 triggers apoptosis programmed 67 keratinocyte 67 caspase activation 67 Histone 67 hypermethylation 67 bleomycin 67 N methyl 67 IGFBP2 67 neurturin 67 acetylcholinesterase 67 PI3K/Akt 67 FGFR1 67 molecule epidermal 67 topoisomerase II inhibitor 67 prostanoid 67 Th1 type 67 Wnt signaling pathway 67 pDC 67 beta subunit 67 Kupffer cells 67 promoter methylation 67 acyl CoA 67 tolerogenic 67 P selectin 67 glucokinase 67 upregulated 67 serotonin receptor 67 suppresses tumor 67 Rab5 67 Akt phosphorylation 67 Recombinant Human 67 CD# molecule 67 paracrine 67 IL6 67 bone morphogenic protein 67 LTB4 67 peroxidase 67 ErbB1 67 tubulin polymerization 67 MDM2 67 immunoregulatory 67 endothelial nitric oxide synthase 67 potent inhibitors 67 lyase 67 hTERT 67 PKC isoforms 67 PGE2 67 tumorigenesis 67 microglial 67 EphA2 67 small molecule tyrosine 67 FGF receptor 67 tumorigenicity 67 Cyclin D1 67 podocyte 67 neuronal cell 67 BCR ABL 67 redox active 67 investigational humanized monoclonal antibody 67 5 hydroxytryptamine 67 CD# expressing 67 superoxide dismutase 67 ERK activation 67 Angiotensin II 67 mitogen activated protein kinases 67 transgenic mouse model 67 neuronal apoptosis 67 alpha subunit 67 MAPK 67 transthyretin 67 Rac1 67 LDL receptor 67 TGF ß1 67 glomerular 67 MDR1 67 LRP5 67 gene polymorphism 67 metalloproteinase 67 TXNIP 67 kinase PI3K Akt pathway 67 protein CETP 67 HER1 67 P2X 67 ABL1 67 induced phosphorylation 67 Src kinases 67 antisense oligonucleotide 66 NFAT 66 carboxyl terminal 66 thioredoxin 66 phospho 66 humanized monoclonal 66 monomeric 66 potential vanilloid 66 N cadherin 66 bispecific 66 CD# receptor 66 small molecule activator 66 myofibroblast 66 VEGFR1 66 5 HT1A 66 ornithine decarboxylase 66 regulates gene expression 66 NOD SCID mice 66 transgenic mouse models 66 Transgenic Mice 66 immunoreactivity 66 receptor inhibitor 66 anaphase promoting complex 66 nucleolin 66 intracellular signaling 66 TGF beta pathway 66 human airway epithelial 66 antitumor effects 66 lung carcinomas 66 receptor alpha 66 MDA MB 66 Fibroblast Growth Factor 66 SSc 66 cortisol synthesis 66 oncogenic transformation 66 methyl D aspartate 66 constitutively 66 factor PlGF 66 FLT3 66 TAp# 66 p# Shc 66 erythropoiesis 66 focal adhesion kinase FAK 66 Fc fusion protein 66 E cadherin expression 66 DU# [002] 66 Stromal 66 radiosensitivity 66 melanocyte 66 anti inflammatory cytokine 66 Secretase 66 cytokeratin 66 anionic backbone 66 phosphatase 66 phosphoinositide 66 tryptase 66 Aß 66 kinase PI3K 66 Bruton tyrosine kinase 66 thioredoxin reductase 66 xenograft tumors 66 RANTES 66 peroxisome proliferator activated 66 Hedgehog pathway 66 alkylating agent 66 Tumor Necrosis Factor 66 HBx 66 5 HT4 receptor 66 cytoprotective 66 Inhibits 66 lysophosphatidic acid LPA 66 Kv#.