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(Click for frequent words.) 73 cytotoxic 73 antitumor activity 71 transgene expression 70 immunoreactivity 70 antitumor 70 biodistribution 69 genotoxic 69 inhibitory activity 69 selective inhibition 69 antitumor efficacy 69 ERK signaling 68 nanomolar 68 tumorigenicity 68 TNF α 68 murine 68 effector function 68 inhibitory effects 68 anticancer activity 68 annexin V 68 induce apoptosis 67 induces apoptosis 67 neurotoxicity 67 interferon IFN 67 antiviral efficacy 67 xenograft models 67 VEGFR2 67 vimentin 67 induced apoptosis 67 antitumor effect 67 enzymatic activity 67 inhibitory effect 67 antiviral activity 67 leukemic cell 67 tumoral 67 xenografts 67 CLL cells 67 bactericidal activity 67 antiproliferative activity 67 toxicity 67 tryptase 66 peripheral blood mononuclear 66 Akt activation 66 WT1 66 carcinoembryonic antigen 66 cathepsin B 66 TNFalpha 66 iNOS 66 colon carcinoma 66 systemic absorption 66 IFN gamma 66 EGF receptor 66 IL 1beta 66 HepG2 cells 66 pro apoptotic 66 NF kappaB activation 66 PDGFR 66 c MYC 65 mRNA expression 65 potent inhibitory 65 transfection efficiency 65 tumorigenic 65 chemotherapeutic agents 65 binding affinity 65 bactericidal 65 EpCAM 65 antitumor effects 65 neurite outgrowth 65 E. faecalis 65 systemic toxicity 65 milatuzumab 65 antiproliferative 65 microglial activation 65 proapoptotic 65 Immunohistochemical analysis 65 transfected 65 apoptotic 65 heparanase 65 nephrotoxicity 65 bleomycin 65 ERK1 2 65 chemotherapeutic drug 65 IL 1ß 65 SIRT2 65 IgG1 65 transfected cells 65 lytic 65 μg ml 65 cytostatic 65 vitro cytotoxicity 65 MDM2 65 peroxidase 65 TGF β 65 IgG antibodies 65 tubulin polymerization 64 UsiRNAs 64 antiapoptotic 64 cytotoxic effects 64 neurotrophic 64 immunomodulation 64 TRAIL R2 64 TLR2 64 TGF ß 64 Aβ 64 VEGF expression 64 anti proliferative 64 haematopoietic 64 antiangiogenic 64 immune stimulatory 64 TNFa 64 thyroid peroxidase 64 anti leukemic 64 PC3 cells 64 receptor inhibitor 64 chemosensitivity 64 immunostaining 64 eNOS 64 TGF beta1 64 somatostatin 64 lung epithelial cells 64 mediated inhibition 64 immunomodulatory 64 apoptotic cells 64 cell lysis 64 phosphate S1P 64 potent inhibition 64 pathophysiological effects 64 coexpression 64 IL #p# 64 NOD SCID mice 64 lymphoid cells 64 Pgp 64 dose dependently 64 hepatoma 64 pharmacokinetic properties 64 assay detects 64 immunological responses 64 hepatocyte 64 elastase 64 ENMD # 64 azacytidine 64 neutralizing antibody 64 pertussis toxin 64 HDAC6 64 pro angiogenic 64 protein tyrosine phosphatase 64 Annexin V 64 HBV replication 64 deacetylation 64 erythropoietic 64 PC# cells 64 adrenoceptor 64 receptor activation 64 HCV replication 64 cytoprotective 64 P selectin 64 replicon 64 ERalpha 64 mitochondrial toxicity 64 HER2 receptor 63 antitumoral 63 E selectin 63 oncoproteins 63 phagocytosis 63 induced cytotoxicity 63 plasma pharmacokinetics 63 ERBB2 63 GRP# 63 cisplatin resistant 63 HCV replicon 63 antiangiogenic activity 63 vivo 63 p# MAPK 63 lymphocyte proliferation 63 ^ sup #m 63 Rap1 63 imetelstat 63 uPAR 63 colorectal tumor 63 endothelial cell 63 Ki# 63 CTGF 63 anti apoptotic 63 immunohistochemical 63 virulence genes 63 VEGF receptor 63 p# activation 63 Notch1 63 CD# [002] 63 etoposide 63 keratinocyte 63 mitogenic 63 myeloma cells 63 substrate specificity 63 matrix metalloproteinases 63 selective agonist 