Related by context. All words. (Click for frequent words.) 71 COPD exacerbations 68 severe exacerbations 67 asthma exacerbations 65 tiotropium 64 asthma exacerbation 63 salmeterol fluticasone 63 oral corticosteroids 62 pulmonary exacerbations 62 TEAEs 62 Exacerbations 62 hypoglycemic events 61 GERD symptoms 61 recurrent genital herpes 61 OADs 61 hyperkalemia 60 bronchospasm 60 TMP SMX 60 antithrombotic therapy 60 reinfarction 60 potassium sparing diuretics 60 gout flares 60 nighttime awakenings 60 thrombotic events 60 interferon therapy 60 infliximab 60 extrapyramidal symptoms 60 RLS symptoms 60 incontinence episodes 59 serum phosphorus 59 salmeterol HFA MDI 59 concomitant medications 59 severe neutropenia 59 APTIVUS r 59 fluticasone salmeterol 59 lung function 59 ribavirin therapy 59 tolvaptan 59 thromboembolic events 59 LTRA 59 acute exacerbations 59 rhinoconjunctivitis 59 systemic corticosteroid 59 COPD 59 severe hypoglycemic 59 acute gout flares 59 severe asthma exacerbations 59 bronchial hyperresponsiveness 59 corticosteroid dose 59 clinically meaningful improvements 59 receiving VELCADE 59 Hypersensitivity reactions 59 HPA axis suppression 59 postoperative AF 58 hour bronchodilation 58 systemic corticosteroids 58 macrovascular events 58 oral corticosteroid 58 depressive episodes 58 severe hypoglycemia 58 OAB symptoms 58 renal dysfunction 58 pyridostigmine 58 EXJADE 58 asthma 58 ADHF 58 laboratory abnormalities 58 COPD exacerbation 58 leukotriene receptor antagonist 58 budesonide formoterol 58 mucosal healing 58 β blockers 58 octreotide LAR 58 Hypotension 58 corticosteroid therapy 58 invasive aspergillosis 58 inhaled steroids 58 HbA1c levels 58 myopathy rhabdomyolysis 58 HBeAg seroconversion 58 dyspnea 58 bronchodilators 58 pulmonary exacerbation 58 autoantibody levels 58 peginterferon alfa 2a 58 syncope 58 clinically meaningful improvement 58 nephrotoxicity 58 ATACAND 58 antiarrhythmic drug 57 upper gastrointestinal bleeding 57 intracranial hemorrhage ICH 57 montelukast 57 thrombotic complications 57 T2DM 57 antihypertensive medications 57 airway inflammation 57 induce orthostatic hypotension 57 adalimumab 57 hypoglycemic episodes 57 airway hyper responsiveness 57 relapsing MS 57 aripiprazole 57 bronchodilator 57 proliferative diabetic retinopathy 57 inhaled corticosteroid 57 macroalbuminuria 57 nocturnal awakenings 57 stable angina 57 renal toxicity 57 hemorrhagic complications 57 arterial thromboembolic events 57 virological response 57 dasatinib 57 long acting bronchodilators 57 cardiac toxicity 57 febrile neutropenia 57 virological failure 57 glucocorticoid therapy 57 dopaminergic therapy 57 FOLFIRI 57 hyperglycemia 57 quetiapine 57 airflow obstruction 57 certolizumab 57 apneas 57 delayed CINV 57 HBeAg positive patients 57 FOLPI regimen 57 torsade de pointes 57 prednisone prednisolone 57 ziprasidone 57 beclomethasone dipropionate 57 reflux symptoms 57 levodopa therapy 57 hypomagnesemia 57 hyperphenylalaninemia HPA due 57 angiotensin converting enzyme inhibitors 57 etanercept 57 relapses 57 nonadherence 57 idraparinux 57 treatment emergent AEs 57 NAbs 57 asthma flare ups 57 IBS symptoms 57 clinically meaningful reductions 56 leucopenia 56 hyperglycaemia 56 symptom flare ups 56 hospitalizations 56 nicardipine 56 posttransplant 56 tapentadol ER 56 rimonabant #mg 56 prodromal symptoms 56 