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(Click for frequent words.) 76 codon 67 cytosine 65 nucleotide sequence 64 intergenic 64 nucleotide 64 thymine 64 mitochondrial gene 63 mRNA molecules 63 nucleotides 63 missense mutations 63 paralogs 63 UTRs 63 rRNA 63 exons 63 amino acid residues 62 mRNAs 62 adenine 62 guanine G 62 untranslated regions 62 nucleotide sequences 62 noncoding 62 polymerases 62 amplicons 62 ORFs 62 RNA sequences 62 homologs 62 dinucleotide 61 tetramers 61 segmental duplications 61 orthologs 61 amino acid substitutions 61 #S rRNA 61 intron 61 polyadenylation 61 indels 61 tRNAs 61 valine 60 Alu elements 60 genes encoding 60 thymine T 60 homologues 60 guanine 60 alleles 60 introns 60 centromeres 60 isoforms 60 cDNAs 59 proto oncogene 59 intronic 59 heterochromatin 59 tRNA synthetase 59 homodimers 59 coding exons 59 X inactivation 59 FGFR2 59 heterochromatic 59 VNTR 59 ribosomal DNA 59 indel 59 coding sequences 59 mammalian organisms 59 contigs 59 cDNA 59 DNA polymerases 59 clades 59 kilobase 59 alternatively spliced 59 virulence genes 58 MLL gene 58 DNA polymerase 58 3' UTR 58 helices 58 3'UTR 58 loci 58 PTPN# 58 viral genomes 58 RNAP 58 centromeric 58 cysteines 58 noncoding regions 58 MSH2 58 intergenic regions 58 viral genome 58 pseudogenes 58 mutations 58 tetramer 58 splice variants 58 cDNA libraries 58 haplotypes 58 cytosine C 58 ultraconserved elements 58 conserved sequences 58 sequence homology 58 homodimer 58 somatic mutations 58 hypermethylation 58 amino acid substitution 58 alanine 58 nucleotide substitutions 58 nucleotide bases 58 globin genes 58 microcephalin 58 #q#.# [002] 58 nonsynonymous 58 primate genomes 57 amino acid residue 57 viral RNA 57 endonuclease 57 tyrosine phosphorylation 57 disulfide bond 57 zebrafish genome 57 chromosome #q# [001] 57 translocations 57 MTHFR gene 57 chromosomal rearrangements 57 SEQ ID 57 V#F mutation 57 amino acid sequence 57 cysteine residues 57 RNA polymerases 57 exon 57 polypeptides 57 ribosomal protein 57 protein coding 57 coding genes 57 pyrimidine 57 transcriptional repressor 57 operons 57 polypeptide 57 mutant alleles 57 6S RNA 57 protein subunits 57 tRNA 57 DNA demethylation 57 telomeric 57 microdeletion 57 autosomal 57 HAR1 57 genes CYP#C# 57 heterodimers 56 germline mutations 56 single nucleotide polymorphism 56 chromosomal DNA 56 mRNA 56 isotypes 56 p# MAPK 56 Supplementary Fig 56 PrP 56 allelic 56 transmembrane proteins 56 messenger RNAs 56 E1A 56 rDNA 56 Transcription factors 56 KLF4 56 Chromosomes 56 haplotype 56 bcl 2 56 substrate specificity 56 microRNA molecules 56 methylated 56 MLH1 56 mRNA transcripts 56 Hh 56 evolutionarily conserved 56 chromosome segregation 56 homozygosity 56 DLX5 56 heterozygotes 56 meiotic recombination 56 mRNA expression 56 bases adenine 56 beta globin 56 protein encoded 56 frameshift mutation 56 ncRNAs 56 matK 56 isotype 56 KIAA# 56 Arabidopsis genome 56 MAPK pathway 56 replicase 56 RecA 56 methyl groups 56 RNA polymerase II 56 kilobases 56 unmethylated 56 S. cerevisiae 56 histone modifications 56 CagA 56 acetylation 56 chromosome #p#.