Related by context. All words. (Click for frequent words.) 75 ASCUS 71 cervical cytology 70 CIN3 70 CIN2 + 70 cytologic 70 chlamydial infection 69 abnormal Pap smear 69 cytological 69 BCG vaccinated 68 grade cervical intraepithelial 68 advanced neoplasia 68 transrectal ultrasound guided 68 cervical intraepithelial neoplasia 68 HGPIN 67 HER2 expression 67 serologic testing 67 PAP smears 67 invasive lobular carcinoma 67 histologically confirmed 66 lymph node biopsies 66 cervical lesions 66 biochemical relapse 66 antibody titer 66 hematopoietic cancers 66 Prostate Specific Antigen PSA 66 neoplasias 66 immunohistochemical 66 genotypic resistance 66 monoinfected patients 66 thyroglobulin 66 prostate cancer CaP 66 Chlamydia trachomatis infection 66 APTIMA HPV 66 Cytogenetic 66 CC genotype 66 breast carcinoma 65 Serologic 65 urine cytology 65 mutated K ras 65 precancerous cervical lesions 65 colorectal adenoma 65 duplex ultrasonography 65 #.#ng/ml 65 seropositivity 65 operable breast cancer 65 nonmetastatic 65 spirometric 65 prostate carcinoma 65 urine dipstick 65 grade squamous intraepithelial 65 microsatellite instability 65 abnormal Pap smears 65 HER2 overexpression 65 epithelial ovarian cancer 65 HRCT 65 microalbumin 65 immunochemical 65 antiretroviral naïve 65 specific antigen PSA 65 urine albumin 65 precancer 65 gastric adenocarcinoma 65 histologically proven 65 seronegative 65 BRCA mutation carriers 64 urothelial carcinoma 64 leiomyomas 64 PSA nadir 64 adenomatous polyps 64 HIV HCV coinfected 64 SGPT 64 enteroviral 64 histologic subtype 64 HIV seropositive 64 GH deficiency 64 Heavy menstrual bleeding 64 undergo prostate biopsy 64 haematologic 64 underwent coronary angiography 64 papillary renal cell carcinoma 64 colposcopic 64 ovarian malignancy 64 liver histology 64 pelvic ultrasound 64 haematological 64 endometrial biopsy 64 relapsed MM 64 Adenomas 64 extracolonic findings 64 T1a 64 reactogenicity 64 tumor histology 64 breast carcinomas 64 advanced adenoma 64 hepatocellular carcinomas 64 clinicopathological 64 vaginal lesions 64 ovarian carcinoma 64 tipranavir ritonavir 64 histological subtype 64 BRCA2 mutation carriers 64 pT3 64 HER2 positive cancers 64 pelvic lymphadenectomy 64 colonoscopy flexible sigmoidoscopy 64 Digital Mammographic Imaging 64 parasitological 64 CIN2 64 Histological 64 FDG-PET/CT 64 initiating antiretroviral therapy 63 cervical carcinoma 63 NMIBC 63 nonalcoholic steatohepatitis NASH 63 abnormal pap smears 63 careHPV 63 CP CPPS 63 hepatitis C genotype 63 recurrent UTI 63 elevated ALT 63 Haptoglobin 63 osteosarcomas 63 thrombophilia 63 peritoneal cancer 63 FDG PET imaging 63 maternal serum 63 lactate dehydrogenase LDH 63 completely resected 63 abnormal Pap 63 serological tests 63 Hemoccult II 63 adenomatous 63 underwent resection 63 HIV uninfected 63 lymphocyte count 63 bladder carcinoma 63 squamous cell lung cancer 63 N. gonorrhoeae 63 mucinous 63 BRCA1 BRCA2 63 TMPRSS2 ERG 63 Prostate specific antigen 63 immunochemical fecal occult 63 de novo AML 63 abnormal Pap test 63 penicillin allergy 63 invasive carcinoma 63 chest radiographs 63 HBsAg 63 FDG PET scans 63 orchitis 63 induced sputum 63 HIV tropism 63 methacholine challenge 63 immunocompetent 63 pT2 63 CMV infection 63 immunostaining 63 diagnosing coronary artery 63 colorectal polyp 63 NNRTI resistance 63 postexposure prophylaxis 63 PCNSL 63 cytogenic 63 PAP smear 63 digital rectal examination 63 testicular