QVAR R 56 HF hospitalization 56 virologic failure 56 4mg/kg 56 AGILECT R 56 tocilizumab 56 MADRS score 56 CIMZIA ™ 56 abatacept 56 airway hyperresponsiveness 56 tipranavir 56 quinidine 56 hematological toxicity 56 annualized relapse 56 NATRECOR R 56 lactic acidosis 56 thromboembolic 56 intracerebral hemorrhage 56 daytime drowsiness 56 DMARDs 56 depressive symptom 56 heparin induced thrombocytopenia 56 cerebrovascular events 56 beta blocker therapy 56 recurrent venous thromboembolism 56 COPAXONE R 56 virologic breakthrough 56 glycated hemoglobin levels 56 treatment emergent adverse 56 tardive dyskinesia TD 56 cardiovascular mortality 56 ADHD symptoms 56 beta2 agonist 56 inhaled corticosteroid therapy 56 Psoriasis Area 56 inhaled corticosteroid ICS 56 Adverse events 56 serum urate 56 platelet reactivity 56 QT prolongation 56 torsades de pointes 56 amiodarone 56 menstrual migraine 56 anticoagulant warfarin 56 imipenem 56 inhaled steroid 56 cranial irradiation 56 FAMPYRA 56 SYMBICORT 56 solifenacin 56 herpes zoster 56 sulfasalazine 56 canakinumab 56 sustained ventricular tachycardia 56 nasal symptoms 56 diabetic gastroparesis 56 periprocedural 56 oral prednisolone 56 lenalidomide dexamethasone 56 plus ribavirin 56 anakinra 56 VAPRISOL 56 Tiotropium 56 OSAHS 56 PegIFN RBV 56 Erythropoietic therapies may 56 DMARD 56 HbA 1c levels 56 hypokalemia 56 DAPT 56 zafirlukast 56 bosentan 56 inhaled corticosteroids 56 5-FU/LV 55 disease progression 55 gouty arthritis 55 mitoxantrone 55 topical calcineurin inhibitors 55 omeprazole Prilosec 55 placebo p = 55 elevated plasma concentrations 55 hematologic adverse 55 achieved ACR# 55 mycophenolate mofetil 55 neutropenic patients 55 mepolizumab 55 virologic response 55 hydroxychloroquine 55 recurrent VTE 55 hypercholesterolaemia 55 antihypertensive therapy 55 LV dysfunction 55 FROVA 55 recurrent wheezing 55 intensive statin therapy 55 aminotransferases 55 candesartan 55 TNF antagonist 55 PASI scores 55 hyperammonemia 55 angioedema 55 hypotension 55 allergic asthma 55 events TEAEs 55 primary generalized tonic 55 depressive symptoms 55 hypoglycaemia 55 Thrombocytopenia 55 lipid lowering medication 55 airway constriction 55 immunosuppressive agents 55 long acting bronchodilator 55 hypoglycemia 55 nocturnal hypoglycemia 55 airflow limitation 55 immunomodulatory therapy 55 neutropaenia 55 ALT flares 55 anemia hemoglobin 55 Toxicities 55 peginterferon 55 tolterodine ER 55 leukotriene receptor antagonists 55 neurocognitive deficits 55 inhaled glucocorticoids 55 visilizumab 55 tranylcypromine 55 hypertensive patients 55 generalized seizures 55 divalproex 55 hemoptysis 55 venous thrombosis 55 posaconazole 55 subcutaneous insulin 55 MS relapses 55 hypopneas 55 rhinitis 55 Perforomist Inhalation Solution 55 intracerebral haemorrhage 55 neovascular 55 myocardial infarctions 55 HbA 1c 55 anticholinergics 55 rhinorrhea 55 metabolic acidosis 55 VIIBRYD 55 hypoglycaemic episodes 55 INVEGA ® 55 inflammatory lesions 55 SAEs 55 VT VF 55 severe hypersensitivity reactions 55 uncontrolled asthma 55 primary hypercholesterolemia 55 neutropenia dehydration dyspnea 55 postoperative bleeding 55 CCyR 55 serologically active patients 55 alanine aminotransferase 55 clopidogrel 55 hypersensitivity reaction 55 serum potassium 55 QVAR ® 55 recurrent ischemia 55 HeFH 55 bezafibrate 55 paroxysmal AF 