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(Click for frequent words.) 75 F actin 72 tropomyosin 72 CaM 72 endonuclease 71 catenin 71 PIP2 71 titin 71 Rab5 71 caveolae 71 pRb 71 intramolecular 70 disulfide bond 70 cadherin 70 kinase domain 70 PDZ domain 70 Vps# 70 cytoplasmic domain 70 fibronectin 69 constitutively active 69 heterochromatic 69 paxillin 69 tetramer 69 uPAR 69 coiled coil 69 neurite outgrowth 69 Cdc# 69 trimeric 69 cell adhesion molecules 69 disulfide bonds 69 VE cadherin 69 phosphorylates 69 cysteine residues 69 EF Tu 69 coexpression 69 cadherins 69 MyD# 68 vesicle fusion 68 SOCS3 68 dimerization 68 COOH terminal 68 SUMOylation 68 alpha subunit 68 calpain 68 deacetylation 68 Fig. 1A 68 Rac1 68 actin filaments 68 guanosine 68 adherens junctions 68 rRNA 68 antigen binding 68 RhoA 68 actin cytoskeleton 68 RecA 68 GAPDH 68 phagocytosis 68 presynaptic 68 disulfide 68 Arp2 3 68 proteolysis 68 NFκB 68 photosystem II 68 Runx2 68 SIRT2 68 flavin 68 PIP3 67 exocytosis 67 centromeric 67 transcriptional activation 67 transmembrane 67 ERK1 2 67 ouabain 67 lysine residues 67 tubulin 67 phosphoprotein 67 MT1 MMP 67 dimer 67 cytokine signaling 67 electrophilic 67 coding genes 67 actin filament 67 cytoskeletal protein 67 vacuolar 67 IL #p# 67 cohesin 67 Aâ 67 proximal tubule 67 covalently 67 protein subunits 67 cysteines 67 postsynaptic 67 actin polymerization 67 CD1d 67 polypeptide chain 67 dimeric 67 Supplementary Fig 67 serine protease 67 vascular endothelial cells 67 dephosphorylation 67 BMP signaling 66 substrate specificity 66 porphyrin 66 phosphatidylinositol 66 focal adhesions 66 ubiquitination 66 spectrin 66 endonucleases 66 JNK1 66 MAP kinase 66 amide 66 GTPase 66 constitutively 66 carboxyl terminal 66 STAT1 66 vimentin 66 phosphorylate 66 p# MAPK 66 oligomerization 66 fig. S1 66 acyl CoA 66 subcellular compartments 66 oligomeric 66 endoplasmic reticulum ER 66 thioredoxin 66 cathepsins 66 conformational changes 66 Hsp# [001] 66 TRAF6 66 ssDNA 66 β catenin 66 transmembrane domains 66 IKKß 66 monomeric 66 RNA binding 66 endocytic 66 cytosolic 66 JAK STAT 66 costimulatory 66 H#K# [002] 66 JNK activation 66 GATA1 66 transmembrane domain 66 adduct 66 neuroligins 66 biotinylated 66 kinetochore 66 interconversion 66 NR2B subunit 66 vinculin 66 homodimers 66 proteolytic 66 microdomains 66 telomeric 66 amino acid residues 66 oxidative phosphorylation 66 disulfide bridges 66 carboxy terminal 66 hydrophobic interactions 66 centromeres 66 mitogen activated protein kinase 66 proline rich 66 cyclin B1 66 ATPase 66 diffusible 66 basolateral 66 NADPH 66 dynamin 66 FOXO3a 65 subunits 65 acinar 65 autophagic 65 homodimer 65 glycosyltransferase 65 caveolin 1 65 uracil 65 pyrimidine 65 FGF signaling 65 intracellular proteins 65 hexamers 65 glucokinase 65 extracellular domain 65 metaphase 65 γ 65 TAp# 65 #BP# 65 oligomer 65 androgen receptor AR 65 hexamer 65 ciliated 65 anaphase promoting complex 65 cyclic AMP cAMP 65 imidazole 65 condensin 65 dynactin 65 transferrin receptor 65 transmembrane protein 65 tRNA synthetase 65 synaptic vesicle 65 covalent bond 65 heterodimer 