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(Click for frequent words.) 65 genetic susceptibility 65 genetically predisposed 62 genetic predisposition 62 hereditary predisposition 60 Genetic variants 59 inherited mutations 58 mitochondrial mutations 58 untreated celiac disease 58 progranulin mutations 58 inherited predisposition 57 Cryptococcus neoformans 57 breast endometrial 57 Hashimoto thyroiditis 57 MYH9 gene 57 cirrhosis liver failure 57 overactivated 57 metabolic abnormalities 57 degenerative neurological diseases 57 inherit predisposition 57 epigenetic changes 57 genetic polymorphisms 57 predispose 57 PTEN mutations 57 GAB2 56 atopic disorders 56 rhinovirus infection 56 familial pancreatic cancer 56 familial predisposition 56 Genetic mutations 56 genetic mutations 56 Genetic mutation 56 Mycoplasma pneumoniae 56 genetic predispositions 55 environmental toxicants 55 immune dysregulation 55 LRP5 55 MTHFR 55 molecular underpinnings 55 testicular germ cell 55 toxoplasma 55 shorter telomeres 55 STAT4 55 MYH9 55 Vitamin D insufficiency 55 susceptibility gene 55 dopamine receptor gene 55 Helicobacter 55 reproductive abnormalities 55 liver scarring 55 neuroinflammation 55 genetic alteration 55 chlamydial infections 55 Chlamydia pneumoniae 55 developmental abnormalities 54 XMRV infection 54 Genetic variations 54 narcolepsy cataplexy 54 Chlamydia psittaci 54 shorter telomere length 54 Meckel Gruber 54 leptin deficiency 54 G6PD deficiency 54 hormonally sensitive 54 Zinc deficiency 54 epigenetic alterations 54 genes predisposing 54 inflammatory bowel diseases 54 Tay Sachs thalassemia 54 genetic alterations 54 mitochondrial dysfunction 54 autoimmune thyroid 54 Genetic predisposition 54 genetic determinants 54 PBDE exposure 54 Nordestgaard 54 Colon polyps 54 spongiform encephalopathies 54 VHL gene 54 impair fertility 54 KRAS oncogene 54 slow metabolizers 54 mtDNA mutations 54 subclinical hyperthyroidism 54 predisposing factors 53 sickle cell cystic fibrosis 53 Hormone pills 53 FGFs 53 glutamate signaling 53 prothrombotic 53 LRRK2 gene 53 predisposing 53 inhibiting COX 53 multifactorial disease 53 neurological degeneration 53 endocrine tumors 53 LRRK2 mutations 53 prostate carcinogenesis 53 chitinase 53 underlying pathophysiology 53 Soy isoflavones 53 oxidized cysteine 53 endogenous retroviruses 53 susceptibility genes 53 inorganic phosphates 53 Folic acid deficiency 53 PB1 F2 53 GFP gene 53 muscular dystrophies 53 AAT deficiency 53 gene variants 53 amyloid plaque formation 53 genetic makeup 53 vitamin B# deficiency 53 hyperactivated 53 atopy 53 precancerous tumors 53 coinfection 53 papillomaviruses 53 airway constriction 53 HGPS 53 familial adenomatous polyposis 53 genetic variants 53 Genetic variation 53 susceptibility 53 molecular abnormalities 53 bacteria Streptococcus pneumoniae 53 disregulation 53 elevated triglyceride levels 53 rotaviruses 53 genetic trait 53 p# mutations 53 dysregulation 53 TMEM#B 53 breast cancer metastasis 53 nerve degeneration 53 chromosomal aberrations 53 genetic polymorphism 53 Prenatal exposure 53 Chronic inflammation 53 microglial cells 53 genetic mutation 53 hereditary deafness 53 herpes viruses 53 genetic variations 53 N. meningitidis 53 infective agent 53 prenatal exposures 52 gene mutations 52 hay fever asthma 52 Creutzfeld Jakob disease 52 Pseudomonas syringae 52 myopathies 52 Viral infections 52 allergic sensitization 52 sCJD 52 APOE ε4 52 neurogenerative diseases 