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(Click for frequent words.) 77 transcriptional activation 76 cytoplasmic 74 ERK1 2 74 mitogen activated protein kinase 73 DNMT1 73 presynaptic 73 proteolytic cleavage 73 dephosphorylation 73 constitutively active 73 phosphorylated 72 transduced 72 GAPDH 72 iNOS 72 nucleolar 72 dimerization 72 proapoptotic 72 Supplementary Fig 72 catenin 72 constitutively 72 transactivation 72 tyrosine phosphorylation 72 Rab5 72 centromeric 72 basolateral 71 beta subunit 71 GLUT4 71 proteolysis 71 transmembrane 71 mRNA expression 71 cytoplasmic domain 71 Cdc# 71 phosphatidylinositol 71 ribonucleoprotein 71 downregulated 71 Rap1 71 coexpression 71 vascular endothelial cells 71 HIF 1alpha 71 Foxp3 71 IRE1 71 Ca2 + 71 deacetylation 71 F actin 71 serine threonine kinase 71 β 71 cytidine 70 caveolin 1 70 eNOS 70 β catenin 70 VE cadherin 70 GTPase 70 ERK2 70 induced apoptosis 70 uracil 70 CaM 70 ß catenin 70 subcellular localization 70 HepG2 cells 70 phosphorylation 70 androgen receptor AR 70 hnRNP 70 γ 70 ER alpha 70 postsynaptic 70 TGF ß 70 neurite outgrowth 70 immunoreactive 70 STAT1 70 endosomal 70 isoforms 70 ATPase 70 phosphorylates 70 chemotactic 70 eIF4E 69 methyltransferase 69 rRNA 69 ERK signaling 69 Smad3 69 pRb 69 endocytic 69 H#K#me# 69 transferase 69 lysates 69 overexpressing 69 adhesion molecule 69 uPAR 69 HIF 1α 69 secretory 69 lysosomal 69 cytochrome c oxidase 69 estrogen receptor alpha 69 autophagic 69 Phosphorylation 69 serine protease 69 p#Kip# 69 receptor tyrosine kinase 69 ERK activation 69 downregulation 69 cytosol 69 phagocytosis 69 genes encoding 69 Vps# 69 neurofilament 69 EGFP 69 ncRNAs 69 extracellular 69 vacuolar 69 Rac1 69 caveolae 69 MAPK 69 synthetase 69 guanosine 69 ERK1 69 M1 muscarinic 69 1alpha 69 activin 69 IL 1beta 69 antiapoptotic 69 fig. S1 69 isoenzyme 69 transmembrane receptor 69 CXCL# 69 p# MAPK 69 histone H3 69 mitochondrial respiration 69 isoform 69 alpha subunit 69 immunoreactivity 69 BMAL1 69 constitutively expressed 69 PIP2 69 morphogen 69 carboxyl terminal 69 hTERT 69 actin polymerization 69 RNA polymerases 69 glycosyltransferase 68 ubiquitination 68 transcriptional repressor 68 TGF ß1 68 Fig. 1C 68 TGF beta1 68 β1 68 mediated phosphorylation 68 exocytosis 68 Fas ligand 68 mediated inhibition 68 ERBB2 68 transmembrane protein 68 microglial 68 kinase domain 68 LNCaP cells 68 E cadherin 68 lysine residues 68 efflux 68 IKKß 68 osteoblast 68 endocytosis 68 glycosylated 68 reductase 68 FasL 68 proximal tubule 68 upregulation 68 heterodimers 68 CD#b 68 triacylglycerol 68 K + ATPase 68 cell adhesion molecule 68 ouabain 68 4E BP1 68 astrocytic 68 1α 68 importin 68 caveolin 68 plasma membrane 68 BMP signaling 68 adenylate cyclase 68 E3 ubiquitin ligase 68 alveolar epithelial cells 68 Aß 68 μM 68 IFN γ 68 cytochrome 68 Sp1 68 ENaC 68 Arp2 3 68 regulated kinase ERK 68 cofilin 68 FKBP# 68 lyase 68 NFAT 68 polyadenylation 68 survivin 68 intracellular 68 PTPN# 68 anaphase promoting complex 68 thioredoxin 68 c myc 68 cells transfected 68 secretory pathway 68 adrenoceptor 68 JAK STAT 68 IL 1ß 68 transferrin receptor 68 