65 TGF ß 65 amyloid peptides 65 Purkinje cell 65 Cathepsin B 65 beta subunit 65 plasminogen 65 osteoclast 65 Ca2 + 65 crosslinks 65 DNMT1 65 4E BP1 65 BCL2 65 Ser# 65 chaperone proteins 65 phosphatase 65 CTCF 65 intestinal epithelial cells 65 PKD1 65 amino terminal 65 LRP6 65 sulfur atoms 65 ß catenin 65 centrosome 65 transferase 65 membrane lipids 65 cytochrome 65 MAP kinases 65 6S RNA 65 receptor molecule 65 catalytically active 65 ligand binding 65 serine threonine 65 adhesion proteins 65 ribosomal protein 65 Htt 65 kinetochores 65 C3 convertase 65 thymidylate synthase TS 65 alpha actinin 65 integral membrane proteins 65 podocytes 65 syntaxin 65 secretase 65 transmembrane receptor 65 Fig. 1C 65 downregulated 65 ATP hydrolysis 65 MAPKs 65 kinesin motor 65 occludin 65 epithelia 65 transcriptional repressor 65 paracellular 65 β 65 proapoptotic 65 heparan sulfate 65 CagA 65 PcG proteins 65 histidine 65 cytokine receptors 65 astrocytic 65 cellular organelles 65 NKG2D 65 RNA polymerase II 65 Rap1 65 ectodomain 65 3' UTR 65 lipid bilayer 65 Wnts 65 glial 65 ubiquitylation 65 forkhead 64 AMPA receptors 64 tetramers 64 transgenic mice expressing 64 PrPC 64 glycosylated 64 constitutively expressed 64 myofibroblasts 64 aggrecan 64 perivascular 64 mitotic spindles 64 supramolecular 64 adhesion molecule 64 clathrin 64 anterior pituitary 64 mammalian tissues 64 histone H3 64 beta amyloid peptide 64 IgG4 64 cytokine receptor 64 cofactor 64 quinone 64 MAPK pathway 64 posttranslational modification 64 tubule 64 matrix metalloproteinases 64 acetylcholine receptor 64 basal lamina 64 BMP4 64 LIS1 64 imine 64 M1 muscarinic 64 metalloproteases 64 Nedd4 64 lipoxygenase 64 ATP synthase 64 focal adhesion 64 receptor mediated endocytosis 64 aminopeptidase 64 cells transfected 64 cytidine 64 PAX5 64 homologs 64 hyperactivation 64 amyloid beta peptides 64 ribosomal 64 peroxidase 64 proteolytic cleavage 64 nAChR 64 cyclic adenosine monophosphate 64 mesenchymal cells 64 Rho GTPases 64 caveolin 64 secrete proteins 64 peptidoglycan 64 catalytic subunit 64 EGFP 64 fibrillar 64 PrP 64 matrix metalloproteinases MMPs 64 fission yeast 64 GPI anchored 64 TXNIP 64 polymerases 64 β1 64 nitric oxide synthase 64 Notch receptor 64 Smad4 64 HIP1 64 N cadherin 64 actinin 64 ERK1 64 Fig. 3b 64 mutant proteins 64 histone protein 64 histone H4 64 glycolipids 64 prostaglandin E2 PGE2 64 Rab# 64 ERK pathway 64 tyrosine 64 Fig. 4B 64 isoleucine 64 isoenzyme 64 mitochondrial respiration 64 soluble proteins 64 TFIIH 64 MAPK 64 ATPases 64 antiparallel 64 leucine zipper 64 polyamine 64 chromatin structure 64 alpha helical 64 toxic beta amyloid 64 RAS RAF MEK 64 ERa 64 APOBEC3G 64 PKC isoforms 64 contractile 64 spindle fibers 64 chromophore 64 ubiquitinated 64 #S subunit 64 nitrogen atoms 64 microtubule binding 64 nuclease 64 transcriptionally 64 colocalization 64 Mice deficient 64 FGFs 64 Fig. 2a 64 endosome 64 serine 64 beta adrenergic receptors 64 glutamate receptor 64 collagen fibers 64 Foxp3 64 MyoD 64 granzyme B 64 Aβ 64 hydrogenase 64 triphosphate 64 nucleolar 64 Fig. 2b 64 caspase activation 64 serine proteases 