55 intravitreal injections 55 EDSS score 55 EDSS scores 55 neuroleptics 55 ipsilateral stroke 55 Pseudomonas aeruginosa infections 55 racemic albuterol 55 hypercalcemia 55 nonfatal MI 55 bronchoconstriction 55 decompensated heart failure 55 timepoints 55 immunosuppressant therapy 55 atopy 55 treprostinil 55 oxycodone CR 55 steroid dexamethasone 55 NPH insulin 55 acute myocardial infarction AMI 55 tirofiban 55 gastrointestinal toxicity 55 lamotrigine 55 constipation nausea 55 acute exacerbation 55 hemodialysis patients 55 fluoxetine Prozac 55 serum BDNF 55 rotigotine 55 antihypertensive medication 55 primidone 55 angina 55 CIMZIA TM certolizumab pegol 55 salmeterol 55 dosage regimens 55 Venous thromboembolism 55 CINV 55 microalbuminuria 55 bronchodilation 55 ventricular fibrillation VF 55 QTc prolongation 55 asymptomatic AF 55 acute asthma exacerbations 55 prolonged QT interval 55 post herpetic neuralgia 55 neurologic sequelae 55 hemoglobin A1c HbA1c 55 atherothrombotic events 55 dosing frequency 55 neuropsychiatric symptoms 55 fondaparinux 55 plasma uric acid 54 syncopal episodes 54 RAPTIVA 54 Secondary endpoints 54 IFN beta 54 intravenous bisphosphonates 54 allergic rhinitis 54 cytopenias 54 MULTAQ 54 hypervolemic hyponatremia 54 plasma HCV RNA 54 Oral corticosteroids 54 inotropic 54 mg BID 54 gout flare 54 FOLFOX4 54 unstable angina 54 Lantus ® 54 voriconazole 54 microvascular complications 54 Etanercept 54 sustained virological response 54 lispro 54 proteinuria 54 comorbid conditions 54 fosamprenavir 54 NSAID therapy 54 interferon ribavirin 54 oral FTY# 54 gastric acidity 54 QTc interval 54 NOMID 54 LEXIVA 54 post thrombotic syndrome 54 RSV infection 54 status epilepticus 54 Fingolimod 54 MCyR 54 antiemetics 54 lipid parameters 54 MACCE 54 LVEF 54 FEV1 54 renal flares 54 elevated intraocular pressure 54 aminotransferase elevations greater 54 thrombocytosis 54 relapsing remitting 54 ARCALYST ® 54 H2 receptor antagonists 54 pyrazinamide 54 teriflunomide 54 urinary symptoms 54 aspirin clopidogrel 54 chronic rhinosinusitis 54 macrovascular disease 54 decompensation 54 nonfatal stroke 54 variceal bleeding 54 Febrile neutropenia 54 Lamictal XR 54 pentoxifylline 54 EBV infection 54 chlorambucil 54 bendamustine 54 clozapine 54 interferon alfa 54 euvolemic 54 diarrhea nausea fatigue 54 aldosterone antagonists 54 paroxetine Paxil 54 anticholinergic medication 54 benazepril 54 postoperative complication 54 anticholinergic drugs 54 acute GvHD 54 sustained virologic response 54 nebulized 54 mcg QD 54 vancomycin 54 abacavir lamivudine 54 insulin detemir 54 exacerbation 54 salmeterol inhalation powder 54 receiving golimumab 54 hypertensives 54 ropivacaine 54 basilar migraine 54 hemorrhagic strokes 54 L dopa 54 VELCADE melphalan 54 perennial allergic rhinitis 54 subsyndromal 54 renal impairment 54 dacarbazine 54 nonvertebral fractures 54 oral antidiabetic drugs 54 coronary revascularization 54 angiographic restenosis 54 serum phosphate 54 incidence ≥ 54 amphotericin B 54 Postoperative complications 54 REMICADE ® 54 myocardial infarction stroke 54 neurologic progression 54 symptomatic VTE 54 glucose lowering 54 atopic 54 elevated IOP 54 streptokinase 54 lichen planus 54 H2 blockers 54 revascularization procedures 54 nonfatal myocardial infarction 54 ALT elevations 54 vasomotor symptoms 54 pyrexia mucositis