orthologs 68 ubiquitylation 68 erythrocytes 68 paxillin 68 homodimer 68 cyclin 68 ribosomal protein 68 aspartate 68 mice lacking 68 E#F# 68 de novo synthesis 68 tumorigenicity 68 TNFalpha 68 phosphoprotein 68 H#K# [002] 68 polyamine 68 RhoA 68 intracellular pH 68 endoplasmic reticulum 68 MAP kinase 68 hydroxylation 68 protein tyrosine phosphatase 68 ectodomain 68 RUNX3 68 CEACAM1 68 transiently transfected 68 6S RNA 68 synaptogenesis 67 oligomerization 67 homodimers 67 microglial activation 67 hippocampal neurons 67 ribonuclease 67 P cadherin 67 COL#A# 67 acyltransferase 67 ATP hydrolysis 67 acetylation 67 amino terminal 67 serine threonine 67 equimolar 67 adipogenic 67 monocyte 67 aminopeptidase 67 cytokine secretion 67 oncogenic transformation 67 EF Tu 67 transgene expression 67 tubulin 67 PrP 67 ectopic expression 67 phosphorylate 67 cathepsin B 67 cyclin B1 67 melanocyte 67 enzymatic activity 67 endonuclease 67 NFkB 67 adipocyte 67 extracellular domain 67 murine 67 Notch1 67 epithelia 67 EBNA1 67 cyclin D1 67 syntaxin 67 TNF α 67 beta actin 67 S nitrosylation 67 proto oncogene 67 microsomal 67 virulence genes 67 Fig. 1B 67 retinoic acid receptor 67 MyoD 67 p# activation 67 IFN gamma 67 alanine 67 flavin 67 GLI1 67 MEK1 67 Akt activation 67 valine 67 dimeric 67 hydrolase 67 mitotic 67 polycystin 67 P selectin 67 phosphoinositide 67 ACh 67 acyl CoA 67 ubiquitin ligase 67 ligand receptor 67 histone acetylation 67 IL #p# 67 protein kinase C 67 synthase 67 operon 67 intracellular signaling 67 MAPK pathway 67 dsRNA 67 fucose 67 chromatin remodeling complex 67 Extracellular 67 phospho 67 c Src 67 STIM1 67 proteolytic 67 miR# 67 p# subunit 67 protein phosphatase 67 plastid 67 erythrocyte 67 NADPH 67 pro angiogenic 67 alternatively spliced 67 TGF β 67 acinar 67 cell motility 67 thymidine 67 TrkB 67 Dpp 67 PBMCs 67 PC# cells 67 heterochromatic 67 splenocytes 67 mRNA 67 bcl 2 67 67 thymocyte 67 SIRT2 67 protein encoded 67 NR2B subunit 67 H#K# [001] 67 oxidase 67 MyD# 67 HIF 1a 67 Fig. 2a 67 PDGFR 66 palytoxin 66 Jhdm2a 66 cDNA 66 calcium ion 66 glioma cells 66 Fig. 1A 66 transmembrane domains 66 FOXO 66 IL 1β 66 mitotic progression 66 TIMP 66 mRNA encoding 66 pyrimidine 66 EGF receptor 66 overexpression 66 amino acid residues 66 mononuclear 66 extracellular signal 66 chloroplast 66 condensin 66 anterior pituitary 66 fig. S2 66 Runx2 66 TGF alpha 66 intracellular calcium 66 apical membrane 66 polypeptide 66 upregulates 66 GlcNAc 66 Klf4 66 Fig. 1a 66 diphosphate 66 cyclic AMP cAMP 66 hyperactivation 66 tropomyosin 66 α 66 GPI anchored 66 serine 66 erythroid 66 cyclic nucleotide 66 wildtype 66 Vpr 66 c Myc 66 enterocytes 66 MT1 MMP 66 Overexpression 66 prolyl 66 glucokinase 66 heme oxygenase 66 transcriptional regulator 66 untranslated regions 66 Upregulation 66 tetramers 66 phospholipid 66 FGFR3 66 Hedgehog signaling 66 transgenic mice expressing 66 PAX5 66 Nampt 66 inducible nitric oxide synthase 66 PLA2 66 receptor mediated 66 Clusterin 66 transfected cells 66 beta amyloid peptide 66 glucose transporter 66 tyrosine kinase 66 muscarinic 66 hepatocyte 66 NFκB 66 histone H4 66 Akt 66 ligand