# 56 PON1 56 rs# [004] 56 genetic loci 56 Sanger sequencing 56 protein isoforms 56 Foxp3 56 chromosomes 56 serine 56 #p# [003] 56 transmembrane protein 56 methyltransferases 56 centrosome 56 subunits 56 biogenesis 56 trinucleotide 55 D. melanogaster 55 lysates 55 isoleucine 55 iNOS 55 RNA transcripts 55 organism genome 55 histone H3 55 FLT3 55 gene rearrangements 55 phosphorylate 55 promoter methylation 55 noncoding RNA 55 ubiquitination 55 chaperone proteins 55 K#N 55 budding yeast 55 cytokinesis 55 phylogenetically 55 SNPs 55 mosaicism 55 cohesin 55 PALB2 55 isoform 55 non coding RNA 55 antisense oligonucleotides 55 constitutively 55 causal variants 55 RNA molecule 55 microRNAs miRNAs 55 Vps# 55 ERBB2 55 eukaryotic cells 55 genomic instability 55 miRNAs 55 MDM2 55 homologous recombination 55 spontaneous mutation 55 H#K# [002] 55 centromere 55 transmembrane domains 55 synuclein 55 H#K#me# 55 homozygote 55 cytochrome b 55 #q# [002] 55 epigenetic alterations 55 homolog 55 nucleosome 55 amino acid valine 55 mutant proteins 55 eukaryote 55 translocates 55 NR#A# gene 55 ERK2 55 pRb 55 blastomeres 55 polymerase 55 IFN gamma 55 transactivation 55 diploid 55 leucine zipper 55 DLC1 55 fig. S1 55 hTERT 55 TP# gene 55 At#g# 55 short hairpin RNAs 55 antisense RNA 55 cytochrome 55 missense 55 apoE4 55 GAPDH 55 heterozygous 55 JAK STAT 55 constitutively active 55 caveolin 55 RNA strand 55 HLA genes 55 Hox gene 55 nucleosides 55 messenger RNAs mRNAs 55 linkage disequilibrium 55 Cre recombinase 55 Sup# 55 transmembrane 55 #S rRNA gene 55 CpG 55 yeast genome 55 chromatin proteins 55 oligomer 55 coexpression 55 orthologous 55 FMR1 55 gene duplications 54 radial glia 54 E#F# 54 constitutively expressed 54 RNA splicing 54 uracil 54 thymidine 54 EphB4 54 deacetylation 54 BCR ABL1 54 cadherin 54 chromosomal regions 54 chromosome #q#.# [001] 54 costimulatory molecules 54 histone modification 54 Cdc# 54 ribosomal RNA 54 chromosome #q# [002] 54 lincRNAs 54 glycoproteins 54 enzymatic activity 54 phenotypes 54 histone proteins 54 splice junctions 54 DSBs 54 IGF2 54 homozygotes 54 gene loci 54 uPAR 54 chromatin structure 54 allelic variants 54 bacterial genomes 54 tRNA genes 54 maternally inherited 54 genetic alterations 54 gene amplification 54 histone protein 54 IGFBP 54 pyrrolysine 54 MALAT1 54 MAPKs 54 telomere DNA 54 ribozyme 54 polymorphisms 54 disulfide bonds 54 activating mutations 54 amplicon 54 metabolic enzymes 54 PAX5 54 CDKN2A 54 cis regulatory 54 MLL2 54 NF1 gene 54 transcriptomes 54 superfamily 54 cathepsin B 54 CGG repeats 54 cell adhesion molecules 54 gene encoding 54 HepG2 cells 54 5 methylcytosine 54 immunodominant 54 hypervariable 54 membrane proximal 54 haploid 54 non coding RNAs 54 exonuclease 54 granzyme B 54 dephosphorylation 54 Plasmodium 54 FOXP2 gene 54 dimers 54 CRISPR 54 chromatid 54 CCL#L# 54 receptor ligand 54 differentially expressed genes 54 presenilin 54 MyD# 54 thrombospondin 54 antisense strand 54 TAp# 54 A. thaliana 54 PDZ domains 54 clonally 54 recombination hotspots 54 UGT#A# * 54 protein tyrosine phosphatase 54 messenger RNA mRNA 54 ciliated 54 C#Y 54 centrosomes 54 RNAs 54 glycosylated 54 