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(Click for frequent words.) 75 orally bioavailable 75 potent inhibitor 74 pan HDAC inhibitor 74 investigational humanized monoclonal antibody 73 investigational oral inhibitor 73 selective antagonist 72 oral prodrug 72 nucleoside analog 72 small molecule defensin 72 orally administered inhibitor 72 Aurora kinase 72 GMX# 72 liposomal formulation 72 NS#/#A protease 72 polymerase inhibitors 71 selective kinase inhibitor 71 CCR2 71 immunomodulatory 71 PTP 1B 71 ENMD # 71 cMET 71 anionic backbone 71 highly selective inhibitor 70 JAK1 70 CCR9 70 immune stimulatory 70 potent inhibitors 70 sodium glucose cotransporter 70 multi kinase inhibitor 70 Preclinical studies suggest 70 small molecule inhibitor 70 Kinase Inhibitor 70 immune modulating 70 Protein Kinase C 70 phosphate S1P 70 induces apoptosis 70 MEK inhibitor 70 immunomodulating 70 HCV protease inhibitor 70 CYC# 70 PRTX 70 histone deacetylase inhibitor 70 HGS ETR2 70 PI3K/mTOR 70 targeting CD# 70 poly ADP ribose polymerase 70 selectively inhibits 69 induce apoptosis 69 Voreloxin 69 Tyrima 69 protein tyrosine phosphatase 1B 69 non nucleoside inhibitor 69 Factor Receptor 69 Sphingomab 69 NS4A 69 fosbretabulin 69 selective inhibitor 69 CCX# 69 potent inhibition 69 5 HT6 receptor 69 Factor VIIa 69 polymerase inhibitor 69 antitumor 69 CYT# potent vascular disrupting 69 PI3K inhibitor 69 VEGF receptor 69 A3 adenosine receptor 69 NS5A 69 Elvitegravir 69 reversible inhibitor 69 serine protease 69 alpha folate receptor 69 antisense inhibitors 69 AAG geldanamycin analog 69 Pralatrexate 69 carbohydrate polymer 69 LPA1 receptor 69 Aurora Kinase 69 SIRT2 69 BAL# [001] 69 kinase inhibitor 69 Tezampanel 69 specific lectin receptors 69 vinca alkaloid 69 selective inhibition 69 glucagon receptor 69 Hsp# inhibitors 69 immunostimulatory 69 selective inverse agonist 69 Enzastaurin 69 Hsp# Inhibitor 69 potently inhibit 68 Epothilones 68 XL# inhibits 68 Gleevec resistant 68 sphingosine 1 68 Carfilzomib 68 γ secretase 68 TTR gene 68 HSP# inhibitor 68 Talabostat 68 angiogenesis inhibitor 68 irreversible inhibitor 68 FGFR 68 IMA# 68 #ME# 68 chemokine receptor 68 histone deacetylase 68 PRT# 68 hypoxia inducible factor 68 IgG1 antibody 68 vascular disrupting agents 68 cytotoxin 68 HDAC Inhibitor 68 cathepsins 68 Flt3 68 Fc fusion protein 68 Blinatumomab 68 TRO# 68 Omacetaxine mepesuccinate 68 vascular disrupting agent 68 Panzem R 68 cyclin dependent kinase inhibitor 68 generation antisense inhibitor 68 histone deacetylase HDAC 68 virus HCV protease inhibitor 68 proteasome inhibitor 68 HCV NS3 protease 68 Xanafide 68 HCV replication 68 JAK#/JAK# 68 antibody MT# 68 PDE4 inhibitor 68 HDACi 68 small molecule inhibitors 68 humanized monoclonal antibody 68 c MET 68 cetuximab Erbitux R 68 2 methoxyestradiol 68 receptor tyrosine kinase inhibitor 68 aberrantly activated 68 5 HT6 68 T#I mutant 68 MAPK pathway 68 XmAb# 68 mitogen activated protein kinase 67 immunotoxin 67 Janus kinase 67 Omacetaxine 67 CA4P 67 novel immunomodulatory 67 EGFr 67 huC# DM4 67 signal transduction