binding 66 Oncogenic 66 receptor kinase 66 transcriptional regulation 66 cyclin dependent kinase 66 keratinocyte 66 thyroid hormone receptor 66 bronchial epithelial cells 66 cofactor 66 aminobutyric acid 66 endothelial nitric oxide synthase 66 Fig. 3a 66 AMPA receptor 66 aggrecan 66 leukocyte 66 receptor activation 66 colocalization 66 anti apoptotic 66 membrane protein 66 actin binding 66 inflammatory cytokine 66 unmethylated 66 PU.1 66 Skp2 66 PAK1 66 PHD2 66 PPARgamma 66 Aβ 66 Fig. 1d 66 potent inhibition 66 cotransporter 66 cytochrome c 66 caspase activation 66 biogenesis 66 TORC2 66 polypeptides 66 leukemia inhibitory 66 VSV G 66 pDC 66 transfected 66 somatostatin 66 NF kappaB 66 Nedd4 66 isomerase 66 trimeric 66 cyclic AMP 66 PKM2 66 MDR1 66 null mice 66 oxidative phosphorylation 66 NF κB 66 beta catenin 66 Immunohistochemical analysis 66 #ß 66 organelle 66 vesicle fusion 66 tyrosine hydroxylase 66 LRP6 66 ciliated 66 C. albicans 66 lactate dehydrogenase 66 protein phosphorylation 66 β actin 66 ERalpha 66 RRM1 66 luciferase reporter 66 metaphase 66 proline rich 66 PPARγ 66 hexose 66 ERK pathway 66 secretase 66 glucocorticoid receptor 66 acetylcholine receptor 66 TORC1 66 clathrin 66 cyclooxygenase COX 66 SUMOylation 66 vimentin 65 myo inositol 65 cytokine receptors 65 histone modification 65 HOTAIR 65 isozymes 65 acetylated 65 XBP1 65 fig. S6 65 prostaglandin synthesis 65 KLF4 65 Macrophage 65 carboxylase 65 fig. S4 65 CD# CD# 65 Fig. 3b 65 Fig. 2b 65 chondrocyte 65 mRNA transcripts 65 overactivation 65 biotinylated 65 nucleolin 65 GRP# 65 SOCS3 65 phosphatidylinositol 3 65 phagocyte 65 apoE 65 Rho GTPases 65 ABCA1 65 encodes protein 65 decarboxylase 65 1beta 65 c Fos 65 striatal 65 phosphatase 65 cystic fibrosis transmembrane conductance 65 eIF2 65 P2X 65 cofactors 65 thymidylate synthase TS 65 Cx# [001] 65 substrate specificity 65 downregulate 65 CD1d 65 cytochromes 65 annexin V 65 PP2A 65 fibronectin 65 glomerular 65 At#g# 65 plasmacytoid dendritic cells 65 calpain 65 adrenergic receptors 65 non coding RNA 65 tumor suppressor protein 65 thymic 65 G6PD 65 proteinase 65 NR2B 65 DNase 65 transcriptionally 65 transmembrane domain 65 deletion mutant 65 endosomes 65 sphingolipid 65 γ secretase 65 missense mutation 65 proinflammatory 65 histone H3 lysine 65 cyclins 65 amyloid β 65 TNFa 65 D aspartate 65 Kupffer cells 65 RANTES 65 NF kappaB activation 65 upregulating 65 upregulated 65 JNK1 65 PPARg 65 matrix metalloproteinase 65 hypoxia inducible factor 65 transcriptional repression 65 V#F mutation 65 ß1 65 FGF signaling 65 tyrosine kinase receptor 65 MAPKs 65 functional polymorphism 65 LDL receptor 65 ncRNA 65 KaiC 65 CRAC channel 65 cAMP signaling 65 hepatocyte growth 65 evolutionarily conserved 65 Sgk1 65 intracellularly 65 receptor subunit 65 tumor suppressor p# 65 covalently bound 65 disulfide bond 65 matrix metalloproteinases 65 PTHrP 65 telomeric 65 Cyclin D1 65 glyceraldehyde 3 65 piRNAs 65 dependent protein kinase 65 p# mitogen activated 65 PGE2 65 Th2 65 synaptic vesicle 65 polymerases 65 heterozygotes 65 metalloproteases 65 beta adrenergic receptors 65 miR #a [002] 65 