Related by context. All words. (Click for frequent words.) 69 Calorie restriction 68 caloric restriction 67 calorie restriction 65 Caloric restriction 65 Sir2 65 S#K# 64 calpain 63 receptor activation 63 insulin secretion 62 SH2 B 62 UCP2 62 TORC2 62 gut microbiota 62 glucocorticoid 62 gluconeogenesis 62 SIRT1 61 mitochondrial function 61 spermidine 61 leptin 61 calorie restriction CR 61 Sirt1 61 intestinal microflora 61 FGF# 61 ubiquinone 61 mitochondrial biogenesis 61 Klotho 61 dietary fats 61 yeast worms 61 glucocorticoid receptor 61 dietary supplementation 60 BMP4 60 estrogen metabolism 60 amylin 60 hormone adiponectin 60 Wnt signaling 60 cholesterol metabolism 60 leptin receptors 60 XBP1 60 PPARγ 60 endocannabinoid signaling 60 p# MAPK 60 adiponectin levels 60 tyrosine phosphorylation 60 Sirt3 60 adipocyte 60 carbohydrate metabolism 60 Sgk1 59 Notch signaling 59 p# activation 59 telomere length 59 TRP channels 59 HPA axis 59 TGF ß 59 cypin 59 leptin receptor 59 telomere shortening 59 synapse formation 59 Leptin 59 casein kinase 59 epigenetic alterations 59 PPAR alpha 59 fatty acid oxidation 59 rapamycin 59 cofilin 59 adiponectin 59 mTOR 59 selenoproteins 59 MnSOD 59 activin 59 superoxide dismutase 59 mutated protein 59 fatty acid synthesis 59 SIRT1 gene 59 signaling pathway 59 cholesterol absorption 59 signaling cascade 59 mTOR signaling 59 KLF4 59 metabolic 59 metabolism 59 tumor suppressor protein 59 proNGF 59 mTORC1 59 NF kappaB pathway 59 CaM kinase II 59 caveolin 1 59 PECAM 1 58 GPx 58 glucagon secretion 58 fatty acid synthase 58 bryostatin 58 tumorigenesis 58 amino acid tyrosine 58 leptin deficient mice 58 signaling cascades 58 proteolysis 58 signaling pathways 58 adult neurogenesis 58 fatty acid metabolism 58 PPAR gamma 58 molecular pathway 58 incretin 58 improves insulin sensitivity 58 forskolin 58 reproductive hormones 58 neurite outgrowth 58 hedgehog signaling 58 estrogen receptor alpha 58 heparan sulfate 58 SGK1 58 mitochondrial enzyme 58 telomerase activity 58 glucose homeostasis 58 cyclophilin D 58 LDL oxidation 58 calorie restriction diet 58 kisspeptin 58 alpha lipoic acid 58 epigenetic changes 58 Src 58 secretory pathway 58 arginine 58 mitochondrial mutations 58 opioid receptor 58 Notch pathway 58 insulin resistance 58 molecular pathways 58 metabolic parameters 58 autophagy 58 fermentable carbohydrates 58 glucose tolerance 58 gallstone formation 58 STAT4 58 lipid metabolism 58 neurohormone 58 folate metabolism 58 commensal bacteria 58 RUNX3 58 neurotransmitter GABA 58 Hsp# [001] 58 hormone secretion 58 calcium homeostasis 58 nicotinamide 58 Cdk5 58 ACh 58 SIR2 58 PPAR γ 58 neural pathway 58 LDLR 58 serum cholesterol 58 lipid oxidation 57 LXRs 57 neurogenesis 57 Akt1 57 TMEM#B 57 PGE2 57 leptin resistance 57 NFκB 57 downregulation 57 ubiquinol 57 microglial activation 57 Wnts 57 dephosphorylation 57 ERK1 2 57 SIRT3 57 FOXO1 57 calcineurin 57 oxidized LDL 57 upregulate 57 epigenetic silencing 57 overexpression 57 metabolic enzymes 57 Bcl xL 57 BMP signaling 57 Irs2 57 atypical neuroleptics 57 hormones leptin 57 insulin sensitivity 57 ovarian hormones 57 progerin 57 lipid synthesis 57 follistatin 57 CatB 57 transgene expression 57 antioxidant supplementation 57 overexpressing 57 STAT1 57 mitochondrial fusion 57 glycemic diet 57 IFN gamma 57 folates 57 cellular metabolism 57 HMG CoA reductase 57 neuropeptide Y