peptide sequences 54 GNAQ 54 noncoding RNAs 54 euchromatin 54 K#R [002] 54 FMR1 gene 54 BARD1 54 miRNA genes 54 ligand receptor 54 extracellular domain 54 TCF#L# gene 54 seminomas 54 glycosylation 54 ribosomal proteins 54 transposable elements 54 IgA deficiency 54 TRF1 54 hepatoma 54 polynucleotide 54 synthases 54 posttranslational modifications 54 mitochondrial genomes 54 antibody antigen 54 site directed mutagenesis 54 dizygotic 54 kDa protein 54 stranded RNAs 54 aneuploidy 54 CTCF 54 globin 54 HLA molecules 54 retrotransposon 54 epitopes 54 outer membrane proteins 54 splice variant 54 ssDNA 53 kinase gene 53 fig. S2 53 dimeric 53 overexpressing 53 c Myb 53 transiently transfected 53 micro RNAs 53 phosphatases 53 histone 53 amino terminal 53 COL#A# 53 c myc 53 dsDNA 53 V3 loop 53 C. albicans 53 glycolipids 53 morphologically 53 proteins encoded 53 riboswitch 53 EZH2 53 proteolytic cleavage 53 receptor gene 53 catenin 53 PDGFR 53 tumor suppressor genes 53 Fig. 2A 53 Pol IV 53 androgen receptor AR 53 receptor tyrosine kinase 53 transmembrane domain 53 imprinted genes 53 protein kinases 53 miRNA expression 53 epigenetic silencing 53 mitogen activated protein kinase 53 S. pombe 53 dimerization 53 shRNAs 53 #p#.# [001] 53 beta globin gene 53 histone H4 53 RUNX3 53 MECP2 gene 53 monozygotic twins 53 proapoptotic 53 karyotype 53 eukaryotic 53 monozygotic 53 leptin receptor 53 Prevotella 53 TNFR1 53 Hsp# [001] 53 condensin 53 polyploid 53 downregulated 53 colocalization 53 histidine 53 RCAN1 53 bacterial genome 53 var genes 53 VKORC1 53 amino acids 53 rs# [002] 53 qRT PCR 53 protein tyrosine kinase 53 serine protease 53 K ras mutations 53 chromosome 53 kDa 53 vesicle fusion 53 deuterostomes 53 lipoxygenase 53 phenotype 53 dNTP 53 HLA alleles 53 mutation 53 mammalian genomes 53 alpha synuclein gene 53 GlcNAc 53 biotinylated 53 transfer RNA tRNA 53 transcriptionally 53 #p#.# [002] 53 homologous chromosomes 53 microdeletions 53 pathogenic mutations 53 nucleotide substitution 53 fibronectin 53 homeobox gene 53 mesoderm 53 Rab# 53 NHEJ 53 germline cells 53 CD1d 53 epitope 53 miRNAs miR 53 TMEM#B 53 leucine isoleucine 53 proline rich 53 B. subtilis 53 rs# [003] 53 Fig. 3b 53 TEL AML1 53 SLC#A# [002] 53 genomic loci 53 molecular subtypes 53 prokaryotes 53 HMGA2 53 chromosomal 53 M. genitalium 53 UGT#B# 53 GSTP1 53 DNA sequences 53 prokaryote 53 PIP3 53 EBNA1 53 breast cancer subtypes 53 TET2 53 methyltransferase 53 phagocytosis 53 transfected cells 53 epigenetically 53 endonucleases 53 chromosomal deletions 53 C. neoformans 53 gp# [002] 53 chromosomal aberrations 53 cytokeratin 53 APOL1 53 apo AI 53 BMP4 53 transcriptional machinery 53 trimeric 53 hydroxylase 53 TRAF6 53 autosomes 53 phenotypically 53 homologous 53 enzymatic reactions 53 pre mRNA splicing 53 c MYC 53 sensu lato 53 codon usage 53 costimulatory 52 prokaryotic 52 miRNA molecules 52 ubiquitin ligase 52 CNTNAP2 52 eukaryotic genomes 52 plastid 52 transgene 52 activating mutation 52 FGFR3 52 chromosome #p# [001] 52 amino acid alanine 52 transduced 52 dimer 52 poly dA 52 KCNQ1 52 defensins 52 ERK1 52 oncoproteins 52 subcellular