PI3 K

Related by string. PI3K * : PI3 kinase pathway . PI3 kinase inhibitors . PI3 kinase inhibitor . PI3 . PI3 kinase . PI3 Kinase / KD . king . KS . KING . k . Ks . Ker . K. . ks . ker . ked . KER . kd . KED : King Juan Carlos . Coretta Scott King . f * k . F * k . Martin Luther King . f * king . Billie Jean King . Howard K. Stern . king Barry Bonds . Burger King Gift Cards . K Wings . DIC K . King Features Syndicate . K Mart * *

Related by context. All words. (Click for frequent words.) 70 FGFR 69 Protein Kinase C 69 phosphoprotein 68 serine protease 68 histone deacetylase HDAC 67 peroxisome proliferator activated 67 4E BP1 67 VEGF receptor 67 protein tyrosine phosphatase 1B 67 PI3K/mTOR 67 Fibroblast Growth Factor Receptor 67 protein kinase inhibitor 66 cathepsins 66 PI3 kinase 66 HER1 66 alpha folate receptor 66 peptibody 66 PI3K inhibitor 66 protein kinase C 66 retinoic acid receptor 66 RAF kinase VEGFR 66 phosphatidylinositol 3 66 antisense inhibitors 65 serine threonine kinase 65 G Protein Coupled 65 ERK pathway 65 NS5A 65 serine threonine 65 isoform selective 65 LRP6 65 PPARg 65 cyclin dependent kinases 65 mitogen activated protein kinase 65 GSK3B 65 protein tyrosine phosphatases 65 histone deacetylase 65 thymidylate synthase TS 65 deacetylase 65 S#P# 65 BRAF kinase 65 RAS RAF MEK 65 IAP inhibitor 65 secreted protein 65 DNA methyltransferases 65 small molecule modulators 64 liposomal formulation 64 kinase PI3K 64 EGFR HER 64 poly ADP ribose polymerase 64 PI3K Akt 64 p# MAPK 64 sphingosine 1 64 chemokine receptor 64 investigational humanized monoclonal antibody 64 RAF kinase 64 Flt3 64 proteolytic cleavage 64 cMET 64 NFκB 64 XL# inhibits 64 antimitotic 64 HER2 HER3 64 JAK inhibitors 64 M1 muscarinic 64 Raf kinase 64 thyroid hormone receptor 64 hypoxia inducible factor 64 proto oncogene 64 Factor Receptor 64 PTP 1B 64 receptor tyrosine kinase 64 ERK1 2 64 anticancer therapeutics 64 cyclin dependent kinases CDKs 64 PI3 kinase inhibitor 64 IGF1R 63 EGF receptor 63 MAPK pathway 63 anionic backbone 63 peptidic 63 p# mitogen activated 63 mediated apoptosis 63 FLT3 63 c Raf kinase 63 glucagon receptor 63 matrix metalloproteinases 63 c MET 63 Gamma secretase 63 myelofibrosis polycythemia vera 63 potent suppressor 63 potent inhibitors 63 uPAR 63 cytokine receptor 63 dimerization 63 reversible inhibitor 63 potent inhibition 63 siRNA binds 63 prodrugs 63 5 HT2A serotonin 63 MCSP respectively 63 receptor activator 63 cell adhesion molecule 63 PKC isoforms 63 potently inhibited 63 mediated inhibition 63 cyclic peptide 63 heterodimers 63 ERK signaling 63 immune stimulatory 63 Prodarsan R 63 agonist compounds 63 cytolytic 63 NS4B 63 Alfacell proprietary ribonuclease 63 Interferon gamma 63 selectively inhibited 63 selectively inhibit 63 cAMP signaling 63 mTOR mammalian target 63 Janus Kinase 63 M2 subunit 63 biologic therapeutics 63 TLR9 agonist 63 glycogen synthase kinase 63 p# MAP kinase 62 biased ligand 62 sulfonylhydrazine class 62 proteasome inhibitor 62 SGLT 62 Macrophage 62 5 HT4 62 HDAC inhibition 62 small molecule inhibitors 62 Upregulation 62 selective inhibition 62 potent inhibitor 62 adipogenic 62 protein tyrosine kinase 