NPY 57 tyrosine 57 protein synthesis 57 hormone leptin 57 phytoestrogen 57 plasma lipids 57 LRP5 57 NF kappaB 57 TGF beta pathway 57 platelet aggregation 57 arginase 57 TGF β 57 sortilin 57 HSF1 57 triacylglycerol 57 melatonin receptor 57 Hh pathway 57 enzymatic activity 57 antioxidant enzyme 57 DNA demethylation 57 breast cancer metastasis 57 HCV replication 57 EGFR signaling 57 hepatic glucose production 57 adaptive immunity 57 thyroid hormones 57 transcriptional repressor 57 histone deacetylases 57 malonyl CoA 57 FGFs 57 folate supplementation 57 Akt3 57 transthyretin 57 STAT3 57 AMPA receptor 57 IKKa 57 cardioprotection 57 autophagic 57 neurotransmitter receptor 57 galanin 57 BDNF 57 PYY 57 lowers blood glucose 56 Klotho gene 56 oxidative damage 56 UCP1 56 mitochondrial respiration 56 TSLP 56 BDNF protein 56 bile acid metabolism 56 lipoprotein metabolism 56 nicotinic acid 56 suppresses appetite 56 p# MAP kinase 56 GRK2 56 calcium supplementation 56 palmitoylation 56 glutamate receptors 56 eNOS 56 FKBP# 56 apoE4 56 iNOS 56 oxidative phosphorylation 56 circadian cycle 56 Th2 56 oxidative stress 56 Hox gene 56 ERK signaling 56 catalase 56 insulin receptors 56 TGFβ 56 hedgehog pathway 56 FGFR4 56 metabolic processes 56 Ghrelin 56 endothelial function 56 5 lipoxygenase 56 protein p# 56 cell signaling pathways 56 LRP6 56 telomere 56 PDE5A 56 Nicotinamide 56 ERa 56 fat diet 56 paracrine 56 cyclopamine 56 neurohormones 56 uncoupling protein 56 dietary interventions 56 signaling molecule 56 RIP1 56 receptor subtypes 56 senescent cells 56 nodulation 56 p#INK#a 56 luteolin 56 SIR2 gene 56 POMC neurons 56 Hedgehog signaling 56 protein 56 amyloid peptide 56 Dietary restriction 56 IRF5 56 glycogen metabolism 56 cellular senescence 56 O GlcNAc 56 TNFa 56 NMDA receptor 56 tumor suppressor p# 56 fat oxidation 56 amino acid 56 antidepressants SSRIs 56 L dopa 56 MEK ERK 56 valine 56 adipokines 56 calcium absorption 56 gut microflora 56 Amino acid 56 polyamines 56 Srcasm 56 low calorie diets 56 beta endorphin 56 platelet activation 56 FGF2 56 CAG repeats 56 muscle protein synthesis 56 ENaC 56 hyperactivation 56 fruitflies 56 octopamine 56 TXNIP 56 PI3K signaling 56 drug metabolizing enzymes 56 podocytes 56 induced oxidative stress 56 intracellular signaling 56 growth hormone secretion 56 nicotinic receptor 56 endothelial dysfunction 56 SUMOylation 56 Akt signaling 56 TRPV4 56 palmitoleate 56 detoxification enzymes 56 pharmacologic intervention 56 curcumin 56 amyloid plaque formation 56 NR2B 56 mutant alleles 56 NF kB pathway 56 endogenous estrogen 56 neuron degeneration 56 HBx 56 EZH2 56 HDAC2 56 catabolism 56 cardio protective 56 dietary fat 56 brassinosteroid 56 ERK2 56 estrogen receptors 56 SIRT6 56 neuroendocrine 56 bone resorption 56 PIP2 56 molecular mechanism 56 phenotype 56 naringenin 56 FasL 56 epigenetically 56 mutant protein 56 TGF beta 56 act synergistically 56 collagen VI 56 Prolla 56 inhibitory effect 56 MMPs 56 CCL5 56 Smad3 56 Smoothened 55 glycation 55 thyrotropin 55 glutamate receptor 55 selective inhibition 55 dopamine transporter 55 CIB1 55 L carnitine 55 adrenal function 55 cholesterol homeostasis 55 antioxidative 55 PTEN protein 55 microglial 55 osteocalcin 55 trans palmitoleic acid 55 proapoptotic 55 p#/CBP 55 NF κB activation 55 hypoxia inducible factor 55 inflammatory cytokines 55 PI3K pathway 55 aldosterone 55 micro