52 detoxify carcinogens 52 Kufs disease 52 EBV infection 52 galanin 52 immunodeficient 52 GRK5 52 inherited genetic mutation 52 gallstone disease 52 Malassezia 52 atopic disease 52 CHD7 52 Magnesium deficiency 52 HLA B# gene 52 JAK2 enzyme 52 Oxidative damage 52 selenium deficient 52 nondemented 52 microvascular disease 52 chromosomal anomaly 52 colorectal tumors 52 act synergistically 52 SGK1 52 Vitamin B# deficiency 52 ovarian hormones 52 neuron degeneration 52 genetic variant 52 Oxidative stress 52 NKX2 52 basal cell nevus syndrome 52 superantigens 52 epigenetic modification 52 dysregulated 52 ADPKD 52 inflammatory rheumatic 52 secondary bacterial infections 52 Herpes virus 52 chronic hepatitis cirrhosis 52 opportunistic pathogens 52 asthmas 52 chromosomal anomalies 52 virus XMRV 52 systemic inflammation 52 genetic susceptibilities 52 Jakob Disease 52 PTPN# 52 immunopathology 52 sortilin 52 mesotheliomas 52 mutations 52 inhaled allergens 52 FTLD 52 cardiometabolic disorders 52 genetic variation 52 asthma bronchitis emphysema 52 thyroid hormone levels 52 excitotoxic 52 neuronal dysfunction 52 protein misfolding 52 CMV infections 52 HER2 neu 52 Froguel 52 p# mutation 52 causative genes 52 endometrial hyperplasia 52 autoimmune 52 herpesviruses 52 germline mutations 52 biologic pathways 52 pathogenetic 52 CHRNA5 gene 52 gallstone formation 51 cardio vascular disease 51 PON1 51 Epstein Barr virus EBV 51 toxoplasma gondii 51 Leptospira 51 abnormal prions 51 CYP#D# gene 51 mutated genes 51 mutated gene 51 nonmelanoma skin cancers 51 diabetic kidney 51 H. pylori bacteria 51 Dilated cardiomyopathy 51 alpha synuclein protein 51 ACAT2 51 parkinsonism 51 hereditary disposition 51 TCF#L# gene 51 oxidative stress 51 radiosensitive 51 genetically inherited 51 chromosome rearrangements 51 BARD1 51 CCR5 delta# 51 immunosuppressed 51 A. fumigatus 51 cytopathic 51 estrogen mimicking 51 SSc 51 DQB1 * 51 SETDB1 51 Sjögren syndrome 51 Bardet Biedl Syndrome 51 amyloid deposition 51 premalignant 51 LIS1 51 de ath 51 meningitis encephalitis 51 Systemic lupus 51 telomeres shorten 51 immuno compromised 51 gut microbiota 51 MIF protein 51 heritable diseases 51 mutant huntingtin protein 51 shiga toxin 51 enteroviruses 51 huntingtin protein 51 insulin resistance 51 Akt signaling 51 fronto temporal dementia 51 eicosanoids 51 hyperinsulinemia 51 precocious puberty 51 MTHFR gene 51 Stress hormones 51 allergic inflammation 51 angiotensin receptor blockers ARBs 51 achromatopsia 51 BRAF gene 51 trigger allergic reactions 51 Francisella 51 genetically disposed 51 eczema hay fever 51 multi factorial disease 51 insulin resistance syndrome 51 nongenetic 51 epigenetic mechanisms 51 LPA gene 51 SORL1 gene 51 Ets2 51 arterial calcification 51 periodontal infection 51 de novo mutations 51 VIPR2 51 IL#R 51 potentially modifiable 51 spinocerebellar ataxia 51 virulence genes 51 #ß HSD1 51 hypovitaminosis D 51 Marc Weisskopf 51 metabolic abnormality 51 predisposes 51 transmissible spongiform encephalopathies 51 brain lesions 51 APOE e4 51 gene mutation 51 insulin resistant 51 Epstein Barr virus 51 familial polyposis 51 Coeliac disease 51 gastric carcinogenesis 51 latently infected 51 Celiac disease affects 51 antiviral cytokines 51 epigenetic inheritance 51 Gluten intolerance 51 leptin resistance 51 intestinal polyps 51 BRCA2 gene mutation 51 thyroid tumors 51 chlamydiosis 51 super spreaders 51 multiple sclerosis psoriasis 51 APOE4 51 Epileptic