localization 52 tyrosine kinases 52 paramyxoviruses 52 ESR1 52 piRNAs 52 encode proteins 52 Th1 52 SORL1 52 methylation 52 fission yeast 52 HOX genes 52 Nup# 52 genotypes 52 VEGF receptor 52 conformational changes 52 operon 52 ribonucleic acid RNA 52 MTHFR 52 IDH1 52 synthase 52 centrioles 52 loxP 52 lognormal 52 tyrosine kinase 52 palmitate 52 ncRNA 52 amino acid 52 insertions deletions 52 3' 52 astrocytic 52 subtypes 52 GenBank accession 52 DHFR 52 actin binding 52 TORC2 52 mammalian genome 52 IRE1 52 dsRNA 52 KaiC 52 GTPase 52 heterozygote 52 aneuploid 52 CDK4 52 CD#b 52 Prox1 52 HDACs 52 genes 52 plastids 52 acyl CoA 52 SIRT3 52 erythrocytes 52 cyclin E 52 mtDNA 52 polypeptide chain 52 differential gene expression 52 Fig. 1A 52 germline 52 testis 52 nucleobases 52 immunoglobulin genes 52 RNA polymerase 52 p# mutation 52 thioredoxin 52 frameshift 52 c KIT 52 microsatellite markers 52 palindromic 52 neuroligins 52 cytosolic 52 clade B 52 SLITRK1 52 emm 52 Amino acid 52 sister chromatid 52 de novo mutations 52 HOTAIR 52 chloroplast 52 transcription factors 52 transgene expression 52 chloroplast genome 52 polyglutamine 52 potent inhibitors 52 acetyl CoA 52 amino acid sequences 52 genetic recombination 52 trimers 52 Fig. 1E 52 proteins 52 binding affinities 52 PTEN gene 52 Supplementary Table 52 overexpressed 52 breast carcinomas 52 Fc receptor 52 Cyclin D1 52 methylated DNA 52 clade C 52 triplet repeats 52 subfamilies 52 lysine residues 52 Activating mutations 52 5 hydroxymethylcytosine 52 beta subunit 52 noncoding DNA 52 chromosome #q 52 melatonin receptor 52 ubiquitylation 52 heterodimer 52 TMPRSS2 ERG 52 Bcl XL 52 CHD7 52 amplifications 52 encodes protein 52 HLA DRB1 52 caveolin 1 52 Fig. 1C 52 miR #a [001] 52 histone deacetylation 52 intracellular signaling 52 yeast Saccharomyces cerevisiae 52 methylation patterns 52 MAPK 52 LRP6 52 HLA B# 52 #S rRNA genes 52 genomic DNA 52 downregulation 52 Alleles 52 chromosomal translocations 52 ectopic expression 52 lincRNA 52 Fig. 2b 52 substituents 52 E cadherin 52 monophyletic 52 cytoplasmic tail 52 LIS1 52 SLC#A# [001] 52 mRNA sequences 52 orthologous genes 52 capsid protein 52 anaphase 52 biosynthesis 52 viral proteins 52 ERK1 2 52 interfering RNAs 52 PAK1 52 #q#.# [001] 52 stilbene 52 glycolytic 52 commensal bacteria 52 serine threonine kinase 52 ABCB1 52 BCR ABL 52 DNA methyltransferase 52 Fig. 3A 52 somatic mutation 52 enolase 52 NR2B subunit 52 IL#R 52 taxa 52 KRAS mutations 52 epigenetic mechanisms 52 CHD5 52 succinate dehydrogenase 52 Golgi apparatus 52 cofactors 52 epigenetic modification 52 ataxin 52 transcriptional activation 52 helicase 52 Vangl2 52 peptide antigens 52 receptor kinase 52 epistasis 52 catalytic subunit 52 mRNA molecule 52 tyrosine 52 ApoE 52 TERT 51 mitochondrial genome 51 morphogen 51 metazoan 51 aT cell 51 transmembrane receptor 51 unmutated 51 miR #a [002] 51 ADAM# 51 Methylation 51 DARPP 51 C#BL 6 51 fatty acid synthesis 51 Fig. 2c 51 LRRK2 gene 51 HbF 51 HBx 51 guanosine 51 polymorphism 51 mitochondrial respiration 51 USP# 51 Fig. 2a 51 malignant transformation 51 c MET 51 TLR3 51 P. falciparum 51 mRNA