62 oral prodrug 62 thrombin receptor 62 targeted radiotherapeutic 62 C5aR 62 CYT# potent vascular disrupting 62 SAR# [002] 62 selectively inhibits 62 tests miRview TM 62 DNA intercalator 62 HCV polymerase 62 eIF4E 62 anti CD3 62 Akt activation 62 small molecule agonists 62 immunotoxin 62 chemokine receptors 62 Wnt beta catenin 62 synthetic peptides 62 mda 7 62 HCV protease 62 kinase pathway 62 coupled receptor GPCR 62 neuronal nicotinic receptors NNRs 62 3 kinase PI3K 62 metalloprotease 62 Factor VIIa 62 ErbB receptors 62 PDGFR 62 serine proteases 62 non nucleoside HCV 62 tyrosine kinase 62 CCR9 antagonist 62 nitric oxide donating prostaglandin 62 methionine aminopeptidase 62 VEGFR 62 AEG# 62 small molecule activators 62 extracellular signal 62 selective kinase inhibitor 62 JAK#/JAK# 62 nicotinic acetylcholine receptor 62 RNA antagonist 62 delta isoform 62 VE cadherin 62 transcriptional activation 62 ErbB1 62 Tie2 62 methyltransferase 62 stem cell pluripotency 62 potent antiproliferative 62 MEK inhibitor 62 cytotoxic T lymphocyte 62 peptidomimetic 62 CoVal TM fusion 62 activin 62 CEA CD# Her2 62 NFkappaB 62 MKC# MT 62 PI3K inhibitors 62 HDACi 62 FGFR1 62 p# alpha [001] 61 MAP kinase 61 intracellular signaling pathways 61 PHD2 61 RANK ligand 61 novel anticancer 61 regulating gene expression 61 5 HT6 61 resolvins 61 Receptors GPCRs 61 kinase inhibition 61 Aurora Kinase 61 androgen receptor AR 61 P#X# 61 kinase inhibitor 61 phosphate S1P 61 ribonuclease 61 receptor tyrosine kinase inhibitor 61 pathophysiological effects 61 chimeric monoclonal antibody 61 factor receptor FGFR 61 rapamycin mTOR 61 Enzastaurin 61 peptide fragment 61 cell signaling pathways 61 NS5B 61 drug metabolizing enzyme 61 A3 adenosine receptor 61 novel peptide 61 antisense oligonucleotide 61 OMP #M# 61 Clusterin 61 extracellular domain 61 FGFs 61 monoclonal antibody mAb 61 vascular disrupting agents 61 drug conjugate 61 CD# molecule 61 Epidermal Growth Factor 61 endosomal release 61 Locked Nucleic Acid LNA 61 antiapoptotic 61 glucan 61 TKB# 61 galectin 61 Pharmos proprietary 61 IL #p# 61 IMiDs R 61 irreversible inhibitor 61 deacetylation 61 Notch receptor 61 Angiotensin converting enzyme 61 neurite outgrowth 61 Fc fusion protein 61 induces apoptosis 61 receptors PPARs 61 Personalized Immunotherapy 61 inverse agonist 61 mTOR inhibitors 61 leukocyte adhesion 61 FGF receptor 61 PDGF receptor 61 HIF PH 61 NF kB pathway 61 orally administered inhibitor 61 antisense inhibitor 61 TGF Beta 61 TNFalpha 61 ERBB2 61 kinase domain 61 pro angiogenic 61 Topoisomerase II 61 oncogenic signaling 61 calcitonin gene related 61 humanized monoclonal antibodies 61 HCV replication 61 IGF IR 61 metabotropic glutamate receptors 61 therapeutic peptide 61 membrane receptors 61 lipoxygenase 61 orally bioavailable mimics 61 Granulocyte Colony Stimulating Factor 61 endothelin receptor 61 TLR8 61 cytoprotective 61 antisense oligonucleotides 61 cyclic nucleotide 61 PI3K AKT 61 histone deacetylases 61 Histone 61 Prodarsan ® 61 nAChR 61 novel VDA molecule 61 guanosine 61 transient receptor 61 Nanobody ® 61 specific lectin receptors 61 Tumor Necrosis Factor 61 GGTase 61 EGFR pathway 61 apoptotic