# 66 GNAQ 66 eIF4E 66 regulator CFTR gene 66 downregulate 66 transfected 66 enkephalin 66 caveolin 66 related apoptosis inducing 66 estrogen receptor alpha 66 transcriptional repressor 66 plasmid encoding 66 vesicular monoamine transporter 66 Janus Kinase 66 RhoA 66 muscarinic 66 antitumor activity 66 PLA2 66 PC# cells 66 decarboxylase 66 p# MAP kinase 66 renal fibrosis 66 Src kinase 66 Mcl 1 66 Angiotensin 66 Wnt beta catenin 66 PKC beta 66 proteinase 66 glial cell 66 proximal tubule 66 myeloma cells 66 ribosomal protein 66 p# activation 66 Id1 66 HDAC enzymes 66 transferase 66 cell acute lymphoblastic 66 Six3 66 oxidase 66 DNA methyltransferase inhibitors 66 apoptotic 66 Mutational 66 cytotoxic T lymphocyte 66 ribonuclease 66 neurokinin 66 orthotopic model 66 papillary renal cell carcinoma 66 CHD5 66 Diffuse Large B 66 costimulatory 66 Inhibition 66 receptor subtypes 66 Abeta# 66 tumor antigen 66 survivin 66 histone deacetylase inhibitor 66 cyclooxygenase 2 66 TNFα 66 sphingolipid 66 inhibitory activity 66 nicotinic acetylcholine receptor 66 Epstein Barr Virus EBV 66 epithelial tumors 66 N Myc 66 basophils 66 TGF β 66 gamma secretase inhibitor 66 Fibroblast 66 immune modulator 66 IGFBP 3 66 SCD1 66 transmembrane protein 66 SMN1 66 protein tyrosine phosphatase 66 lymphangiogenesis 66 elastase 66 EGFRvIII 66 Alfacell proprietary ribonuclease 66 guanosine 66 heparanase 66 orally administered inhibitor 66 angiogenesis inhibitor 66 inhibit angiogenesis 66 chondrocyte 66 lymphotoxin 66 alpha#beta# integrin 66 amino terminal 66 replicon 66 TMEM#B 66 CTLA 4 66 experimental autoimmune encephalomyelitis 66 COX2 66 Aurora Kinase 66 cyclase 66 small molecule Hedgehog 66 TGFß 66 amyloid β 66 NF κB 66 glycosyltransferase 66 metastatic malignant 66 vascular disrupting agent 66 osteoclast 66 Rb#/p# 66 JAK#/JAK# 66 Polymorphisms 66 ubiquitin ligase 66 Angiotensin converting enzyme 66 5 HT6 receptor 66 protein kinase C 66 SH2 domain 66 huN# DM1 66 FGFR2 66 dimeric 66 geldanamycin 66 undergo apoptosis 66 B Raf 66 EZH2 66 peripheral blood mononuclear 66 neuroinflammatory 66 inhibits angiogenesis 66 transgene expression 66 C5aR 66 regulator CFTR protein 65 Dendritic Cells 65 AAG geldanamycin analog 65 Ras pathway 65 BMP2 65 liposomal formulation 65 erythropoietin receptor 65 alveolar epithelial cells 65 Etoposide 65 glucose transporter 65 somatostatin receptors 65 mesenchymal cell 65 receptor CD# 65 naturally occurring molecule 65 microsomal 65 deacetylase 65 TSLP 65 effector memory 65 mitotic kinesin 65 Beta catenin pathway 65 Receptor Antagonist 65 apoptosis induced 65 diphosphate 65 calcitonin gene related 65 mGluR2 NAM 65 dose dependently 65 Lp PLA 2 65 RANK Ligand 65 reductase 65 phospholipase C 65 muscarinic receptors 65 LDLR 65 ptau 65 NMDA N 65 microvascular endothelial cells 65 SGLT 65 Microtubule 65 urothelial 65 antibody mediated 65 cell adhesion molecules 65 IL8 65 5HT 65 PPARg 65 PKC# 65 Tissue Factor 65 cyclic peptide 65 ENaC 65 clusterin 65 synaptogenesis 65 Sertoli cell 65 receptor partial agonist 65 HDAC2 65 monocyte chemoattractant protein 65 overactivation 65 signal transduction inhibitor 65 pro inflammatory cytokine 65 cells overexpressing 65 Caspase 65 NFkB 65 Modulates 65 novel VDA molecule 65 Cdc# 65 type glutamate receptor 65 glioma cells 65 tenascin C 65 GRP# 65 transiently transfected 65 anaplastic lymphoma kinase 65 lysyl oxidase 65 HDAC6 65 GABAergic 65 BMAL1 65 agonist compounds 65 factor EGF 65 MyD# 65 acinar 65 highly selective inhibitor 65 prolyl 65 Cx# [001] 65 CGRP 65 glioblastoma