germ cell 63 nonmelanoma skin cancers 63 colonoscopic 62 chlamydial infections 62 subclinical disease 62 Serological 62 pretest probability 62 Non inferiority 62 Cervista HPV HR 62 KRAS mutation 62 undergone radical prostatectomy 62 Asymptomatic 62 MRSA colonization 62 PCa 62 basal cell carcinoma BCC 62 recurrent metastatic 62 LTBI 62 allogeneic HSCT 62 #q# deletion 62 serum PSA 62 KRAS mutations 62 benign nodules 62 biochemical recurrence 62 thyroid carcinoma 62 chlamydial 62 hormone receptor status 62 renal cell carcinomas 62 colonoscopy sigmoidoscopy 62 prospectively enrolled 62 ELISpot 62 epithelial tumors 62 retrospective cohort 62 hyperplastic 62 IgA deficiency 62 chronic prostatitis 62 recurrent glioblastoma multiforme 62 precancers 62 metaplasia 62 transvaginal sonography 62 myelodysplastic myeloproliferative diseases 62 bronchoalveolar lavage 62 alanine aminotransferase ALT 62 LSIL 62 undetectable HBV DNA 62 HNSCC 62 external genital lesions 62 test FOBT 62 atypical hyperplasia 62 histological diagnosis 62 mg/m2 dose 62 SLNB 62 hematological parameters 62 Squamous 62 bone density measurements 62 idiopathic PAH 62 pre malignant lesions 62 coronary calcification 62 conventional cytology 62 virus HBV 62 GISTs 62 bacteraemia 62 ductal lobular 62 genomewide 62 CIN3 + 62 pretreatment serum 62 pCR 62 HER2 amplification 62 ertapenem 62 clinico pathological 62 recurrent bladder 62 Cervista HPV 62 invasive lobular 62 sero positive 62 Mantoux test 62 prostate cancer PCa 62 congenital toxoplasmosis 62 extracolonic 62 genotype 1b 62 malignant lymphoma 62 vesicoureteral reflux 62 intact parathyroid hormone 62 basal cell nevus syndrome 62 Histologic 62 core needle biopsies 62 HBeAg negative 62 Adjuvant chemotherapy 62 squamous 62 thyroid nodules 62 precancerous cervical 62 microscopic hematuria 62 clinically asymptomatic 62 endometrial hyperplasia 62 bone scintigraphy 62 TT genotype 62 urothelial cancer 62 diabetes mellitus DM 62 B7 H3 61 anal HPV 61 RAS mutations 61 MenACWY 61 HbF 61 serum concentrations 61 ritonavir boosted 61 clinicopathologic 61 D Dimer 61 QuantiFERON 61 baseline LDH 61 K ras mutations 61 carotid IMT 61 neutrophil counts 61 syndromic 61 underwent surgical resection 61 obstructive coronary artery 61 Viral load 61 UGT#A# * 61 surgically resectable 61 Gram stain 61 hematologic parameters 61 seminoma 61 trichomonas 61 T1c 61 endometrial carcinoma 61 chlamydia infection 61 gastric cardia 61 proctitis 61 PSADT 61 atrophic gastritis 61 BCR ABL mutations 61 posttreatment 61 BRCA deficient 61 smoldering myeloma 61 plasma folate 61 esophageal gastric 61 microbiologically evaluable 61 malignant lesions 61 HNPCC 61 multivariable adjusted 61 BARACLUDE ® 61 serologic 61 FluCAM arm 61 histopathologic examination 61 advanced adenomas 61 transgenic rats 61 genital ulcer 61 retrospectively analyzed 61 anemia hemoglobin 61 lamivudine resistant 61 cutaneous melanoma 61 F FDG PET 61 squamous intraepithelial lesions 61 immunohistochemical analysis 61 murine models 61 stratifying patients 61 chest radiography 61 MGUS 61 HCV antibody 61 transabdominal 61 premalignant lesion 61 preoperative PSA 61 gonococcal infection 61 bacteriuria 61 Fine needle aspiration 61 submucosal 61 aminotransferase levels 61 fluoroquinolone resistant 61 BRCA2 carriers 61 malignant nodules 61 relapsed ALL 61 nodal metastasis 61 virologic responses 61 cervical smears 61 inflammatory biomarkers 61 cranial irradiation 