pathway 61 targeted antifolate 61 NFAT 61 Epidermal Growth Factor Receptor 61 tumor vasculature 61 cytostatic 61 CD# expressing 61 osteoclast activity 61 accumulate preferentially 61 immuno modulatory 61 MTP inhibitor 61 receptor alpha 61 PPARγ 61 ALK inhibitors 61 thromboxane A2 61 kidney urologic 61 PI3 Kinase 61 PECAM 61 PDE4 inhibitor 61 polyadenylation 61 pyrimidine 61 CCR9 61 AT1R 61 coagulation cascade 61 γ secretase 61 phosphoinositide 3 61 dasatinib Sprycel 61 Cathepsin B 61 cAMP dependent 61 selective modulator 61 ATL# [001] 61 pRb 61 oral kinase inhibitor 61 Integrin 61 β catenin 61 RON Notch 61 romazarit 60 epigenetic therapies 60 PSMA ADC 60 bispecific 60 mTOR kinase 60 Kinases 60 superoxide dismutase 60 acetylcholine receptor 60 Immunotherapeutic 60 radiolabeled 60 adrenoceptor 60 triphosphate 60 MET VEGFR2 60 FGFR3 60 PDE4 60 apoptosis inducer 60 rxRNA 60 engineered RAP peptides 60 PPAR alpha 60 hepatoma 60 potent inducer 60 histone deacetylases HDAC 60 NF kappa B 60 chemokine 60 cellular pathways 60 CCR1 60 SIRT2 60 NS#/#A protease 60 Tß4 60 MT#/MEDI-# 60 delta opioid receptor 60 telomerase inhibitor 60 selective inhibitor 60 Janus kinase 60 ENaC 60 HER2 HER2 60 TRAIL receptor 60 cyclooxygenase COX 60 immune modulator 60 virulence genes 60 peptide fragments 60 MAPK 60 Factor Xa 60 potently inhibits 60 VEGFR1 60 receptor gamma 60 somatostatin receptor 60 Chemokine Receptor 60 HCV NS3 protease 60 CBLC# 60 homodimers 60 c MYC 60 metabotropic glutamate receptor 60 sodium glucose cotransporter 60 intracellular proteins 60 short hairpin RNAs 60 glutamate receptor 60 potent anticancer 60 Kinase Inhibitor 60 peptide CGRP 60 JAK3 60 receptor ligand 60 cytochrome P# 60 proteasome inhibitors 60 molecularly targeted 60 catenin 60 signaling cascades 60 regulated kinase 60 HIF 1alpha 60 virus AAV 60 NTDDS 60 gamma amino butyric 60 BCR ABL 60 ligand binding 60 #T# L1 60 RAS MAPK pathway 60 Integrins 60 clinically validated targets 60 alkylating agent 60 cyclin dependent kinase CDK 60 cell adhesion molecules 60 c myc gene 60 proapoptotic 60 EGFR HER2 60 selective antagonists 60 apoptosis proteins 60 estrogen receptor beta 60 CCR2 receptor 60 MEK inhibitors 60 taxane derivative 60 Hypoxia Inducible Factor 60 prostaglandin E2 PGE2 60 metalloenzymes 60 prostaglandin D2 60 NR2B subunit 60 PI3K 60 Stapled Peptide 60 topoisomerase II 60 THR beta agonist 60 short hairpin RNA 60 pan HDAC inhibitor 60 intracellular signaling 60 Tumor necrosis factor 60 antiangiogenesis 60 oral JAK1 60 IGF 1R 60 auristatin 60 receptor mediated 60 MKC# MKC# PP 60 Onconase 60 topoisomerase 60 TGR5 60 B lymphocyte stimulator 60 splice variants 60 IAP inhibitors 60 protein kinases 60 cytidine 60 Wnt signaling pathway 60 trans splicing 60 XOMA 3AB 60 aspartyl 60 fusion enhancers 60 Pathway Inhibitor 60 mertansine 60 metaglidasen 60 CRAC channel 60 cyclin dependent kinase 60 eIF 4E 60 small molecule tyrosine 60 SGLT2 60 NS5b 60 Exherin TM 60 development peramivir neuraminidase 60 thymidylate synthase 60 HIV integrase inhibitors 60 caveolin 1 60 activate SIRT1 60 Panzem 60 humanized monoclonal 60 selective agonist 60 glutamyl 60 isotype 60 ENMD # 60 antibody