inhibitor 67 G Protein Coupled 67 JAK2 inhibitor 67 ON #.Na 67 PPARgamma 67 CDK inhibitor 67 humanized antibody 67 PEGylated Fab fragment 67 IMiDs R 67 Sapacitabine 67 peptide antigens 67 HER3 67 IAP inhibitor 67 Preclinical studies 67 Aflibercept 67 XL# XL# 67 antiapoptotic 67 stable nucleic acid 67 binds selectively 67 5 HT4 receptor 67 chimeric monoclonal antibody 67 sphingosine kinase 67 selective agonist 67 p# mitogen activated 67 erlotinib Tarceva ® 67 small molecule tyrosine 67 Interferon alpha 67 pathophysiological effects 67 polysaccharide polymer 67 selectively binds 67 mGluR5 negative 67 soluble tumor necrosis 67 selective modulator 67 Abl 67 PKC isoforms 67 PDGFR 67 novel VDA molecule 67 PI3 kinase 67 AT1R 67 antifibrotic 67 Archexin 67 MTP inhibitor 67 oral JAK1 67 Symadex 67 androgen receptor AR 67 T#I [002] 67 OXi# 67 mitogenic 67 PI3K Akt 67 antisense oligonucleotide 67 NS5b 67 cyclin dependent kinases CDKs 67 SERMs 67 Pegylated 67 DNA intercalator 67 radezolid 67 antibody fragment 67 Sym# 67 SGLT2 67 alkylating agent 67 AEG# 67 Eg5 67 cytoprotective 67 Raf kinase 67 histone deacetylase HDAC inhibitor 67 Hedgehog signaling pathway 67 Hsp# inhibition 67 CENP E 67 xenograft models 67 selective orally bioavailable 67 prolyl 67 Pathway Inhibitor 67 CCR9 antagonist 67 Tumor Necrosis Factor 67 MET VEGFR2 67 VEGFR2 67 CYP#A# CYP#D# 67 glucocorticoid receptor 67 antibody MAb 67 SAR# [004] 67 preclinically 67 lysophosphatidic acid LPA 66 IGF 1R 66 favorable pharmacokinetic profile 66 nucleoside analogues 66 siRNA binds 66 docetaxel Taxotere R 66 C5aR 66 Dasatinib 66 anti amnesic 66 Bezielle 66 E#F# 66 CORT # 66 Guanilib 66 Epidermal Growth Factor Receptor 66 JAK2 66 imatinib Gleevec ® 66 Upregulation 66 potent topoisomerase II 66 Cathepsin B 66 bevacizumab Avastin R 66 tyrosine kinase receptor 66 Onconase 66 RGB # 66 M2 subunit 66 peroxisome proliferator activated 66 RNAi therapeutic targeting 66 oral antiviral 66 siRNA therapeutic 66 muscarinic 66 dasatinib Sprycel ® 66 novel peptide 66 ganetespib 66 small molecule agonists 66 HER1 66 c Raf kinase 66 receptor partial agonist 66 protein kinase inhibitor 66 splice variants 66 immunomodulator 66 HGS ETR1 66 selectively inhibited 66 histone deacetylases 66 HuLuc# 66 SPC# [001] 66 Liposomal 66 Nedd4 66 type glutamate receptor 66 UsiRNAs 66 ErbB3 66 neuroprotectant 66 Traficet EN 66 somatostatin 66 mitogen activated ERK kinase 66 Orally administered 66 ALN TTR 66 antagomirs 66 molecularly targeted 66 acetylcholinesterase 66 LY# [003] 66 Vidofludimus 66 5 HT2A serotonin 66 targeted antifolate 66 mGluR4 66 ERK1 2 66 JAK inhibitors 66 myelofibrosis polycythemia vera 66 thrombopoietin 66 mertansine 66 IL #E 66 LPA1 66 Recombinant Human 66 humanized anti 66 TRAIL induced apoptosis 66 PXD# 66 VEGF pathway 66 CD# molecule 66 MET RET 66 CD# CEA 66 histone deacetylase inhibitors 66 serine threonine 66 targeted radiotherapeutic 66 thrombin receptor 66 pro apoptotic 66 isoform selective 66 humanized monoclonal antibodies 66 potently inhibited 66 Receptors GPCRs 66 partial agonist 66 peripherally acting 