Related by context. All words. (Click for frequent words.) 74 sporadic ALS 70 neurodegenerative disorder 70 frontotemporal dementia 69 familial ALS 69 TMEM#B 68 progressive neurodegenerative disorder 67 susceptibility gene 67 ADPKD 66 NF1 66 neurodegenerative disease 65 ataxias 65 mitochondrial dysfunction 65 susceptibility genes 65 alpha synuclein gene 65 DNA methylation patterns 64 autosomal dominant 64 motor neuron diseases 64 motor neuron degeneration 64 Alzheimer pathology 64 PTPN# 64 prion disease 64 sCJD 64 protein tau 64 neurofibrillary tangles 64 neuronal dysfunction 64 muscular dystrophies 63 MYH9 gene 63 medulloblastomas 63 molecular abnormalities 63 mitochondrial disorders 63 amyloid deposition 63 MGUS 63 demyelination 63 Kufs disease 63 spinocerebellar ataxia 63 essential thrombocythemia 63 autosomal recessive 63 metabolic abnormalities 63 APOE4 63 familial adenomatous polyposis 63 demyelinating diseases 63 inherited neurological disorder 63 p# mutations 63 chromosomal rearrangement 63 NF2 63 #q#.# [001] 62 mtDNA mutations 62 monogenic 62 inherited mutations 62 GBA mutations 62 neuropsychiatric disorders 62 senile plaques 62 LRRK2 gene 62 #q#.# [002] 62 SORL1 62 synaptogenesis 62 familial pancreatic cancer 62 causative genes 62 ApoE gene 62 Parkinsonian Syndromes 62 underlying pathophysiology 62 myotonic dystrophy 62 neuropathologic 62 TTR amyloidosis 62 Leukemias 62 pathogenic mechanisms 62 Myotonic dystrophy 62 alpha synuclein protein 62 tumor suppressor protein 62 progranulin 62 Idiopathic pulmonary fibrosis 62 DLX5 62 Parkinson Disease PD 62 Alzheimer disease AD 62 Hutchinson Gilford progeria 61 inherited retinal degeneration 61 NAFLD 61 FXTAS 61 disease NAFLD 61 LIS1 61 epigenetic modification 61 HGPS 61 pathophysiologic 61 transgenic mouse models 61 amyloid deposits 61 subclinical 61 dyskeratosis congenita 61 neuropathological 61 Hashimoto thyroiditis 61 FGFR1 61 protein misfolding 61 Alzheimer Disease AD 61 progranulin mutations 61 degenerative disorder 61 CDH1 61 familial hypercholesterolemia 61 autosomal dominant disorder 61 Chronic lymphocytic leukemia 61 motor neuron disease 61 missense mutation 61 IL#R 61 TCF#L# 61 Lewy bodies 61 CALHM1 61 epilepsies 61 Alzheimers disease 61 SSc 61 pancreatic adenocarcinoma 61 MECP2 gene 61 LRRK2 mutation 61 SOD1 gene 61 missense mutations 61 PICALM 61 basal cell nevus syndrome 61 genomic instability 61 MAPK pathway 61 chromosomal translocations 61 PTEN mutations 61 neuropsychiatric disorder 61 ependymoma 61 epigenetic alterations 61 neuroinflammation 61 fatal neurodegenerative disorder 61 TCF#L# gene 61 Meckel Gruber 61 Dysregulation 60 gastric carcinoma 60 chromosomal instability 60 ciliopathies 60 LQTS 60 CHD7 60 PAOD 60 mitochondrial mutations 60 neurodegeneration 60 etiologic 60 CNTNAP2 60 LRP5 60 tau protein 60 K ras mutations 60 HNPCC 60 BRAF gene 60 neuroblastomas 60 LRRK2 60 fatal neurodegenerative 60 diabetes mellitus DM 60 chromosome #p#.