cells 65 cytolytic activity 65 Epidermal Growth Factor Receptor 65 proteolysis 65 neuronal dysfunction 65 Notch1 65 Transcription Factor 65 MT1 MMP 65 Superoxide 65 Cystic Fibrosis Transmembrane conductance 65 Smoothened 65 matrix metalloproteinase 65 mda 7 65 TORC2 65 histone acetylation 65 D aspartate 65 vinca alkaloid 65 histone acetyltransferase 65 cytotoxin 65 antibody MT# 65 hydroxylase 65 antitumor efficacy 65 sodium glucose cotransporter 65 inflammasome 65 sunitinib Sutent ® 65 collagen degradation 65 fatty acid oxidation 65 p# deficient 65 lymphoid organs 65 Ii protein 65 adipokine 65 capillary endothelial cells 65 multikinase inhibitor 65 Lymphocytic 65 selective kinase inhibitor 65 Cytochrome P# 65 depsipeptide 65 RNase L 65 TLR7 65 SOCS3 65 Preclinical studies suggest 65 interferon γ 65 demonstrated antitumor activity 65 EGFR mutant 65 PAR1 65 RANK ligand 65 CDK4 65 MTP inhibitor 65 lytic 65 immune stimulatory 65 NY ESO 65 β cells 65 GPR# [002] 65 GSK 3ß 65 integrin alpha 65 haematopoietic 65 ER alpha 65 humanized antibody 65 MetAP2 65 APOPTONE 65 glial fibrillary acidic 65 orthotopic 65 partial agonist 65 Catenin 65 TET2 65 topoisomerase II 65 Selective Inhibitor 65 TGF Beta 65 Orally administered 65 ErbB receptors 65 HSP# inhibitor 65 Caveolin 1 65 thrombopoietin receptor 65 Purkinje cell 65 enzyme inhibitor 65 catalytic subunit 65 epithelial cell 65 secreted protein 65 Bcl XL 65 osteoclast formation 65 cis retinoic acid 65 Huntingtin 65 polysaccharide polymer 65 hepatic lipase 65 soluble receptor 65 metalloprotease 65 inhibitory effect 65 antisense inhibitors 65 factor PDGF 65 Signaling Pathway 65 PDGF BB 65 Camptothecin 65 Skp2 65 receptor tyrosine kinase inhibitor 65 E2F 65 inhibiting tumor 65 CD#c 65 Liposomal 65 oncogenic 65 transgenic mice expressing 65 EpCAM 65 5alpha reductase 65 Antitumor 65 MCF7 65 transcriptional regulation 65 survivin expression 65 hepatocyte growth 65 nucleoside analog 65 RUNX3 65 receptor monoclonal antibody 65 small molecule agonists 65 CCL2 65 EGF receptors 65 Novel Oral 65 AKT1 65 Jhdm2a 65 Pentraxin 2 65 casein kinase 65 thymidine kinase 65 secretase 65 succinate dehydrogenase 65 Apoptosis 65 aberrant activation 65 bronchial epithelial cells 65 PI3K inhibitor 65 peptidic compound 65 Raf MEK ERK 65 stably expressing 65 HDAC Inhibitor 65 dihydrofolate reductase 65 cAMP signaling 65 aromatase 65 leukotriene pathway 65 NS5B polymerase 65 alveolar macrophages 65 glucocerebroside primarily 65 EphB2 65 Camptosar ® irinotecan 65 leukocyte infiltration 65 Vidaza azacitidine 65 Jurkat cells 65 EGFP 65 cytokine receptor 65 Abl 65 intracellular protein 65 neuroblastoma cells 65 integrin receptor 65 overexpressed 65 humanized anti 65 apoptosis inducing 65 Androgen receptor 65 actin polymerization 65 pegylated liposomal doxorubicin 65 inflammatory cytokine 65 Nampt 65 cyclin D1 65 adrenocortical 65 tropomyosin 65 cyclin dependent kinases 65 Gleevec resistant 65 activating mutations 65 Topoisomerase II 65 specific lectin receptors 65 ALB # 65 intestinal epithelium 65 receptor molecule 65 inhibits apoptosis 65 cytolytic 65 gastrin 65 tyrosine kinase inhibitor 65 mutated p#