MT# 60 enkephalin 60 fast skeletal troponin 60 dopamine D2 60 potently inhibit 60 secretase 60 secretory pathway 60 selectively binds 60 TRPV1 agonist 60 PAR1 60 viral proteins 60 VEGFR2 59 isotypes 59 Aplidin 59 delipidation 59 Eg5 59 ghrelin receptor 59 assay detects 59 small molecule defensin 59 mutant BRAF 59 secretory phospholipase A2 sPLA2 59 Sudhir Agrawal D.Phil 59 mTOR inhibition 59 4 PDE4 enzyme 59 anti secretory 59 Nanobody 59 retinoid X 59 effector function 59 isomerase 59 intracellular protein 59 histone acetyltransferase 59 anti amnesic 59 Anticalins R 59 TNF α 59 proteinase 59 CXCR4 59 PIK3CA 59 cytoplasmic domain 59 multi kinase inhibitor 59 receptor subtype 59 CB2 receptor selective 59 constitutively expressed 59 topoisomerase II inhibitor 59 cyclin dependent kinase inhibitor 59 N acetyl 59 CCR2 59 p# subunit 59 selective antagonist 59 including eniluracil ADH 59 activin receptor type 59 p# inhibitor 59 Trastuzumab DM1 59 receptor PPAR 59 pharmacodynamic markers 59 Litx 59 Archexin 59 CD# CEA 59 NKG2D 59 CD# ligand 59 COX2 59 5alpha reductase 59 PathHunter 59 Pralatrexate 59 adhesion molecule 59 Preclinical studies suggest 59 alpha TNFa 59 beta amyloid peptide 59 LSD1 59 tensin homolog 59 HIF 1α 59 IgG1 monoclonal antibody 59 therapeutic monoclonal antibody 59 histone deacetylase HDAC inhibitors 59 sphingolipid 59 bacterial enzyme 59 Smac mimetics 59 inhibit oxidative stress 59 IL 1β 59 inhibit viral replication 59 nucleotide analog 59 AKT inhibitor 59 targeting CD# 59 anti fibrotic 59 tumor antigen 59 pyrimidines 59 phosphatidylinositol 59 selective orally bioavailable 59 drug conjugates ADCs 59 cytotoxin 59 CCR3 59 2A receptor agonist 59 Homspera TM 59 Protein kinase 59 predictive biomarker 59 HER2 receptor 59 receptor inhibitor 59 E2F 59 tyrosine kinases 59 REGN# 59 downstream effector 59 CENP E 59 hypoxia selective 59 acetylcholinesterase 59 potent cytotoxic 59 glycosyltransferase 59 c myc 59 tumor vascular disrupting 59 FOXO3a 59 miR #b [002] 59 transmembrane proteins 59 proliferator activated receptor 59 epothilone 59 AAG geldanamycin analog 59 E3 ligase 59 immune modulatory 59 TNF receptors 59 leukotriene pathway 59 microtubule associated 59 oncogenesis 59 lipopeptide 59 peptide antigens 59 casein kinase 59 hepatocyte growth 59 regulated kinase ERK 59 neuronal nicotinic receptor NNR 59 JAK kinases 59 ErbB 59 Protein Kinase 59 JAK2 enzyme 59 enhance ApoA 59 inhibit angiogenesis 59 Cdc7 59 mGluR2 NAM 59 hydrolase 59 BCL2 59 cholesteryl ester transfer 59 MEK1 59 autocrine 59 HGS ETR2 59 TIMP 1 59 interleukin IL 59 Histone Deacetylase 59 oligomerization 59 Kinase 59 RNAi therapeutic targeting 59 IMA# 59 Solazed TM 59 vesicular monoamine transporter 59 sphingosine kinase 59 alkylating 59 glycolipids 59 K + ATPase 59 TMEM#B 59 highly selective endothelin 59 lipid nanoparticle 59 Aurora kinase 59 protein kinase inhibitors 59 NFkB 59 tiapamil 59 RDEA# potent 59 phospholipase 59 vivo potency 59 peptide hormone 59 RIP1 kinase 59 5 HT2A inverse 59 quinone 59 viral protease 59 immune modulating 59 secretory phospholipase A2 59 tubulin inhibitor 59 triggers apoptosis 59 GSK3 59 GPx 59 Cyclin E 59 proprietary