# 60 apoE 60 EBV infection 60 biologic pathways 60 Parkinson disease PD 60 narcolepsy cataplexy 60 prion diseases 60 inherited neurodegenerative disorder 60 transgenic mouse model 60 geographic atrophy 60 genetic underpinnings 60 commonly mutated genes 60 chromosomal regions 60 parkinsonism 60 Epstein Barr virus EBV 60 KIBRA 60 penetrance 60 neurofibromatosis type 60 APOE gene 60 primary biliary cirrhosis 60 nonalcoholic fatty liver 60 BRAF mutation 60 genetic mutations 60 neurodevelopmental disorder 60 Sjögren syndrome 60 ADAM# 60 Angelman syndrome 60 breast cancer metastasis 60 ccRCC 60 holoprosencephaly 60 causative gene 60 dominantly inherited 60 degenerative neurological disorder 60 carcinoid 60 Cowden syndrome 60 genetic loci 60 microRNA expression 60 astrocytomas 60 APOL1 60 STAT4 60 retinal degeneration 60 SOD1 60 MSH2 60 spontaneous mutations 60 de novo mutations 60 sortilin 60 myeloproliferative disorders 60 Glioblastoma multiforme GBM 60 fatal neuromuscular disorder 60 SORL1 gene 60 acute leukemias 60 nonalcoholic steatohepatitis NASH 60 microcephalin 60 lung adenocarcinoma 60 oncogenesis 60 LRRK2 mutations 60 Friedreich ataxia 60 histone deacetylases 60 cellular pathways 60 endophenotypes 60 cardiac channelopathies 59 Wnt signaling pathway 59 synaptic function 59 alpha synuclein 59 brain lesions 59 T1D 59 cyclin E 59 #p#.# [002] 59 epigenetic changes 59 tyrosine phosphorylation 59 aneuploidies 59 Cholangiocarcinoma 59 hereditary predisposition 59 systemic amyloidosis 59 IDH1 59 neurofibrillary 59 myeloid 59 FLT3 59 presymptomatic 59 facioscapulohumeral muscular dystrophy 59 IGFBP2 59 Prion diseases 59 Clusterin 59 underlying molecular mechanisms 59 genetically inherited 59 progressive degeneration 59 Genetic variants 59 myeloproliferative neoplasms 59 neuropsychiatric diseases 59 nonsense mutations 59 CFTR gene 59 Niemann Pick disease 59 Genetic variation 59 BARD1 59 Peutz Jeghers syndrome 59 synuclein 59 1 diabetes T1D 59 pathophysiological mechanisms 59 tau pathology 59 Six3 59 genetic determinants 59 Retinitis pigmentosa 59 amyloid beta plaques 59 miR #a [001] 59 CNVs 59 genetic polymorphisms 59 myelofibrosis polycythemia vera 59 Relapsing remitting MS 59 evolutionarily conserved 59 APOE e4 59 nerve degeneration 59 immunodeficiencies 59 Glioblastoma 59 lysosomal storage disease 59 ependymomas 59 demyelinating 59 underlying vasculopathy 59 Diabetic neuropathy 59 pleural mesothelioma 59 paraneoplastic 59 PsA 59 NKX2 59 EoE 59 untreated celiac disease 59 Leydig cell 59 beta amyloid plaques 59 telomere dysfunction 59 rs# [002] 59 motor neurones 59 mutations 59 neuropilin 59 TTR gene 59 apoE4 59 MELAS 59 huntingtin gene 59 FSHD 59 supratentorial 59 germline mutations 59 nasopharyngeal carcinoma 59 JAK mutations 59 genetic abnormalities 59 gene rearrangements 59 cAMP signaling 59 spinocerebellar ataxia type 59 Epstein Barr 59 Pulmonary fibrosis 59 chromosome abnormality 59 Smad3 59 tauopathies 59 amyloid peptide 59 Fanconi anemia 59 SLC#A# [002] 58 γ secretase 58 premalignant 58 Psoriatic arthritis 58 neurodegenerative diseases 58 Neuregulin 1 58 microdeletions 58 GRP# 58 protein alpha synuclein 58 lysosomal storage diseases 58 systemic lupus erythematosus 58 neurologic disorder 58 chromosomal translocation 58 frontotemporal 58 herpesviruses 58 SMAD4 58 NPHP 58 LKB1 58 relapsing remitting 58 hyperinsulinemia 58 hypermethylated 58 PDGFR 58 MYCN amplification 58 proto oncogene 58 apolipoprotein E gene 58 aetiological 58 neurodevelopmental disorders 58 CNTNAP2 gene 58 NKG2D 58 generalized epilepsy 58 molecular pathway 58 mutant protein 58 T2D 58 clusterin 58 