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(Click for frequent words.) 74 cortical 73 anterior cingulate 72 hippocampus 72 striatal 70 cerebellar 70 basal ganglia 70 thalamic 70 neuronal 69 posterior cingulate 69 caudate 69 cortices 68 gyrus 68 subcortical 68 medial temporal 68 somatosensory cortex 68 postsynaptic 68 prefrontal cortical 68 cingulate 67 hippocampal neurons 67 parietal 67 GABAergic interneurons 67 dentate gyrus 67 presynaptic 67 rCBF 66 posterior cingulate cortex 66 ventromedial 66 synaptic plasticity 66 prefrontal 66 hypothalamic 66 dendritic spines 66 synaptic 66 microglial 66 inferior frontal 66 cortical regions 66 gyri 66 neuronal activity 66 midbrain 66 ACh 66 orbitofrontal 65 parahippocampal gyrus 65 medial temporal lobe 65 pyramidal neurons 65 entorhinal cortex 65 visual cortex 65 mRNA expression 65 BDNF gene 65 subgenual cingulate 65 BDNF 64 striatum 64 medial frontal cortex 64 cortex 64 superior temporal gyrus 64 hippocampal volume 64 glutamatergic 64 parietal cortex 64 temporoparietal 64 neuronal plasticity 64 fusiform gyrus 64 lateral orbitofrontal cortex 64 Hippocampal 64 dorsolateral prefrontal 64 globus pallidus 64 Purkinje cells 64 dopamine signaling 64 medial frontal 63 cortical activation 63 glutamate receptors 63 dorsolateral 63 amygdala 63 primary visual cortex 63 middle frontal gyrus 63 granule cells 63 anterior cingulate gyrus 63 medial prefrontal 63 synaptic transmission 63 serotonergic 63 orbital frontal cortex 63 neurons 63 noradrenergic 63 sensorimotor 63 CA1 63 cortico 63 lateral hypothalamus 63 excitatory 63 cerebellum 63 cortical neurons 63 parietal cortices 63 arcuate nucleus 63 white matter hyperintensities 63 synaptic function 63 BMP signaling 63 rostral 63 amygdalae 63 ventromedial prefrontal cortex 63 factor BDNF 63 parietal regions 63 hindbrain 63 HPA axis 62 hippocampal formation 62 cholinergic 62 mesolimbic 62 parietal lobes 62 putamen 62 dopaminergic neurons 62 dopamine receptors 62 inferior parietal 62 neurogenesis 62 ERK1 2 62 periventricular 62 Aß 62 astrocytic 62 cAMP signaling 62 premotor 62 myocyte 62 frontotemporal 62 dorsolateral prefrontal cortex 62 medial prefrontal cortex 62 cingulate gyrus 62 TrkB 62 neuronal dysfunction 62 neocortical 61 fronto 61 temporal lobe 61 cingulate cortex 61 neural 61 precuneus 61 frontal parietal 61 dopaminergic 61 caudate nucleus 61 insular cortex 61 perirhinal cortex 61 inhibitory interneurons 61 hippocampi 61 tau protein 61 Neuronal 61 corpus callosum 61 transmembrane 61 striatal dopamine 61 limbic 61 afferents 61 prefrontal brain 61 neuroimaging studies 61 vmPFC 61 rostral anterior cingulate cortex 61 neuropeptide Y 61 noradrenaline 61 neuron 61 osteoblast 61 basal forebrain 61 oculomotor 61 NMDA receptors 61 Broca area 61 ventral striatum 61 Purkinje cell 61 temporoparietal junction 61 myocytes 61 prefrontal regions 61 somatosensory 61 prefrontal lobe 61 corticospinal 61 subventricular zone 61 frontal cortex 60 efferent 60 primary somatosensory cortex 60 D2 receptor 60 angular gyrus 60 medial orbitofrontal cortex 60 inferior frontal gyrus 60 anterior cingulate cortex 60 nigrostriatal 60 cerebral hemispheres 60 cytoskeletal 60 motoneurons 60 DISC1 60 demyelination 60 progranulin 60 catecholamine 60 dorsal prefrontal cortex 60 neuroanatomical 60 CREB protein 60 dorsal anterior cingulate cortex 60 cortical thinning 60 S#A# [002] 60 locus coeruleus 60 brain derived neurotrophic 60 substantia nigra 60 prefrontal cortex 60 medial temporal lobe MTL 60 