seizures 51 encephalitis inflammation 51 mitochondrial disorders 51 gene variation 51 chemically inactivated 51 BRCA1 mutations 51 rheumatoid arthritis lupus 51 Autoimmune diseases 51 insulin resistance precursor 51 intestinal inflammation 51 type2 diabetes 51 congenital disorders 51 metabolize codeine 51 Plasmodium parasites 51 Flame retardants 51 fast metabolizers 51 FMRP protein 51 proNGF 51 genus Plasmodium 51 olfactory dysfunction 51 senescent cells 51 precancerous colon polyps 51 severe obstructive pulmonary 51 gut microbes 51 KIF6 gene 51 HIV HCV coinfected 51 alpha synuclein gene 51 motor neuron diseases 51 Human papillomavirus 51 genotoxic stress 51 APOE gene 51 serotonin deficiency 51 histone deacetylases 51 TP# mutation 51 osteopontin 51 PPARγ 51 mutant genes 51 BRCA2 gene 51 prion infection 51 mammary cells 51 hormonal disturbances 51 shortened telomeres 51 misregulation 50 asthmatic symptoms 50 nonhereditary 50 inhaled fibers 50 SERT gene 50 mental retardation epilepsy 50 transmissable 50 CYP#B# 50 immune suppressing 50 lipid synthesis 50 epigenetic markers 50 normal gut flora 50 Toxoplasmosis 50 clefting 50 herpes zoster shingles 50 dominantly inherited 50 gene variant 50 Wwox 50 obesity insulin resistance 50 neurological abnormalities 50 neuroligins 50 causal pathway 50 metabolic syndrome 50 airway hyper responsiveness 50 endocrine dysfunction 50 V. vulnificus 50 polygenic 50 disease NAFLD 50 NOD2 50 metabolic alterations 50 monogenic 50 PKCi 50 vascular inflammation 50 Folic acid supplements 50 #q# deletion 50 cancerdefine 50 irreversible blindness 50 Hutchinson Gilford progeria 50 interleukins 50 spontaneous mutations 50 Darapladib 50 NAFLD 50 insoluble plaques 50 dietary interventions 50 carotid atherosclerosis 50 atherosclerosis 50 polyglutamine diseases 50 autoimmunity 50 HFE gene 50 M. vaccae 50 commonly mutated genes 50 bacteria Helicobacter pylori 50 unknown etiology 50 axonal damage 50 congenital deficiency 50 herpes simplex encephalitis 50 micro RNAs 50 undiagnosed celiac disease 50 hyperinsulinism 50 bacterium Neisseria meningitidis 50 recurrent wheezing 50 dysplastic lesions caused 50 MGUS 50 murine leukemia virus 50 T. gondii 50 protein tumor necrosis 50 metabolic disturbances 50 hantavirus infection 50 helicobacter 50 coinfected 50 TCF#L# 50 inflammatory bowel disease 50 GBA mutations 50 Salmonella Campylobacter 50 maternally derived 50 TGFBR1 * 6A 50 adiponectin levels 50 underactive thyroid gland 50 microglial 50 autoimmune disorders 50 type 1diabetes 50 Coronaviruses 50 HLA DQ2 50 infectious mononucleosis 50 transgenic rats 50 uncontrolled epilepsy 50 pancreas pancreatitis 50 immuno suppressed 50 candida infections 50 SIRT3 50 oesophageal adenocarcinoma 50 mitochondrial DNA mutations 50 penile cancers 50 encephalitis meningitis 50 phytoestrogen 50 allergic diseases 50 IUGR 50 untreated sleep apnea 50 vitamin D deficiency 50 Neisseria meningitides 50 overactivation 50 herpes infection 50 genetic abnormalities 50 subclinical infection 50 Psychiatric disorders 50 debilitating neurodegenerative disorder 50 Atopic dermatitis 50 Iron deficiency anemia 50 Autoimmune disorders 50 SIRT1 gene 50 cervical cancer genital warts 50 Bordetella pertussis 50 adrenal cortex 50 chromosomal alterations 50 JAK2 mutation 50 T1DM 50 arthritis lupus 50 Nonalcoholic fatty liver 50 ALI ARDS 50 leaky gut 50 oxidative damage 50 Candida species 50 cystic fibrosis chronic pancreatitis 50 telomere