frontotemporal dementia FTD 58 DLC1 58 arterial calcification 58 progressive degenerative 58 onset Alzheimer disease 58 aetiology 58 Karlseder 58 VHL gene 58 ceroid lipofuscinosis NCL 58 non coding RNA 58 PARP inhibition 58 pathological hallmark 58 phenotypes 58 TP# mutation 58 HLA B# 58 HER2 overexpression 58 neuronal degeneration 58 prostate adenocarcinoma 58 mesotheliomas 58 FSGS 58 GBM tumors 58 ALK mutations 58 imatinib resistance 58 ERBB2 58 JAK2 58 neurofibromas 58 #q# deletion 58 synovial sarcoma 58 CYP#C# [002] 58 cognitive impairment 58 Lafora disease 58 #q# [001] 58 autoinflammatory diseases 58 neuro degenerative disease 58 methylation patterns 58 pilocytic astrocytomas 58 IDH mutations 58 WT1 58 genetic variants associated 58 neuron degeneration 58 virulence genes 58 amyloid plaques 58 neural crest 58 genetic syndromes 58 inflammatory bowel diseases 58 ataxia telangiectasia 58 amyloid cascade 58 nonalcoholic steatohepatitis 58 nasopharyngeal carcinoma NPC 58 SCA5 58 somatic mutation 58 Brugada Syndrome 58 incurable neurological disorder 58 proliferative diabetic retinopathy 58 molecular biomarkers 58 osteopontin 58 mosaicism 58 β amyloid 58 epigenetic silencing 58 SNP rs# [001] 58 serine protease 58 IDH1 mutation 58 genes predisposing 58 Squamous 58 epigenetic markers 58 prostate cancer CaP 58 nonmelanoma skin cancers 58 dystrophies 58 epigenetic regulation 58 hippocampal function 58 gene locus 58 MLH1 58 engineered RAP peptides 58 diagnose Alzheimer disease 58 gene APOE4 58 inflammatory demyelinating 58 epigenetic inheritance 58 Neurodegenerative diseases 58 p# activation 58 lymphoid 58 G#S mutation 58 hamartomas 58 chromosome #q# [001] 58 Methylation 58 CaM kinase II 58 sporadic Creutzfeldt Jakob 58 lymphocytic 58 NADPH oxidase 58 degenerative neurological disease 58 B7 H3 58 miRNA genes 58 renal fibrosis 58 FMRP protein 58 V#F mutation 58 huntingtin 58 protein tyrosine phosphatase 58 prosopagnosia 58 Brugada syndrome 58 MTHFR gene 58 PTEN protein 58 neurological manifestations 57 CagA 57 antiphospholipid syndrome 57 ERK signaling 57 malignant lymphoma 57 NF1 gene 57 LHON 57 lipid abnormalities 57 Bardet Biedl syndrome 57 Gorlin syndrome 57 amyloid pathology 57 malignant transformation 57 tau aggregates 57 MC1R 57 abnormal prion protein 57 apolipoprotein E APOE 57 Leber Congenital Amaurosis LCA 57 chromosomal aberrations 57 sclerosis ALS 57 TACI mutations 57 epithelial tumors 57 PKC enzyme 57 white matter hyperintensities 57 onset Alzheimer 57 Neurofibromatosis type 57 neurological disorder affecting 57 regulates gene expression 57 mGluR2 NAM 57 ZNF# 57 myeloproliferative diseases 57 vWD 57 TGF b 57 hematologic disorders 57 leukaemias 57 nonhereditary 57 miRNA expression 57 inherited predisposition 57 epigenetically 57 aberrant methylation 57 homozygous FH 57 hypermethylation 57 protein misfolding diseases 57 Glioma 57 Myasthenia gravis 57 frontotemporal lobar degeneration 57 melatonin receptor 57 colorectal carcinoma 57 GISTs 57 GSTP1 57 debilitating neurodegenerative disorder 57 IDH1 mutations 57 beta amyloid peptides 57 Wwox 57 Lewy body 57 cognitive dysfunction 57 distinct subtypes 57 cortical dysplasia 57 aneuploidy 57 euthymic patients 57 T2DM 57 dermatomyositis 57 autosomal recessive disorder 57 MMP# 57 SOD1 