sepsis febrile 54 dysthymia 54 CDAI 54 ertapenem 54 amoxicillin clavulanate 54 A1c levels 54 pharmacotherapy 54 BENICAR 54 myocardial infarction MI 54 Torsades de Pointes 54 angina pectoris 54 emesis 54 corticosteroids 54 myocardial infarction 54 VaD 54 EDARBI 54 serum calcium levels 54 IIIa inhibitor 54 glycosylated hemoglobin HbA1c 54 UA NSTEMI 54 left ventricular dysfunction 54 oral antidiabetes drugs 54 carotid stenosis 54 mcg kg REBETOL 54 omalizumab 54 PREZISTA r 54 coagulopathy 54 Sjögren syndrome 54 antiplatelet medication 54 PRADAXA #mg 54 postherpetic neuralgia 54 ARIXTRA 54 progression TTP 54 fluticasone 54 Treatment emergent adverse 54 infliximab Remicade 54 anticoagulation therapy 54 Natalizumab 54 analgesic medications 54 NSAID induced 54 short acting bronchodilator 54 hypomanic episodes 54 antibiotic prophylaxis 54 NATRECOR ® 54 gastrointestinal perforation 54 p = NS 54 nasal polyposis 54 corticosteroid 54 Obstructive sleep apnea 54 alanine aminotransferase ALT 54 ICD shocks 54 angiotensin converting enzyme inhibitor 54 ribavirin RBV 53 C1 INH deficiency 53 nonsignificant 53 myocardial ischemia 53 infusion reactions 53 nortriptyline 53 DULERA 53 MAO inhibitors 53 mg dose 53 tumor shrinkage 53 tumor regressions 53 HbA 1C 53 splenectomized patients 53 transaminase elevations 53 genotypic resistance 53 HIV HCV coinfected 53 INVEGA R 53 daytime sleepiness 53 Secondary endpoints include 53 A1C levels 53 eptifibatide 53 apneic 53 efalizumab 53 secondary efficacy endpoint 53 oral antidiabetes 53 ACTOplus met 53 familial ALS 53 hepatotoxicity 53 vasovagal syncope 53 ZYVOX 53 FOLPI 53 Unstable angina 53 leukopenia 53 nadolol 53 azathioprine 53 TYSABRI treated 53 antiplatelet medications 53 paroxysmal atrial fibrillation 53 BARACLUDE ® 53 partial remissions 53 acting beta agonists 53 thrombocytopenia 53 fluid overload 53 comorbidities 53 NYHA Class II 53 bacteriuria 53 anticholinergic agents 53 dysglycemia 53 antihypertensive agents 53 divalproex sodium 53 ACE inhibitor 53 CMV infection 53 pancytopenia 53 budesonide 53 verapamil 53 Crohn Disease Activity 53 ischemic stroke 53 inhaled fluticasone 53 rosuvastatin #mg 53 invasive candidiasis 53 opioid analgesia 53 symptom severity 53 CANCIDAS 53 overt nephropathy 53 adrenal function 53 relapsing multiple sclerosis 53 neutrophil counts 53 hypoxemia 53 nasal symptom 53 refractory NSCLC 53 TMC# r 53 unknown etiology 53 cytogenetic response 53 cardiogenic shock 53 blood phenylalanine Phe 53 chlorthalidone 53 severe hypoglycaemia 53 hypophosphatemia 53 lopinavir r arm 53 QT intervals 53 proton pump inhibitor PPI 53 daytime alertness 53 nasal allergy symptoms 53 HBeAg positive 53 Ulcerative colitis 53 bronchopulmonary dysplasia 53 affective psychoses 53 hematologic toxicity 53 vasodilators 53 NovoLog ® Mix 53 thiazide 53 Corticosteroids 53 serum phosphorous 53 ischemic complications 53 subclinical hypothyroidism 53 vasospasm 53 GERD symptom 53 rizatriptan 53 AA Amyloidosis 53 cytogenetic responses 53 rehospitalization 53 lipid lowering medications 53 myelosuppression 53 anemia neutropenia 53 haloperidol Haldol 53 beta agonists 53 coinfected patients 53 elevated ALT 53 tachyarrhythmias 53 psoriatic arthritis PsA 53 frequent awakenings 53 postsurgical pain 53 8mg/kg 53 antiplatelet therapy 53 BROVANA 53 sotalol 53 PEGylated interferon beta 1a 53 