61 HbA1C 61 LVNC 61 renal tumors 61 adenoma recurrence 61 sonographic diagnosis 61 MLH1 61 S. aureus isolates 61 pyridostigmine 61 serologically 61 urolithiasis 61 oesophageal adenocarcinoma 61 longitudinal cohort study 61 erythrocyte sedimentation rate 61 microbiologic 61 radical retropubic prostatectomy 61 Subgroup analyzes 61 gene rearrangements 61 guaiac 61 antiandrogens 61 abacavir Ziagen 61 acute rhinosinusitis 61 pegylated interferon alfa 61 thyrotropin levels 61 HepC 61 abnormal pap 61 T1DM 61 ANCA associated 61 virological response 61 Estrogen Receptor 61 often detect precancerous 61 carotid stenosis 61 mammographically 61 familial aggregation 61 Abdominal ultrasound 61 aged ≥ 61 achieved sustained virological 61 gastric carcinoma 61 Prostate Specific Antigen 61 varicella infection 61 K ras gene 61 DEXA scan 61 multivariate analyzes 61 oncologic outcomes 61 Oncotype 61 NMP# 61 precursor lesions 61 Hurthle cell 61 perfusion abnormalities 61 bullous 61 genital herpes infections 61 hypereosinophilic syndrome 61 demyelinating 61 histologic 61 response pCR 61 pathologic examination 61 abdominal ultrasound 61 postoperative complication 61 limiting generalizability 61 immunohistochemical staining 61 HBeAg seroconversion 61 low expressors 60 extracapsular extension 60 obstructive coronary 60 Myelosuppression 60 grade cervical dysplasia 60 Sjögren syndrome 60 liposomal amphotericin B 60 neoplastic lesions 60 cranial radiation 60 Immunohistochemical staining 60 bowel polyps 60 cytomegalovirus infection 60 Venous thromboembolism 60 differentiated thyroid 60 endometrioid 60 seminomas 60 prostate specific 60 microarray experiments 60 primary aldosteronism 60 histopathological 60 electrophysiologic 60 underwent radical prostatectomy 60 proton MR spectroscopy 60 T2DM 60 circulating endothelial cells 60 C. trachomatis 60 Legg Calvé Perthes disease 60 #q# deletion syndrome 60 methylation markers 60 albumin excretion 60 chronic periodontitis 60 System IPSS 60 colon rectal 60 methicillin sensitive 60 latent tuberculosis TB 60 intraobserver 60 VCUG 60 ovarian endometrial 60 prospective multicentre 60 detecting precancerous 60 prostate adenocarcinoma 60 heterozygotes 60 antibiotic regimens 60 DAS# scores 60 Acute myeloid leukemia 60 d dimer 60 cervicitis 60 latent tuberculosis infection 60 platelet reactivity 60 metastatic neuroendocrine tumors 60 postexposure 60 subclinical atherosclerosis 60 D dimer 60 poor metabolizers 60 amoxicillin clavulanate 60 coinfection 60 aneuploidy screening 60 malignant neoplasm 60 pharmacologic stress 60 Her2/neu 60 scintigraphic 60 clomipramine 60 monoclonal gammopathy 60 enteroviral infection 60 intraepithelial neoplasia 60 KRAS mutations occur 60 pulmonary angiography 60 serum lipid levels 60 carcinoid tumor 60 perfusion MRI 60 Neisseria gonorrhoeae 60 adrenalectomy 60 fetal chromosomal 60 OGTT 60 liver biopsies 60 malignant ovarian 60 sputum specimens 60 detect precancerous lesions 60 pelvic malignancies 60 hepatorenal syndrome 60 multivariate Cox 60 G6PD deficiency 60 abnormal Pap tests 60 primary hyperparathyroidism 60 immunopathology 60 Papillary 60 RhD negative 60 haematuria 60 PCR assay 60 hepatic fibrosis 60 hormone receptor negative 60 florbetaben 60 CSF biomarkers 60 endocrine therapies 60 metastatic lymph nodes 60 untreated celiac disease 60 mIU L 60 symptomatic carotid stenosis 60 BRAF V#E mutation 60 trials RCTs 60 plasma pharmacokinetics 60 K#N 