63 overexpression 63 63 osteoinductive 63 LTB4 63 E#F# 63 CCR2 63 IL 1β 63 cytolytic 63 transfection 63 isotypes 63 CD1d 63 HIF 1alpha 63 ERK activation 63 Clusterin 63 micronuclei 63 estrogen receptor alpha 63 vasodilatory 63 inhibitory concentration 63 hTERT 63 caveolin 1 63 overexpressing 63 IgA antibodies 63 activin 63 autophagic 63 pharmacokinetic interactions 63 intracellular 63 radiolabeled 63 serum antibodies 63 glycosylated 63 IFN α 63 PHD2 63 Rab5 63 genotoxicity 63 cytokeratin 63 peptide antigens 63 pRb 63 pleiotropic 63 CEACAM1 63 IgG4 63 humoral immune responses 63 DNA intercalator 63 CD# CD# 63 alveolar epithelial cells 63 inducible nitric oxide synthase 63 gene amplification 63 redox active 63 radiosensitivity 63 degranulation 63 FasL 63 tyrosine phosphorylation 63 potently inhibited 63 IL #E 63 CD#c 63 adipogenic 62 HDACi 62 chlamydial 62 ligand TRAIL 62 innate immune responses 62 potent cytotoxic 62 pharmacodynamic PD 62 BCL2 62 CCR9 62 antiproliferative effects 62 vascular endothelial cells 62 flavopiridol 62 EGFR HER2 62 imatinib therapy 62 NKG2D 62 Eg5 62 CYP#B# 62 mitogen activated protein kinase 62 apoptotic pathway 62 oncoprotein 62 miR #a [002] 62 TRAIL induced apoptosis 62 microglial 62 trophoblast cells 62 LPS induced 62 HBx 62 BAL# [001] 62 bortezomib 62 EGFr 62 GPx 62 5alpha reductase 62 potent inhibitor 62 estrogen receptor beta 62 EphB4 62 GM CSF 62 PGE2 62 effector functions 62 busulfan 62 TGF ß1 62 Nedd4 62 HER2 overexpression 62 homodimers 62 retapamulin 62 effector memory 62 adenoviral 62 HER2/neu 62 Jhdm2a 62 FOXP3 62 nanomolar range 62 vivo potency 62 isoform 62 Vidofludimus 62 IgG antibody 62 neuroblastoma cells 62 #ß 62 BCR ABL mutations 62 humoral immunity 62 HbF 62 Smad3 62 phosphatidylinositol 3 62 XL# inhibits 62 RRM1 62 intratumoral 62 PKC delta 62 immunological 62 mucociliary clearance 62 ERK phosphorylation 62 pyrimidine 62 PI3K inhibitor 62 VE cadherin 62 antibody mediated 62 paracrine 62 tumor necrosis 62 xenograft tumors 62 posttranslational modification 62 ectopic expression 62 p#NTR 62 Tie2 62 histone acetylation 62 phagocyte 62 prostate epithelial cells 62 immunotoxicity 62 chemoresistance 62 nitric oxide synthase 62 Bcl xL 62 gastric mucosa 62 human tumor xenografts 62 antibody titers 62 c myc 62 β amyloid 62 imatinib Gleevec 62 clusterin 62 activated lymphocytes 62 mutant p# 62 Overexpression 62 erlotinib Tarceva ® 62 chemotherapeutics 62 adducts 62 lipopolysaccharide 62 catalase 62 IFNg 62 neutrophil 62 immunostimulatory 62 potent inhibitors 62 PPARgamma 62 ACh 62 viral antigen 62 Fas ligand 62 syngeneic 62 Omacetaxine mepesuccinate 62 MnSOD 62 CD# expression [002] 62 lymphotoxin 62 methylated DNA 62 heterodimers 62 airway hyper responsiveness 62 mesothelin 62 NS#/#A protease 62 MGd 62 N cadherin 61 DHFR 61 antiviral potency 61 cholera toxin 61 isoenzyme 61 p# antigen 61 DFMO 61 antibody responses 61 EphA2 61 serine threonine 61 outer membrane proteins 61 cyclin E 61 anti CD3 61 oligomerization 61 prostaglandin E 61 antioxidant enzyme 61 kinase inhibition 61 peroxynitrite 61 serine protease 61 NEUGENE 61 AT1R 61 LNCaP cells 61 alkylating agent 61 leukocyte 61 c MET 61 IFN alpha 61 membrane permeability 61 unconjugated 61 IFN γ 61 IGF IR 61 antitumour 61 vWF 61 β catenin 61 rhIL 7 61 pharmacodynamic properties 61 cholesterol homeostasis 61 poly ADP ribose polymerase 61 downregulation 61 