mutations 57 squamous cell lung cancer 57 interferon pathway 57 PCNSL 57 amyloid plaque 57 gastric carcinogenesis 57 EZH2 57 DNA rearrangements 57 chromatin structure 57 inactivating mutations 57 phenotype 57 progressive neurodegenerative disease 57 fronto temporal dementia 57 diagnostic biomarker 57 gliosis 57 myotonic muscular dystrophy 57 Abeta# 57 HbF 57 mutated genes 57 N Myc 57 ataxia 57 Huntingtin 57 pathophysiologic mechanism 57 DISC1 57 exfoliation glaucoma 57 adenocarcinomas 57 IgA deficiency 57 Alzheimer disease 57 transgene expression 57 Aortic stenosis 57 rs# [004] 57 pathophysiological 57 ADAMTS# 57 ADDLs 57 Fas ligand 57 activating mutation 57 mutant proteins 57 hereditary deafness 57 causal variants 57 dopamine receptor gene 57 ANCA associated 57 Kaposi sarcoma 57 Essential tremor 57 CYP#A# gene 57 germline mutation 57 prostate carcinogenesis 57 Becker muscular dystrophy 57 cardiac fibrosis 57 leukemia ALL 57 excitotoxicity 57 ABCB1 57 alternative splicing 57 sequence homology 57 COX2 57 GNAQ 57 5 methylcytosine 57 incurable neurodegenerative disease 57 Bardet Biedl Syndrome 57 KRAS oncogene 57 cognitively normal 57 MIF protein 57 Cryptococcus neoformans 57 phenotypic expression 57 MDM2 57 non alcoholic steatohepatitis 57 antibody mediated 57 SCN5A 57 IKZF1 57 Htt 57 Genetic predisposition 57 gastric cancers 57 corticobasal degeneration 57 homozygosity 57 gene MECP2 57 epigenetic mechanisms 57 Symadex 57 dystrophy 57 TOMM# 57 EGFR mutations 57 protein clumps 57 APOE ε4 57 Insulin resistance 57 beta1 integrin 57 Velculescu 57 PGRN 57 childhood leukemias 57 thymoma 57 FMR1 gene 57 progressive neurological disorder 57 spongiform 57 WDR# 57 neuroimaging studies 57 HOTAIR 57 synovial cells 57 glycosylated 57 perilipin 57 SH#B# 57 pulmonary hypertension PH 57 MTHFR 57 Upregulation 57 G#S [002] 57 TSC1 57 autism susceptibility genes 57 gene mutation 57 DQB1 * 57 cell signaling pathways 57 molecular subtypes 57 retinitis pigmentosa RP 57 degenerative neurological diseases 57 NOMID 57 esophageal squamous cell carcinoma 57 subclinical atherosclerosis 57 leukemia AML 57 circadian genes 57 Pleural mesothelioma 57 TGFBR1 * 6A 57 gene APOE 57 gastric adenocarcinoma 57 transcriptional regulation 57 Leber hereditary optic neuropathy 57 multigenic 57 BRAF V#E 57 inhibitory receptor 57 Li Fraumeni syndrome 56 cardiac hypertrophy 56 JAK2 mutation 56 Endometrial cancer 56 kidney urologic 56 gene expression patterns 56 osteosarcomas 56 HNSCC 56 PML RARA 56 Mitochondrial 56 mitochondrial fusion 56 lateral sclerosis ALS 56 parainfluenza virus 56 neuroendocrine 56 unknown etiology 56 Epstein Barr Virus 56 mucinous 56 IL 7R 56 oligodendrogliomas 56 misfolded protein 56 crystallin 56 degenerative disorders 56 FGFR3 56 neuronal stem cells 56 ORMDL3 56 histone modifications 56 AAT deficiency 56 neurofibroma 56 microglial cells 56 arrhythmogenic 56 neurobiological disorder 56 HBeAg negative 56 hippocampal dysfunction 56 beta amyloid peptide 56 vascular cognitive impairment 56 NOTCH1 56 Mendelian disorders 56 Epstein Barr Virus EBV 56 Wnt pathway 56 TAp# 56 Haptoglobin 56 dysregulation 56 proband 56 autosomal 56 gene fusions 56 paraganglioma 56 NOD2 56 mGluR 56 autosomal dominant inheritance 56 chemoresistance 56 functional polymorphism 56 leukoencephalopathy 