60 Leydig cell 60 carcinoids 60 PPCM 60 osteopenic 60 postoperative radiotherapy 60 cystoscopic 60 urodynamic 60 juvenile idiopathic arthritis 60 Phenylketonuria PKU 60 caspofungin 60 antibiotic susceptibility 60 serum TSH 60 NSTE ACS 60 Immunohistochemical analysis 60 sCJD 60 Lymph node 60 attain statistical significance 60 International Prognostic Scoring 60 nasal polyposis 60 HepG2 cells 60 Kruskal Wallis test 60 metastatic gastric 60 lupus anticoagulant 60 AGTR1 60 HPV subtypes 60 dysglycemia 60 thyroid deficiency 60 oral squamous cell 60 clinicopathological features 60 ultrasonographic 60 flutamide 60 abdominal ultrasounds 60 AGHD 60 LHRH receptor positive 60 prostate abnormalities 60 hamartomas 60 sustained virologic response 60 elevated LDH 60 arthrography 60 Multicenter AIDS 60 histopathologic 60 elevated CRP 60 intravascular hemolysis 60 serum creatinine levels 60 endometrial biopsies 60 mammographic density 60 antiandrogen 60 intravenous bisphosphonates 60 diagnostic modality 60 imatinib resistance 60 PCA3 scores 60 premenopause 60 % CI #.#-#.# [003] 60 lymphocytosis 60 TMPRSS2 ERG fusion 60 chest radiograph 60 Coronary angiography 60 cytoreduction 60 Leukemias 60 Pharmacokinetics PK 60 pathologic diagnosis 60 LV dysfunction 60 plasma creatinine 60 hypogonadal 60 euthymic patients 60 bronchoalveolar 60 normal karyotype 60 flavopiridol 60 USPSTF recommends 60 pentoxifylline 60 neoplasia 60 lesional 60 needle aspiration 60 cTnT 60 odds ratios ORs 60 clinically localized prostate 60 urothelial bladder cancer 60 LRAT 60 CYP#D# gene 60 HIV coinfected 60 Waldenstrom macroglobulinemia 60 prolonged QT interval 60 Mitomycin C 60 NHANES III 60 M#V mutation 59 upper endoscopy 59 chronic myeloid 59 lactose malabsorption 59 Helicobacter pylori infection 59 serum prostate 59 angiographically 59 deCODE BreastCancer TM 59 FDG PET scan 59 herpesviruses 59 ADPKD 59 endoscopic biopsy 59 invasive ductal 59 lactate dehydrogenase 59 intestinal metaplasia 59 Naive Patients 59 irinotecan chemotherapy 59 ABCB1 59 serogroup B 59 colorectal cancer CRC 59 colorectal neoplasms 59 colorectal carcinoma 59 cisplatin resistant 59 Prostatic 59 trastuzumab Herceptin ® 59 cisplatin chemotherapy 59 Hormonal therapy 59 ethambutol 59 seroconverted 59 p# biomarker 59 adenoma detection 59 histologic diagnosis 59 Colon polyps 59 LHRH agonists 59 galiximab 59 epoetin alpha 59 AVODART 59 renal scarring 59 Multivariate logistic regression 59 dysplastic lesions 59 intestinal polyps 59 Flu Cy 59 venous thromboembolic disease 59 thyroid stimulating hormone TSH 59 minimally symptomatic 59 Chlamydia infection 59 AST ALT 59 mucosal lesions 59 invasive aspergillosis 59 NIH CPSI 59 ano genital warts 59 abdominal computed tomography 59 serum IgE 59 Postoperative complications 59 mL/min/#.# m 2 59 systemic amyloidosis 59 glomerular filtration 59 posttransplant 59 cutaneous squamous cell carcinoma 59 visceral metastases 59 affective psychoses 59 carotid plaques 59 monozygotic twin 59 polyposis 59 lymphocyte counts 59 undergoing radical prostatectomy 59 moderately emetogenic 59 microdeletions 59 histological subtypes 59 HBeAg 59 histologic findings 59 sensitivity specificity 59 corticosteroid dose 59 fecal immunochemical test 59 colorectal neoplasia 59 metastatic malignant 59 Relapsing remitting MS 59 axillary lymph nodes 59 Screening Trial DMIST 59 coinfected 59 empiric treatment 59 CYP#D# genotype 59 confidence interval #.#-#.