RNAs 55 estrogen receptor beta 55 TGF b 55 serotonin transporter 55 creatine supplementation 55 benfotiamine 55 aromatase 55 hippocampal neurogenesis 55 CoQ 55 IKK2 55 IGF2 55 dietary nitrate 55 serotonin receptor 55 glutamine 55 physiological mechanisms 55 intestinal flora 55 RBP4 55 Dietary fiber 55 nematode Caenorhabditis elegans 55 orexin 55 utrophin 55 ubiquitylation 55 Th2 cytokines 55 metabolizing enzyme 55 PPARg 55 endocannabinoid system 55 Mcl 1 55 tau phosphorylation 55 Wnt#b 55 metabolic pathways 55 FANCD2 55 beta1 integrin 55 postprandial glycemia 55 myelination 55 fructose intake 55 hepatic steatosis 55 antitumor efficacy 55 calorie diets 55 insulin secreting cells 55 BCL#A 55 synaptic function 55 receptor protein 55 CPT1c 55 neuronal plasticity 55 Th1 55 NPD1 55 pleiotropic effects 55 telomere maintenance 55 laforin 55 Sonic hedgehog 55 neurite 55 CLA supplementation 55 lipoic acid 55 Th2 cells 55 PTHrP 55 alpha synuclein gene 55 neurotransmitters serotonin 55 axonal transport 55 gastric motility 55 ADAM# 55 cellular pathways 55 mutant worms 55 metabolic pathway 55 p# mutations 55 Nrf2 55 sirtuin 55 palmitate 55 TGF beta signaling 55 protein kinase C 55 Kv#.# 55 IGF1 55 hippocampal neurons 55 deacetylation 55 cAMP signaling 55 TRF1 55 heme oxygenase 1 55 Akt 55 CEACAM1 55 pRb 55 remyelination 55 Wnt proteins 55 inhibitory 55 protein tyrosine phosphatases 55 lipid levels 55 PTEN gene 55 amino acid tryptophan 55 pancreatic islet 55 biochemical pathway 55 proteolytic 55 JAK2 enzyme 55 antiapoptotic 55 NAD + 55 cyclic AMP 55 DLC1 55 prostaglandin synthesis 55 Tregs 55 folate 55 atherogenesis 55 HepG2 cells 55 c MYC 55 microtubule dynamics 55 receptor gene 55 intestinal absorption 55 FOXO 55 hormone aldosterone 55 LDL cholesterol concentrations 55 retinoic acid 55 ghrelin 55 glucose metabolism 55 cysteine 55 telomerase enzyme 55 p# pathway 55 genotoxic stress 55 chromatin structure 55 antioxidant enzymes 55 LDL receptor 55 synaptogenesis 55 TSP1 55 carcinogenesis 55 Aβ 55 TLR2 55 mRNA expression 55 somatostatin 55 neuropeptide Y 55 macrophage activation 55 SREBP 55 soy isoflavones 55 gastric carcinogenesis 55 cholecystokinin CCK 55 TNFalpha 55 BH4 55 phosphorylation 55 bacterial virulence 55 activate AMPK 55 Vpu 55 neurofibromin 55 mammary cancers 55 FoxO3 55 glycolipids 55 amyloid formation 55 DHFR 55 amino acid glutamine 55 anti inflammatory cytokine 55 neurotrophic 55 telomeres 55 inhibitory effects 55 proteins 55 Phosphorylation 55 Dpp 55 magnesium supplementation 55 G6PD 55 FoxO1 55 aneuploidy 55 epigenetic inheritance 55 colorectal carcinogenesis 55 C EBP alpha 55 SIRT1 protein 55 IL 1β 55 Hh 54 genetic alteration 54 NMDA receptors 54 airway remodeling 54 EphB2 levels 54 neuronal signaling 54 leucine 54 Pin1 54 MEF2 54 epigenetic mechanisms 54 allopregnanolone 54 Ketosis 54 NKT cells 54 intestinal epithelium 54 MAPK 54 fatty acid biosynthesis 54 PCSK9 54 orexin receptors 54 Genetic variation 54 lactobacilli 54 synaptic plasticity 54 blood glucose concentrations 54 SOCS1 54 lowfat diet 54 gamma tocopherol 54 metabolizing enzymes 54 GH secretion 54 E4 variant 54 bone metabolism 54 leptin deficient 54 placental function 54 neuromuscular junction 54 MC4R 54 amyloid β 54 cyclooxygenase 54 corticosterone levels 54 hyperactivated 54 vasodilatation 54 oxidant stress 54 cPLA2 54 serum lipid 54 PTPN# 54 glutamate signaling 