fulvestrant 61 mucin 61 tumor antigen 61 CDK inhibitor 61 thioredoxin 61 5FU 61 promoter methylation 61 antigenic epitopes 61 topoisomerase 61 demonstrated antitumor activity 61 microvascular endothelial cells 61 hematopoietic 61 anionic 61 Th2 61 Foxp3 61 HepG2 61 topoisomerase II 61 highly immunogenic 61 splenocytes 61 epithelial cell 61 glomerular 61 glucocorticoid receptor 61 FKBP# 61 TLR9 61 seliciclib 61 p# alpha [001] 61 Abeta# 61 TIMP 61 immunofluorescence 61 mutational status 61 Darinaparsin 61 AhR 61 P cadherin 61 downregulated 61 glioblastoma cells 61 myeloperoxidase 61 M1 muscarinic 61 survivin 61 potent antitumor activity 61 epithelial tumors 61 receptor mediated 61 lymph node metastasis 61 Th2 cytokines 61 prostanoid 61 FISH fluorescence 61 p# subunit 61 subcellular localization 61 transcriptional regulation 61 beta galactosidase 61 T#M 61 platelet aggregation 61 ERCC1 61 osteoblast 61 cleavable linker 61 lactate dehydrogenase LDH 61 vitro studies 61 active metabolite 61 IGF 1R 61 MMP9 61 nucleolin 61 chemotherapeutic 61 HIF 1a 61 viral kinetics 61 HDAC inhibition 61 Xanafide 61 Fc receptor 61 Etoposide 61 biofilm formation 61 anti angiogenic 61 ApoB 61 prostaglandin E2 PGE2 61 miRNA expression 61 Aß 61 Jurkat cells 61 vitro 61 constitutively active 61 immunohistochemical staining 61 IGFBP 3 61 lactate dehydrogenase 61 B7 H3 61 HuR 61 proteolysis 61 androgen receptor AR 61 glioma cells 61 B7 H1 61 proteasome inhibitors 61 polymyxin B 61 hENT1 61 selectively binds 61 proinflammatory 61 cells transfected 61 TLR7 61 HCV protease 61 ß catenin 61 ERa 61 EGFR tyrosine kinase inhibitors 61 STAT3 signaling 61 renal toxicity 61 ENaC 61 TUNEL 61 MT1 MMP 61 supernatants 61 ovarian carcinoma 61 oncogenic 61 inhibit tumor 61 HER2 expression 61 azoles 61 acetylcholinesterase 61 CD#b 61 BALB c mice 61 RNAi mediated 61 phosphorylate 61 apolipoprotein B 61 SOCS3 61 isoforms 61 adenylate cyclase 61 interleukin IL -# 61 hepatic fibrosis 61 heterologous 61 C. difficile toxins 61 VSV G 61 culture supernatants 61 apoptosis induced 61 bile acid 61 doxorubicin 61 erythropoiesis 61 transmembrane protein 61 leukemic stem cells 61 preclinically 61 bFGF 61 DNMT1 61 ADAMTS# 61 tumor regressions 61 cytopathic 61 cyclic AMP cAMP 61 p#Kip# 61 Superoxide 61 alkaline phosphatase ALP 61 microvessel density 61 pharmacodynamic endpoints 61 TGF alpha 61 oxidase 61 GLI1 61 N Myc 61 immunized mice 61 neutralizing antibody responses 61 upregulation 61 EGFR expression 61 dephosphorylation 61 oncogenic transformation 61 tumor cells 61 FGFR4 61 polyamines 61 lysate 61 transgenic mice expressing 61 de novo synthesis 61 MAPK pathway 61 thrombopoietin 61 leukocyte recruitment 61 antioxidant enzymes 61 ON #.Na 61 immunofluorescence staining 61 mycobacterial 60 glucocorticoid 60 HLA DR 60 excitotoxic 60 tyrosine kinase inhibitor 60 Upregulation 60 chloride secretion 60 triphosphate 60 Th1 cells 60 PARP1 60 pDCs 60 tumor xenograft models 60 act synergistically 60 Mcl 1 60 CHO cells 60 immunohistochemical analysis 60 Elevated serum 60 aberrantly activated 60 S#A# [002] 60 bronchial epithelial cells 60 proto oncogene 60 constitutively expressed 60 Cyclin E 60 Fibroblast Growth Factor Receptor 60 murine models 60 MTT assay 60 inducible 60 wildtype 60 MET amplification 60 receptor CD# 60 fibrin deposition 60 benzimidazole 60 granzyme B 60 HEK# cells 60 adrenocortical 60 protein kinase