66 systemically administered 66 Vorinostat 66 CXCR7 66 tyrosine kinase inhibitors 66 potently inhibits 66 tubulin inhibitor 66 epithelial tumors 66 PSN# [002] 66 CTAP# Capsules 66 Chemokine Receptor 66 D aspartate NMDA receptor 66 investigational antibody 66 EGFR inhibitors 66 immunoregulatory 66 RAF kinase 66 receptor CXCR4 66 plasma kallikrein inhibitor 66 mTOR mammalian target 66 IAP inhibitors 66 LSI #P 66 neuronal nicotinic receptor NNR 66 Tumor necrosis factor 66 mGluR2 NAM 66 immune modulatory 66 FBPase 66 Squalamine 65 peptidomimetic 65 TNF Tumor Necrosis Factor 65 replicon 65 CD# monoclonal antibody 65 anti angiogenic agent 65 agonism 65 related apoptosis inducing 65 EGF receptor 65 metaglidasen 65 VAPRISOL 65 potent anti angiogenic 65 PEGylated anti 65 phosphatases 65 epothilones 65 Rigel R# 65 Cathepsin S 65 Androgen Receptor 65 MEK inhibitors 65 humanized monoclonal 65 tubulin binding 65 IL 1β 65 VIPR2 65 endothelin receptor 65 HCV protease inhibitors 65 peptidic compound 65 Bortezomib 65 proto oncogene 65 thymidylate synthase 65 sunitinib Sutent ® 65 adhesion molecule 65 reversible inhibitors 65 Cethromycin 65 PKC# 65 Smoothened 65 Presents Preclinical Data 65 serine threonine kinase 65 mda 7 65 neuroprotective properties 65 topoisomerase II inhibitor 65 EGFR pathway 65 cytochrome P 65 Hedgehog inhibitor 65 MT# MEDI 65 antisense inhibitor 65 JAK3 65 dihydrofolate reductase 65 Seliciclib 65 IL #p# 65 evaluating tivozanib 65 FLT3 65 NPC 1C 65 agonists antagonists 65 short interfering RNA 65 anti secretory 65 aurora kinase 65 Alfacell proprietary ribonuclease 65 phosphorylate 65 surface glycoprotein 65 THR beta agonist 65 Thiovir 65 costimulatory 65 glycosylated 65 mGlu2 3 65 Personalized Immunotherapy 65 receptor inhibitor 65 Curaxins 65 Panzem R NCD 65 Kinases 65 LY# [002] 65 interferon IFN 65 proteasome inhibitors 65 anti CD3 65 castrate resistant prostate cancer 65 MET amplification 65 enzyme inhibitor 65 Angiolix 65 mediated inhibition 65 NEUGENE antisense 65 hedgehog pathway 65 INCB# [001] 65 HGS ETR1 mapatumumab 65 potent antiproliferative 65 Bavituximab 65 small molecule Hedgehog 65 #beta HSD1 65 prostaglandin E2 PGE2 65 NS5B polymerase 65 selectively inhibit 65 IgG1 monoclonal antibody 65 CRAC channel 65 CBLC# 65 adenoviral 65 ARRY # 65 phosphatidylinositol 3 65 Hedgehog pathway 65 Phase 2b Clinical Trial 65 hepatoprotective agent 65 soluble receptor 65 NR2B selective 65 EpCAM 65 5 HT2A receptor 65 cell adhesion molecule 65 Bevirimat 65 optimized siRNA 65 EGFR HER2 65 neuraminidase inhibitor 65 Locked Nucleic Acid LNA 65 exon skipping 65 non nucleoside HCV 65 Akt activation 65 selective adenosine 65 avidin 65 ImmunoVEX HSV2 65 phosphorylates 65 butyrylcholinesterase 65 PI3K 65 PNP inhibitor 65 IMiDs ® 65 pertuzumab 65 dasatinib Sprycel 65 seliciclib 65 TLK# 65 N methyl 65 Immunohistochemical analysis 65 SCH # 65 resolvins 65 GRN#L 65 Epratuzumab 65 ASONEP 65 DNA methyltransferases 65 secretory phospholipase A2 sPLA2 65 Anti Tumor 65 MEK1 65 EphA2 65 IGF1R 65 K ras mutations 65 mitotic kinesin 65 HCV NS5B polymerase 65 