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(Click for frequent words.) 71 ERK1 2 70 myofibroblasts 70 catenin 70 astrocyte 70 vimentin 69 paxillin 69 lysosomal 69 microglial 69 mitogen activated protein kinase 68 β catenin 68 renal fibrosis 68 MAP kinase 68 BMP signaling 68 TGF β 68 vascular endothelial cells 68 astrocytic 68 F actin 68 tau protein 68 EGF receptor 68 TGF beta1 68 Htt 68 protein kinase C 67 proteolysis 67 Wnt pathway 67 Wnt signaling 67 transmembrane protein 67 Rab5 67 neurite outgrowth 67 epithelia 67 glia 67 basolateral 67 SIRT2 67 intramolecular 67 transcriptional activation 67 presynaptic 67 autophagic 67 serine protease 67 focal adhesions 67 TGFβ 67 AMPA receptors 67 intracellular signaling 67 Smad3 67 autocrine 67 ERK signaling 67 caveolin 1 67 MDSCs 67 TGF ß 66 serotonergic 66 Wnt 66 NMDA receptor 66 proto oncogene 66 Cdc# 66 axonal 66 c myc 66 microglial activation 66 S1P 66 synaptogenesis 66 transmembrane 66 NKG2D 66 Rac1 66 osteoclast 66 kinase pathway 66 PIP3 66 cell adhesion 66 modulatory 66 MT1 MMP 66 mutant protein 66 endothelial 66 DNMT1 66 glutamatergic 66 receptor tyrosine kinase 66 homodimers 66 E cadherin 66 Aâ 66 epithelial 66 RhoA 66 palytoxin 66 ß catenin 66 extracellular signal 66 adhesion molecule 66 TGF ß1 66 pRb 66 ERK pathway 66 miR# 65 noradrenergic 65 cAMP signaling 65 VEGF receptor 65 transcriptional repressor 65 Hedgehog signaling 65 cytoskeletal 65 oligodendrocyte 65 neuronal differentiation 65 neuronal 65 postsynaptic 65 disulfide bond 65 primary cilium 65 paracrine 65 pyramidal neurons 65 VE cadherin 65 keratinocyte 65 uPAR 65 osteoblast 65 ATPase 65 phagocytosis 65 LRP6 65 histone acetylation 65 tubulin 65 perivascular 65 striatal 65 axon guidance 65 FGFR3 65 HDAC6 65 JAK STAT 65 cytosol 65 TGF b 65 adipocyte 65 constitutively active 65 lymphangiogenesis 65 cell adhesion molecules 65 Aβ 65 NR2B 65 deacetylation 65 interneurons 65 JAK2 65 antiapoptotic 65 hepatocyte growth 65 TGFß 65 SOCS3 65 CXCL# 65 miR #a [002] 65 N cadherin 65 Notch1 65 eNOS 65 NR2B subunit 65 actin binding 65 γ 65 astrocytes 64 ectopic expression 64 synapse formation 64 ubiquitylation 64 SOD1 64 MEK1 64 Rap1 64 oligomers 64 spectrin 64 tyrosine kinase 64 oligomerization 64 apoptotic pathway 64 proteoglycan 64 cardiac myocytes 64 pro angiogenic 64 neuronal dysfunction 64 thioredoxin 64 occludin 64 activin 64 syntaxin 64 GAPDH 64 cardiac fibroblasts 64 synaptic 64 HIF 1α 64 glial cells 64 Smoothened 64 GABAergic interneurons 64 estrogen receptor alpha 64 substrate specificity 64 caveolin 64 reductase 64 regulated kinase ERK 64 mRNA expression 64 cadherin 64 transcriptional regulation 64 glial cell 64 Ca2 + 64 morphogen 64 NMDA receptors 64 cell adhesion molecule 64 exocytosis 64 neuronal degeneration 64 ubiquitination 64 MAPK pathway 64 mutant huntingtin 64 acinar 64 kinase domain 64 Dysregulation 64 tropomyosin 64 PDGFR 64 site directed mutagenesis 64 Smad 64 c MET 64 ß1 64 FUS1 64 HIF 1a 64 p#NTR 64 flavin 64 actin cytoskeleton 64 S#A# [002] 64 huntingtin protein 64 plasminogen 64 glycosylated 64 beta amyloid peptide 64 Wnt signaling pathway 64 PKC isoforms 64 cysteine residues 64 neuromuscular junction 64 