54 leptin signaling 54 demethylation 54 plasma kallikrein 54 phosphorylate 54 DNA methylation patterns 54 apoptotic pathway 54 adenosine receptors 54 4E BP1 54 carbohydrate restriction 54 transcriptional activation 54 GABAergic 54 breast epithelial cells 54 p# protein 54 Mdm2 54 receptor subtype 54 muscarinic receptors 54 AMPK 54 Skp2 54 secretion 54 GSTT1 54 cardiac myocytes 54 adipose cells 54 clusterin 54 Rab# 54 ACAT2 54 abscisic acid 54 Jhdm2a 54 adipogenic 54 plasma lipid 54 excitatory neurotransmitter 54 ABCA1 54 Wnt1 54 telomere lengths 54 CaMKII 54 Th2 responses 54 spermatogenesis 54 FGFR2 54 glycogen synthesis 54 osteoclast formation 54 GBM tumors 54 Thiamine 54 hippocampal synapses 54 histone modifications 54 cerevisiae 54 amyloid deposition 54 GluR1 54 Low density lipoprotein 54 CHD5 54 nitrite nitrate 54 enterolactone 54 cyclins 54 cell motility 54 osteopontin 54 epigenetic modifications 54 gene expression 54 lipid accumulation 54 acetylation 54 nitric oxide synthase 54 proto oncogene 54 neurohormonal 54 S6K 54 BACE1 54 H#K# [001] 54 mutant huntingtin protein 54 neuroinflammatory 54 Cdc# 54 gut microbes 54 pea aphid 54 HtrA2 54 TNFα 54 lipoxygenase 54 protein SIRT1 54 genetic polymorphism 54 hypermethylation 54 microbiota 54 FASPS 54 lipogenesis 54 cognitive function 54 Wnt pathway 54 Foxp3 54 COX2 54 GLI1 54 apoA 54 HMGA2 54 postprandial insulin 54 satiety hormone 54 MAPK pathway 54 enzyme 54 cannabinoid receptors 54 HbF 54 Nrf2 gene 54 adrenergic receptors 54 proinflammatory cytokine 54 adipocytes 54 cyclin D1 54 MeCP2 54 interferon beta 54 thyroid hormone 54 p#Kip# 54 intracellular pH 54 TrkB 54 PDGFR 54 XBP 1s 54 thermogenesis 54 Adiponectin 54 N Myc 54 haematopoietic 54 mammalian cells 54 motor neuron degeneration 54 NF kB 54 neuronal cells 54 EphB2 54 transmembrane receptor 54 chlorogenic acid 54 obestatin 54 intestinal mucosa 54 dopamine neurons 54 ALDH2 54 plasminogen 54 melanocyte stimulating hormone 54 inhibiting COX 54 ketogenic 54 glutamate 54 mitochondrial metabolism 54 gut flora 54 thyroid hormone receptor 54 oxysterols 54 PHD2 54 RAR beta 54 resveratrol 54 adipogenesis 54 calorie diet 54 hormone angiotensin II 54 PP2A 54 NF kappaB activation 54 homeostatic mechanisms 54 myeloid cells 54 membrane fusion 54 glucose transporter 54 ubiquitination 54 SOCS3 54 overactivation 54 caveolin 54 Arginine 54 silymarin 54 MDM2 54 neuronal dysfunction 54 SMN2 54 mitogen activated protein kinase 54 neuro degeneration 54 Rap1 54 fat diets 54 baroreflex 54 resistin 54 receptor gamma 54 rolipram 54 immunological mechanisms 54 CaPre ™ 54 NFkB 54 PIP3 54 carnosine 54 oligosaccharides 54 DAF #a 54 pro inflammatory cytokines 54 Fas ligand 54 inhibitory neurotransmitters 54 NPY AgRP neurons 54 cardiac fibrosis 54 Neu5Gc 54 glycemia 54 thioredoxin 54 APOE4 54 IRE1 54 copper zinc superoxide 54 pathophysiological 54 AgRP neurons 54 endoxifen 54 AdPLA 53 morphogen 53 ARF1 53 c myc 53 c Abl 53 dietary modification 53 p#NTR 53 glucosides 53 neurodegeneration 53 cholinergic tone 53 dopamine signaling 53 skeletal muscle mass 53 serum calcium levels 53 cyclin B1 53 PKC beta 53 HGPS 53 pancreas secretes insulin 53 antioxidant nutrients 53 Fc receptor 53 monounsaturated fatty acid 53 cannabinoid receptor 53 Kuro o 53 bacterial flora 53 transcriptional repression 53 JAK STAT 53 MUFAs 53 multivitamin supplements 53 CLA isomers 53 