triggers apoptosis 65 TNFalpha 65 RNA antagonist 65 anti fibrotic 65 PCK# 65 CCR5 antagonist 65 antitumoral 65 JAK inhibitor 65 HCD# [002] 65 vidofludimus 65 ZK EPO 65 Plicera 65 AMPA kainate 65 TRX1 65 catenin 65 mediated apoptosis 65 Akt inhibitor 65 IGFBP2 65 VA# [002] 65 vinca alkaloids 65 adipogenic 65 novel topoisomerase 64 phosphoinositide 3 64 DAVANAT 64 tubulin polymerization 64 tumor specific antigen 64 Aurora kinase inhibitor 64 partial agonists 64 homodimers 64 CTLA 4 64 HER2 receptor 64 MUC1 64 mGluR5 NAM 64 proprietary polysaccharide 64 XL# anticancer compounds 64 anticancer therapeutics 64 peptibody 64 GLYX 64 tumor vasculature 64 vWF 64 p# subunit 64 Glufosfamide 64 ZOLINZA 64 chronic eosinophilic leukemia 64 APOPTONE 64 OMP #M# 64 Epidermal Growth Factor 64 substrates inhibitors 64 orally dosed 64 Marqibo TM 64 Aliskiren 64 HIF 1alpha 64 dimerization 64 Mutational 64 anticancer activity 64 Panzem 64 oral isoform selective HDAC 64 hypereosinophilic syndrome 64 HQK 64 KSP inhibitor 64 AKT inhibitor 64 TNF α 64 tyrosine kinase inhibitor 64 PEG SN# 64 Cyclin E 64 Panzem NCD 64 oral dihydropyrimidine dehydrogenase DPD 64 bispecific 64 cytochrome P# #A# 64 subtype selective 64 transient receptor 64 anticancer agent 64 NKG2D 64 nilotinib Tasigna ® 64 antiproliferative effects 64 Systemic Delivery 64 c myc 64 factor receptor FGFR 64 pRb 64 sulfonylhydrazine class 64 factor HGF 64 anticancer compound 64 dopamine D2 64 allosteric modulator NAM 64 Sphingosine 1 64 delafloxacin 64 PEGylated 64 ADP receptor antagonist 64 IMiDs ® compound 64 prodrug 64 aspartyl 64 VEGF receptors 64 Janus Kinase 64 Cannabinor 64 Pafuramidine 64 accumulate preferentially 64 depsipeptide 64 SAR# [002] 64 therapeutic monoclonal antibody 64 antiproliferative activity 64 inhibit VEGF 64 RAS RAF MEK 64 acetylcholinesterase AChE 64 nucleoside analogs 64 immune modulator 64 Linaclotide 64 kidney urologic 64 DHFR 64 RDEA# 64 triciribine phosphate monohydrate 64 virulence genes 64 RANK Ligand 64 FUS1 64 administered subcutaneously 64 anti leukemic 64 assay detects 64 Survivin 64 MKC# MT 64 BiTE ® 64 PDGF receptor 64 HMG CoA reductase inhibitors 64 Wnt signaling pathway 64 CD4 monoclonal antibody 64 chemokine receptors 64 siRNA mediated 64 beta 1a 64 hyaluronidase enzyme 64 potent anticancer 64 ribonuclease 64 LymphoStat B belimumab 64 Hsp# inhibitor 64 Tarvacin TM 64 viral polymerase 64 #HT#A 64 imatinib Gleevec 64 peroxidase 64 Elotuzumab 64 B lymphocyte stimulator 64 hypoxia selective 64 MEK Inhibitor 64 protein kinases 64 uricase 64 tyrosine kinase 64 BCR ABL 64 anti EGFR antibody 64 extracellular domain 64 CK2 64 Angiocept 64 small molecule activator 64 novel anticancer 64 anticancer agents 64 Maribavir 64 EGFR tyrosine kinase inhibitor 64 product candidate Lpathomab 64 neurotrophic 64 pegylated 64 HCV polymerase inhibitors 64 Factor Xa 64 RAV# 64 huN# DM1 64 Inhibitor 64 BMS # 64 FGFs 64 gamma secretase 64 imatinib resistant 64 HDAC 64 Deforolimus 64 Methylnaltrexone 64 vivo validation 64 YONDELIS 64 selective serotonin 2C receptor 64 oncoproteins 64 MGCD# [001] 