neurotrophin 64 sGC 64 acetylcholine receptors 64 MDM2 64 phosphatidylinositol 3 64 Skp2 64 XBP1 64 Wnt beta catenin 64 Notch signaling 64 mitochondrial respiration 64 oligomeric 64 IGFBP2 64 caveolae 64 Th2 64 pDCs 64 secretory pathway 64 inflammatory cytokine 64 motoneurons 64 monocyte 64 metalloproteases 64 p# MAPK 64 tetramer 64 nAChR 64 IL 1beta 64 quinone 64 hippocampal neurons 63 AT1R 63 cofactor 63 coexpression 63 adipogenic 63 proinflammatory 63 malignant transformation 63 focal adhesion 63 MMPs 63 neuronal cell 63 neurotrophic 63 PIP2 63 TGF beta 63 Kv#.# 63 NKX#.# 63 IL6 63 extracellular 63 costimulatory 63 ERK2 63 AMPA receptor 63 neurotrophic factors 63 calcium homeostasis 63 ACh 63 5 HT1A 63 endocytic 63 Vascular endothelial growth 63 sensory axons 63 dopaminergic neurons 63 signaling cascades 63 cortical neurons 63 Th1 63 endothelial cell 63 PGE2 63 Purkinje cell 63 operon 63 mTOR signaling 63 neurite 63 integrins 63 MyD# 63 Src 63 H#K# [002] 63 tyrosine phosphorylation 63 nucleolar 63 neuronal migration 63 polyamine 63 acyl CoA 63 dephosphorylation 63 dopaminergic 63 NFκB 63 Nedd4 63 mesoderm 63 cellular senescence 63 glutamate receptors 63 Akt activation 63 endoplasmic reticulum 63 lymphoid cells 63 CD1d 63 phosphoprotein 63 secretory 63 calpain 63 demyelination 63 oncoprotein 63 E#F# 63 synaptic transmission 63 potent inhibition 63 c MYC 63 PPARgamma 63 PC# cells 63 plasma membrane 63 cytosolic 63 TRPV1 receptors 63 neuronal plasticity 63 T#M 63 Mcl 1 63 GRP# 63 vacuolar 63 membrane protein 63 TNFalpha 63 LIS1 63 effector memory 63 GSK3 63 stromal cells 63 downstream effector 63 melanocyte 63 mesenchymal cells 63 Mesenchymal 63 ABCA1 63 lymphoid 63 beta catenin 63 nitric oxide synthase 63 c Myc 63 MAPK 63 cystic fibrosis transmembrane conductance 63 primary cilia 63 Runx2 63 TrkB 63 TAp# 63 transgenic mouse model 63 ouabain 63 inhibitory 63 cholinergic 63 intracellular proteins 63 ciliated 63 hydroxylation 63 upregulates 63 fibrogenesis 63 matrix metalloproteinases 63 EGFr 63 endocytosis 62 GABAergic neurons 62 neuropilin 62 selective inhibition 62 microtubule 62 endosomes 62 cytokine signaling 62 vascular endothelial 62 calcineurin 62 BMP4 62 TNFa 62 dimerization 62 prostaglandin synthesis 62 transgenic mice expressing 62 c Src 62 IL 1β 62 cathepsin B 62 secretase 62 Fas ligand 62 neuronal cells 62 myogenesis 62 Microtubule 62 p# activation 62 dendritic spines 62 morphogens 62 nAChRs 62 cilium 62 upregulation 62 SIRT3 62 Fig. 1C 62 monomeric 62 acetylcholine receptor 62 granule cells 62 mediated inhibition 62 cyclin D1 62 HIF 1alpha 62 P cadherin 62 epithelial cell 62 Th1 cells 62 CD#b 62 heterodimers 62 HER3 62 p#Kip# 62 dopamine signaling 62 tau aggregates 62 FGF2 62 HOTAIR 62 synaptic function 62 glycosyltransferase 62 NKT cells 62 DISC1 62 IL #p# 62 VEGFR2 62 Aurora kinase 62 histone deacetylases 62 NFkB 62 transactivation 62 carcinoembryonic antigen 62 Rho GTPase 62 TNF receptors 62 prostate epithelial cells 62 FKBP# 62 efferent 62 ERK1 62 mitogenic 62 FGF signaling 62 neovascularization 62 osteogenic 62 RAS RAF MEK 62 hedgehog pathway 62 mutant proteins 62 phosphatases 62 evolutionarily conserved 62 leukemic cell 