immunocompetent patients 53 RSV infections 53 Thal Dex 53 airway responsiveness 53 dyspnoea 53 neuroleptic 53 alteplase 53 acute bronchospasm 53 acute myocardial infarctions 53 ocular toxicity 53 adjunctive placebo 53 tolterodine 53 atrioventricular block 53 recurrent stroke 53 acid suppressive medication 53 CP CPPS 53 prodrome 53 homozygous familial hypercholesterolemia 53 morbidity mortality 53 #mg dose [001] 53 ARCOXIA 53 adrenal suppression 53 polypharmacy 53 clopidogrel Plavix 53 imatinib therapy 53 untreated psychosis 53 TNF inhibitor 53 receiving XGEVA 53 ULORIC 53 acute gout 53 RBC transfusions 53 pruritis 53 APTIVUS 53 Primary endpoints 53 RLAI 53 severe psoriasis 53 postoperative atrial fibrillation 53 acute coronary syndrome 53 corrected QT interval 53 acute coronary 53 prazosin 53 symptomatic hypotension 53 FOLFOX 53 active ankylosing spondylitis 53 Calcineurin inhibitors 53 Lactic acidosis 53 eosinophilia 53 orthostatic hypotension 53 MICARDIS ® 53 cerebral ischemia 53 systemic lupus erythematosus SLE 53 acute decompensation 53 dexamethasone 53 glucocorticoid 53 ADEs 53 receiving ISENTRESS 53 anti TNF 53 opioid induced bowel dysfunction 53 IPAH 53 symptom exacerbation 53 recurrent infections 53 Angioedema 53 sertraline Zoloft 53 clomipramine 53 moderate renal impairment 53 endometrial hyperplasia 53 liver histology 53 euthymic patients 53 hypocalcemia 53 C. difficile infection 53 ischemic strokes 53 colorectal adenoma 53 baseline HbA1c 53 hepatic encephalopathy HE 53 warfarin 53 acute coronary syndromes ACS 53 post herpetic neuralgia PHN 53 intravascular hemolysis 53 odanacatib 53 recurrent DVT 53 generalized tonic clonic seizures 53 polyp recurrence 53 PPIs 53 lupus nephritis 53 partial onset seizures 53 intermittent hypoxia 53 loop diuretics 53 arrhythmias 53 nocturnal hypoglycaemia 53 obstructive apnea 53 elevated triglyceride levels 53 co morbidities 53 AVELOX 53 Chronic Bronchitis 53 acting beta agonist 53 oral antidiabetic medication 53 antihypertensive drugs 53 IPL# 53 cilostazol 53 venous thromboembolic disease 53 antiarrhythmic drugs 53 ZOLINZA 53 diabetic kidney 53 Cladribine tablets 53 hypercholesterolemia 53 hallucinations dyskinesia 53 generalized edema 53 serum phosphate levels 53 antithrombotics 53 abrupt discontinuation 53 IBS C 53 refractory ischemia 53 antiplatelet agents 53 allergen immunotherapy 53 toxicities 53 allergic inflammation 53 citalopram 53 hyperalgesia 53 thromboembolic disease 53 intermittent dosing 53 ischemic cardiomyopathy 53 non metastatic osteosarcoma 53 N acetylcysteine 53 apnea hypopnea index 53 tegaserod 53 relapsed SCLC 53 adefovir 53 clinically meaningful 53 lacosamide 53 Tardive dyskinesia 53 HbA1c 53 postoperative mortality 53 bolus injection 53 velafermin 53 riociguat 53 ritonavir boosted 52 onset atrial fibrillation 52 CK MB 52 KETEK 52 oxcarbazepine 52 SSc 52 thromboembolism 52 biologic therapy 52 tumor lysis syndrome 52 akathisia 52 Hypoglycemia 52 irbesartan 52 thrombolytic therapy 52 prednisone 52 β blocker 52 Perforomist TM Inhalation Solution 52 % CI #.#-#.