anterior pituitary 60 hippocampal volumes 60 myelination 60 periaqueductal gray 60 orbitofrontal cortex OFC 60 cerebral cortical 60 parietal lobe 60 Wnt signaling 60 neuronal cell 60 Rab5 60 glucose metabolism 60 left ventricular diastolic 60 cytosolic 60 hyperactivation 60 electrophysiological 60 mPFC 60 chromatin remodeling 60 contractile 60 laterality 60 IL 1beta 60 autoregulation 60 monocyte 60 hypometabolism 60 dorsomedial 60 rat hippocampus 60 nAChRs 60 cypin 60 temporal cortex 60 medial temporal lobes 59 neuronal circuits 59 inhibitory 59 cortexes 59 hypocretin neurons 59 anterior temporal 59 hypothalamic pituitary adrenal axis 59 POMC neurons 59 #ß 59 PTPN# 59 auditory cortex 59 adrenocortical 59 SVZ 59 N acetylaspartate 59 thalamus 59 neuropathological 59 inferior parietal lobule 59 forebrain 59 perivascular 59 vermis 59 astrocyte 59 premotor cortex 59 cerebral cortex 59 parahippocampal 59 posterior parietal cortex 59 neurones 59 COMT 59 ventral pallidum 59 dendritic spine 59 monoamine 59 interneurons 59 SOCS3 59 serotonin transporter 59 AMPA receptors 59 contractility 59 amygdale 59 vascular endothelial cells 59 TRPV1 receptors 59 NAc 59 Aβ 59 paraventricular nucleus 59 synaptogenesis 59 phosphorylated tau 59 tyrosine phosphorylation 59 coexpression 59 leptin receptor 59 voxel 59 axonal damage 59 electroencephalographic 59 hypoperfusion 59 receptor subtypes 59 circadian genes 59 beta endorphin 59 glial 59 D2 receptors 59 amyloid β 59 serotonin neurons 59 posterior parietal 59 hormone secretion 59 adult neurogenesis 59 nociceptive 59 PBMCs 59 neuromuscular junction 59 occipital cortex 59 axonal 59 fusiform 59 dopamine transporter 59 C1q 59 NR2B 59 dysbindin 59 excitatory synapses 59 CaMKII 59 p# mutations 59 neuronal migration 59 adipokines 59 rACC 59 neuronal signaling 59 neurotransmission 59 beta adrenergic receptors 59 H#K#me# 58 amyloid deposits 58 IL 1ß 58 subcortical regions 58 cardiac myocytes 58 SLC#A# [002] 58 modulatory 58 GABA receptor 58 antioxidant enzyme 58 cortical thickness 58 lateral habenula 58 anterior insula 58 habenula 58 anterior cortex 58 neuritic plaques 58 NKT cell 58 orbitofrontal cortex 58 Brodmann Area 58 serotonergic neurons 58 mitochondrial respiration 58 fractional anisotropy 58 immunoreactive 58 neural plasticity 58 neuroD2 58 neuritic 58 c Fos 58 Hypothalamic 58 nAChR 58 locomotor activity 58 autophagic 58 agonist induced 58 attentional 58 eNOS 58 NR2B subunit 58 intercellular communication 58 neurone 58 sulcal 58 Fig. 1C 58 term potentiation LTP 58 afferent 58 Brain derived neurotrophic 58 neurophysiological 58 term potentiation 58 P cadherin 58 IFN γ 58 calcium homeostasis 58 middle temporal gyrus 58 ABCA1 58 radial glia 58 demyelinated 58 histone acetylation 58 lateral ventricle 58 neuronal cells 58 amyloid deposition 58 nucleus accumbens 58 proteolysis 58 VMAT2 58 GH secretion 58 transcriptional regulation 58 FKBP# 58 inducible nitric oxide synthase 58 glutamatergic neurons 58 DLPFC 58 sensory gating 58 lesional 58 lateral prefrontal cortex 58 osteoblastic 58 superior colliculus 58 AMPA receptor 58 occipital lobe 58 prefrontal cortices 58 focal adhesions 58 cytosol 58 neuronal function 58 subcortical structures 58 frontostriatal 58 left ventricular LV 58 HOTAIR 58 neuronal differentiation 58 neurite outgrowth 58 Dysregulation 57 CA3 57 hippocampal function 57 gamma oscillations 57 Sgk1 57 NFKBIA 57 Prefrontal 57 neurofibrillary tangles 57 neuronal synapses 57 medial prefrontal cortex mPFC 57 nerve cells 