follicle stimulating hormone FSH 53 mitochondrial oxidative phosphorylation 53 dietary intake 53 catabolic 53 pyrimidine 53 NKT cell 53 TSC1 53 normal prion protein 53 PKC alpha 53 gene amplification 53 Notch receptor 53 cell signaling pathway 53 receptor subunit 53 mRNAs 53 brain neurochemistry 53 HuR 53 FOXO3a 53 rhTSH 53 Shh signaling 53 γ secretase 53 bile acid 53 superoxide dismutase SOD 53 thrombospondin 53 huntingtin protein 53 naturally occurring enzyme 53 kinase domain 53 CYP#C# [001] 53 starch digestion 53 PTH secretion 53 EGF receptor 53 PARP inhibition 53 Th# cells 53 costimulatory 53 dysregulation 53 hormone insulin 53 lipolysis 53 neurotransmitter acetylcholine 53 HDAC6 53 polyglutamine 53 catenin 53 dysregulated 53 SRY gene 53 NADPH oxidase 53 Cyclin D1 53 inhibitory neurons 53 glucocorticoids 53 arterial stiffening 53 non heme iron 53 xanthine 53 salicylates 53 DMT1 53 intermittent hypoxia 53 insulin sensitizing 53 serine proteases 53 plantarum 53 immune responses 53 ACE2 53 EAAT2 53 metformin 53 pressure natriuresis 53 ceramide 53 isoflavones 53 estrogen receptor 53 serotonin signaling 53 bifidobacteria 53 Genetic variants 53 cardioprotective effects 53 HIF 1a 53 mitochondrial dysfunction 53 uric acid levels 53 calmodulin 53 chromatin remodeling 53 X inactivation 53 mice lacking 53 Prox1 53 antibody mediated 53 mutant proteins 53 Th2 immune 53 magnesium intake 53 TLR4 53 GSTM1 gene 53 hypothalamic 53 osteoclast activity 53 SOD1 53 telomeric 53 DISC1 53 ectopic expression 53 coenzyme Q# 53 OGG1 53 defensins 53 gene p# 53 cardiolipin 53 autoregulation 53 beta adrenergic receptors 53 ß amyloid 53 mTOR inhibitors 53 LKB1 53 PPAR delta 53 klotho 53 soluble fibers 53 GAPDH 53 probiotic supplementation 53 aP2 53 MMP# 53 L arginine 53 angiotensin II 53 SOX3 gene 53 evolutionarily conserved 53 genomic instability 53 triglyceride metabolism 53 ferulic acid 53 mammary cells 53 dopamine receptor 53 astrocyte 53 insulin signaling pathways 53 allergenic protein 53 glycolysis 53 PKMzeta 53 chitinase 53 Cyclin E 53 glycoproteins 53 hepcidin 53 cathepsins 53 RANKL 53 S nitrosylation 53 biochemical cascade 53 IL 1beta 53 DASH diet 53 hepatotoxic 53 galactose 53 stimulates insulin secretion 53 peptide YY 53 MHC genes 53 GSTP1 53 renal fibrosis 53 chromosomal instability 53 receptor inhibitor 53 IL6 53 Clusterin 53 effector functions 53 H#K# methylation 53 CYP#E# 53 TERT 53 protein phosphorylation 53 acetyl groups 53 secretase 53 PIK3CA 53 endothelial nitric oxide synthase 53 enzyme phosphodiesterase 53 DGAT1 53 mRNA translation 53 vitamin K1 53 MIF protein 53 atopic disease 53 acetyl L carnitine 53 calcitriol 53 histone 53 androgen receptor 53 spontaneous mutation 53 oestrogens 53 biochemical processes 53 antidiabetic 53 OCT4 53 Dysregulation 53 Notch1 53 induced neuronal 53 CD#L 53 transcriptional regulation 53 FOXP3 53 H#K# [002] 53 innate immune responses 53 endocannabinoids 53 chromium supplementation 53 tumor suppressor 53 intestinal permeability 53 naturally occurring molecule 53 probiotic bacteria 53 sumoylation 53 suppressor gene 53 HOTAIR 53 methylation 53 bile salts 53 sGC 53 endothelin 53 IGFBP2 53 uPAR 53 neprilysin 53 isoleucine 53 circadian cycles 53 lymphotoxin 53 phenotypic expression 53 fibrogenesis 53 gamma aminobutyric acid 53 phosphorylates 53 lipoprotein levels 53 fatty acid supplementation 53 Bifidobacterium