64 candidate deforolimus 64 Luteinizing Hormone Releasing Hormone 64 ENaC 64 immunomodulatory properties 64 Curaxin CBLC# 64 Preclinical Data 64 fusion protein 64 nucleoside reverse transcriptase inhibitor 64 AMN# [001] 64 novel histone deacetylase 64 Tyrosine Kinase Inhibitor 64 protease 64 vanilloid receptor 64 membrane receptors 64 IMPDH 64 regulated kinase 64 p# MAPK 64 CR# vcMMAE 64 HDAC inhibitors 64 investigational pan BCR 64 TLR7 agonist 64 prostanoid 64 TG# [003] 64 GSK3B 64 antisense drug 64 nanoviricides 64 multikinase inhibitor 64 IgG1 64 ErbB 64 fusion proteins 64 siRNA therapeutics 64 activin 64 retinoic acid receptor 64 Meets Primary Endpoint 64 demonstrated antitumor activity 64 trastuzumab Herceptin R 64 ® C1 esterase 64 targets Galectin receptors 64 apoptosis proteins 64 Immunotherapeutic 64 thalidomide Thalomid 64 Interferon gamma 64 uric acid lowering 64 Ocrelizumab 64 XYOTAX TM 64 tumor antigen 64 Aurora kinases 64 factor Xa 64 benzimidazole 64 Pharmacokinetics PK 64 Anticalins ® 64 NS4B 64 androgen independent 64 HuMax EGFr 64 LRP6 64 GW# [003] 64 Factor VEGF 64 docetaxel Taxotere ® 64 Kahalalide F 64 tezampanel 64 Granulocyte Colony Stimulating Factor 64 IMC A# 64 small molecule modulators 64 rhIL 7 64 NXL# 64 Debio 64 pan histone deacetylase 64 5 HT2A inverse 64 apoptotic pathway 64 isotype 63 receptor PPAR 63 mGluR5 antagonists 63 familial amyloidotic polyneuropathy FAP 63 alefacept 63 vimentin 63 GPC3 63 antiangiogenic 63 Antisense 63 IL 1ß 63 Genasense ® oblimersen 63 ALN PCS 63 effector function 63 glutamate receptors 63 ligand TRAIL 63 matrix metalloproteases 63 PDX pralatrexate 63 MAPK 63 milatuzumab 63 Valortim R 63 TLR8 63 factor TNF receptor 63 FasL 63 polyglutamate 63 investigational monoclonal antibody 63 Beta catenin pathway 63 Cdc7 63 serotonin receptor 63 Dendritic Cells 63 Pentraxin 2 63 glycolipids 63 geldanamycin 63 cyclooxygenase 63 BRAF kinase 63 Platelet Derived Growth 63 TPO receptor 63 mTOR inhibitors 63 Tarvacin 63 Ridaforolimus 63 alkylating 63 essential thrombocythemia ET 63 miR #a [001] 63 IL8 63 Romidepsin 63 Epstein Barr Virus EBV 63 NEUGENE 63 S1P 63 Fibroblast Growth Factor Receptor 63 inhibitor RG# 63 HGS# 63 DiLA2 63 SGLT 63 oxidative stress inducer 63 SYN# 63 ATL# [001] 63 mTOR inhibitor 63 certain protein tyrosine 63 Golimumab 63 protein tyrosine kinase 63 oral isotype selective HDAC 63 Cytotoxic T 63 BRAF inhibitor 63 Nanobody 63 ERK pathway 63 bortezomib Velcade 63 p# alpha [001] 63 vitro cytotoxicity 63 small molecule chemotherapeutic 63 XL# XL# XL# XL# 63 cathepsin K 63 c MYC 63 Palifosfamide 63 telomerase reverse transcriptase 63 GLP toxicology studies 63 receptor agonists 63 EZN 63 beta actin 63 radiolabeled 63 Polymerase Inhibitor 63 WT1 63 CD# expressing 63 Zysolin TM 63 ALV# 63 Antiviral Activity 63 COX2 63 PDE4 63 teriflunomide 63 Anticalin ® 63 cyclin dependent kinases 63 mutational status 63 R#/MEM # 63 oral picoplatin 63 PI3K/Akt pathway 63 targeting PCSK9 63 PD LID 63 MCSP respectively 63 antitumor activity 63 Multimeric 63 small molecule glucokinase 63 CEQ# 63 insulin