57 noradrenalin 57 declarative memory 57 dysregulation 57 NMDA receptor 57 extracellular 57 echogenicity 57 glomerular 57 receptor gene 57 calpain 57 immunoreactivity 57 dorsal root ganglia 57 brain 57 TGF ß 57 basolateral 57 pineal 57 osteoclast 57 ERK signaling 57 synapses 57 stromal 57 frontal temporal 57 apoE4 57 norepinephrine 57 neural circuits 57 BMAL1 57 aggrecan 57 F actin 57 TGF ß1 57 FGF2 57 inferior temporal gyrus 57 neurotransmitter receptors 57 CD#b 57 p# activation 57 endoplasmic reticulum ER 57 acetylcholine 57 inhibitory neurons 57 transgenic mice expressing 57 inhibitory transmitter 57 protein tau 57 temporal lobes 57 catenin 57 brainstem 57 neurosteroid 57 nitrotyrosine 57 nNOS 57 exocytosis 57 serine protease 57 corticospinal tract 57 ventral prefrontal cortex 57 hypothalamic pituitary 57 β amyloid 57 PrP 57 DNA methylation patterns 57 temporal parietal 57 CHI#L# 57 morphogen 57 mitogen activated protein kinase 57 phosphorylated 57 cardiac autonomic 57 huntingtin 57 muscarinic receptors 57 mu opioid 57 activated microglia 57 γ secretase 57 synaptic proteins 57 β cell 57 subcellular 57 parenchymal 57 glutamate 57 IKKß 57 vascular endothelial 57 PON1 57 infarcts 57 left ventricular systolic 57 serotonin receptors 57 gliosis 57 cAMP 57 neural cells 57 innervation 57 myocardial 57 dopamine neuron 57 Androgen receptor 57 deficient mice 57 TMEM#B 57 acetylcholine receptor 57 VE cadherin 57 PIP2 57 ERK2 57 glucocorticoid 57 Alzheimer disease pathology 57 nicotinic receptors 57 GluR1 57 circadian clock genes 57 remyelination 57 TRPV4 57 frontal lobe 57 pontine 57 Ca2 + 57 Supplementary Fig 57 dopamine 57 miR# 57 glutamine 57 brain cortex 57 serotonin receptor 57 myelinated axons 57 regulated kinase ERK 57 caveolin 1 57 anterior temporal lobe 57 endogenous opioid 56 matrix metalloproteinase 56 ipsilateral 56 centrosome 56 endothelial cell 56 capillary density 56 Dpp 56 Leydig cell 56 MAPK pathway 56 iNOS 56 IGF2 56 adipogenic 56 urothelial 56 dopamine receptor 56 inhibitory neurotransmitters 56 Sp1 56 PDGFR 56 mRNA encoding 56 hyperintensities 56 neuroendocrine 56 cultured hippocampal neurons 56 CB1 receptors 56 acetylcholine neurotransmitter 56 stathmin 56 calcineurin 56 amyloid beta plaques 56 corticotropin releasing factor 56 β catenin 56 neuronal connections 56 detrusor 56 HepG2 cells 56 heterozygotes 56 ultrastructural 56 excitatory neurotransmitter glutamate 56 overactivity 56 transcriptional activity 56 histone modifications 56 triacylglycerol 56 fatty acid oxidation 56 synapse formation 56 μ opioid receptor 56 occipital lobes 56 induced apoptosis 56 palytoxin 56 mice lacking 56 ventral 56 vagal 56 sensorimotor cortex 56 alexithymia 56 nitric oxide synthase 56 MT1 MMP 56 TNFalpha 56 baroreflex 56 prefrontal cortex PFC 56 vasopressin receptors 56 3'UTR 56 podocytes 56 myelinated 56 medulla 56 MAP kinase 56 amygdala reactivity 56 impaired endothelial 56 cognition 56 CaM kinase II 56 mammalian brain 56 dopamine D2 receptor 56 ncRNAs 56 synaptic vesicles 56 intergenic 56 ventricular dilatation 56 cyclic AMP 56 subthalamic nucleus 56 diffusion tensor 56 plasticity 56 neural tissues 56 kalirin 56 caveolae 56 visuospatial 56 downregulate 56 planum temporale 56 neurotransmitter 56 synuclein 56 proteoglycan 56 estrogen receptor alpha 56 CaM 56 GABAergic 56 aldosterone 56 neural circuitry 56 kinase domain 56 alpha synuclein protein 56 gene polymorphisms 56 hippocampal atrophy 56 mdx mice 56 insoluble plaques 56 neocortex 56 dopamine neurons 