dysfunction 50 airway remodeling 50 astrocyte cells 50 immunodeficiencies 50 bronchitis emphysema 50 cerebrovascular diseases 50 macrovascular complications 50 Neurological disorders 50 etiologic 50 hormonally responsive 50 hepatitis B infection 50 predisposed 50 motor neuron degeneration 50 asthma eczema 50 cardiac fibrosis 50 plasma kallikrein 50 folate deficiency 50 squamous cell lung cancer 50 galactosemia 50 biologically predisposed 50 Smad3 50 autosomal dominant disorder 50 phyto oestrogens 50 Epstein Barr 50 spirochetes 50 Pneumococcal pneumonia 50 Wolbachia infection 50 CDH1 50 MYCN amplification 50 chromosomal rearrangement 50 activin 50 beta catenin protein 50 Variant CJD 50 Entamoeba histolytica 50 amyloid protein plaques 50 lichen planus 50 anal cancers 50 protein misfolding diseases 50 apoC III 50 impaired glucose metabolism 50 tumor suppressor protein 50 chronic hepatitis 50 V Leiden 50 Bacterial infections 50 microbiome 50 ApoE4 gene 50 Prion diseases 50 CXCL5 50 chronic respiratory illnesses 50 trans palmitoleic acid 50 Fatty liver 50 endotoxin exposure 50 Boston DbTechNo Results 50 AAT Deficiency 50 IGFBP2 50 precancerous condition 50 mutation 49 El Sohemy 49 neuro developmental disorders 49 lactose malabsorption 49 periodontal infections 49 IGF1 49 lupus scleroderma 49 BRAF protein 49 male hormone androgen 49 Maternal obesity 49 allergic airway 49 unhealthier lifestyles 49 beta1 integrin 49 ApoE gene 49 asthmatic airways 49 chromosomal instability 49 nonmelanoma skin cancer 49 mycobacterium tuberculosis 49 sirtuin enzymes 49 gene BRCA2 49 potent inducer 49 hypo pigmentation 49 SHANK3 49 parainfluenza virus 49 ADAMTS# 49 ORMDL3 49 ferulic acid 49 demethylating 49 SORL1 49 polycyclic aromatic hydrocarbons PAHs 49 PARP inhibition 49 lung cancer asbestosis 49 thyroid disorders 49 predisposing factor 49 SOD2 gene 49 elevated CRP 49 presymptomatic 49 amyloid accumulation 49 inflammatory demyelinating 49 GRNCM1 49 hormonally active 49 testicular tumors 49 immunocompromised individuals 49 familial ALS 49 prediabetic 49 Treg cell 49 KIBRA 49 immunological 49 nonalcoholic steatohepatitis 49 Infected birds 49 biochemical imbalance 49 bowel cancers 49 generalized vitiligo 49 bacterium infects 49 orexin receptors 49 neuroblastomas 49 immunological mechanisms 49 viral infections 49 MC1R 49 Thyroid hormone 49 C. pneumoniae 49 proliferative disorders 49 metabolic dysfunction 49 modifier genes 49 inhalant allergies 49 mutated protein 49 epithelial cancers 49 mycobacteria 49 respiratory viral infections 49 cardiovascular disease hypertension 49 amyloid beta plaques 49 biological predisposition 49 endometrial cancers 49 aggravate allergies 49 MC1R gene 49 abnormal lipid levels 49 Ascherio 49 CagA 49 subclinical 49 cause cardiac channelopathies 49 neurotoxic effects 49 Mycobacterium leprae 49 neuropeptide Y NPY 49 FASPS 49 commensal bacteria 49 telomere lengths 49 vaginosis 49 Sporadic CJD 49 NF1 49 experimentally induced 49 non alcoholic steatohepatitis 49 oxidant stress 49 BRIP1 49 unexplained vaginal bleeding 49 airway hyperresponsiveness 49 BCL#A 49 occupational exposures 49 PIK3CA 49 hypokalemia hypomagnesemia 49 mitochondrial defects 49 cybrid 49 gene p# 49 Polymorphic Ventricular Tachycardia CPVT 49 deleterious mutations 49 HLA genes 49 LXRs 49 IDH mutations 49 toxicants 49 causally linked 49 alpha1 antitrypsin deficiency 49 ductal breast cancer 49 fatty liver disease 49 Alzhemier 49 IKK2 49 