translation 51 vav 51 SRY gene 51 lineages 51 PrPSc 51 exocytosis 51 mutant worms 51 p#/CBP 51 differentially regulated 51 genome rearrangements 51 PTP1B 51 fig. S4 51 megabases 51 BRAF V#E 51 fungal genomes 51 WT1 51 immunoblotting 51 selenoproteins 51 MyoD 51 CYP#B# 51 RhoA 51 CAG repeats 51 nucleic acid molecules 51 myosins 51 #S rDNA 51 dehydrogenase 51 oligonucleotide probes 51 phylogenies 51 telomere shortening 51 antiparallel 51 mesothelin 51 ligand binding 51 tumor suppressor p# 51 segmental duplication 51 caveolae 51 CCR7 51 cell adhesion molecule 51 phospholipid 51 normal prion protein 51 mtDNA mutations 51 mitochondrion 51 hypermethylated 51 coiled coil 51 serotype 51 herpesviruses 51 cofactor 51 IKZF1 51 monomeric 51 Vpu 51 LRAT 51 Phosphorylation 51 Chk1 51 STAT1 51 gene locus 51 metazoans 51 WNK1 51 protein phosphorylation 51 enantiomers 51 phospholipase 51 hemoglobin molecule 51 gene deletions 51 Fig. 3a 51 functional polymorphism 51 MiRNAs 51 CYP#C# [002] 51 microRNA expression 51 anterior pituitary 51 Yamanaka recipe 51 Klf4 51 calpain 51 CD8 + 51 chromosome #q#.# [002] 51 RNA molecules 51 GPx 51 ligands 51 PHLPP 51 sporadic ALS 51 Dpp 51 VHL gene 51 MYBPC3 51 #p# [001] 51 transcriptional regulation 51 Xenopus 51 demethylase 51 JNK1 51 hepatocellular carcinomas 51 APOBEC3G 51 pharmacodynamic biomarkers 51 BMP2 51 hexamers 51 moieties 51 DNase 51 antigen binding 51 receptor protein 51 nanomolar 51 ZNF# 51 GLI1 51 mitotic spindle 51 oncogenes 51 chromatin immunoprecipitation 51 RASSF1A 51 prion strains 51 PKD1 51 Rap1 51 proline 51 flagellum 51 glycoprotein 51 oxidized lipids 51 tumor suppressor protein 51 SOCS3 51 microarray experiments 51 CTL epitopes 51 hexamer 51 CpG islands 51 evolutionary lineages 51 PCR amplification 51 TSC1 51 #q# [001] 51 Caenorhabditis elegans 51 transfection 51 nucleic acid sequences 51 metalloprotease 51 Fas ligand 51 CNVs 51 MIF protein 51 secretory pathway 51 perilipin 51 alpha helices 51 APOC3 51 Aβ 51 desaturase 51 receptor molecule 51 CD#c 51 F actin 51 RNA ribonucleic acid 51 Micromonas 51 N glycan 51 subcellular compartments 51 proteinase 51 IFN γ 51 R#W [002] 51 oligomerization 51 Chlamydomonas 51 eukaryotes 51 mRNA encoding 51 cytokine receptor 51 MMP9 51 protein complexes 51 interfering RNA 51 mutational 51 overexpressing cells 51 HCMV 51 bivalent 51 PTEN phosphatase 51 TMPRSS2 ERG fusion 51 haemagglutinin 51 cis 51 melanocyte 51 effector proteins 51 germline mutation 51 placentals 51 LKB1 51 recombination 51 deleterious mutations 51 oxidative phosphorylation 51 c Myc 51 H#K# [001] 51 missense mutation 51 FGFR1 51 tumor suppressor gene 51 telomere dysfunction 51 COOH terminal 51 CPEB 51 polynucleotides 51 Argonaute 51 oncogenic transformation 51 K ras gene 51 triphosphate 51 QTLs 51 XBP1 51 synthetase 51 NKG2D 51 ribonucleotide 51 uncharacterized 51 SMN1 51 phosphorylation 51 eukaryotic cell 51 BMAL1 51 RNA strands 51 transcriptional coactivator 51 epigenetic modifications 51 polyploidy 51 metabolizing enzymes 51 spontaneous mutations 51 HMGCR 51 laminin 51 endostatin 51 MC4R 51 huntingtin 51 SCN5A 51 protein p# 51 nestin