64 oligomers 64 beta tubulin 64 C3b 64 microglial 64 HipA 64 P selectin 64 secretory pathway 64 5' triphosphate 64 mRNA molecules 64 hydroxylation 63 pyrophosphate 63 Integrins 63 IRE1 63 messenger molecule 63 Hedgehog signaling 63 threonine 63 sarcomere 63 c myc 63 prostaglandin synthesis 63 helicase 63 dystroglycan 63 cyclic peptide 63 proteosome 63 KaiC 63 evolutionarily conserved 63 intermolecular 63 TGF beta pathway 63 Fig. 3A 63 proteoglycan 63 cyclic AMP 63 N Myc 63 extracellular domains 63 E3 ligase 63 serine threonine kinase 63 untranslated regions 63 heterodimers 63 Rubisco 63 BMAL1 63 E cadherin 63 intestinal epithelium 63 mRNA expression 63 tumor suppressor proteins 63 SNARE complex 63 MEK1 63 KIAA# 63 HER2 receptor 63 p# activation 63 fig. S6 63 guanine 63 Phosphorylation 63 mononuclear 63 kD 63 polyadenylation 63 secretory 63 mitogen activated protein kinases 63 TGF beta1 63 mitochondrial membranes 63 ERBB2 63 phytochrome 63 mitotic progression 63 oxidases 63 bilayers 63 matrix metalloproteinase 63 tenascin C 63 sequence homology 63 lamina 63 SNAREs 63 p#Kip# 63 PPARg 63 palytoxin 63 plasma membrane 63 HDAC6 63 alanine 63 epithelial cell 63 Kinesin 63 GluR1 63 amyloid fibrils 63 proteinase 63 platelet adhesion 63 transduced 63 beta globin 63 endogenous ligand 63 transthyretin 63 polypeptides 63 microRNA molecule 63 cardiac fibroblasts 63 Fas ligand 63 metalloproteinases 63 regulates gene expression 63 subcellular localization 63 cytoplasmic 63 ligand receptor 63 synaptic vesicles 63 trypsin 63 acetyl CoA 63 receptor tyrosine kinase 63 MDCK cells 63 cytoskeletal 63 cysteine residue 63 S nitrosylation 63 nucleolin 63 cyclase 63 Notch1 63 alpha helix 63 miR# 63 dimers 63 hnRNP 63 proteoglycans 63 downregulate 63 membrane proximal 63 interneurons 63 isoforms 63 polycystin 63 phosphoinositide 63 antiapoptotic 63 stromal cells 63 XPB 63 overactivation 63 receptor gamma 63 non coding RNA 63 tyrosine phosphorylation 63 cofactors 63 CPEB 63 CCL# 63 mRNA translation 63 epoxide 63 hydrolases 63 NKX#.# 63 C1q 63 stilbene 63 collagens 63 tyrosine residues 63 antibody antigen 63 SWI SNF 63 c Src 63 TGF b 63 mitogenic 63 ligases 63 ERK signaling 63 neuromuscular junction 63 actin dynamics 63 chromatid 63 amino acid substitutions 63 alpha Gal 63 osteoblastic 63 overexpressing cells 63 GLUT4 63 actin myosin 63 Polycomb 63 lysosomal 63 multinucleated 63 fig. S2 63 glycoproteins 63 enterocytes 63 degrading enzyme 63 KATP channels 63 protein actin 63 messenger RNAs mRNAs 63 IFN g 63 pericytes 63 tumor suppressor protein 63 HIF 1a 63 prion proteins 63 synuclein 63 GTPases 63 ubiquitin ligase 63 cytoskeletal proteins 63 NHEJ 63 SH2 domain 63 RANTES 63 intermediate filaments 63 isozymes 63 inhibitory effects 63 primary cilium 63 AMPA receptor 63 Vpr 63 #S proteasome 63 regulated kinase ERK 63 Fig. 1c 63 cytochrome c oxidase 63 mitotic spindle 63 glycogen synthase 63 degranulation 63 dsRNA 63 moieties 63 μ opioid receptor 63 PAK1 63 intronic 63 phosphatases 63 luminal surface 63 phosphorylated 62 protein fragment 62 collagen fibrils 62 coactivator 62 tumorigenicity 62 