Mycobacterium bovis 49 olfactory receptor 49 Ischaemic heart 49 cytomegalovirus CMV 49 Li Fraumeni 49 NPHP 49 underactive thyroids 49 asthma rhinitis 49 MIF gene 49 thyroid dysfunction 49 urethritis 49 CALHM1 49 HNSCC 49 PPAR γ 49 intestinal ulcers 49 phenotypic variability 49 genetic makeups 49 Hypertrophic cardiomyopathy 49 Leydig cell 49 prion disease 49 mutated K ras 49 parasite Plasmodium falciparum 49 Clusterin 49 asymptomatic carriers 49 Human papilloma virus 49 neuroinflammatory 49 yeast overgrowth 49 obstructive lung 49 Ankara MVA 49 tanned indoors 49 Alzheimer disease vascular dementia 49 APOL1 49 improves insulin sensitivity 49 viral bacterial 49 glomerulonephritis 49 recurrent miscarriages 49 TAT2 49 iodine deficient 49 estrogen metabolism 49 Brd4 49 autosomal recessive disease 49 Hyperthyroidism 49 protein tau 49 Borrelia 49 pathophysiological mechanisms 49 Pdx1 49 immunodeficiency 49 neuronal synapses 49 ARID1A 49 prenatal exposure 49 biochemical abnormalities 49 NAT2 49 Glucocorticoids 49 Toxoplasma 49 epigenetic regulation 49 MAOA gene 49 Staphylococcus bacteria 49 genetic underpinnings 49 activated microglia 49 Shigella bacteria 49 promoter hypermethylation 49 gene rearrangements 49 airway inflammation 49 enterocolitis 49 asthma hay fever 49 ZNF# 49 CYP#A# gene 49 Propionibacterium acnes 49 corn borer moths 49 mammary gland tumors 49 cardiac hypertrophy 49 estrogenic effects 49 intestinal biopsy 49 statins cholesterol lowering 49 genetic variants associated 49 E4 variant 49 vitamin D synthesis 49 prion infections 49 familial hypercholesterolemia FH 49 endocrine disrupters 49 INF2 49 IgA deficiency 49 precancerous cervical 49 herpes virus infection 49 suppressed immune 49 klotho 49 coccidia 49 severe dehydrating diarrhea 49 insulin secreting beta 49 hormone adiponectin 49 abnormal hemoglobin 49 prodynorphin 49 Human papillomavirus HPV 49 neuronal apoptosis 49 Hakonarson 49 heterotaxy 49 gastric carcinoma 49 endocrine disrupting chemicals EDCs 49 Leukemias 49 Bacterial infection 49 smaller freshwater crocodiles 49 MCAD deficiency 49 Fragile X gene 49 Male pattern baldness 49 Hsp# [001] 49 emphysema chronic bronchitis 49 organophosphate exposure 49 Streptococcus pneumoniae Haemophilus influenzae 49 GSTM1 49 oxysterols 49 microcephalin 49 alpha1 antitrypsin AAT deficiency 49 activate p# 49 neurologic disorders 49 underlying molecular mechanisms 49 Methylmercury 49 oncogenic transformation 49 colon polyps 49 genital herpes infections 49 eczema asthma 49 NADPH oxidase 49 recessive trait 49 Epstein Barr Virus EBV 49 gastroenteritis conjunctivitis 49 wart virus 49 resistin 49 Creutzfeldt Jacob 49 mammary cancers 49 Periodontal disease 49 behavioral disinhibition 49 amyloid β 49 Infant botulism 49 latent TB infection 49 prostate abnormalities 49 recurrent infections 49 dermatophytes 49 GSTT1 49 C. neoformans 49 epithelial tissues 48 autoimmune diseases 48 familial hypercholesterolemia 48 primordial germ cells 48 androgen excess 48 genes 48 muscular dystrophy cystic fibrosis 48 lactose tolerance 48 LCMV infection 48 Parkinson degenerative 48 Plasmodium ovale 48 leptin resistant 48 bacterial parasitic 48 Untreated sleep apnea 48 systemic scleroderma 48 recessive genetic 48 interferon pathway 48 chromosomal translocations 48 calcium oxalate stones 48 Basal Cell 48 fat malabsorption 48 COX enzymes 48 HLA DRB1 48 Shumyatsky 48 Inflammatory bowel diseases 48 premature wrinkling 48 Bardet Biedl