C 60 adrenocorticotropic hormone ACTH 60 intratumoral injection 60 nucleoside analogues 60 nephrotoxic 60 CCR7 60 inhibits protein synthesis 60 basophils 60 CD# protein 60 tumor vasculature 60 circulating lymphocytes 60 EGFRvIII 60 Th1 type 60 ganciclovir 60 GAP #B# 60 immunotoxin 60 TPMT 60 GHRH 60 chemotherapeutic agent 60 GSK3 60 HDAC 60 humoral responses 60 phospho 60 favorable pharmacokinetic profile 60 upregulating 60 MCF7 60 Aâ 60 miR #a [001] 60 spermidine 60 REP# 60 immunomodulatory effects 60 inflammatory cytokine 60 Cisplatin 60 lymphangiogenesis 60 telomerase activity 60 MDR1 60 microsomal 60 Preclinical studies 60 c Fos 60 renal fibrosis 60 HDAC2 60 gamma tocotrienol 60 cytokines IL 60 mTOR inhibitors 60 dopamine transporter 60 vascular disrupting 60 anti fibrotic 60 IFN g 60 CD8 responses 60 hypoxia inducible factor 60 synthase TS 60 IFN ß 60 mutant huntingtin 60 lysosomal 60 dermatophytes 60 cyclic adenosine monophosphate cAMP 60 CD4 + T lymphocytes 60 aT cell 60 thrombogenic 60 TIMP 1 60 CD8 + 60 matrix metalloproteinase 60 MEK ERK 60 pro inflammatory cytokines 60 CD# expression [001] 60 cAMP 60 overlapping toxicities 60 MUC1 60 immunoreactive 60 PlGF 60 S1P 60 HER3 60 H#K#me# 60 RANK Ligand 60 mucins 60 secretory pathway 60 cytotoxic agents 60 qRT PCR 60 phosphorylated 60 Aurora kinase 60 immune modulating 60 #HT#A 60 cationic lipid 60 Macrophage 60 immunocytochemistry 60 Trastuzumab 60 GPC3 60 V#F mutation 60 Western blotting 60 parathyroid hormone PTH 60 TACE 60 proteinase 60 UCP2 60 Cytotoxic T 60 RQ PCR 60 osteogenic 60 tissue transglutaminase 60 targeting CD# 60 chemotactic 60 intravesical 60 HPA axis 60 caspase activation 60 RANTES 60 NKX#.# 60 Hedgehog signaling 60 depsipeptide 60 mitochondrial biogenesis 60 prostaglandin E2 60 Pharmacokinetics PK 60 transduced 60 Phosphorylation 60 paxillin 60 intracellular uptake 60 immune responses 60 CDDO Im 60 MAP kinase 60 amyloid deposition 60 cytokine secretion 60 adipocyte differentiation 60 GSTP1 60 annexin 60 deacetylase inhibitors 60 FUS1 60 mTOR signaling 60 PARP inhibition 60 hemagglutination 60 picomolar 60 related apoptosis inducing 60 #β estradiol 60 glutamate receptors 60 urinary excretion 60 solithromycin 60 ara C 60 cyclooxygenase COX 60 immunoblotting 60 Th# 60 leukemic cells 60 Trp p8 60 methicillin susceptible Staphylococcus aureus 60 vascular permeability 60 polyamine 60 STAT1 60 interferon gamma 60 dihydrofolate reductase 60 bacterial virulence 60 valine 60 murine model 60 uM 60 GRN#L 60 factor G CSF 60 inhibit viral replication 60 cytotoxicity assays 60 BCR ABL 60 cytokine signaling 60 splice variants 60 heme oxygenase 60 immunotoxins 60 trans retinoic acid 60 immune modulatory 60 immunogenic 60 cellularity 60 monocyte 60 cathepsins 60 synthetase 60 serum antibody 60 PTP 1B 60 hCG beta 60 steroidogenic 60 NFκB 60 ABCA1 60 SGK1 60 glycolipids 60 neuropilin 60 ß amyloid 60 stably transfected 60 ERK pathway 60 anti inflammatory cytokine 60 invadopodia formation 60 molecularly targeted 60 NQO1 60 phosphatases 60 daunorubicin 60 Azedra 60 bioactivity 60 sarcomatoid 60 FGFR3 60 MetAP2 60 airway responsiveness 60 bacterial colonization 60 proteoglycan 60 cytosolic 60 frataxin 60 N methyl 60 nonionic 60 pharmacodynamic effects 60 dopamine reuptake 60 colocalization 60 intestinal permeability 60 metastatic neuroendocrine tumors 60 HIF 1α 60 osteogenic differentiation 