62 cytochrome 62 isoform 62 myeloid cells 62 cell motility 62 muscarinic receptors 62 podocyte 62 intestinal epithelium 62 LKB1 62 STAT3 62 Src kinase 62 vesicle fusion 62 Purkinje cells 62 fatty acid oxidation 62 habenula 62 P selectin 62 aberrantly activated 62 HDAC2 62 homodimer 62 E3 ligase 62 RNA splicing 62 intercellular communication 62 amyloid peptide 62 receptor gamma 62 anti apoptotic 62 neurites 62 neurotransmission 62 CaM 62 neurofibrillary tangles 62 proapoptotic 62 mediated apoptosis 62 microtubule dynamics 62 apical membrane 62 oncomodulin 62 Syk 62 apoE 62 STAT1 62 chemotaxis 62 POMC neurons 62 Overexpression 62 cytochrome c 62 hypothalamic 62 Cx# [001] 62 osteoblast differentiation 62 cellular pathways 62 huntingtin 62 dimeric 62 neurotrophins 62 overactivation 62 diffusible 62 GABAergic 62 isoforms 62 serine threonine 62 CCR7 62 Phosphorylation 62 cadherins 62 TGFb 62 GSK 3ß 62 β 62 FOXO 62 focal adhesion kinase FAK 62 hypoxia inducible factor 62 PI3K Akt 62 nociceptive 62 ubiquitin ligase 62 alpha synuclein 62 phosphorylates 62 receptor activation 62 hematopoietic 62 IKKß 62 beta1 integrin 62 mesenchymal cell 62 subcellular localization 61 alveolar macrophages 61 PDGF receptor 61 immunoreactivity 61 dorsal horn 61 guanosine 61 haematopoietic 61 phosphate S1P 61 pericytes 61 glomerular 61 transcriptionally 61 mTORC1 61 centromeres 61 thymidylate synthase TS 61 myoepithelial cells 61 MAPKs 61 microRNA miR 61 endonuclease 61 myocyte 61 C1q 61 Foxp3 61 junctional 61 induced apoptosis 61 EZH2 61 Six3 61 GABAA receptors 61 cerebellar 61 p# mutations 61 chondrocyte 61 integrin 61 Nurr1 61 interleukin 1beta 61 costimulation 61 Eg5 61 #HT#A 61 iNOS 61 LDL receptor 61 polyglutamine 61 androgen receptor 61 Arp2 3 61 mGluR 61 semaphorin 61 cyclic AMP 61 #ß 61 glucocorticoid receptor 61 factor HGF 61 FasL 61 Sertoli cells 61 dynamin 61 serine threonine kinase 61 goblet cells 61 amyloid beta peptides 61 MEK ERK 61 TrkA 61 depolarizing 61 γ secretase 61 P#X# 61 telomere maintenance 61 chemokine receptor 61 excitatory 61 K + ATPase 61 CagA 61 coding RNA 61 potent inhibitors 61 receptor subtypes 61 c Myb 61 atherogenesis 61 urocortin 61 actin filaments 61 β amyloid 61 adenylate cyclase 61 Tie2 61 intercellular signaling 61 NF κB 61 TERT 61 biogenesis 61 CTGF 61 intracellular 61 hypermethylation 61 Myosin II 61 synuclein 61 transmembrane domains 61 decarboxylase 61 adhesion molecules 61 Notch pathway 61 Wnt proteins 61 IL 1ß 61 axon 61 serotonin receptor 61 cytokine receptor 61 osteogenic differentiation 61 Pgp 61 cultured neurons 61 Golgi apparatus 61 tumor microenvironment 61 MMP2 61 androgen receptor AR 61 ERBB2 61 hypothalamic pituitary 61 cathepsins 61 Abeta protein 61 hepatic stellate cells 61 peroxisomal 61 Brodmann Area 61 MAP kinases 61 non coding RNA 61 fibronectin 61 cAMP 61 leukocyte 61 chaperone proteins 61 Alu RNA 61 Integrin 61 SVZ 61 retinal ganglion cells 61 RNA polymerase II 61 IL #E 61 Rb#/p# 61 connexin# 61 chemoattractant 61 amyloid β 61 TGF Beta 61 neoplastic 61 ER alpha 61 OGG1 61 transmembrane receptor 61 H#K#me# 61 cyclins 61 KLF2 61 neuronal stem cells 61 Clusterin 61 microglial cells 61 lymphotoxin 61 EGFP 