# [007] 52 agomelatine 52 QVA# 52 peg IFN 52 oral levofloxacin 52 neurologic symptoms 52 rufinamide 52 PREZISTA r arm 52 azacitidine 52 ACTEMRA TM 52 thiazides 52 serum ALT 52 steroid inhalers 52 tricyclic antidepressant 52 serum uric acid 52 bothersome symptom 52 somatostatin analogs 52 composite endpoint 52 Apidra ® 52 reperfusion injury 52 conventional antipsychotics 52 dysuria 52 anaphylactoid reactions 52 salmeterol fluticasone propionate 52 DOXIL 52 mg QD 52 severe oral mucositis 52 sweat chloride 52 clopidogrel therapy 52 cardiovascular morbidity 52 hypoventilation 52 Relapses 52 ruboxistaurin 52 ceftriaxone 52 formoterol fumarate 52 unfavorable cytogenetics 52 immunosuppressive therapies 52 Inhaled corticosteroids 52 angiotensin receptor blockers 52 hypotensive 52 5 Fluorouracil 52 quetiapine XR 52 PsA 52 lung fibrosis 52 renal insufficiency 52 ximelagatran 52 placebo 52 BYSTOLIC 52 ventricular arrhythmia 52 sinus rhythm 52 chronic GVHD 52 Isoniazid 52 neurocognitive function 52 neurologic complications 52 Chronic cough 52 retinal thickness 52 paclitaxel Taxol 52 fingolimod 52 glycemia 52 hepatorenal syndrome 52 CDAD 52 CIMZIA TM 52 chronic bronchitis AECB 52 budesonide pMDI 52 nonallergic rhinitis 52 hyperuricemia 52 monoamine oxidase inhibitors 52 symptomatic hypoglycemia 52 Overactive bladder 52 venlafaxine Effexor 52 #.#mg/dL 52 antidepressant efficacy 52 heavy menstrual bleeding 52 events AEs 52 desvenlafaxine succinate 52 aldosterone antagonist 52 sertraline 52 gastric pH 52 BENICAR HCT 52 RAS blockers 52 systolic hypertension 52 acute myocardial infarction 52 thromboembolic disorders 52 BoNTA 52 NNT = 52 sJIA 52 antiplatelet 52 nephrotoxic 52 Allergic Rhinitis 52 Relapsing remitting MS 52 PONV 52 nortriptyline Pamelor 52 highly emetogenic 52 Traficet EN 52 diuretic chlorthalidone 52 bacteremia 52 NSTEMI 52 Hydroxyurea 52 hematologic toxicities 52 abacavir 52 alkylating agent 52 neurologic dysfunction 52 Scale EDSS score 52 PANSS scores 52 anaphylactic reactions 52 receiving VICTRELIS 52 idarubicin 52 headache abdominal pain 52 ibandronate 52 erythropoietic 52 adrenal insufficiency 52 phenelzine 52 abciximab 52 Pioglitazone 52 oral vancomycin 52 serum calcium 52 fluorouracil 52 p = #.# [003] 52 ischemic cardiovascular 52 HCV infection 52 acute migraine 52 diabetes mellitus DM 52 pramipexole 52 Zileuton 52 sUA 52 DFMO 52 AGILECT ® 52 morphometric vertebral fractures 52 carvedilol 52 balsalazide 52 xanthine oxidase inhibitor 52 postprocedure 52 deep venous thromboses 52 phenytoin 52 dexamethasone Decadron 52 hyperlipidaemia 52 gemifloxacin 52 â ‰ ¥ 52 Bosentan 52 interpersonal psychotherapy 52 fulminant 52 CrCl 52 elevated uric acid 52 zoledronic acid 52 serum bicarbonate 52 zoster 52 COREG 52 discontinuations due 52 icatibant 52 antimuscarinic 52 chronicity 52 palifermin 52 EFFEXOR XR 52 Glucocorticoids 52 p = .# [002] 52 ramipril 52 neutropenic fever 52 atypical antipsychotic 52 mixed hyperlipidemia 52 hepatic encephalopathy 52 non hematological toxicities 52 colectomy 52 dopamine antagonists 52 serum HCV RNA 52 acetylcysteine 52 PSA nadir 52 milrinone 52 Non inferiority 52 P. aeruginosa infections 52 fibrinolytic 52 Allergic asthma 52 tiotropium bromide 52 recurrent atrial fibrillation 52 statistically significant improvement 52 gastrointestinal bleeds 52 PICSO ® 52 Community Acquired Pneumonia 52 vWD 52 optic neuritis 52 upper airway obstruction 52 SPIRIVA ® 52 hyperresponsiveness 52 transaminase levels 52 nonfatal heart 52 nasal obstruction 52 coagulation abnormalities 52 Allergic rhinitis 52 psychotic symptoms 52 atopic sensitization 52 rhythm disturbances