epithelial cells lining 62 intracellular signaling 62 KLF4 62 histone modifications 62 CIB1 62 cathepsin B 62 nucleophilic 62 GLI1 62 FKBP# 62 depolarization 62 FGFR4 62 globin gene 62 dendritic spine 62 dipeptide 62 DDB1 62 ChR2 62 helicases 62 plasmin 62 glyceraldehyde 3 62 monocyte 62 methyl groups 62 extracellular signal 62 cofilin 62 melanocyte 62 synthases 62 tRNAs 62 mRNA encoding 62 acetyl groups 62 Amino acid 62 CXCL# 62 transcriptional machinery 62 lipid membranes 62 binding affinity 62 homolog 62 SOD1 protein 62 cell adhesion molecule 62 reductase 62 substituents 62 bacterial enzyme 62 TrkB 62 glutamate transporters 62 PcG 62 calcineurin 62 metalloproteinase 62 dermal papilla 62 Syt II 62 Sp1 62 cytochrome c 62 PGC 1α 62 Golgi apparatus 62 mitochondrial membrane 62 covalent bonds 62 ribonuclease 62 COL#A# 62 leukemic cell 62 protein tyrosine phosphatase 62 methyltransferase 62 isoenzymes 62 RNA strand 62 RNA sequences 62 H#K# [001] 62 SAP# 62 ganglioside 62 somites 62 genes encoding 62 FasL 62 T#M 62 Fig. 3a 62 EGF receptor 62 donor acceptor 62 thiol 62 sialic acids 62 selenoproteins 62 protein filaments 62 WNK1 62 Wnt pathway 62 heterochromatin 62 lipid molecules 62 membrane fusion 62 microtubule dynamics 62 protein myosin 62 Fig. 3B 62 biogenesis 62 eNOS 62 fibroblast 62 FGFR1 62 adhesion molecules 62 c Myb 62 transactivation 62 MDSCs 62 hydrolase 62 Myosin II 62 fibrillin 1 62 intergenic regions 62 proton pump 62 neurofilament 62 virulence genes 62 cAMP signaling 62 Fig. 1d 62 integrins 62 lytic 62 adenylate cyclase 62 keratinocyte 62 inflammatory cytokine 62 avidin 62 CD#c 62 lipid membrane 62 phagocytic cells 62 cytokinesis 62 IL 1β 62 cellular prion protein 62 retinal neurons 62 excitatory neurons 62 ATPase activity 62 SMAD4 62 Dpp 62 enzymatic pathways 62 glomerular 62 hexose 62 cytokine secretion 62 Smad 62 TGFb 62 activin 62 RAD# [001] 62 erythrocytes 62 thymine 62 exonuclease 62 globular proteins 62 ATP adenosine 62 centrosomes 62 podocyte 62 BH3 62 histone 62 nicotinamide adenine dinucleotide NAD 62 prolyl 62 synaptogenesis 62 iNOS 62 lipid bilayers 62 OCT4 62 lipid rafts 62 galectins 62 TNFR 62 esterase 62 phagocyte 62 cysteine 62 KLF2 62 glomerulus 62 junctional 62 ESCRT 62 topoisomerase 62 Tie2 62 CaMKII 62 ubiquitin molecules 62 tumor suppressor p# 62 diphosphate 62 p# NTR 62 umbilical vein 62 nucleotide sequences 62 RNA polymerases 62 major histocompatibility complex 62 angiotensinogen 62 PARP1 62 eukaryotic cell 62 kinesins 62 electrostatic interactions 62 trimers 62 FSH receptor 62 Figure 1C 62 microRNA molecules 62 trophoblasts 62 p#NTR 62 phospholipase 62 sulfur atom 62 Aß peptide 62 sister chromatids 62 LDL receptor 62 PTPN# 62 DSBs 62 presenilin 62 FGFR3 62 mPGES 1 62 COOH 62 metalloprotease 62 operons 62 covalently linked 62 protein phosphatase 62 metabolic enzymes 62 osteoclast formation 62 actin 62 fig. S4 62 ankyrin 62 ribosomal DNA 62 PHD2 62 RNAP 62 eicosanoid 62 focal adhesion kinase FAK 62 cypin 62 punctate 62 morphogen 62 insulin signaling pathway 62 VEGF receptor 62 genes encode proteins 62 oxidized LDL 62 di GMP 62 polypeptide 