61 transferase 61 annexin V 61 Shh signaling 61 tumorigenesis 61 acetylation 61 polypeptides 61 nucleolin 61 chromosome condensation 61 SGK1 61 TXNIP 61 Cyclin D1 61 immunoregulatory 61 N methyl 61 secreted protein 61 ERK5 61 EGFR signaling 61 alveolar epithelial cells 61 suppressor cells 61 transgene expression 61 Klf4 61 lysosome 61 Id1 61 methyltransferase 61 PAR1 61 polyamines 61 gene inactivation 61 hedgehog signaling 61 phosphorylate 61 gliosis 61 Huntingtin 61 histone H3 61 ependymal cells 61 Upregulation 61 peroxisome proliferator activated 61 matrix metalloproteinase 61 neuronal synapses 61 CENP E 61 downregulation 61 synaptic vesicles 61 neural cells 61 CCR2 61 FGFR1 61 bone morphogenetic protein 61 apoptosis pathway 61 PARP1 61 neuronal signaling 61 phospho 61 Prox1 61 signal transduction 61 Integrins 61 lung epithelial cells 61 NKT cell 61 membrane fusion 61 GluR1 61 Ras pathway 61 adrenergic receptors 61 colony stimulating factor 61 N Myc 61 cohesin 61 mGluRs 61 glutamate receptor 61 PECAM 1 61 caspase activation 61 ErbB2 61 hypothalamic pituitary adrenal axis 61 Treg cells 61 mRNA cleavage 61 CYP#B# 60 endogenous ligands 60 PKD1 60 Vps# 60 tau proteins 60 ligands 60 induces apoptosis 60 receptor mediated 60 telomere dysfunction 60 serine 60 GTPase 60 JAK STAT signaling 60 radial glia 60 Histone 60 RNAi pathway 60 rRNA 60 PML RARA 60 protein phosphorylation 60 histone modifications 60 endothelial nitric oxide synthase 60 protein tau 60 senile plaques 60 FAK 60 myogenic 60 cyclization 60 Macrophage 60 phosphatase 60 microtubules 60 structural rearrangements 60 CaMKII 60 CD#L 60 cytoskeleton 60 gamma secretase 60 TET2 60 EphB4 60 zebrafish embryo 60 oligodendrocytes 60 angiogenic 60 oxidative phosphorylation 60 fibrillar 60 PPARγ 60 neurofibromin 60 Mutational 60 afferent 60 osteoclast formation 60 HDACs 60 cellular organelles 60 adipogenesis 60 podocytes 60 MMP9 60 actin 60 neurofilament 60 ectodomain 60 RANKL 60 glioma cells 60 fibroblasts 60 CEACAM1 60 retinal neurons 60 posttranslational modification 60 neural crest 60 T lymphocyte 60 neuroligins 60 cytokine IL 60 PTPN# 60 Hh 60 tumorigenicity 60 PTHrP 60 calcium ion 60 overexpression 60 ChR2 60 porphyrins 60 Lyn kinase 60 estrogen receptor beta 60 chromophore 60 EGF receptors 60 amyloid deposits 60 XBP 1 60 FLT3 60 molecular mechanisms underlying 60 5' triphosphate 60 urothelial 60 tyrosine kinase receptors 60 MEF2 60 Leydig cells 60 protein conformation 60 ADAM# 60 beta subunit 60 Hsp# [001] 60 NADPH oxidase 60 glucose transporter 60 actin polymerization 60 tyrosine kinase receptor 60 aberrant activation 60 CCL# 60 hydrolases 60 tumor angiogenesis 60 RAD# [001] 60 Tubulin 60 selectively inhibited 60 progerin 60 hTERT 60 EP1 receptor 60 pyruvate kinase 60 hematopoietic progenitors 60 enzymatic activity 60 metaphase 60 glycosylation 60 transporter proteins 60 toxic beta amyloid 60 remyelination 60 tyrosine 60 cytoplasmic domain 60 RecA 60 synaptic vesicle 60 focally 60 adenosine A2A receptor 60 cysteines 60 tubule 60 glucokinase 60 Kupffer cells 60 TNF α 60 mesenchymal 60 Schwann cells 60 GPR# [002] 60 mononuclear 60 palmitoylation 60 beta globin gene 60 protein fragment 