# 59 serologic tests 59 EUS FNA 59 CCyR 59 multiple logistic regression 59 CFTR gene mutations 59 recurrent venous thromboembolism 59 tipranavir r 59 candidemia 59 NSABP B 59 histopathologic findings 59 antigen PSA 59 epithelial ovarian 59 gadobutrol 59 homocysteine concentrations 59 specific antigen 59 Acute Myeloid Leukaemia AML 59 axillary dissection 59 complete cytogenetic response 59 underwent prostate biopsy 59 cervical vaginal 59 erythema nodosum 59 bronchial hyperresponsiveness 59 prospectively evaluated 59 EBV infection 59 radical prostatectomy RP 59 aspartate aminotransferase AST 59 serum urate levels 59 KRAS status 59 spontaneous regression 59 ocular toxicity 59 radiographic findings 59 axillary lymph node 59 pyelonephritis 59 unfavorable cytogenetics 59 Ishak fibrosis score 59 Multiple logistic regression 59 prognostic biomarker 59 chlamydia gonorrhea syphilis 59 EBUS FNA 59 pre eclamptic 59 CI -#.# 59 microscopic colitis 59 p = #.# [003] 59 nondemented 59 leukocyte count 59 GnRH agonists 59 anterior uveitis 59 extensive metabolizers 59 tuberculin skin testing 59 elevated transaminases 59 parasitaemia 59 pmol L 59 somatic mutations 59 ALT flares 59 R entecavir 59 anal lesions 59 OSAHS 59 MRSA isolates 59 HPV# 59 follicular lymphoma FL 59 nonpregnant women 59 Prostatitis 59 histologically 59 BRAF V#E 59 abnormal mammogram 59 prophylactic cranial irradiation 59 univariate analyzes 59 Intervention Trial 59 transaminase elevations 59 bronchogenic carcinoma 59 intestinal biopsy 59 genomic biomarker 59 atypical ductal hyperplasia 59 screening colonoscopy 59 resectable 59 recurrent miscarriage 59 psychiatric outpatients 59 tPSA 59 immunosuppressed patients 59 core needle biopsy 59 coinfected patients 59 dosing cohort 59 choroidal vasculopathy 59 APOE e4 59 familial clustering 59 % CI #.#-#.# [005] 59 neurocognitive impairment 59 vesicoureteral reflux VUR 59 radiolabeled TM# 59 #ng/ml 59 abnormal mammograms 59 mycophenolate mofetil MMF 59 pancreatic resection 59 germline mutations 59 tamoxifen Nolvadex ® 59 tryptase 59 chemosensitivity 59 Multivariate analyzes 59 postintervention 59 antimicrobial prophylaxis 59 localized renal 59 relapsing remitting MS RRMS 59 recurrent VTE 59 varicoceles 59 CMV infections 59 antiphospholipid antibodies 59 4CMenB 59 recurrent glioma 59 narcolepsy cataplexy 59 chromosomal mutations 59 poliovirus vaccine 59 MALT lymphoma 59 suicide attempters 59 adverse cytogenetics 59 ELISPOT 59 adjuvant cisplatin 59 mildly symptomatic 59 BRCA carriers 59 MMSE scores 59 ALT normalization 59 HCV genotype 59 E. faecalis 59 telomere lengths 59 etiologic 59 prospectively randomized 59 endometrial cancers 59 deletion 5q 59 malignant ascites 59 SCIg 59 mercaptopurine 59 Regular checkups 59 transrectal ultrasound 59 Forodesine HCl 59 perioperative complications 59 esophagogastroduodenoscopy 59 pheochromocytomas 59 â ‰ ¥ 59 overnight polysomnography 59 E selectin 59 hepatic lesions 59 cervical abnormalities 59 HCV Genotype 59 Immunohistochemical 59 albumin excretion rate 59 decompensated liver disease 59 invasive prenatal 59 testicular tumors 59 serum ferritin 59 lymphomas leukemias 59 ErbB2 positive 59 prognostically 59 lichen planus 59 lobular breast cancer 59 GABHS 59 LRTI 59 serum antibody 59 aneuploid 59 perioperatively 59 allele frequencies 59 cervical biopsies 59 ductal cancer 59 premalignant 59 carcinoid tumors 59 karyotypes 59 hyperphenylalaninemia HPA due 59 