syndrome 48 methylation markers 48 embryonic tissues 48 hypermethylated 48 darker pigmentation 48 teratogens 48 bowel polyps 48 maternally transmitted 48 Beta thalassemia 48 ki ll 48 kidney urologic 48 gastro intestinal diseases 48 genital lesions 48 CYP#C# [002] 48 inherited genetic mutations 48 oxidized lipids 48 genetic defects 48 synovial cells 48 neuroendocrine 48 pancreatic islet 48 thrifty gene 48 phenotypic variation 48 etiologic agent 48 Lupus nephritis 48 Seasonal allergies 48 unmeasured factors 48 neurodevelopment 48 meningococcus 48 NF KappaB 48 Buffenstein 48 amino acid homocysteine 48 immunocompromised 48 NF kB pathway 48 dust mites pollen 48 hyperhomocysteinemia 48 pre cancerous growths 48 polycystic ovarian syndrome PCOS 48 Hh pathway 48 spirochete 48 MHC genes 48 neuro degenerative disorders 48 CIB1 48 CFH gene 48 wasting Creutzfeldt Jakob 48 Apobec3 48 tau protein tangles 48 genomic imprinting 48 rheumatoid arthritis multiple sclerosis 48 amyloid deposits 48 periodontitis 48 ADAM# 48 infectious prion proteins 48 neurodegenerative disorder 48 subclinical hypothyroidism 48 hormone IGF 48 prostate pancreatic 48 signaling cascades 48 aldehyde dehydrogenase 48 chlamydial infection 48 Uterine cancer 48 TACI mutations 48 SOD1 gene 48 sphingolipids 48 leukaemias 48 genetically predetermined 48 amyloid peptide 48 Wernicke Korsakoff syndrome 48 glaucoma ischemia 48 atherosclerosis hardening 48 UVB induced 48 defective gene 48 Rheumatic fever 48 obstructive pulmonary disease 48 FTIs 48 divide uncontrollably 48 Respiratory Syncytial Virus RSV 48 RANKL 48 methicillin susceptible Staphylococcus aureus 48 herpes zoster virus 48 Escherichia coli O# 48 pancreatic carcinogenesis 48 hormone aldosterone 48 allergic dermatitis 48 M1 macrophages 48 potent carcinogen 48 HLA B# 48 arterial plaques 48 intracellular bacteria 48 HbF 48 pathogenic bacterium 48 chromosome translocations 48 inflammatory bowel syndrome 48 oestrogens 48 primary biliary cirrhosis 48 Alport syndrome 48 Notch1 48 methylxanthines 48 elevated homocysteine 48 Carcinoid tumors 48 diease 48 untreatable blindness 48 germline mutation 48 growth hormone secretion 48 HSV1 48 Wnt#b 48 acute myelogenous leukemia AML 48 IRF6 48 avian strain 48 bile acid metabolism 48 endogenous estrogen 48 dyskeratosis congenita 48 allergic eczema 48 demyelinating disease 48 glitazones 48 sexually transmitted HPV 48 androgen deficiency 48 neurodevelopmental disorder 48 neural degeneration 48 UCP2 48 gamma globin gene 48 apoE 48 NF kB signaling 48 coma convulsions 48 prostaglandin synthesis 48 ABCB1 48 flavonoid compounds 48 gene polymorphism 48 prion gene 48 stimulate neurogenesis 48 neurodegeneration 48 bacteria Mycobacterium tuberculosis 48 Breteler 48 C. trachomatis 48 #q#.# [001] 48 apolipoprotein E gene 48 eicosanoid 48 microfilariae 48 inherited retinal degeneration 48 hemorrhagic colitis 48 neuronal plasticity 48 chlamydial 48 lupus rheumatoid arthritis 48 Alpha synuclein 48 Rh incompatibility 48 noninfectious 48 beta carotene supplementation 48 interstitial nephritis 48 cirrhosis liver cancer 48 glucose intolerance 48 prostaglandin E2 48 oncogenic 48 DHFR 48 hippocampal function 48 faulty BRCA genes 48 malfunctioning mitochondria 48 Anders Wimo 48 bacterial symbionts 48 chronic bronchitis emphysema 48 easily transmittable 48 overactive thyroid gland 48 EP3 receptor 48 haptoglobin 48 opportunistic pathogen 48 familial dysautonomia 48 IGFBP 3 48 osteosarcomas