56 Leber congenital amaurosis 56 autoimmune thyroid 56 debilitating autoimmune 56 neuronal plasticity 56 prodrome 56 chromosomal abnormalities 56 COL#A# 56 medulloblastoma 56 microdeletion 56 MLL2 56 Alzheimer disease pathology 56 AhR 56 TGF β 56 basal cell carcinoma BCC 56 molecular pathways 56 BCL#A 56 XMRV infection 56 phenotypic variation 56 prion protein 56 genetic alterations 56 5q 56 Pulmonary hypertension 56 VIPR2 56 neuroblastoma tumors 56 Mild Cognitive Impairment 56 A3 adenosine receptor 56 hepatocellular carcinomas 56 mycosis fungoides 56 degenerative neurological condition 56 HMGA2 56 CP CPPS 56 malignant mesothelioma 56 tau tangles 56 #p# [001] 56 hereditary spastic paraplegia 56 micro RNA 56 PTEN gene 56 allelic variants 56 myelogenous leukemia 56 carcinoids 56 primary progressive aphasia 56 mutated protein 56 Brodmann Area 56 hypothalamic pituitary adrenal axis 56 genetic heterogeneity 56 progranulin protein 56 Acute myeloid leukemia 56 chromosomal anomalies 56 misfolding 56 mutation 56 genetic abnormality 56 Male pattern baldness 56 ACh 56 elevated triglyceride levels 56 hypoperfusion 56 cellular prion protein 56 Synovial sarcoma 56 immunocompetent 56 multidrug resistance 56 neurocognitive impairment 56 biochemical pathways 56 mGluR5 antagonist 56 mutated gene 56 protein kinase C 56 molecular mechanisms underlying 56 Sporadic CJD 56 RIP1 56 acute myelogenous leukemia AML 56 catenin 56 receptor gene 56 acute promyelocytic leukemia 56 MIF gene 56 airway hyperresponsiveness 56 developmental abnormalities 56 MALT lymphoma 56 somatic mutations 56 subclinical hyperthyroidism 56 autoantibody 56 myopathies 56 molecular signaling pathways 56 Parkinsonian 56 progressive neurodegenerative 56 Pseudomonas aeruginosa infections 56 Aß 56 Notch1 56 PTP 1B 56 Alzheimer disease vascular dementia 56 granulomatous 56 MYH9 56 beta catenin 56 VEGF receptor 56 Obstructive sleep apnea 56 Fibroblasts 56 mitochondrial diseases 56 congenital disorders 56 RNAi therapeutic targeting 56 cell adhesion molecule 56 apoptotic pathway 56 T1DM 56 hereditary nonpolyposis colorectal cancer 56 Gleevec resistant 56 microchimerism 56 C1q 56 Fragile X syndrome 56 cerebrospinal fluid CSF 56 systemic lupus erythematosus SLE 56 ASDs 56 neuro degenerative disorder 56 vimentin 56 sarcomatoid 56 Sezary syndrome 56 atypical hyperplasia 56 LEOPARD syndrome 56 diabetic nephropathy 56 JAK3 56 chromosomal alterations 56 cholesterol metabolism 56 Chronic pancreatitis 56 FGFR2 56 dysbindin 56 obesity insulin resistance 56 PKCi 56 Vascular dementia 56 micro RNAs 56 cypin 56 nondemented 56 MEF2A 56 NFkB 56 neuro degenerative diseases 56 ALDH2 56 myeloproliferative 56 atherosclerotic lesions 56 Polyneuropathy 56 tumor suppressor genes 56 amyloid beta peptides 56 ApoE4 gene 56 selective inhibition 56 FASPS 56 CYP#D# gene 56 cerebellar 56 homeobox gene 56 CDH# 56 glomerulonephritis 56 IRAK1 56 incurable genetic 56 LRP6 56 monogenic diabetes 56 endostatin 56 Trichomonas vaginalis 56 astrocytic 56 LDL receptor 56 glutamate signaling 56 inherited neurodegenerative 56 epithelial cancers 56 atypical hemolytic uremic syndrome 56 amnestic MCI 56 epigenetic modifications 56 myoclonus 56 clefting 56 autoantigen 56 KIF6 gene 56 mitochondrial toxicity 56 Irritable bowel syndrome IBS 