ribosomal 65 isoleucine 65 IGFBP 65 P gp 65 ligand 65 cohesin 65 Fig. 2C 65 transthyretin 65 immunofluorescence microscopy 65 mRNAs 65 nNOS 65 cyclooxygenase 65 PPAR gamma 65 costimulation 65 phospholipase 65 focal adhesions 65 tumorigenic 65 monocyte chemotactic protein 65 cyclin dependent kinase inhibitor 65 dynactin 65 glutathione GSH 65 meiotic recombination 65 SMAD4 65 S#A# [002] 65 hepatoma 65 VEGF receptor 65 TIMP 1 65 acetyl CoA 65 FGFR4 65 messenger ribonucleic acid 65 PGC 1α 65 glycolytic 65 supernatants 65 nucleolus 65 steroidogenic 65 Histone 65 ERa 65 hypothalamic pituitary 65 perivascular 65 gene encoding 65 c MYC 65 agonist induced 65 Htt 65 Fig. 1D 65 calcineurin 65 cadherin 65 HSP# 65 Phenylalanine 65 glutamate receptor 65 short hairpin RNAs 65 autocrine 65 5' triphosphate 65 N Myc 65 lipoxygenase 65 E3 ligase 65 CDK4 65 downregulates 65 beta globin gene 65 TGFß 65 NMDAR 65 cytokine receptor 65 phosphate dehydrogenase 65 SMN1 65 Kv#.# 65 Drosha 65 sFlt 1 65 MALAT1 65 mTOR signaling 65 hydrolases 65 coactivators 65 Leydig cells 65 beta globin 65 centromeres 65 LPS induced 65 paracrine 65 noncoding RNA 65 actin cytoskeleton 65 PECAM 1 65 thrombin receptor 65 MMP9 65 immunoblotting 65 mitochondrial 65 oligomeric 65 mPGES 1 65 muscarinic receptors 65 FUS1 65 sphingomyelin 65 β amyloid 65 globin genes 65 splice variants 65 mitogenic 64 TGFβ 64 guanine nucleotide exchange 64 Cathepsin B 64 homozygotes 64 heterodimer 64 colony stimulating factor 64 Aâ 64 aldose reductase 64 TRPV4 64 ribosomal proteins 64 cysteine 64 globin 64 adduct 64 stably transfected 64 BCL2 64 MAP kinases 64 membrane proximal 64 Caspase 64 peroxisome 64 dynamin 64 inverse agonist 64 Pgp 64 HER2 neu 64 vasoactive 64 lymphoid 64 #β estradiol 64 Cyclin E 64 apoptotic cells 64 apoptotic 64 TGF b 64 EphA2 64 cystic fibrosis transmembrane 64 metalloprotease 64 CpG 64 fluorescently labeled 64 Tubulin 64 proximal tubular 64 miRNA expression 64 intercellular adhesion molecule 64 glutamate receptors 64 synaptic vesicles 64 viral proteins 64 dehydrogenase 64 cytochrome P# 64 lymphangiogenesis 64 trophoblast cells 64 BubR1 64 CCL# 64 Rho kinase 64 cellular prion protein 64 mutant proteins 64 carboxy terminal 64 PrPC 64 differentially regulated 64 osteogenic differentiation 64 chromatin remodeling 64 phagocytic 64 NAD + 64 immunodominant 64 secretory proteins 64 metabolic enzymes 64 phosphorylase 64 intronic 64 EGFR protein 64 Gly 64 sarcoplasmic reticulum 64 PGC1 64 translationally 64 alveolar macrophages 64 leukemic cell 64 histone deacetylases 64 immunostimulatory 64 dinucleotide 64 ß amyloid 64 Notch signaling 64 SGK1 64 APOBEC3G 64 Dysregulation 64 noncoding 64 pyruvate kinase 64 carcinoembryonic antigen 64 prostate epithelial cells 64 vWF 64 receptor mediated endocytosis 64 chemokine receptor 64 Cre recombinase 64 inhibitory effects 64 subunit 64 GluR1 64 intestinal epithelial cells 64 nitrotyrosine 64 nM 64 tau phosphorylation 64 chromosome condensation 64 IgG1 64 oncoprotein 64 histone 64 ^ sup #m 64 EZH2 64 transcription factor 64 apoptosis pathway 64 HMG CoA reductase 64 receptor signaling 64 mTORC1 64 