60 μM 60 antigenicity 60 thymidylate synthase TS 60 catenin 60 thymocytes 60 ganglioside 60 PECAM 1 60 ErbB2 60 antisense inhibition 60 decitabine 60 eotaxin 60 glycosyltransferase 60 AST ALT 60 natriuretic peptides 60 fosbretabulin 59 synthases 59 tenascin C 59 collagen degradation 59 sensitizer 59 vidofludimus 59 eIF4E 59 sequence homology 59 fluconazole resistant 59 Cytotoxicity 59 oral prodrug 59 dimerization 59 nucleases 59 PTPN# 59 physiologically relevant 59 histone deacetylase inhibitor 59 regulated kinase 59 ^ Tc 59 potent anti angiogenic 59 IL #R 59 TSLP 59 C. albicans 59 selective modulator 59 CD#L 59 hydroxyl radical 59 SensoLyte ® 59 adrenomedullin 59 microtubule targeting 59 collagens 59 viral antigens 59 transgenic rats 59 Immunohistochemical staining 59 tyrosine kinase receptor 59 TGFβ 59 endothelial activation 59 TLR3 59 NFkappaB 59 intracellular bacteria 59 receptor tyrosine kinase 59 CYP3A 59 beta subunit 59 pegylated 59 cytotoxic T lymphocyte 59 orthotopic 59 SSc 59 diffusible 59 lyase 59 fibrogenesis 59 glutathione GSH 59 cells PBMCs 59 #ME# 59 ABCB1 59 interferon γ 59 activate p# 59 cultured cells 59 epithelia 59 plasma lipid 59 CD4 + CD# 59 Immunohistochemical 59 rifamycins 59 hepatocyte growth 59 thyroglobulin 59 enzyme inhibition 59 HIF PH inhibitors 59 BCL#A 59 serum biomarkers 59 costimulation 59 proteolytic cleavage 59 aspartate aminotransferase 59 effector cells 59 antiandrogens 59 colorectal carcinoma 59 cell adhesion molecule 59 adhesion molecule 59 homodimer 59 serum cortisol 59 prognostic significance 59 CD# expressing 59 interleukins 59 avidin 59 selective inhibitor 59 neuronal cell 59 azole 59 immunomodulator 59 soluble CD# 59 nitrotyrosine 59 oxidative metabolism 59 oligomer 59 cytokine 59 alkaline phosphatase 59 sunitinib Sutent ® 59 Kupffer cells 59 uPA 59 alkylating 59 cyclin dependent kinase inhibitor 59 vivo efficacy 59 axonal degeneration 59 inhibited tumor 59 NF kB pathway 59 suppressor cells 59 mediated apoptosis 59 plasmacytoid dendritic cells 59 ER alpha 59 nM 59 myeloid 59 GSK3B 59 cytidine 59 HAAH 59 LPA1 receptor 59 S/GSK# 59 EGFR receptor 59 oligomeric 59 platelet reactivity 59 bronchodilatory 59 viral titers 59 GLUT4 59 cystic fibrosis transmembrane conductance 59 tubulin 59 ApoA1 59 N. gonorrhoeae 59 STAT3 59 Granulocyte Colony Stimulating Factor 59 intestinal mucosa 59 FK# 59 Nampt 59 CXCR4 expression 59 metalloproteinase 59 neuroprotective properties 59 Leydig cell 59 phosphorylates 59 antimicrobial peptides 59 thymidine 59 overexpressing cells 59 pDC 59 Transferrin 59 Preclinical studies suggest 59 selectively inhibited 59 non nucleoside 59 thyrotropin 59 mononuclear 59 Aplidin 59 mitochondrial respiration 59 glomerular filtration 59 CYP #A# 59 antigen 59 EP1 receptor 59 KIT mutations 59 p# biomarkers 59 thymidine kinase 59 LHRH receptor 59 EGFR 59 delta isoform 59 RAR beta 59 adrenal cortex 59 T#I [002] 59 SPINK1 59 pegylated liposomal doxorubicin 59 serotonin receptor 59 endotoxins 59 fig. S2 59 mycophenolate mofetil 59 Lp PLA 2 59 viral infectivity 59 paricalcitol 59 neoplastic 59 FLT3 59 monomeric 59 chemotaxis 59 5' triphosphate 59 TNFα 59 monoclonal anti 59 gastrointestinal stromal tumors GISTs 59 lymphoid 59 aromatase 59 transactivation 59 EGFR HER 59 neuroprotective effects 59 osteopontin 59 integrin expression 59 pyrimidines 59 endothelial nitric oxide synthase 59 Valortim R