56 MAPK 56 EAAT2 56 myofibroblasts 56 MMP2 56 EEG recordings 56 raphe 56 T2 weighted images 56 phenotype 56 Htt 56 ERK activation 56 functional polymorphism 56 Hcrt 56 palmitoylation 56 fatty acid metabolism 56 organogenesis 56 rs# [004] 56 lateralized 56 myometrium 56 synapse 56 visuomotor 56 dendrite 56 plasma leptin 56 chromosomal regions 56 epithelia 56 mirror neuron 56 CD8 + 56 dorsal horn 56 inflammatory cytokine 56 proinflammatory mediators 56 proteolytic cleavage 56 DARPP 56 GLUT4 56 lipoprotein lipase 56 retinal nerve 56 CD# + [001] 56 extracellular signal 56 LDLR 56 galanin 56 chondrocyte 56 neuroligins 56 fig. S4 56 LDL receptor 56 amygdalas 56 neuronal circuitry 56 nicotinic receptor 56 Fig. 3b 56 non coding RNA 56 serotonin signaling 56 Prox1 56 genotoxic stress 56 microglial activation 56 PKMzeta 56 NPY 56 pro angiogenic 56 arteriolar 56 TGFβ 55 conduction velocity 55 atherosclerotic lesions 55 insulin signaling pathways 55 β cells 55 baroreceptor 55 ouabain 55 hepatocellular 55 N myc 55 miRNA expression 55 PHD2 55 COL#A# 55 MEF2 55 chromosome #q 55 hippocampal cells 55 sensory neurons 55 mTORC1 55 pyramidal cells 55 transcriptional activation 55 TOP2A gene 55 cerebellar cortex 55 acinar 55 intracellular calcium 55 renal fibrosis 55 transgene expression 55 Abeta protein 55 myocardial tissue 55 Fig. 1A 55 dopaminergic neuron 55 IL #p# 55 mineralocorticoid 55 thyrotropin 55 beta amyloid peptides 55 acinar cells 55 striated muscle 55 D aspartate 55 protein kinase C 55 steroidogenic 55 upregulates 55 5 HT2C receptor 55 gamma aminobutyric acid GABA 55 acetylcholine receptors 55 GABAA receptors 55 fractional shortening 55 CEACAM1 55 adrenal cortex 55 Neurogenesis 55 phasic 55 vasopressin 55 cerebellar vermis 55 proinflammatory cytokine 55 Histologic 55 baroreceptor reflex 55 intraparietal sulcus 55 retinoid X 55 mutant mice 55 brain visual cortex 55 granzyme B 55 amyloid peptide 55 cohesin 55 junctional 55 platelet activation 55 leptin signaling 55 tau proteins 55 CYP#B# 55 hyperintensity 55 ventricular myocardium 55 polyamine 55 intracellular signaling 55 microvascular 55 PrPC 55 heterochromatic 55 Sirt1 55 catalase 55 autonomic dysfunction 55 neuronal degeneration 55 1alpha 55 neurofilament 55 neuropeptide 55 hematopoiesis 55 ubiquitin ligase 55 myocardium 55 inferior parietal cortex 55 orexin neurons 55 TGF beta pathway 55 5 HT1A 55 TIMP 1 55 chromosomal deletions 55 retinal neurons 55 lateral ventricles 55 Prolactin 55 ABCB1 55 knockout mice 55 pDCs 55 SIRT3 55 paxillin 55 55 LRP6 55 accumbens 55 beta catenin 55 polyglutamine 55 NR#A# 55 glial cell 55 synapse maturation 55 ERK pathway 55 mitochondrial proteins 55 erythrocytes 55 SUMOylation 55 transmembrane protein 55 cadherin 55 cellular prion protein 55 lymphangiogenesis 55 leptin deficient mice 55 epigenetic silencing 55 neural progenitor cells 55 intraventricular 55 cortical plasticity 55 Wnt 55 phospholipase A2 55 cognitive functions 55 hepatocyte 55 neurotransmitter glutamate 55 fronto temporal 55 somatostatin 55 UCP2 55 microvessels 55 mitochondrial enzyme 55 RUNX3 55 methylation patterns 55 superior temporal sulcus 55 E3 ubiquitin ligase 55 Amino acid 55 presenilin 55 spermatogenesis 55 ventricular enlargement 55 maturational 55 amygdala neurons 55 Cdc# 55 neuroepithelial cells 55 myo inositol 55 ciliary 55 corticosterone 55 MDR1 55 MLH1 55 hyperexcitability 55 toxic beta amyloid 55 Wnt pathway 55 constitutively 55 adhesion molecule 55 isoforms 55 excitatory neurotransmitter 55 cotransporter 55 cofilin 55 brain circuitry 55 neurochemical 55 T2 lesions 55 Clusterin 55 skeletal muscle 55 Fas ligand 55 Dopaminergic 55 Sonic Hedgehog 55 microstructural 55 acyl CoA 55 photoreceptor 55 glutamate receptor 55 Kir#.