cyclooxygenase 2 64 peptidase 64 TRAIL induced apoptosis 64 isoenzymes 64 NKG2D 64 cAMP 64 Wnt signaling 64 CTCF 64 IFNg 64 cyclic adenosine monophosphate 64 TGF β1 64 tumor suppressor proteins 64 vesicle formation 64 factor HGF 64 degranulation 64 Notch receptor 64 translocates 64 peroxidase 64 HDAC 64 adrenal cortex 64 Bcl 64 CPEB 64 antiproliferative activity 64 posttranslational modification 64 amyloidogenic 64 cell adhesion molecules 64 NKT cell 64 Cytochrome 64 TRPV3 64 chromatin structure 64 #HT#A 64 dimers 64 transporter proteins 64 adenoviral 64 β2 64 clusterin 64 regulates gene expression 64 potently inhibit 64 nitric oxide synthase NOS 64 ATP synthase 64 homologue 64 endogenous 64 nucleoprotein 64 Oct4 64 nitric oxide synthase 64 NS3 64 hydroxylase 64 vascular endothelial 64 alpha Gal 64 cyclase 64 Mcl 1 64 ribosomal DNA 64 ERK phosphorylation 64 adipogenesis 64 induce apoptosis 64 Peroxisome proliferator activated 64 hexamer 64 multiprotein complex 64 intramolecular 64 mitochondrial proteins 64 HDAC6 64 thymocytes 64 N cadherin 64 porphyrin 64 Saccharomyces cerevisiae 64 antibody antigen 64 secreted protein 64 μ opioid receptor 64 granzyme B 64 fig. S3 64 Western blotting 64 pro inflammatory cytokine 64 lacZ 64 procaspase 3 64 cell lysates 64 peroxisomal 64 adrenocortical 64 Bcl xL 64 S. cerevisiae 64 GTPases 64 kinase pathway 64 glutathione S transferase 64 lamina 64 vasodilatory 64 hypothalamic 64 MMP2 64 cholesterol homeostasis 64 receptor gamma 64 E1A 64 telomerase RNA 64 histidine 64 leucine zipper 64 3'UTR 64 mannose 64 glycoproteins 64 osteocalcin 64 C#BL 6 mice 64 Flt3 64 plasmacytoid 64 Sertoli cell 64 homolog 64 HBx 64 SCD1 64 superoxide dismutase 64 3' UTR 64 mesoderm 64 metalloproteinase 64 CD# + [001] 64 cytoplasmic tail 64 diffusible 64 ErbB4 64 Amino acid 64 mitogen activated protein kinases 64 primary cilium 64 LIS1 64 viral RNA 64 contractility 64 CD#c 64 WNK1 64 DNA methyltransferase 64 glutamyl 63 palmitate 63 triphosphate 63 TNFR 63 fluorescently tagged 63 inducible 63 RecA 63 FGF2 63 stem cell pluripotency 63 Fc receptor 63 adenosine diphosphate ADP 63 apoE4 63 replicon 63 potently inhibited 63 eicosanoid 63 dimer 63 5 HT1A 63 TMEM#B 63 LRAT 63 monocytes macrophages 63 BMP2 63 fluorescence intensity 63 myosin 63 intron 63 RAD# [001] 63 transcriptional silencing 63 budding yeast 63 C3 convertase 63 activating mutations 63 ATPase activity 63 gene rearrangements 63 glutamatergic 63 HUVEC 63 Cytoplasmic 63 osteoblastic 63 pro apoptotic 63 JAK2 enzyme 63 proteoglycan 63 umbilical vein 63 exonuclease 63 neutrophil 63 thymidine kinase 63 induces apoptosis 63 catabolism 63 NFkappaB 63 membrane fusion 63 gastric carcinomas 63 sortilin 63 #S proteasome 63 CFTR 63 transcription factors 63 paralogs 63 effector memory 63 beta tubulin 63 neuroblastoma cells 63 N acetyl 63 monomeric 63 epithelial cells lining 63 alpha synuclein protein 63 effector protein 63 Or#b 63 tetramer 63 transduction 63 Fig. 2c 63 NKX#.# 63 nuclease 63 c MET 63 peripheral tissues 63 metalloproteinases 63 antigen receptor 63 telomerase reverse transcriptase 63 catalytic subunit 63 antigen binding