60 TORC1 60 HPA axis 60 granzyme B 60 receptor signaling 60 hyperactivation 60 centrosome 60 SUMOylation 60 Rab# 60 neurotransmitter glutamate 60 inhibitory synapses 60 excitotoxicity 60 HSCs 60 glioblastoma cells 60 coiled coil 60 prostaglandin E 60 glycan 60 polyadenylation 60 NF kappaB activation 60 NF kappaB pathway 60 microglia 60 isoenzymes 60 S#P# 60 beta adrenergic receptors 60 neuroligin 60 UCP2 60 somatostatin receptors 60 cyclooxygenase 2 60 ligase 60 histone 60 transmembrane proteins 60 intermolecular 60 adrenal cortex 60 midbrain 60 neurones 60 signaling cascade 60 PDGFR alpha 60 constitutively 60 Aß 60 micro RNAs 60 NFAT 60 centrosomes 60 keratinocytes 60 PTEN protein 60 pyrimidines 60 electrophilic 60 intracellular calcium 60 PTP 1B 60 Rho GTPases 60 neurturin 60 cytokine secretion 60 glutamate transporter 60 fibrocytes 60 cytochrome P 60 JNK activation 60 intermediate filaments 60 bone morphogenic protein 60 mutant SOD1 60 receptor subtype 60 melatonin receptor 60 transcriptional regulator 60 cytoskeletal proteins 60 activating mutation 60 adherens junctions 60 leptin signaling 60 conformational changes 60 epigenetic silencing 60 TGF alpha 60 CTLA 4 60 inhibitory effects 60 EF Tu 60 Hh pathway 60 virulence genes 60 tumor suppressor protein 60 cellular prion protein 60 stroma 60 Supplementary Fig 60 60 EphA2 60 chemokine 60 β1 60 thalamic 60 TRAF6 60 TGF β1 60 proteolytic cleavage 60 JAK2 enzyme 60 transcriptional repression 60 catalase 60 chromatin structure 60 genomic instability 60 miR #a [001] 60 factor BDNF 60 SH2 domain 60 Dpp 60 sphingolipid 60 porphyrin 60 subcortical 60 endoplasmic reticulum ER 60 GABAB receptors 60 galectins 60 Sgk1 60 cardiomyocyte 60 WNK1 60 progranulin 60 beta actin 60 airway remodeling 60 phosphorylated 60 metalloprotease 60 carboxyl terminal 60 6S RNA 60 sortilin 60 MYCN 60 condensin 60 Notch receptor 60 basal ganglia 60 endoplasmic reticulum stress 60 ERK activation 60 RANK ligand 60 epithelial mesenchymal transition 60 fibrotic 60 epithelium 60 peroxynitrite 60 GPC3 60 DNA methyltransferases 60 druggable target 60 ENaC 60 fibroblast growth 60 cyclin dependent kinase 60 colocalization 60 transgenic mouse models 60 effector cells 60 midgut 59 PPAR gamma 59 PPARg 59 amyloid peptides 59 extracellular matrix proteins 59 oxidases 59 CaM kinase II 59 cyclin E 59 hematopoietic cells 59 WT1 59 oncogenic 59 axons 59 protein tyrosine kinase 59 phosphoinositide 59 ligases 59 S nitrosylation 59 beta amyloid plaques 59 GLI1 59 FGFR 59 bcl 2 59 P#X# receptor 59 glutamate signaling 59 constitutively expressed 59 inhibitory interneurons 59 inosine 59 COL#A# 59 hexose 59 TGF beta signaling 59 Brain derived neurotrophic 59 KLF4 59 beta arrestin 59 PU.1 59 #S proteasome 59 epithelial mesenchymal 59 amyloid fibrils 59 NMDAR 59 GPIHBP1 59 glycolipids 59 mediated phosphorylation 59 thyroid hormone receptor 59 Golgi 59 protein misfolding 59 neuroepithelial cells 59 dystroglycan 59 alpha synuclein protein 59 helicase 59 lipoxygenase 59 dorsolateral 59 dendritic 59 suppressor gene 59 circadian clock genes 59 E3 ubiquitin ligase 59 lymphatic vessels 59 neuregulin 59 lytic 59 Pten 59 SNAREs 59 p# pathway 59 oxysterols