56 Systemic lupus erythematosus SLE 56 airway remodeling 56 constitutively active 56 metaplasia 56 Cockayne syndrome 56 hematopoietic cells 56 diabetic kidney 56 incurable neurological 56 secretory pathway 56 hyperplastic 56 mRNA decay 56 ApoE4 56 genetic locus 56 neoplasm 56 BMPR2 56 dysbindin gene 56 Relapsing remitting 56 chromosome rearrangements 56 lung fibrosis 56 systemic autoimmune 56 cognitive deficits 56 pheochromocytoma 56 dysregulated 56 neuroligins 56 demyelinating disease 56 TGF beta signaling 55 glial cell 55 arthritis RA 55 TP# gene 55 S#A# [002] 55 Fatty liver 55 fibrotic disease 55 ARID1A 55 uveal melanoma 55 multisystem disease 55 Bulimia nervosa 55 APOE genotype 55 PB1 F2 55 amyloids 55 Autoimmune diseases 55 Mutational 55 GPR# [002] 55 Retinopathy 55 KLF# 55 tumor suppressor gene 55 SGK1 55 prognostic markers 55 metabolic enzymes 55 pancreatic endocrine 55 Nedd4 55 Muscular dystrophy 55 motor neuron 55 Chlamydia pneumoniae 55 Arrhythmogenic Right Ventricular Cardiomyopathy 55 neuritic plaques 55 BRAF protein 55 HLA genes 55 5 HTTLPR 55 apolipoprotein E 55 mediated apoptosis 55 IL 1ß 55 copper zinc superoxide 55 malignant pancreatic 55 Uveal melanoma 55 insulin resistance syndrome 55 nicotinic receptor 55 Amyloid 55 neurocognitive deficits 55 poorer prognosis 55 genetic variants 55 dopaminergic neurons 55 SCD1 55 Hedgehog signaling 55 allograft rejection 55 systemic scleroderma 55 homozygote 55 hypovitaminosis D 55 SOD1 protein 55 optica 55 HCV infection 55 hypometabolism 55 HLA DR4 immune 55 neurosyphilis 55 beta catenin protein 55 neuroprotective therapies 55 Parkinsons disease 55 seminomas 55 hepatic fibrosis 55 myalgic encephalomyelitis ME 55 T#I [002] 55 epigenome 55 leptin resistance 55 pRb 55 LPA1 55 telomere shortening 55 papillary thyroid cancer 55 postoperative delirium 55 SIRT1 gene 55 Mycoplasma pneumoniae 55 Creutzfeld Jakob disease 55 herpes viruses 55 Dystrophin 55 chemokine receptor 55 Irritable bowel syndrome 55 Korsakoff syndrome 55 Hereditary angioedema HAE 55 Hemolytic Uremic Syndrome HUS 55 costimulatory 55 Amyloid Beta 55 myositis 55 Medulloblastoma 55 Lou Gehrigs disease 55 Pervasive Developmental Disorder 55 cystatin 55 Diabetic nephropathy 55 dementias 55 behavioral abnormalities 55 Atopic dermatitis 55 CAG repeats 55 nongenetic 55 steatohepatitis 55 CYT# potent vascular disrupting 55 genomic variation 55 M. pneumoniae 55 TXNIP 55 idiopathic PAH 55 malignant pleural mesothelioma 55 luminal cells 55 polyglutamine diseases 55 pDCs 55 Metastases 55 synaptic dysfunction 55 Notch signaling 55 chromosome #q# [002] 55 myasthenia gravis MG 55 IRF6 55 fungoides 55 Major depressive disorder 55 Vitamin D insufficiency 55 amyloid beta proteins 55 polymorphic ventricular tachycardia 55 genes encoding 55 JAK2 gene 55 BRCA1 mutations 55 Alleles 55 hereditary degenerative 55 Leber congenital amaurosis LCA 55 JAK2 enzyme 55 generalized vitiligo 55 Oxidative stress 55 HSV1 55 Cyclin D1 55 autonomic dysfunction 55 embryonal rhabdomyosarcoma 55 glioblastoma tumors 55 pathogenesis 55 CYP#B# 55 p# mutation 55 Inflammatory Bowel Disease 55 R#W [002] 55 genomic alterations 55 mild cognitive impairment 55 biochemical mechanisms 55 etiological 55 prion infection 55 #p# [003] 55 liver scarring 55 amyloid beta protein