# 55 neurotransmitters dopamine 55 microglial cells 55 dysregulated 55 BDNF protein 55 orthologs 55 TSC1 55 secretory 55 TGF β 55 differential gene expression 55 cyclic AMP cAMP 55 NMDAR 55 intestinal epithelium 55 serum BDNF 55 Rap1 55 ENaC 55 axon guidance 55 downregulated 55 fMRI scans 55 prefrontal lobes 55 myogenic 55 dystroglycan 55 hyperinsulinemia 55 NR1 55 intronic 55 synaptic inputs 55 FGF# 55 chromosome #q#.# [001] 55 locomotor 55 CD8 T 55 phagocytosis 55 mechanotransduction 55 TSP1 55 vasomotor 55 lipid rafts 55 synovial 55 hypothalamic pituitary adrenal HPA 55 homeostatic 54 cognitive deficits 54 ovarian hormones 54 MMP# 54 Kupffer cells 54 proinflammatory cytokines 54 cortisol secretion 54 gamma aminobutyric acid 54 Aâ 54 syntaxin 54 hypothalamic neurons 54 beta amyloid fragments 54 repolarization 54 proximal tubule 54 occipital regions 54 adenosine receptors 54 vimentin 54 endocannabinoid system 54 mammillary bodies 54 GPi 54 synaptic vesicle 54 MECP2 gene 54 Immunohistochemical analysis 54 DQB1 * 54 cholecystokinin CCK 54 neuropeptides 54 focal adhesion 54 adiponectin 54 fig. S1 54 c Src 54 Notch signaling 54 E cadherin expression 54 Notch1 54 pDC 54 hypothalamus 54 pulvinar 54 ciliated 54 limbic system 54 glucocorticoid receptors 54 IGFBP2 54 Acetylcholine 54 neurodegeneration 54 dorsal striatum 54 abnormal neuronal 54 GRK2 54 fibrocytes 54 mitochondrial oxidative 54 3' UTR 54 protein tyrosine phosphatase 54 glucose transporter 54 dopamine neurotransmitter 54 striatal neurons 54 microvessel density 54 alkaline phosphatase 54 GFAP 54 clefting 54 EphB2 levels 54 lymphocyte 54 dopamine D1 54 DNMT1 54 catabolism 54 upregulation 54 Rab# 54 cognitive affective 54 Macrophage 54 TIMP 54 allopregnanolone 54 tau pathology 54 LPS induced 54 suprachiasmatic nucleus 54 sensory cortex 54 opioid peptides 54 plasma folate 54 proto oncogene 54 5 hydroxytryptamine 54 HIF 1a 54 #BP# 54 SIRT1 gene 54 brain lesions 54 intracerebral 54 cytokine interleukin 54 myosin II 54 telomerase activity 54 MAP kinases 54 overexpressing 54 extracellular dopamine 54 thioredoxin 54 neural correlates 54 RNA polymerase II 54 IGFBP 3 54 ventrolateral 54 TAp# 54 inhibin B 54 FGFs 54 Neural stem cells 54 osteocalcin 54 hepatic glucose production 54 sortilin 54 MyD# 54 electrophysiological recordings 54 sarcomere 54 secretory cells 54 ß amyloid 54 lateralization 54 neutrophil 54 voxels 54 atherosclerotic lesion 54 neurite 54 2A receptor 54 ontogeny 54 GABAB receptors 54 KLF4 54 histone H4 54 enteric nervous 54 cell adhesion molecule 54 neural substrates 54 intestinal permeability 54 RIP1 54 auditory neurons 54 serotonin synthesis 54 HbF 54 affective psychoses 54 urinary excretion 54 glucose uptake 54 transthyretin 54 H#K# [002] 54 ventral tegmental area 54 prodynorphin 54 subthalamic nucleus STN 54 anhedonia 54 NF kB signaling 54 fasting insulin 54 ganglion cells 54 receptor subtype 54 diastolic function 54 ovariectomized rats 54 FasL 54 missense mutations 54 LKB1 54 cell adhesion molecules 54 PU.1 54 endothelial nitric oxide synthase 54 amyloid beta plaque 54 neuropeptide Y NPY 54 Fc receptor 54 microRNA molecules 54 gadolinium enhanced 54 ganglion cell 54 c Myb 54 neuronal pathways 54 neurotransmitter dopamine 54 serine 54 neurocognitive function