HCV infected 59 BALB c mice 59 HIV seroprevalence 59 β blockers 59 nondiagnostic 59 BRCA mutations 59 gonococcal infections 59 IgG antibody 59 viral kinetics 59 fosbretabulin 59 serum IGF 59 susceptibility loci 59 CIMZIA TM certolizumab pegol 59 myeloperoxidase 59 lymphadenectomy 59 HCV antibodies 59 BCG refractory 59 K#R [002] 59 treatment naive genotype 59 mycosis fungoides 59 MMSE score 59 fetal aneuploidy 59 gonococcal 59 adjuvant therapies 59 euthyroid 59 transcranial Doppler 59 liver metastasis 59 HIV1 59 nonadherent 59 ER CHOP 58 missense mutations 58 Chlamydia trachomatis 58 thyroid stimulating hormone 58 immunohistochemistry IHC 58 precancerous condition 58 nonmelanoma 58 pulmonary TB 58 Trichomonas vaginalis 58 chorioamnionitis 58 anagrelide 58 seroprevalence 58 suppressive therapy 58 Inhibin B 58 HCV replicon 58 IL#B 58 urethritis 58 VFEND 58 Epstein Barr virus EBV 58 humoral responses 58 leukocytosis 58 Chlamydia psittaci 58 dysmenorrhoea 58 presymptomatic 58 VUR 58 cytogenetic 58 parasitemia 58 bacterial prostatitis 58 abnormal cervical 58 NATRECOR ® 58 % CI #.#-#.# [008] 58 dysplastic lesions caused 58 herpes zoster shingles 58 malignant polyps 58 Follicular Lymphoma 58 ductal carcinomas 58 cirrhotic 58 cirrhotic patients 58 deep venous thromboses 58 stavudine d4T 58 chromosomal aberrations 58 premorbid 58 CHD mortality 58 postoperative infections 58 Radical prostatectomy 58 MAGE A3 ASCI 58 C telopeptide 58 Gorlin syndrome 58 pulmonary dysfunction 58 invasive carcinomas 58 prognostic variables 58 prospectively defined 58 umol L 58 microalbumin test 58 etiologic agent 58 Secondary efficacy endpoints 58 BRCA1 mutation carriers 58 idiopathic myelofibrosis 58 HER2 gene 58 colorectal liver metastases 58 invasive cervical cancer 58 prenatally diagnosed 58 genomic alterations 58 clinically evaluable 58 M#V 58 axillary node dissection 58 Opportunistic infections 58 lymphovascular invasion 58 node metastases 58 CYP#D# inhibitor 58 antimicrobial susceptibility 58 Familial Hypercholesterolemia 58 preoperative chemotherapy 58 cervical adenocarcinoma 58 aromatase inhibitor therapy 58 troponin T 58 chemoradiation therapy 58 tumorigenicity 58 MGd 58 Amplicor 58 im peramivir 58 sonographic appearance 58 inconclusive Pap 58 sputum cytology 58 inecalcitol 58 Immunohistochemistry 58 kidney cysts 58 smoldering multiple myeloma 58 intima media thickness 58 overt nephropathy 58 Fecal Occult Blood 58 refractory prostate cancer 58 thorough QT 58 subclinical hyperthyroidism 58 prognostic indicators 58 thymoma 58 evaluable subjects 58 HIV seronegative 58 bronchoalveolar lavage BAL 58 alanine aminotransferase 58 intensive statin therapy 58 esophagogastric 58 HBV infections 58 RRM1 58 morphologic 58 lamivudine refractory patients 58 DXA scan 58 thymectomy 58 acute lymphoid leukemia 58 unresectable tumors 58 nonnucleoside reverse transcriptase inhibitors 58 differentially expressed genes 58 serum testosterone 58 congenital CMV infection 58 polysaccharide vaccines 58 faecal occult blood 58 prognostic significance 58 HSCT 58 esophageal squamous cell carcinoma 58 vulvovaginal candidiasis 58 affective psychosis 58 medically inoperable 58 imatinib therapy 58 intravesical therapy 58 FGFR2 gene 58 VKORC1 58 ischemic lesions 58 aminotransferase 58 Recurrences 58 Zolinza 58 neurocognitive function 58 hsCRP levels 58 engineered urethras 58 neurosensory 58 hypercalciuria 58 transferrin saturation 58 riociguat