polysaccharide 59 aurora kinase 59 Vascular endothelial growth 59 1beta 59 HDACs 59 GATA3 59 autophagic 59 Pharmos pipeline 59 progesterone receptor 59 tRNA synthetase 59 CYC# 59 Oncogenic 59 pleiotropic 59 vWF 59 HepDirect prodrug 59 alpha subunit 59 ligases 59 tyrosine kinase receptor 59 Rigel R# 59 GPR# [002] 59 DNA methyltransferase 59 phosphatases 59 #ME# 59 EGFr 59 mononuclear 59 TRAIL induced apoptosis 59 Voreloxin 59 BiTE 59 glycosylated 59 CCX# 59 downregulated 59 NOX E# 59 cytochrome P 59 EGF receptors 59 bioactive lipids 59 CYP#A# CYP#D# 59 thapsigargin 59 muscarinic 59 covalently bound 59 Pertuzumab 59 tropomyosin 59 antisense molecules 59 CB2 receptor 59 dephosphorylation 59 polyglutamate 59 HDAC 59 PLA2 59 orally bioavailable 59 PKM2 58 bispecific antibody 58 Galectin 58 binds selectively 58 investigational monoclonal antibody 58 Extracellular 58 TLR9 58 gastrin 58 colony stimulating factor 58 5 lipoxygenase 58 bradykinin 58 polyketides 58 FBPase 58 Liposomal 58 fusion proteins 58 pharmacophore 58 LDL receptor 58 Angiotensin 58 immunoregulatory 58 NF KB 58 protein interleukin 58 encodes protein 58 cMet 58 interferon lambda 58 SmartChip TM Real 58 potent topoisomerase II 58 antimetastatic 58 SOD1 58 enzyme inhibitor 58 peptidic compound 58 isoenzyme 58 PI3K pathway 58 SH2 domain 58 Aptamer 58 platform HDL Mimetic 58 inhibit EGFR 58 DNA gyrase 58 Secretase 58 sarcosine 58 immunomodulatory 58 JAK2 inhibitors 58 HER2 ErbB2 58 TORC2 58 Annexin V 58 Selective Inhibitor 58 chemically modified siRNA 58 intracellular pathway 58 siRNA compounds 58 CagA 58 novel orally administered 58 Rosetta Genomics Nasdaq ROSG 58 myeloproliferative diseases 58 receptor mediated endocytosis 58 inhibit vascular endothelial 58 MAP kinase pathway 58 CD# expression [001] 58 antisense inhibition 58 integrin receptors 58 factor HGF 58 nucleic acid molecules 58 5 HT2C 58 radiolabeling 58 cytokines IL 58 Cytochrome P# 58 Bruton tyrosine kinase 58 microtubule inhibitor 58 interferon γ 58 included Raf kinase 58 lysophosphatidic acid 58 β1 58 alpha#beta# 58 bile acid 58 leukotriene B4 58 intercellular adhesion molecule 58 inhibiting tumor 58 PLK1 58 histone deacetylation 58 dihydrofolate reductase 58 CTLA 4 58 CRACM 58 Cytotoxic T 58 IIB ActRIIB 58 siRNA therapeutic 58 endogenous ligands 58 gamma secretase inhibitor 58 thrombopoietin 58 histone deacetylase inhibitors 58 WT1 58 carboxyl terminal 58 MDRNA proprietary 58 Angiocept 58 compound AEZS 58 Delta opioid receptor 58 Poly ICLC 58 beta defensins 58 Notch pathway 58 receptor CXCR4 58 Notch signaling pathway 58 Myolimus 58 Squalamine 58 Peroxisome proliferator activated 58 lymphotoxin 58 antibody MAb 58 SMARTICLES ® 58 tyrosine kinase inhibitor 58 Sphingosine 1 58 Nedd4 58 antitumoral 58 MMP9 58 coactivator 58 aurora kinase inhibitor 58 receptor subtypes 58 cyclin B1 58 transmembrane receptor 58 tyrosine kinase receptors 58 Aganocide ® 58 NPC 1C 58 E#F# 58 PSN# [002] 58 therapeutic monoclonal antibodies 58 PKC alpha 58 gonadotropin releasing hormone GnRH 58 Fleximer R 58 actinin 58 Beta catenin pathway 58 PEG SN# 58 glucokinase 58 AKIP ™ 58 alvespimycin 58 CDK5 58 subtype selective 58 EF Tu 58 