sensitizing 63 FK# 63 HDAC inhibitor 63 endogenous ligands 63 small molecule activators 63 selective inhibitors 63 flavopiridol 63 antiangiogenic activity 63 Phase 2a Clinical Trial 63 Azedra 63 interleukin IL -# 63 Antigen Specific 63 pharmacological chaperone 63 Annamycin 63 cytokine signaling 63 Topoisomerase II 63 Copegus ribavirin 63 PPARγ 63 chemotherapeutic drug 63 ESBA# 63 intranasal formulation 63 compound perifosine 63 Pruvel ™ 63 PARP inhibitor 63 Sudhir Agrawal D.Phil 63 otelixizumab 63 transmembrane protein 63 Bafetinib 63 INGN 63 HDACs 63 GGTase 63 MKC# MKC# PP 63 BAY #-# 63 Gamma secretase 63 MT#/MEDI-# 63 polyclonal antibody 63 P2Y 63 Dapagliflozin 63 thioredoxin 63 Receptor Antagonist 63 Aganocide R 63 Ceflatonin 63 SGLT2 inhibitors 63 Fleximer 63 pDCs 63 TLE3 63 somatostatin analogue 63 kinase inhibition 63 Bruton tyrosine kinase 63 biomodulator 63 delivered RNAi therapeutic 63 viral proteins 63 apoptosis inducing 63 IFN gamma 63 Perifosine 63 selective antagonists 63 CagA 63 virus AAV 63 FGFR4 63 PS# [001] 63 5 HT2B receptor 63 matrix metalloproteinases MMPs 63 potent cytotoxic 63 Elesclomol 63 PSN# [001] 63 specific protein tyrosine 63 annexin V 63 peptidic 63 hematological cancers 63 Apoptone 63 receptor tyrosine kinase 63 Telaprevir VX 63 #D#C# 63 inflammasome 63 acetonide FA 63 TRIOLEX 63 antisense inhibition 63 forodesine 63 dextromethorphan quinidine 63 class anticancer quinolone 63 oral Factor Xa 63 FOLOTYN ® 63 CB2 receptor 63 cytostatic 63 Zorbtive TM 63 survivin 63 MEK inhibitor RDEA# 63 Signal transduction 63 ISIS # 63 nilotinib Tasigna 63 Smac mimetic 63 small molecule thrombopoietin 63 ARIKACE ™ 63 antisense oligonucleotides 63 FGFR1 63 thymalfasin 63 Aganocide 63 cyclin dependent kinase CDK 63 5 HT4 63 Belimumab 63 CRTH2 63 OMP #R# 63 Galectins 63 JAK2 inhibitors 63 opioid receptor antagonist 63 mTOR kinase 63 telomerase therapeutic 63 deacetylase 63 Oligonucleotide 63 compound PMX # 63 Lenocta 63 cyclin dependent kinase 63 reverse transcriptase 63 protein mTOR 63 Zoraxel 63 PI3K inhibitors 63 V#F mutation 63 N acetylgalactosamine 6 63 TACI Ig 63 JVRS 63 Vidaza ® 63 MORAb 63 p#/CBP 63 cytotoxic T lymphocyte 63 PLK1 63 IL 1beta 63 inhaled formulation 63 TRAIL R2 63 immunomodulation 63 c KIT 63 vesicular monoamine transporter 63 OncoVEX GM CSF 63 inhibits protein synthesis 63 Chemophase 63 Th2 cytokines 63 Selective Inhibitor 63 vosaroxin 63 sorafenib tablets 63 PML RARA 63 pharmacokinetic interactions 63 receptor subtype 63 Monoclonal Antibody 63 humanised monoclonal antibody 63 Small Molecule 63 solithromycin 63 thymidylate synthase TS 63 generation Hsp# inhibitor 63 thyroid hormone receptor 63 HCV polymerase 63 Macrophage 63 Novel Oral 63 single stranded oligonucleotides 63 allosteric modulator 63 RAS MAPK pathway 63 histone acetyltransferase 63 atacicept 63 receptor agonist 63 developing Bicifadine serotonin 63 epigenetic therapies 63 mineralocorticoid receptor 63 alvespimycin 63 AhR 63 ocular formulation 63 obatoclax 63 pleiotropic 63 VE cadherin 63 AtuRNAi 63 Iloperidone 63 Protein Kinase 63 TLR9 agonist