62 Src kinase 62 HDACs 62 Smad3 62 Cx# [001] 62 lysates 62 peripheral tissues 62 hematopoietic progenitor cells 62 signaling cascades 62 amino acid histidine 62 cyclic nucleotide 62 chemotactic 62 globin genes 62 subunit 62 beta actin 62 sGC 62 protein complexes 62 isomerase 62 mutant SOD1 62 bacterial virulence 62 HIF 1alpha 62 mRNA transcripts 62 ACh 62 autocrine 62 cytosine 62 sphingomyelin 62 IL6 62 proto oncogene 62 glycolytic 62 thymine T 62 downregulation 62 apical membrane 62 FANCD2 62 encodes protein 62 lamellar 62 nAChRs 62 intracellular Ca 2 61 transmembrane proteins 61 replicase 61 neuronal signaling 61 centromere 61 intron 61 protein conformation 61 Microtubule 61 globin 61 bcl 2 61 DNA gyrase 61 cyclins 61 thioester 61 p# subunit 61 Ubx 61 acyl 61 basolateral membrane 61 covalently bound 61 H2AX 61 TGF ß1 61 fluorophore 61 glycan 61 astrocyte 61 DNase 61 laminae 61 helices 61 ligands 61 importin 61 Integrin 61 triacylglycerol 61 steroidogenic 61 alkene 61 tyrosine hydroxylase 61 adenylyl cyclase 61 nucleases 61 upregulates 61 MHC molecules 61 enzymatic activity 61 amino acid residue 61 Skp2 61 alternatively spliced 61 fibril formation 61 Pol IV 61 mutated protein 61 fluorescently tagged 61 overexpressing 61 FtsZ 61 vesicle 61 histone proteins 61 inhibitory synapses 61 CD#b 61 neuronal pathways 61 Cyclin D1 61 PI3K AKT 61 receptor subunit 61 mediated inhibition 61 carboxyl 61 conformational 61 CD# expression [001] 61 immunoreactivity 61 furin 61 calmodulin 61 netrin 1 61 tumor stroma 61 MnSOD 61 heme oxygenase 61 oncoprotein 61 gp# [002] 61 IGF1R 61 extracellular matrix proteins 61 myocytes 61 cytosol 61 multivesicular bodies 61 neurite 61 eukaryotic cells 61 TORC2 61 pentamer 61 effector cells 61 PKC delta 61 operon 61 amine oxidase 61 site directed mutagenesis 61 isoprenoid 61 collagenous 61 intercellular communication 61 microglial activation 61 bile acid 61 translationally 61 antigen receptor 61 muscarinic receptors 61 integrin 61 farnesyl 61 streptavidin 61 casein kinase 61 mesoderm 61 morphogens 61 desaturase 61 unpaired electrons 61 Notch signaling 61 ectopic expression 61 sortilin 61 membrane protein 61 ligand induced 61 monolayers 61 thrombospondin 61 oncoproteins 61 covalent 61 mitochondrial gene 61 c MYC 61 Sgk1 61 synthetase 61 transcriptional regulators 61 At#g# 61 intracellularly 61 microtubule 61 costimulatory molecules 61 MMP2 61 malonyl CoA 61 Drp1 61 lymphotoxin 61 upregulation 61 HSP# 61 anaphase 61 E1A 61 receptor ligand 61 pDCs 61 chondrocyte 61 proteasomes 61 histone acetylation 61 beta. 61 MDR1 61 GABAergic interneurons 61 5 hydroxymethylcytosine 61 bispecific 61 adipogenic 61 secreted protein 61 alpha helices 61 calcium ion 61 mice lacking 61 PPARγ 61 ErbB receptors 61 Eg5 61 mesenchyme 61 adipocyte 61 myoepithelial cells 61 α 61 tubules 61 actin fibers 61 Nod1 61 ERK2 61 amyloid formation 61 infarcted myocardium 61 SGK1 61 actin myosin interaction 61 lymphangiogenesis 61 Rho proteins 61 bilayer 61 proline 61 synaptotagmin 61 pro angiogenic 61 Rad# 61 flagellar 61 immunoreactive 61 ligand binding domain 61 MLL gene 61 cytochromes