fibroblast growth 58 5 HT2C receptor 58 isoenzymes 58 glucocorticoid receptor 58 penetrating peptides 58 vanilloid receptor 58 oral Janus kinase 58 5 HT4 receptor 58 receptor agonists 58 synthetic cannabinoid compounds 58 VEGF receptors 58 effector molecules 58 hedgehog pathway 58 vivo pharmacology 58 IgG1 58 EphA2 58 adrenergic receptors 58 engineered proteases 58 mitogen activated ERK kinase 58 HDAC enzymes 58 integrin alpha 4 58 cortisol synthesis 58 tubulin binding 58 5 HT2A receptor 58 novel therapeutic antibodies 58 Hedgehog signaling 58 Catenin 58 polymerase inhibitors 58 PARP inhibitors 58 Panzem NCD 58 cyclin E 58 oncoprotein 58 TGF ß 58 biologic pathway 58 NMDA N 58 VIPR2 58 #beta HSD1 58 telomerase reverse transcriptase 58 anticancer compound 58 retaspimycin 58 N acetylgalactosamine 58 siRNA therapeutics 58 novel orally bioavailable 58 mRNA expression 58 ubiquitin ligase 58 related apoptosis inducing 58 matrix metalloproteinase 58 P selectin 58 histone methyltransferase 58 HMG CoA reductase 58 adrenoceptor agonist 58 Myeloperoxidase 58 Signaling Pathway 58 defensin 58 vascular disrupting 58 Syk 58 SCD1 58 K RAS 58 NNRs 58 IL 1beta 58 carcinoembryonic antigen 58 Dysregulation 58 selective inhibitors 58 #S proteasome 58 ligase 58 histone acetylation 58 attach auristatin 58 STAT3 58 siRNA mediated 58 MT1 MMP 58 novel immunomodulatory 58 kinase PI3K Akt pathway 58 ErbB3 HER3 58 HDAC6 58 tumor suppressor protein 58 ß catenin 58 CDK4 58 monomeric 58 miR #a [002] 58 Locked Nucleic Acid 58 polyclonal antibody 58 Rho kinase 58 molecular biomarkers 58 corticosteroid dexamethasone 58 Tissue Factor 58 kallikrein 58 vacuolar 58 cytokine signaling 58 Fas ligand 58 nucleosides 58 DGAT 58 suppresses tumor 58 PI3K/Akt pathway inhibitor 58 TLR9 agonists 58 lipid metabolites 58 chromatin structure 58 diagnostic biomarkers 58 KLF4 58 HuLuc# 58 PAK1 58 Hsp# Inhibitor 58 protein tyrosine phosphatase 58 protein kinase 58 effector functions 58 heterocyclic 58 Curaxin 58 OMP #R# 58 basic fibroblast 58 nanomolar concentrations 58 Pentraxin 2 58 JAK1 58 Platelet Derived Growth 58 HCV protease inhibitors 57 JAK2 inhibitor 57 mitotic kinesin 57 receptor antagonists 57 transcriptional regulation 57 somatostatin 57 Cyclosert 57 methyl CpG binding 57 optimized siRNA 57 GABAA receptors 57 hydrolases 57 prolyl hydroxylase inhibitors 57 neurokinin 1 57 small molecule inhibitor 57 eotaxin 57 methyl D aspartate 57 survivin 57 phosphoinositide 57 tumorigenicity 57 p# activation 57 redox active 57 Maxy G# 57 cathepsin K inhibitor 57 include VALSTAR TM 57 SGLT 2 57 JAK2 57 Systemic Delivery 57 beta lactamases 57 interleukin IL -# 57 certain protein tyrosine 57 biologic pathways 57 nalbuphine ER 57 phosphorylates 57 generation purine nucleoside 57 MYCN 57 ErbB3 57 mGluR5 antagonists 57 PAM4 57 potent activator 57 allosteric 57 cell signaling pathway 57 anti CD3 monoclonal 57 trastuzumab DM1 57 Tumour Necrosis Factor 57 selective estrogen receptor modulator 57 benzimidazole 57 monoclonal antibody MAb 57 phosphorylated proteins 57 Wnts 57 Temsirolimus 57 Ecallantide 57 downregulation 57 5HT 57 HDAC Inhibitor

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